Abstract: The present invention provides a labeling method for improving signal intensity of time-resolved fluorescence; and the labeling method can be applied in the detection of olaquindox or gentamicin. The olaquindox antibody complex immunolabelled by time-resolved fluorescence prepared in the present invention has a more stable structure, stronger fluorescence signal, and higher detection sensitivity.
Abstract: Ossicular prostheses, and methods for producing such, are disclosed for treatment of middle ear damage caused by a malady of the middle ear such as cholesteatoma. The ossicular prostheses comprises a strut component attached to a disc via a rigid or flexible connecting joint. The strut is attachable to a head or footplate of a subject's stapes. The disc is attachable to the subject's existing tympanic membrane, or, alternatively, to an artificial tympanic membrane graft. In some embodiments, a scaffold is used to support the ossicular prosthesis and the tympanic membrane graft.
Type:
Grant
Filed:
January 21, 2020
Date of Patent:
April 22, 2025
Assignee:
The Board of Regents of the University of Oklahoma
Inventors:
Rong Z. Gan, Betty Tsai Do, Marcus A. Brown
Abstract: The present invention relates to the technical field of electrocatalytic electrode preparation, and discloses a lead dioxide-carbon nanotube adsorptive electrochemical submicroelectrode, a preparation method, and use thereof. The electrochemical submicroelectrode according to the present invention comprises multiple layers of orderly arranged spherical lead dioxide submicroholes communicating with each other, where the carbon nanotubes are partially or completely inserted (in the form of twigs) in the lead dioxide hole and in the wall of the hole. The combined effect of adsorption and catalysis inside the submicroreactor effectively solves the problems of low catalytic efficiency and diffusion control associated with the conventional flat lead dioxide electrode, thus greatly improving the electrochemical catalytic performance of the electrode.
Type:
Grant
Filed:
September 2, 2020
Date of Patent:
April 22, 2025
Assignee:
NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY
Abstract: Wood template-supported phase change material (PCM) composite having thermal energy storage applications. A wood template-supported PCM may include a wood template that has had at least a portion of its xylan and/or lignin removed and saturated with a PCM. The PCM may be stabilized with a cross linkable network for improved infiltration into the wood template. The wood template-supported PCM composite may be formed by extracting xylan and/or lignin from the wood to create a wood template, densifying at least a portion of the wood template, and inserting a PCM into the wood template.
Type:
Grant
Filed:
September 30, 2022
Date of Patent:
April 22, 2025
Assignees:
Alliance for Sustainable Energy, LLC, Board of Regents, The University of Texas System
Inventors:
Shuang Cui, Charles William Booten, Judith Cecilia Vidal, Yudong Li, Kyle Edward O'Neil Foster, Xiaowen Chen, Kelsey Mary Lynch, Hongbing Lu, Bernadette Karen Magalindan, Gustavo Felicio Perruci
Abstract: A method of delivering cells to a target tissue is provided comprising depositing a hydrogel pre-gel comprising magnetic particle-loaded cells to the target tissue and, prior to or during gelation of the hydrogel, drawing the magnetic particle-loaded cells to the tissue with a magnetic field, followed by gelation of the hydrogel to lock the cells in place on the tissue. The cells may be mesenchymal stem cells, such as adipose-derived mesenchymal stem cells, and the target tissue may be adventitial tissue of an aneurysm in a blood vessel. Also provided are devices useful in the method.
Type:
Grant
Filed:
October 18, 2019
Date of Patent:
April 22, 2025
Assignees:
University of Pittsburgh—Of the Commonwealth System of Higher Education, Vanderbilt University
Inventors:
David A. Vorp, Aneesh Krishna Ramaswamy, Justin Sol Weinbaum, Kory James Blose, Timothy Kwang-Joon Chung, Trevor Kickliter, Yogev Baruch, John A. Curci
Abstract: A method is described for improving water retention in soil, which involves mixing a super absorbing resin (SAR) composite with the soil. The SAR composite comprises a natural pozzolan and at least one polymer or copolymer. The SAR composite may be in the form of granules having an average longest dimension of 0.2-10 mm, though the SAR composite may be pelletized or formed in other sizes. The SAR composite may release water at a faster rate in a soil when exposed to drought conditions.
Type:
Grant
Filed:
May 12, 2022
Date of Patent:
April 22, 2025
Assignee:
Imam Abdulrahman Bin Faisal University
Inventors:
Ayhan Bozkurt, Omer Aga, Huseyin Tombuloglu, Ismail Anil, Seyda Tugba G. Anil
Abstract: Apparatuses, systems, and methods for Raman spectroscopy are described. In certain implementations, a spectrometer is provided. The spectrometer may include a plurality of optical elements, comprising an entrance aperture, a collimating element, a volume phase holographic grating, a focusing element, and a detector array. The plurality of optical elements are configured to transfer the light beam from the entrance aperture to the detector array with a high transfer efficiency over a preselected spectral band.
Type:
Grant
Filed:
May 18, 2023
Date of Patent:
April 22, 2025
Assignee:
Wayne State University
Inventors:
Gregory William Auner, Michelle Ann Brusatori, Changhe Huang
Abstract: The present disclosure to an electrolyte membrane containing a polyfluorene-based ionomer, and more particularly, to an electrolyte membrane containing a polyfluorene-based ionomer which has a fluorene main chain composed of only a carbon-carbon bond and a side chain composed of a perfluorosulfonic acid group. The electrolyte membrane containing the polyfluorene-based ionomer has high proton conductivity, excellent chemical durability, excellent mechanical property, and excellent volume stability.
Type:
Grant
Filed:
September 13, 2021
Date of Patent:
April 22, 2025
Assignees:
Hyundai Motor Company, Kia Corporation, Industry-Academic Cooperation Foundation Gyeongsang National University
Inventors:
Il Seok Chae, Jong Kil Oh, Bo Ki Hong, Ki Hyun Kim, Soon Ki Kwon, Mi Jeong Kim, Han Sol Ko
Abstract: The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.
Type:
Grant
Filed:
March 8, 2023
Date of Patent:
April 22, 2025
Assignee:
University of Central Florida Research Foundation, Inc.
Abstract: The present disclosure generally relates to a method of manufacturing a spiral sheet product via an additive manufacturing process, the method comprising: obtaining an electronic file representing a geometry of the spiral sheet product; and controlling an additive manufacturing apparatus to manufacture, via the additive manufacturing process, the spiral sheet product according to the geometry specified in the electronic file. The geometry of the spiral sheet product comprises: a geometric model of a spiral body revolving around a longitudinal axis, the spiral body comprising spiral sections repeating along the longitudinal axis; each spiral section comprising unit cells repeating along a spiral length of the spiral section; and each unit cell comprising a geometric pattern, such that the repetitive geometric pattern functionalizes the spiral sheet product that is arrangeable into a flat sheet product that is larger than a build chamber of the additive manufacturing apparatus.
Type:
Grant
Filed:
August 23, 2021
Date of Patent:
April 22, 2025
Assignee:
Nanyang Technological University
Inventors:
Wen See Tan, Jia An, Tzyy Haur Chong, Chee Kai Chua
Abstract: The disclosure discloses a strain of Lactobacillus crispatus capable of preventing and/or treating Helicobacter pylori infection, and belongs to the technical fields of microorganisms and medicine. The disclosure provides a strain of Lactobacillus crispatus CCFM1118. The Lactobacillus crispatus CCFM1118 can inhibit Helicobacter pylori, specifically embodied in that: (1) the diameter of an inhibition zone of supernatant of the Lactobacillus crispatus CCFM1118 on Helicobacter pylori can reach 13.14 mm; and (2) the Lactobacillus crispatus CCFM1118 can significantly reduce the adhesion of Helicobacter pylori to AGS cells. Therefore, the Lactobacillus crispatus CCFM1118 has great application prospects in inhibiting Helicobacter pylori (not for the purposes of disease diagnosis and treatment) and preparing Helicobacter pylori inhibitors.
Abstract: An integrated device and a method for continuously capturing, storing and separating a flue gas in an underground rock stratum are provided. An injection well, a monitoring well and an emission well are arranged in sequence at locations from near to far from a flue gas emission source. The injection well, the monitoring well and the emission well are respectively drilled to different depths in a storage rock stratum. A horizontal injection channel is arranged at bottom end of the injection well. During migrating the flue gas in the storage rock stratum, CO2 and sulfur nitride are absorbed by a rock porous medium and gradually enriched, and meanwhile, the CO2 and sulfur nitride, after chemically reacting with water, minerals and biomass in a rock, are gradually mineralized to achieve storage; and separated N2 is gradually migrated upwards to the emission well to achieve separation.
Abstract: A sensing circuit for detecting hardware trojans in a target integrated circuit is provided. The sensing circuit includes an array of magnetic tunnel junction circuits where each magnetic tunnel junction circuit including one or more magnetic tunnel junctions. Characteristically, each magnetic tunnel junction circuit configured to provide data for and/or determine a temperature map or a current map of the target integrated circuit.
Abstract: A drug for the prevention or treatment of sepsis is provided. The drug comprises an exosome containing a circRNA MOTOR, and a nucleotide sequence corresponding to the circRNA MOTOR is shown in SEQ ID NO: 1.
Type:
Grant
Filed:
November 21, 2024
Date of Patent:
April 22, 2025
Assignee:
SOUTHEAST UNIVERSITY
Inventors:
Wei Huang, Haibo Qiu, Ke Fang, Jianfeng Xie, Ling Liu, Yi Yang, Ran Yang
Abstract: The present invention relates to a Si-containing high-strength and low-modulus medical titanium alloy, and an additive manufacturing method and use thereof. The additive manufacturing method comprises alloy ingredient design, powder preparation, model construction and substrate preheating, and additive manufacturing molding; wherein the Si-containing high-strength and low-modulus medical titanium alloy is designed in the ingredient proportion of Ti 60-70 at. %, Nb 16-24 at. %, Zr 4-14 at. %, Ta 1-8 at. %, Si 0.1-5 at. %.
Type:
Grant
Filed:
October 29, 2020
Date of Patent:
April 22, 2025
Assignee:
South China University of Technology
Inventors:
Yuanyuan Li, Chao Yang, Xuan Luo, Dongdong Li, Yanguo Qin, Ning Li
Abstract: A method of making high performance concrete, the method may include adding ground glass powder (GP), nanosilica (nS) powder, cement, silica fume, fly ash, and sand to create a homogenized mixture. The method may also include homogenizing the mixture by mixing and adding water and superplasticizer to the homogenized mixture to obtain a slurry. The method may also include mixing the slurry until a high flowability mixture is obtained. The method may then include adding a first microsteel fiber (T1) to the high flowability mixture; adding a second microsteel fiber (T3) to the high flowability mixture; adding a third microsteel fiber (T4) to the high flowability mixture; and casting the high flowability mixture.
Type:
Grant
Filed:
October 18, 2024
Date of Patent:
April 22, 2025
Assignee:
KING SAUD UNIVERSITY
Inventors:
Mohammad Iqbal Khan, Galal Mohamed Fares, Yassir Mohammed Abbas
Abstract: Methods and apparatus for electrochemical analysis of water include acid cleaning a quartz crystal microbalance (QCM), stabilizing a QCM in analyte solution, and analyzing the solution by chronoamperometry and measuring a frequency shift of the QCM. The method may further include cleaning the QCM in an acid solution prior to stabilizing the QCM in analyte solution. The apparatus may provide at least semi-automated electrochemical analysis of water including determining a concentration of an analyte in a water sample, and communicating the concentration of the analyte over a network. The analyte may be manganese.
Type:
Grant
Filed:
February 28, 2023
Date of Patent:
April 22, 2025
Assignee:
Queen's University at Kingston
Inventors:
Yu Pei, Zhe She, Sarah Jane Odessa Payne
Abstract: Embodiments of the present disclosure provides a method and device for constructing a multi-dimensional coupled vibration identification model for a roll system of a strip mill, the method comprising: performing preprocessing, signal decomposition, and reconstruction of the multi-dimensional data for the roll system of the strip mill monitored through technical monitoring by multiple sensors during a working process of the strip mill, and performing feature extraction of the reconstructed data using a wavelet packet energy approach; obtaining an initial multi-dimensional coupled vibration feature local identification model for the roll system of the strip mill based on Support Vector Machine (SVM) by using a Gaussian radial basis function as a kernel function of the SVM model; and training the initial multi-dimensional coupled vibration feature local identification model for the roll system of the strip mill using a multi-source heterogeneous information fusion approach based on the feature vector to obtain t
Abstract: The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with the expression of the glycosyl-phosphatidylinositol (GPI)-linked GDNF family protein ?-receptor 4 (GFR?4).
Type:
Grant
Filed:
September 27, 2023
Date of Patent:
April 22, 2025
Assignees:
The Trustees of the University of Pennsylvania, University of Florida Research Foundation, Incorporated
Inventors:
Donald L. Siegel, Vijay Bhoj, Christoph Rader, Rebecca Goydel
Abstract: A method and system for 3D contour reconstruction of AM parts based on light field imaging, belonging to the field of image reconstruction technology is provided. The method includes constructing an EPI-UNet framework, where a preset light field dataset is used to construct a training set, learning labels from the disparity maps corresponding to the preset light field dataset are obtained, and EPI-UNet framework is trained to obtain a predicted disparity vector with the training set and learning labels. Two mappings including disparity and depth mapping, and disparity and 3D mapping, are established to get 3D contour of the AM part. The experiments of validation for accuracy and 3D contour reconstruction of AM parts were performed. By applying light field multi-view vision to the AM process and combining the rich angle and spatial domain view information of the light field, this disclosure provides a reliable quality assurance for AM monitoring.