Abstract: A device includes a detector transistor, a sensing pad, a first conductive ring, a second conductive ring, a first transistor, and a second transistor. The sensing pad is over the detector transistor. The first conductive ring is over the sending pad. The second conductive ring is over the first conductive ring. The first transistor has a source/drain region electrically coupled to the first conductive ring. The second transistor has a source/drain region electrically coupled to the second conductive ring.

Abstract: A droplet gripper for a polarizable droplet including a top plate formed of magnetically responsive material and movable in a defined sequence in response to a regionalized electromagnetic field. The gripper further has electret sheets downwardly depending from the top plate. The electret sheets are separated from each other and are chargeable to the same polarities so as to capture the droplet between them due to electret-induced polarization on droplet (EPD). The gripper may be included in a Multiphysics droplet robotic system for automatically manipulating and moving a liquid droplet. The system includes a programmable control matrix that generates a movable regionalized electromagnetic field through coils so as to engage the magnetic material on the top plate and move the EPD gripper and a captured polarizable drop in the defined sequence along a specific path as well as to achieve other microfluidic operations according to a control matrix program.

Abstract: Systems and methods are provided for trapping and electrically monitoring molecules in a nanopore sensor. The nanopore sensor comprises a support structure with a first and a second fluidic chamber, at least one nanopore fluidically connected to the two chambers, and a protein shuttle. The protein shuttle comprises an electrically charged protein molecule, such as Avidin. The nanopore can be a Clytosolin A. A method can comprise applying a voltage across the nanopores to draw protein shuttles towards the nanopores. The ionic current through each or all of the nanopores can be concurrently measured. Based on the measured ionic current, blockage events can be detected. Each blockage event indicates a capture of a protein shuttle by at least one nanopore. Each blockage event can be detected through a change of the total ionic current flow or a change in the ionic current flow for a particular nanopore.

Abstract: Disclosed herein are devices comprising stretchable interdigitated electrode arrays and methods for fabricating the devices. The devices are capable of acting as elongation sensors by sensing a change in the capacitance of the device as the distance between the interdigitated fingers changes when the device is elongated or compressed. The device may be coupled to other devices such as to be able to sense elongation or compression of the coupled device. The interdigitated fingers of the device are supported by a substrate and may be fabricated using traditional microfabrication techniques.

Abstract: Six-membered high-entropy foam for hydrogen production by water splitting and preparation method are provided. The foam consists of Ni, Fe, Cu, Co, Mo, and Pt, comprising 10 at %-25 at % of Ni, 10 at %-25 at % of Fe, 10 at %-25 at % of Cu, 10 at %-25 at % of Co, 10 at %-25 at % of Mo, and 10 at %-25 at % of Pt. Catalyst loading of the foam can reach a range of 0.8 mg/cm2-3.2 mg/cm2, which is much higher than the effective catalyst loading of most nano-catalysts. When used as catalyst for hydrogen production by water splitting, the hydrogen evolution overpotential of the surface of the six-membered high-entropy foam is within a range of 36 mV-60 mV, and the foam operates stably at industrial-level current density (500 mA/cm2). The preparation method does not require harsh environment such as high temperature or high vacuum, making the method simple and easy to implement, with low-cost raw materials.

Abstract: Various embodiments relate generally to the field of nucleic acid amplification and detection, in particular loop-mediated isothermal nucleic acid amplification and the detection of amplicons using designed detection probes. Moreover, various embodiments also relate to methods and kits for determining the presence or quantity of point mutations in a target nucleic acid molecule in a sample using loop-mediated isothermal amplification, which may be used for identifying genetic variants. In one aspect, the detection probe is a single-stranded probe comprising a nucleotide sequence fully complementary to a nucleotide sequence of the probe binding site comprising the point mutation. In another aspect, the detection probe comprising a nucleotide complementary to the point mutation at the penultimate base relative to the 3? end of the detection probe.

Abstract: Disclosed is a unit cell circuit of a memory cell array, the unit cell circuit having a sub-cell array including a plurality of memory cells each connected to a supply line, and an assist circuit connected to the sub-cell array through the supply line that pre-charges the supply line with a supply voltage during a stand-by mode based on a control signal and blocks the supply line upon initiation of a write operation.

Abstract: The present invention belongs to the field of new material technology and relates to a bismuth/bismuth titanate heterojunction hollow nanospheres and methods for preparing the same and applications thereof. The bismuth/bismuth titanate heterojunction hollow nanospheres is obtained by adding a bismuth salt and tetrabutyl titanate into an organic solvent, mixing evenly, adding an inorganic alkali solution to generate a precipitation, then sequentially adding an organic amine and an organic acid, performing a solvothermal treatment to obtain bismuth titanate hollow nanospheres, and then thermally reducing the bismuth titanate hollow nanospheres with a borohydride under an inert atmosphere. The bismuth/bismuth titanate heterojunction hollow nanospheres provided not only exhibit significant photocatalytic activity in degrading tetracycline hydrochloride but also enable a tighter binding of the metal to the photocatalytic material, thus offering superior structural stability.

Abstract: Provided herein are isolated nucleic acids that encode a stable form of Rrm2 for the use of increasing the intracellular Rrm2 protein levels and cytosolic 2-deoxy-ATP (dATP) levels. Further provided herein are methods for treating a cardiac disease or disorder, e.g., myocardial infarction or myocardial ischemia, by administering the isolated nucleic acids, a polypeptide encoded by the isolated nucleic acids, or composition comprising the isolated nucleic acids to a subject in need thereof.

Abstract: Systems, methods, and devices disclosed herein include three-dimensional bioprinting technologies which produce cell scaffolds with a high degree of complexity and precision. A bioprinting ink mixture can be formed with coated gold nanoparticles in an alginate-gelatin solution. Upon bioprinting a 3D scaffold microstructure from the bioink mixture, an imaging procedure is performed on the 3D scaffold microstructure using the coated gold nanoparticles as a contrasting agent. A microstructure characterization is determined from the imaging procedure, and a virtual 3D reconstruction of the microstructure characterization can be generated for presentation on a graphical user interface (GUI) of a computing device.

Abstract: A composite material includes a polymer and a paint char material. The paint char material includes pyrolyzed paint sludge and in some forms is a hybrid paint char. The hybrid paint char includes lignin.

Abstract: Phonon engineered, lanthanide doped upconverting nanoparticles with very low phonon energies and tunable methods of synthesis that adjust OA:OM ratio and reaction temperature are provided. Low phonon energy KPb2X5 (X=Cl, Br) upconverting nanoparticles, both doped and undoped, exhibit dramatically suppressed multiphonon relaxation, enhancing upconversion emission from higher lanthanide excited states and enabling room temperature observation of avalanche like upconversion by Nd3+ ions. Intrinsic optical bistability (IOB) of the materials can provide bit level functionality to all optical computing. The IOB of Nd3+ doped nanocrystals, which are either bright or dark at the same excitation power based on power history, illustrate the functionality. High contrast switching and IOB are enabled via the photon avalanche process, which sustains population inversion between the ground and the first excited 4fN states of Nd3+ ions.

Abstract: Disclosed is a method for fast automatic calibration of a phased array based on a residual neural network. A phase setting matrix is set and an amplitude and a phase of a array far-field complex signal are measured with a network analyzer to obtain an amplitude and phase vector of the array far-field complex signal. A real part, an imaginary part, and a magnitude of the far-field measured complex signal value are separated and normalized, and mapped to RGB three-channel image data. Datasets are automatically generated according to a preset amplitude-phase error range by a simulation software, the datasets are proportionally divided into a training set and a test set to be input into the residual neural network for training to obtain a calibration model. Measured data is input into the calibration model for automatic estimation of the amplitude-phase error of the phased array.

Abstract: An acquisition unit acquires image data indicating at least a chest and an abdomen of a test subject. A detection unit detects the displacement of each of the chest and abdomen of the test subject by using the image data. A display control unit performs control so that the movement image of each of the chest and abdomen is displayed based on the detected displacement of the chest and abdomen. When the movement of the chest and the movement of the abdomen are synchronized with each other, the display control unit performs control so that the display form of the chest movement image and the display form of the abdomen movement image are the same as each other.

Abstract: An ultra-micro electrode that performs electrochemical analysis and a method of manufacturing the same is provided. The method includes preparing an insulating member having a capillary shape with a hollow region, preparing a conductive wire including a conductive material with an oxidation resistance greater than an oxidation resistance of copper, inserting the conductive wire into the hollow region of the insulating member, manufacturing half-finished products by applying heat and an external force to the insulating member having the conductive wire inserted therein to stretch the insulating member and the conductive wire so that a central portion of the insulating member is thin and the insulating member and the conductive wire are ruptured at central portions thereof, forming a groove by etching the conductive wire located on a ruptured surface of each half-finished product, and forming a filling layer by filling the groove with a conductive material by a plating process.

Abstract: Briefly, embodiments of an apparatus including at least one computing device that includes at least one processor and at least one non-transitory storage medium, for example, are described. The at least one non-transitory storage medium, in an embodiment, includes executable instructions stored thereon in which executing the instructions by the at least one processor are to result in processing sensor measurements, including images, from at least one optical sensor array, of at least one object. In an embodiment, for example, sensor measurements are processed with a three-dimensional pose estimation model to produce at least one substantially view-invariant morphometric measurement estimate of the at least one object.

Abstract: In an embodiment. the present disclosure pertains to environmental biospecimen recovery after in-droplet gel encapsulation (eBRIDGE) platforms for co-culturing multiple microorganisms in gel microspheres and then transferring single-cell-derived clonal populations from within the gel microspheres into separate water-in-oil emulsion droplets for further processing and analysis. In some embodiments. the gel-encapsulated bacteria are released by lysing the gel matrix using an enzyme. The methods of the present disclosure provide a single workflow that goes from environmental microbial harvesting and amplification to functional interrogation of their characteristics.

Abstract: The present invention provides a compound having the structure wherein A is a ring structure, with or without substitution; X1 is C or N; X2 is N, O, or S; Y1 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 2 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y3 is H-(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y 4 is H-(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); Y5 is H, -(alkyl), -(alkenyl), -(alkynyl), -(cycloalkyl), (haloalkyl), -(alkyl)-O-(alkyl) or -(alkyl)-(cycloalkyl); a and P are each present or absent and when present each is a bond.

Abstract: In a Byzantine computing environment in which a database is sharded or partitioned among multiple clusters of computing nodes, consensus for and execution of data transactions (e.g., transactions that require and/or affect data of one or more shards) are achieved in a resilient manner. Within some clusters, multiple primary replicas concurrently propose transactions for processing in parallel by all replicas. For some multi-shard transactions, shards involved in the transactions may be logically ring-ordered; each shard in turn achieves consensus among its nodes to commit the transactions, and then executes its portion of the operation after consensus is obtained among all shards. For some other multi-shard transactions, involved shards first determine whether local data constraints are satisfied, after which data modifications are made in parallel.

Abstract: A compound represented by chemical formula 1, a salt, a stereoisomer, a solvent or a hydrate thereof, an antibacterial composition including the compound, and uses thereof are disclosed. The antibacterial composition is suitable for inhibiting bacterial infections, preventing, alleviating or treating bacterial infectious disease, and for preventing, alleviating or treating inflammation caused by a bacterial infection. The compound specifically binds to p62 protein so as to activate p62, thereby increasing the activity of autophagy, which is inhibited by a bacterial infection, and thus has antibacterial activity against various bacteria, can inhibit bacterial infectivity and has the excellent effect of enabling prevention, alleviation or treatment of bacterial infectious disease and inflammation caused by an infection.