Abstract: The invention provides nitrile-containing protease inhibitors caged to ruthenium compounds. The nitrile-caged ruthenium compounds provide inactivated inhibitors that can be delivered to surface or site for activation, for example, but exposure to light. The invention also provides methods for delivering protease inhibitors to subjects for the therapeutic treatment of conditions such as cancer.

Abstract: The present invention relates to shape memory polymers and waterborne coating materials and, more particularly, to waterborne shape memory polymer coatings.

Abstract: The present disclosure relates to an immune signature of tumor infiltrating leukocytes. In particular, the disclosure provides methods and kits for determining the immune signature of tumor infiltrating leukocytes for use in assessing risk of cancer recurrence and long term survival, and for developing a treatment regimen for a cancer patient.

Abstract: An aspect of the invention relates to a golf swing analyzing apparatus, comprising: an arithmetic section operating to use the output of an inertial sensor to calculate bending moment acting on the golf club, the inertial sensor being attached to the golf club.

Abstract: A method for fabricating a semiconductor device includes forming a first mask on a substrate, forming a first side wall of a fin by performing a first etching of the substrate using the first mask, forming a second mask on the substrate, the second mask being different from the first mask, and forming a second side wall of the fin by performing a second etching of the substrate using the second mask.

Abstract: A frequency of somatic mutations in a biological sample (e.g., plasma or serum) of a subject undergoing screening or monitoring for cancer, can be compared with that in the constitutional DNA of the same subject. A parameter can derived from these frequencies and used to determine a classification of a level of cancer. False positives can be filtered out by requiring any variant locus to have at least a specified number of variant sequence reads (tags), thereby providing a more accurate parameter. The relative frequencies for different variant loci can be analyzed to determine a level of heterogeneity of tumors in a patient.

Abstract: The present application is related to compounds which are novel neurotrophin mimetics. The application also discloses the treatment of disorders associated with p75 expression, such as degradation or dysfunction of cells expressing p75 in a mammal by administering an effective amount of such compounds.

Abstract: Apparatus and method that includes amplifiers for transceiver antenna elements, and more specifically to power amplifying an RF (radio frequency) signal using a distributed power amplifier having electronic devices (such as field-effect transistors) that are thermally and/or mechanically connected to each one of a plurality of antenna elements (also called coil elements) to form a hybrid coil-amplifier (e.g., for use in a magnetic-resonance (MR) imaging or spectroscopy machine), and that is optionally adjusted from a remote location, optionally including remotely adjusting its gains, electrical resistances, inductances, and/or capacitances (which controls the magnitude, phase, frequency, spatial profile, and temporal profile of the RF signal)—and, in some embodiments, the components are compatible with, and function in, high fields (such as a magnetic field of up to and exceeding one tesla or even ten tesla or more and/or an electric field of many thousands of volts per meter).

Abstract: Disclosed herein are vectors, plants and methods of transforming plants to increase translation efficiency. Specifically disclosed are methods of implementing a regulatory element endogenous to a target plant species and operatively associating said regulatory element with a heterologous gene of interest. Examples of regulatory sequences are disclosed including 5? UTR sequences of chloroplast genes, such as a psbA gene.

Abstract: The disclosure provides methods of preventing or treating heart failure in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof.

Abstract: A method for estimating capacitance weight errors of a digital-to-analog converter and a successive approximation (SA) analog-to-digital converter (ADC) using the same are disclosed, and the SA ADC includes a comparator, a capacitor set, a switch set and a controller. The capacitor set includes a primary capacitor array including a plurality of binary-weighted capacitors, and a secondary capacitor array including a plurality of binary-weighted capacitors with known capacitance weights. The controller controls the switch set and repeats the steps of pre-charging the primary capacitor array, redistributing electric charges to the primary capacitor array and the secondary capacitor array, and performing a successive approximation binary searching on the primary capacitor array and the secondary capacitor array to calculate the capacitance weight error of each capacitor in the primary capacitor array. The calculated capacitance weight errors are used for calibrating the output of the successive approximation ADC.

Abstract: The invention provides tandem single nucleotide polymorphisms and methods for their use, for example, in diagnosing Down Syndrome.

Abstract: A method for resolving disputes between users in network communications using digital arbitration. The method comprising the steps of agreeing on a contract between the users and choosing a set of arbitrators; appealing to the arbitrators by a first user, if he/she suspects the second user violates the agreement; and giving the information needed to reconstruct a resource of the second user, if a large enough number of arbitrators agree that the second user actually violated the agreement.

Abstract: The present invention relates to a pharmaceutical composition for inhibiting angiogenesis comprising an isolated peptide comprising the heparin-binding domain of insulin-like growth factor-binding protein-5 (IGFBP-5), a method for inhibiting angiogenesis using the peptide, a pharmaceutical composition for the prevention or treatment of cancer comprising the peptide, a method for treating cancer using the peptide, a novel angiogenesis-inhibiting peptide derived from heparin-binding domain of IGFBP-5, a polynucleotide encoding the peptide, an expression vector comprising the polynucleotide and a transformant comprising the vector.

Abstract: A polarization sensitive spectral interferometer apparatus and method for analyzing a sample by optical energy reflected from the sample. The polarization sensitive spectral interferometer apparatus and method determines polarization properties of the sample by optical energy reflected from the sample.

Abstract: A semiconductor device has gate-all-around devices formed in respective regions on a substrate. The gate-all-around devices have nanowires at different levels. The threshold voltage of a gate-all-around device in first region is based on a thickness of an active layer in an adjacent second region. The active layer in the second region may be at substantially a same level as the nanowire in the first region. Thus, the nanowire in the first region may have a thickness based on the thickness of the active layer in the second region, or the thicknesses may be different. When more than one active layer is included, nanowires in different ones of the regions may be disposed at different heights and/or may have different thicknesses.

Abstract: The present invention provides an ophthalmic device, and method of use thereof, for an individual wearing an ophthalmic lens to increase ocular surface boundary lubrication. The invention device comprises an ophthalmic lens and a sacrificial mechanism disposed on the ophthalmic lens, wherein the sacrificial mechanism comprises a plurality of surface bound receptors, such as PRG4, hyaluronic acid, and DNA aptamers, that reversibly bound to a lubricating composition comprising a gel forming agent, a surfactant, or a combination thereof, effectively inhibiting or preventing protein and lipid adsorption on the surface of the lens, and mitigate shear stress and reduce the friction between the lens and the ocular surface of the individual in need.

Abstract: The present invention relates to compositions comprising esterified lignin and poly(lactic acid). In various embodiments, the present invention provides fibers comprising the esterified lignin and poly(lactic acid) blend, carbon fibers made therefrom, and methods of making the fiber and the carbon fibers.

Abstract: The present disclosure is directed to an elastic polymer having characteristics of swelling by absorbing liquid and, and applications of preparation of gel electrolyte and absorbing the liquid by the polymer. The polymer is obtained by binding a poly(oxyethlene) L-NHm with a compound R being one elected from the group consisting of an acid, an anhydride and a combination thereof.

Abstract: The present invention relates to polynucleotides encoding adult plant pathogen resistance proteins. Also provided are transgenic plants expressing these polynucleotides to enhance the resistance of the plants to pathogens.