Abstract: A renal tube assay device can include: a container having an inlet port and an outlet port; a matrix material in the container; and a lumen in the matrix material extending from the inlet port to the outlet port. The lumen can include a luminal surface with at least one low density region that has a lower density compared to another adjacent region of the matrix material that is located at least partially around the at least one low density region. The low density region can have a form of a bubble, bulge, capsule, or the like. The low density region can bulge into the lumen. A port can be adapted for receiving a pipette tip. The matrix material can include a hydrogel. The container can be located in a cell culture dish.

Abstract: The present invention relates to the field of intelligent vehicles, and more specifically, to a human-machine shared control method based on trajectory prediction. It comprises: establishing a road-vehicle model based on vehicle-related parameters and then designing a path-tracking controller; further predicting the driver's driving trajectory, evaluating the driving risk, and switching the control power between the automatic system and the human driver based on the driving risk. The present invention ensures that when the driver's inputs will cause high risk to the vehicle, the driver's input is deprived of; and that when the driver's driving inputs will not cause high risk to the vehicle, the driving is carried out by the driver, so that in the case where the automatic system is having a problem, the driver can effectively realize a safe intervention, and the safety of the intelligent driving is improved.

Abstract: Disclosed herein transgene construct comprising (i) a first nucleotide sequence, wherein the activity of the protein encoded by said first nucleotide sequence causes death of germ cells in the presence of an exogenous induction agent and (ii) a second nucleotide sequence which targets said construct to avian germ cells, methods of using the same and a transgenic avian provided by such methods.

Abstract: In some embodiments, the systems and methods of the disclosure can efficiently and accurately classify neurodegenerative disorder(s) and/or movement disorder(s) of a subject (e.g., a patient) using at least quantitative features associated with one or more regions of interest determined from one or more sets of image data of the subject's brain. The method may include processing one or more sets of MRI image data of the subject's brain to extract one or more quantitative features for one or more regions. The one or more quantitative features may include a first quantitative and a second quantitative feature. The method may further include classifying at least the one or more quantitative features into one or more classes associated with neurodegenerative dementia disorder, neurodegenerative movement disorder, non-neurodegenerative movement disorder and/or heathy control. The method may include generating a report including a classification of at least the one or more quantitative features.

Abstract: The invention provides a compound of formula (I): or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, wherein R1-R6 have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as contraceptive agents.

Abstract: A method for predicting remote sensing image time series based on reservoir computing utilizes temporal spectral information of remote sensing images to study prediction methods for high-dimensional short-term sequences. Based on the theoretical model of a nonlinear dynamical system and using the spatiotemporal transformation equation and its conjugate equation, a multi-layer reservoir computing model is constructed to achieve multi-step prediction on a time dimension. Only a small number of short-term samples are required to predict dynamic temporal information. Compared with the traditional neural network training process, the method is low-cost training. Different from traditional reservoir computing, the method converts the observed high-dimensional data into reservoir computing and uses intrinsic dynamics of the observation/target system to analyze remote sensing time series data.

Abstract: A surgical instrument may include a multi-lumen catheter configured to be inserted within the tissue. The multi-lumen catheter may include a first lumen that may enable a flow of a fluid, a second lumen that may receive a navigation probe that may facilitate an ability to locate the region of interest within the tissue, and an expandable membrane that may be situated toward a distal end of the first lumen to form an expandable cavity. The expandable cavity may be configured to expand or contract based on the flow of the fluid through the first lumen. The surgical instrument may include a fluid line, coupled to the first lumen, that may supply the fluid to the first lumen to enable the expandable cavity to expand or withdraw the fluid from the first lumen to enable the expandable cavity to contract.

Abstract: Methods and compositions for increasing one or more plant growth characteristics in a plant are disclosed. The compositions comprise one or more microbial isolates that promote plant growth. Methods include providing an effective amount of a composition comprising one or more microbial isolates that promote one or more plant growth characteristics.

Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

Abstract: The present invention belongs to the field of new material technology and relates to a bismuth/bismuth titanate heterojunction hollow nanospheres and methods for preparing the same and applications thereof. The bismuth/bismuth titanate heterojunction hollow nanospheres is obtained by adding a bismuth salt and tetrabutyl titanate into an organic solvent, mixing evenly, adding an inorganic alkali solution to generate a precipitation, then sequentially adding an organic amine and an organic acid, performing a solvothermal treatment to obtain bismuth titanate hollow nanospheres, and then thermally reducing the bismuth titanate hollow nanospheres with a borohydride under an inert atmosphere. The bismuth/bismuth titanate heterojunction hollow nanospheres provided not only exhibit significant photocatalytic activity in degrading tetracycline hydrochloride but also enable a tighter binding of the metal to the photocatalytic material, thus offering superior structural stability.

Abstract: Provided herein are isolated nucleic acids that encode a stable form of Rrm2 for the use of increasing the intracellular Rrm2 protein levels and cytosolic 2-deoxy-ATP (dATP) levels. Further provided herein are methods for treating a cardiac disease or disorder, e.g., myocardial infarction or myocardial ischemia, by administering the isolated nucleic acids, a polypeptide encoded by the isolated nucleic acids, or composition comprising the isolated nucleic acids to a subject in need thereof.

Abstract: Disclosed is a unit cell circuit of a memory cell array, the unit cell circuit having a sub-cell array including a plurality of memory cells each connected to a supply line, and an assist circuit connected to the sub-cell array through the supply line that pre-charges the supply line with a supply voltage during a stand-by mode based on a control signal and blocks the supply line upon initiation of a write operation.

Abstract: A measuring apparatus for a concrete structure includes an eddy current sensor configured to contact the concrete structure; a ground penetrating radar (GPR) sensor configured to contact the concrete structure; at least one memory storing one or more instructions; and a controller operably connected to the eddy current sensor, the GPR sensor, and the at least one memory, wherein the one or more instructions, when executed by the controller, cause the apparatus to: provide a first input signal to the eddy current sensor and a second input signal to the GPR sensor, obtain a first moisture content of a portion of the concrete structure based on an output of the eddy current sensor, obtain a second moisture content of the portion of the concrete structure based on an output of the GPR sensor, and obtain a final moisture content of the portion of the concrete structure based on at least one of the first moisture content and the second moisture content.

Abstract: The present invention provides a compound having the structure wherein A is a ring structure, with or without substitution; X1 is C or N; X2 is N, O, or S; Y1 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 2 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y3 is H-(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 4 is H-(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y5 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); a and P are each present or absent and when present each is a bond.

Abstract: Systems, methods, and devices disclosed herein include three-dimensional bioprinting technologies which produce cell scaffolds with a high degree of complexity and precision. A bioprinting ink mixture can be formed with coated gold nanoparticles in an alginate-gelatin solution. Upon bioprinting a 3D scaffold microstructure from the bioink mixture, an imaging procedure is performed on the 3D scaffold microstructure using the coated gold nanoparticles as a contrasting agent. A microstructure characterization is determined from the imaging procedure, and a virtual 3D reconstruction of the microstructure characterization can be generated for presentation on a graphical user interface (GUI) of a computing device.

Abstract: The present invention provides non-peptide compounds that mimic the streptococcal SspB Adherence Region (BAR) and function as inhibitors of P. gingivalis adherence to streptococci. The invention also provides methods of making and using the inhibitors.

Abstract: A liquid crystal alignment member for spatial light phase modulation includes: a silicon substrate; a base portion including pixel electrodes arranged in a matrix with a period of 3 ?m or less; a lattice-shaped wall structure configured by a dielectric material; a base layer connected to the lattice-shaped wall structure; and a plurality of liquid crystal-filling microspace separated from each other by the lattice-shaped wall structure, wherein the lattice-shaped wall structure is arranged at least between adjacent pixel regions; the liquid crystal-filling microspace includes a shape anisotropy in a first axial direction and a second axial direction in a plane parallel to the base portion; when WA is a space width of the first axial direction and WB is a space width of the second axial direction, WA is smaller than WB; and a base groove extending to the second axial direction is formed in the base layer.

Abstract: Disclosed herein are new metallated MOF catalysts, preferably, Rh-PCM-101 or Rh-AsCM-102, as well of methods using such catalysts in hydroformylation reactions and in tandem hydroformylation/enolization reactions. In a specific embodiment, a metallated phosphine MOF catalyst according to the disclosure, preferably Rh-PCM-101, is used in a single-step hydroformylation process to transform propene into 2-ethyl-2-hexenal.

Abstract: Crosslinked films having electro-optic activity, compositions and compounds for making the films, methods for making the films, and devices that include the films are disclosed.

Abstract: The present disclosure provides a method for evaluating a geological storage amount of carbon dioxide (CO2) in a fractured-vuggy carbonate reservoir, including: performing image identification on a three-dimensional scanned image of a rock sample to obtain identified rock information; inputting the identified rock information to a computational fluid dynamics-based numerical simulator for constructing a fractured-vuggy rock structure model, and obtaining geometric topological information of the rock sample based on the fractured-vuggy rock structure model; inputting relevant parameters of the rock sample and the geometric topological information to a multi-scale multi-phase flow numerical model for numerical simulation of multi-phase flow migration of CO2 in models of different scales and obtaining a multi-scale numerical simulation result; and calculating a multi-scale CO2 storage efficiency based on the multi-scale numerical simulation result.