Abstract: A method of fabricating composite filaments is provided. An initial composite filament including a core and a cladding (such as a Pt-group metal) is cut into smaller pieces (or is first mechanically reduced and then cut into smaller pieces). The smaller pieces of the filaments are inserted into a metal matrix, and the entire structure is then further reduced mechanically in a series of reduction steps. The process can be repeated until the desired cross sectional dimension of the filaments is achieved. The matrix can then be chemically removed to isolate the final composite filaments with the cladding thickness down to the nanometer range. The process allows the organization and integration of filaments of different sizes, compositions, and functionalities into arrays suitable for various applications.

Abstract: Mouth guards having electrodes, sensors, and/or accelerometers for determining one or more physiological conditions of a subject. Processing circuitry receives the outputs of the electrodes, sensors, and/or accelerometers. Optionally, at least a portion of the processing circuitry can be positioned within a helmet that is worn by a subject. The mouth guard can optionally be tethered to the helmet.

Abstract: A three-dimensional data processing and recognizing method including scanning and re-constructing an object to be detected so as to obtain three-dimensional data for recognition of the object to be detected; and extracting data matching to features from the three-dimensional data, so that the extracted data constitutes an interested target in order to display and recognize the object to be detected. A quick method to recognize an object to be detected, such as the shapes of cuboid, cylinder, and cutting tool, and so on.

Abstract: Described herein is a method, and compositions useful with the method, of analyzing a tissue from a subject. The method includes contacting a probe conjugate (10) including a probe molecule (12), to a biological tissue 146 from a subject. The probe conjugate (10) is contacted with the biological tissue (14) under a well defined and easily controlled force field(s) and that tends to result in an interaction between the molecular probe (12) and the tissue (14) and/or tends to disrupt such interactions. The resulting interaction of the molecular probe (12) with the tissue (14) is then quantified. The analytical methods may be useful for diagnostic and prognostic applications as well as in the discovery of novel drug delivery systems and novel therapeutic substances and targets.

Abstract: A fiberized single photon sensitive spectrometer on a 32-channel PMT sensor is highly sensitive with broad detection dynamic range. The spectrometer enables accurate and high speed detection, identification and analysis of biological samples labeled with multiple fluorescent markers, such as compositions of multi-color fluorescence signals or radiation emitted by multiple fluorescence dyes. A fiberized optical input of the spectrometer allows an easy and efficient coupling to any measurement system based on fiber collection of the analyzed fluorescence. The spectrometer provides highly accurate DNA sequencing. A 32 channel PMT single photon detector has a detection dynamic range of more than 20 bits and has a frame rate of about 3300 frames per second. The dynamic range of the detector's pixels reaches 108 photocounts per second.

Abstract: Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences form HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.

Abstract: A method for minimizing power losses in an alternating current (AC) machine is provided. The method includes determining a first rotor flux signal based on signals of voltage and current inputs to the AC machine, and extracting a ripple component of the rotor flux signal. The method further includes determining a power compensating value that corresponds to a stored energy value of the AC machine, determining a second rotor flux signal that serves to minimize power losses, and providing the second rotor flux signal to a power inverting unit that adjust accordingly the voltage and current input signals provided to the AC machine.

Abstract: Disclosed are microfluidic devices and systems for the desalination of water. The devices and systems can include an electrode configured to generate an electric field gradient in proximity to an intersection formed by the divergence of two microfluidic channels from an inlet channel. Under an applied bias and in the presence of a pressure driven flow of saltwater, the electric field gradient can preferentially direct ions in saltwater into one of the diverging microfluidic channels, while desalted water flows into second diverging channel. Also provided are methods of using the devices and systems described herein to decrease the salinity of water.

Abstract: An electrolyzer device comprises a container configured to receive liquid to be electrolyzed; an anode arranged in the container and operatively connected to a power supply; a cathode arranged in the container so as to surround at least a portion of the anode and operatively connected to the power supply; a first pipe in liquid connection with the container, the first pipe including an intake port arranged in the vicinity of the cathode relative to the anode; and a second pipe in liquid connection with the container.

Abstract: The present invention relates to materials, methods and apparatuses for performing imprint lithography using amorphous metallic materials. The amorphous metallic materials can be employed as imprint media and thermoplastic forming processes are applied during the pattern transfer procedure to produce micron scale and nanoscale patterns in the amorphous metallic layer. The pattern transfer is in the form of direct mask embossing or through a serial nano-indentation process. A rewriting process is also disclosed, which involves an erasing mechanism that is accomplished by means of a second thermoplastic forming process. The amorphous metallic materials may also be used directly as an embossing mold in imprint lithography to allow high volume imprint nano-manufacturing. This invention also comprises of a method of smoothening surfaces under the action of the surface tension alone.

Abstract: The invention provides methods of identifying DNA methylation profiles for neurological and psychiatric conditions including autism spectrum disorders, methods of treating such conditions, and methods of identifying therapeutics for the treatment of such neurological and psychiatric conditions.

Abstract: Provided herein are methods for preventing or alleviating the symptoms of and inflammation associated with inflammatory diseases and conditions of the gastrointestinal tract, for example, those involving the esophagus. Also provided herein are pharmaceutical compositions useful for the methods of the present invention.

Abstract: An electrode system include a flowable and cohesive surface contact element comprising a hydrophilic polymer swollen with an electrolyte fluid, the contact element having a Q? ratio of at least 5 as defined by the equation Q ? = W W W G wherein WG is the dry weight of the hydrophilic polymer and WW is weight of water in the sample after absorption of the electrolyte fluid comprising water and an electrolyte salt. The surface contact element can consist essentially of the hydrophilic polymer swollen by the electrolyte fluid. Another electrode system includes a contact element including a crosslinked hydrophilic polymer matrix. The contact element has a Q? ratio of at least 5 as defined by the equation Q ? = W W W G . The contact elements can also have a Q? ratio of at least 6, at least 7, at least 10 or even at least 11.

Abstract: This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) Lumican and/or (ii) Extracellular matrix protein 1 and/or (iii) Carboxypeptidase N; and (c) comparing the amount(s) of the protein(s) to a baseline value that is indicative of the amount of the protein in a subject that does not have myocardial ischemia, wherein a statistically significantly increased amount of the protein(s) compared to the baseline value is indicative of myocardial ischemia. Other proteins indicative of myocardial ischemia are also described, as are methods for treating a subject based on a diagnostic procedure of the invention, and kits for carrying out a method of the invention.

Abstract: A long-distance polarization and phase-sensitive reflectometry based on random laser amplification for extending a sensing distance includes a long-distance polarization and phase-sensitive reflectometry of a distributed Raman amplification based on optical fiber random lasers generated by unilateral pumps, a long-distance polarization and phase-sensitive reflectometry of a distributed Raman amplification based on optical fiber random lasers generated by bilateral pumps, and a long-distance polarization and phase-sensitive reflectometry of a Raman amplification based on a combination of optical fiber random lasers generated by unilateral pumps and a common Raman pump source, which are applied in optical fiber perturbation sensing and have a capability of greatly improving a working distance of a sensing system and a high practicability.

Abstract: Provided is a damping device including a cylindrical body sealed with an inner cover and an outer cover at both ends, a support rod coupled to one end of the cylindrical body to perform an axial motion, the support rod including a moving plate having a damping orifice in the cylindrical body, the support rod including a nut configured to adjust a length of the support rod at an inner side end received in the cylindrical body, and a buffering device configured to store elastic energy in one of a first spring and a second spring based on a moving direction of the moving plate, the buffering device including the first spring inserted in the inner cover, the second spring inserted in the outer cover, and a lubricant in the cylindrical body.

Abstract: There is provided a communication system including a transmitting section and a receiving section which includes a plurality of receivers. The transmitting section includes a communication unit which receives a plurality of signals respectively from the plurality of receivers, and stores a plurality of time-reversed signals corresponding to the received plurality of signals with respect to the plurality of receivers, and a first conversion unit which converts, by a first factor, a plurality of information sequences to be respectively transmitted to the plurality of receivers and forward the plurality of converted information sequences to the communication unit. The communication unit generates, based on the plurality of converted information sequences, a plurality of output signals to be respectively transmitted to the plurality of receivers, each of the plurality of the output signals including a location-specific signature unique to the corresponding receiver.

Abstract: An apparatus, a method, and a recorded medium for conductivity and susceptibility reconstruction are disclosed. The apparatus for conductivity and susceptibility reconstruction includes: a susceptibility reconstruction part configured to reconstruct a susceptibility from a change in phase according to an increase in time of a multi-echo gradient echo image; a zero echo phase estimation part configured to estimate a phase at zero echo time based on a linearity of the phase change; and a conductivity reconstruction part configured to reconstruct a conductivity from the estimated zero echo phase. According to an embodiment of the invention, a multi-echo gradient echo sequence is used to not only obtain in vivo susceptibility but also obtain conductivity simultaneously. Also, an embodiment of the invention can improve the accuracy of the susceptibility measurements.

Abstract: There is provided a power factor correction circuit including: a power conversion circuit unit controlling an inductor current according to a switching signal applied to a main switch to convert an external input voltage into an output voltage having a predetermined range; an imbalance detection circuit outputting an imbalance state signal when the external input voltage is in an unbalanced state by using the inductor current; and a soft start circuit unit performing soft starting by adjusting the switching signal when the imbalance state signal is output by the imbalance detection circuit unit.

Abstract: Novel compounds which are derivatives of tetra-O-methyl nordihydroguaiaretic acid (NDGA), as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof are provided. These NDGA derivatives have a nitroimidazole moiety and these derivatives show preferential toxicity to hypoxic cells as hypoxic cytotoxins. Their cytotoxicity toward hypoxic cells is a result of abstraction of hydrogen from target molecules by free radicals formed in the reduction of the nitro group. This makes the disclosed compounds an effective anti cancer drug because hypoxic cells are generally considered to be more resistant to anti cancer drugs than normal cells. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment for cancers, including hepatocellular carcinoma, breast cancer and prostate cancer, are also provided.