Abstract: This invention is about a cell-penetrating drug carrier and the application thereof. The mentioned cell-penetrating drug carrier can approach the target cell through using a proper recognizable sequence, so that the cell-penetrating drug carrier can be used to specifically delivery wanted drug to target cell. Through carrying wanted drug into the cytoplasm of the target cell by cell-penetrating peptide, the drug accumulation volume in the target cell can be efficiently increased. Preferably, through using proper bioinert polymer, the cell-penetrating peptide and the recognizable sequence can be kept from been digested before approaching the target cell.

Abstract: A checkpointing method for creating a file representing a restorable state of a virtual machine in a computing system, comprising identifying processes executing within the virtual machine that may store confidential data, and marking memory pages and files that potentially contain data stored by the identified processes; or providing an application programming interface for marking memory regions and files within the virtual machine that contain confidential data stored by processes; and creating a checkpoint file, by capturing memory pages and files representing a current state of the computing system, which excludes information from all of the marked memory pages and files.

Abstract: An organometallic complex and an organic light-emitting diode including the same, the organometallic complex being represented by Formula 1 below:

Abstract: The present invention relates a kit for detecting a nucleic acid and a method of detecting a nucleic acid for enabling a multiplexed-detection and real-time detection of a target nucleic acid by using properties of a graphene oxide.

Abstract: Described herein are devices and methods for high throughput purification of particles. In some cases, methods and devices described herein can be used to remove erythrocytes and purify leukocytes and raise the quality of umbilical cord blood and other transplant grafts, thereby significantly improving patient outcomes.

Abstract: An austenitic steel matrix-nanoparticle composite and a producing method thereof are provided. The composite includes: an austenitic steel matrix that includes an alloying element; and a nanoparticle that grows in situ in the matrix and that is formed in the matrix. The nanoparticle grows from the alloying element included in the austenitic steel matrix. The method includes: preparing an austenitic steel matrix including an alloying element; and heating the austenitic steel matrix. In the method, the nanoparticle grows in situ in the matrix from the alloying element which is solid-dissolved in the austenitic steel matrix by the heating.

Abstract: The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer. The methods also relate to generating a drug-resistant cytotoxic immune cell line and uses thereof in conjunction with cytotoxic drugs.

Abstract: A system and method for Machine-to-Machine (M2M) communication over a transmission medium, including a novel random access protocol that is easy to implement, energy efficient, scalable and compatible with the limited-power and low complexity requirements of IoT devices. The proposed protocol utilizes a form of multiple hypothesis testing at the IoT gateway to determine the number of active IoT devices operating in the transmission medium to optimize the power levels of a Successive Interference Cancellation (SIC) receiver in order to distinguish between signals transmitted from different IoT devices on the same time and frequency. The use of beamforming exploits the power and spatial domains without excessively increasing the SIC power levels and address channel access delay problems by reducing the probability of collision and consequently lowering the average back-off delay.

Abstract: An apparatus and computerized method optimizes or generates a sigma profile for a molecule by receiving a sigma profile for the molecule, calculating an activity coefficient for the molecule using the sigma profile for the molecule, calculating a solubility for the molecule using the activity coefficient for the molecule, optimizing or adjusting the sigma profile for the molecule by adjusting the sigma profile using an objective function and one or more constraints, providing the sigma profile to an output device communicably coupled to a processor.

Abstract: Techniques for opening a target tissue using nanodroplets are provided. An exemplary method can include targeting a region of tissue for opening, delivering a plurality of nanodroplets to the region, and applying an ultrasound beam at the region such that the nanodroplets cavitate, or convert to microbubbles that cavitate, thereby causing the target tissue to open.

Abstract: Synthesis of novel and unique PAMAM (poly-amidoamine) polymers. PAMAM polymers can be grown by systematic alternation between ethylenediamine (EDA) and methacrylate. By taking advantage of the alternating terminal ends, successive generations G1 and G0.5 were combined under acidic conditions with Pluronic P123 as a liquid-crystal template. The resulting polymer was imaged with TEM and the product was circular and amorphous of no characteristic size ranging between about 5 nm to about 600 nm, with remarkable electrochemical activity unseen in any of the generations of PAMAM. Applications of this electroactive poly-amidoamine organic polymer include use as a new electron transfer reagent for amperometric biosensors.

Abstract: Embodiments of the disclosure concern methods and compositions related to generation and/or use of proofreading reverse transcriptases, including those that are thermophilic or hyperthermophilic. The disclosure encompasses specific recombinant polymerases and their use. In some embodiments, the polymerases are utilized for RNA sequencing in the absence of generation of a cDNA intermediate.

Abstract: The magnetic adsorbent for organic pollution removal is an adsorbent material, preferably in the form of microcapsules, for adsorbing organic pollutants, such as methylene blue, onto the microcapsules from contaminated water. Each of the magnetic adsorbent microcapsules is formed from magnetic iron oxide (Fe3O4) particles embedded in a nitrogen-enriched porous carbon matrix. To make the magnetic adsorbent microcapsules, urea and formaldehyde are mixed to form a pre-polymer solution. Magnetic Fe3O4 is mixed with an aqueous epoxy resin in hexane to form a mixture, which is then sonicated and added to the pre-polymer solution to form a polymeric solution. A surfactant, such as sodium lauryl sulfate, is added to the polymeric solution to form a suspension of magnetic microcapsules. The magnetic microcapsules are washed, filtered and dried before annealing in a tube furnace to form the adsorbent microcapsules, which are then washed and dried.

Abstract: Circuits for self-powered image sensors are provided. In some embodiments, an image sensor is provided, the image comprising: a plurality of pixels, each of the plurality of pixels comprising: a photodiode having an anode and a cathode connected to a constant voltage level; a first transistor having: a first input connected to the anode of the photodiode; a first output connected to a reset bus; and a first control configured to receive a discharge signal; and a second transistor having: a second input connected to the anode of the photodiode; a second output connected to a pixel output bus; and a second control configured to receive a select signal; and a third transistor having: a third input coupled to each first output via the reset bus; a third output configured to be coupled to an energy storage device; and a third control configured to receive an energy harvest signal.

Abstract: The invention relates to quantum dot and photodetector technology, and more particularly, to quantum dot infrared photodetectors (QDIPs) and focal plane array. The invention further relates to devices and methods for the enhancement of the photocurrent of quantum dot infrared photodetectors in focal plane arrays.

Abstract: A method of forming an integrated circuit is disclosed. The method includes: (i) forming at least a pair of optoelectronic devices from at least a first wafer material arranged on a semiconductor substrate, the first wafer material different to silicon; (ii) etching the first wafer material to form a first recess to be filled with a second material; (iii) processing the second material to form a waveguide for coupling the pair of optoelectronic devices to define an optical interconnect; and (iv) bonding at least one partially processed CMOS device layer having at least one transistor to the second semiconductor substrate to form the integrated circuit, the partially processed CMOS device layer arranged adjacent to the optical interconnect. An integrated circuit is also disclosed.

Abstract: The invention includes methods and apparatuses for patient transfer from a rollable chair to a bed and back. A rollable chair includes a first frame having a seat; a second frame coupled to the first frame, the second frame having a backrest configured to move relative to the first frame; and a third frame coupled to the first frame, the third frame having a track having a curvilinear length configured to allow the first frame to rotate and to translate relative to the third frame. A bed includes a chair-receiving frame configured to couple to the first frame of the rollable chair. The rollable chair and the bed work in tandem to transfer a patient, for example using coordinated, automated motions.

Abstract: Some embodiments are directed to managing transactions in a computer system, which receives information indicating a first node has at least one right with regard to a second node such that the first node is associated with the second node. An identity network is created, based, on the association between the first node and the second node, representing undirected ties between a plurality of nodes, the plurality of nodes including at least the first and second node. Using the identity network, a rights network is created representing directed ties between the plurality of nodes based, at least in part, on the undirected ties of the identity network and the at least one right the first node has with regard to the second node. The rights network is used to determine whether a transaction initiated by the first node is permissible based, at least in part, on the rights network.

Abstract: The present invention introduces a new compact Voltage Regulator Module (VRM) solution that hybrids a buck converter with a resonant switched-capacitor auxiliary circuit that is connected at the load side. By using a new control concept of the present invention, the auxiliary circuit effectively mimics increased capacitance during loading and unloading transient events, reducing the burden on both the input and output filters, and reduces the current stress.

Abstract: Provided are a composition for inhibiting growth or proliferation of chronic myelogenous leukemia (CML) cancer stem cells, a pharmaceutical composition for preventing or treating CML, a method for preventing or treating CML, and a method of screening for a growth or proliferation inhibitor of CML cancer stem cells by blocking nutrient signaling in CML cancer stem cells.