Abstract: Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and ingrowth of cells from the multicellular bodies and that is resistant to adherence of cells to it. Three-dimensional constructs can be assembled by printing or otherwise stacking the multicellular bodies and filler bodies such that there is direct contact between adjoining multicellular bodies, suitably along a contact area that has a substantial length. The direct contact between the multicellular bodies promotes efficient and reliable fusion. The increased contact area between adjoining multicellular bodies also promotes efficient and reliable fusion.

Abstract: A neutron detector includes a pressure vessel, an electrically conductive field cage assembly within the pressure vessel and an imaging subsystem. A pressurized gas mixture of CF4, 3He and 4He at respective partial pressures is used. The field cage establishes a relatively large drift region of low field strength, in which ionization electrons generated by neutron-He interactions are directed toward a substantially smaller amplification region of substantially higher field strength in which the ionization electrons undergo avalanche multiplication resulting in scintillation of the CF4 along scintillation tracks. The imaging system generates two-dimensional images of the scintillation patterns and employs track-finding to identify tracks and deduce the rate and direction of incident neutrons. One or more photo-multiplier tubes record the time-profile of the scintillation tracks permitting the determination of the third coordinate.

Abstract: An example includes an apparatus for separating cells from a fluid sample, including a plenum, defining: a centrally located top inlet, and respective side outlets disposed below the inlet and to the side of the inlet; and a bottom outlet disposed below the top inlet, to the side of the two or more outlets, wherein the plenum is configured to receive a fluid and cells suspension through the inlet, and direct it to the bottom outlet, against respective side-walls extending between the bottom outlet and the two or more side outlets, and wherein the distance between each of the two or more side outlets and the bottom outlet is selected to encourage cells to exit through the bottom outlet under a force. Lateral/vertical distance between the inlet and side outlets can provide lateral fluid travel, thereby allowing time for gravity to bias cells toward an outlet.

Abstract: Compositions with antifungal activity and methods of using such compositions are provided herein. In particular the compositions are peptides of SEQ ID NO: 1 and variations thereof. The peptides may contain L or D amino acids and may be circularized, dimerized or otherwise modified to make the compositions resistant to proteolysis. The compositions may be used to inhibit microbial growth and in particular fungal growth.

Abstract: The present invention provides a new method for detecting or monitoring a liver disease in a subject that has no indication of any liver pathologies, by measuring the amount of concentration of albumin mRNA in an acellular blood sample from the subject, and then comparing the amount or concentration of albumin mRNA with a standard control.

Abstract: Semiconductor devices and methods of forming the same are provided. A first gate stack is formed over a substrate, wherein the first gate stack comprises a first ferroelectric layer. A source/channel/drain stack is formed over the first gate stack, wherein the source/channel/drain stack comprises one or more 2D material layers. A second gate stack is formed over the source/channel/drain stack, wherein the second gate stack comprises a second ferroelectric layer.

Abstract: Systems and methods for producing scaffolds are disclosed. The system includes a polymer solution and a non-solvent, which are sprayed into receiving portions of support elements. After scaffolds are formed on the support elements, the support elements permit elongation of the scaffolds. Composites formed from a plurality of scaffolds are also disclosed.

Abstract: Polymers produced by a process comprising contacting one or more olefins with a catalyst system comprising an activator and a Salan catalyst disposed on a support.

Abstract: A cold cathode field emission electron source capable of emission at levels comparable to thermal sources is described. Emission in excess of 6 A/cm2 at 7.5 V/?m is demonstrated in a macroscopic emitter array. The emitter has a monolithic and rigid porous semiconductor nanostructure with uniformly distributed emission sites, and is fabricated through a room temperature process which allows for control of emission properties. These electron sources can be used in a wide range of applications, including microwave electronics and x-ray imaging for medicine and security.

Abstract: The present invention relates to methods and compositions for increasing production of methyl ketones in a genetically modified host cell that overproduces ?-ketoacyl-CoAs through a re-engineered ?-oxidation pathway and overexpresses FadM.

Abstract: A multicore fiber includes six or more of core elements having a core, a first clad surrounding the outer circumferential surface of the core and a second clad surrounding the outer circumferential surface of the first clad, and includes a clad surrounding the core elements. All of expressions are satisfied: n1>n2>n3, n1>n4, n3<n4, wherein the refractive index of the core is n1, the refractive index of the first clad is n2, the refractive index of the second clad is n3, and the refractive index of the clad is n4. The core elements are disposed so that the inter-center pitch between the cores adjacent to each other is disposed at regular spacing and the centers of the cores are annularly disposed.

Abstract: A polyimide precursor, a polyimide using the polyimide precursor, and a polyimide film using the polyimide. The polyimide film has excellent adhesiveness to a metal layer or an adhesive, and has improved heat resistance. The polyimide solution may be used as a coating material.

Abstract: Methods and materials for preparing organic semiconducting layers include, for example, one used in an organic semiconductor device including a substrate with a nano structured surface and an organic semiconductor film overlying the nanostructured surface. The semiconductor film is typically formed from macroscopically ordered polymer fibers made from selected conjugate polymer compounds. Such polymer fibers synthesized from selected conjugated polymer compounds and directionally aligned in organic semiconductor devices can provide these devices improved functional properties, including for example, unexpectedly high field effect saturation mobilities.

Abstract: The present invention provides a method of predicting the risk of a patient for developing cutaneous adverse drug reaction to non-nucleoside reverse transcriptase inhibitors such as nevirapine by using HLA-B*3505 allele and/or polymorphisms in the CCHCR1 gene.

Abstract: A system and method for tracking and tracing motions of multiple incoherent sound sources and for visualizing the resultant overall sound pressure distribution in 3D space in real time are developed. This new system needs only four microphones (although more could be used) that can be mounted at any position so long as they are not placed on the same plane. A sample configuration is to mount three microphones on the y, z plane, while the 4th microphone on a plane perpendicular to the y, z plane. A processor receives signals from the microphones based on the signals received from noise sources in unknown locations, and the processor determines the locations of these sources and visualizes the resultant sound field in 3D space in real time. This system works for broadband, narrowband, tonal sound signals under transient and stationary conditions.

Abstract: Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the compositions have a refractive index of about 1.30 to about 1.40. Methods of synthesizing the compositions are also provided and include the steps of heating an amount of water; adding a buffering agent to the water to form a buffer solution; mixing a poly(ethylene glycol) and a viscoelastic polymer into the buffer solution to form a reactive mixture; adding a plurality of antioxidant particles to the reactive mixture; and removing suspended gas bubbles from the reactive mixture. Methods of preventing oxidative damage to an eye lens of a subject are further provided and include administering the foregoing polymeric compositions to the eye lens of the subject.

Abstract: Embodiments of the invention are directed to a method of inhibiting proliferation of a cell induced by asTF that includes exposing the proliferating cell to an inhibitor of asTF at a concentration sufficient to attenuate asTF induced proliferation. In an embodiment, the proliferating cell is a cancer cell such as a breast cancer cell. The inhibitor of asTF may be an anti-asTF antibody, such as a monoclonal antibody or an antibody fragment, a small molecule, a peptide, nucleic acid, and combinations thereof.

Abstract: A method for manufacturing a permanent-magnet motor rotor includes manufacturing a rotary shaft, a permanent magnet, a front end cover, a rear end cover, and a magnetic yoke unit, where the magnetic yoke unit contains multiple pole shoe parts and one iron core part, where each pole shoe part and the iron core part are connected therebetween via a connecting strip; manufacturing a rotor spacer; all positioning holes of the magnetic yoke unit correspond to the permanent-magnet through hole of the rotor spacer to form a permanent-magnet passage; inserting the permanent magnet into the permanent-magnet passage; inserting tightening bolts; cutting off the mid-section of each connecting strip, overlapping the pole shoe parts to form a rotor pole shoe, overlapping the iron core parts to form a rotor iron core; and arranging respectively the front end cover and the rear end cover on a front end and a rear end.

Abstract: Described herein is the generation of optimized H5N1 and H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on H5N1 and H1N1 influenza isolates. Provided herein are optimized H5N1 and H1N1 influenza HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure.

Abstract: The present invention provides a method for screening drugs for suppressing inflammasome activity, using macrophages derived from induced pluripotent stem cells (iPS cells) having mutant NLRP3 gene.