Patents Assigned to University
  • Substituted (E)-N?-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
    Patent number: 9555024
    Abstract: In one aspect, the invention relates to substituted (E)-N?-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: January 31, 2017
    Assignee: University of Utah Research Foundation
    Inventors: Hariprasad Vankayalapati, Venkataswamy Sorna, Steven L. Warner, Bret Stephens, David J. Bearss, Sunil Sharma
  • Three-dimensional nano-structure array
    Patent number: 9556018
    Abstract: A three-dimensional nano-structure array includes a substrate and a number of three-dimensional nano-structures. Each three-dimensional nano-structure has a first peak and a second peak aligned side by side. A first groove is defined between the first peak and the second peak. A second groove is defined between the two adjacent three-dimensional nano-structures. A depth of the first groove is lower than that of the second groove.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: January 31, 2017
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Zhen-Dong Zhu, Qun-Qing Li, Li-Hui Zhang, Mo Chen, Yuan-Hao Jin, Shou-Shan Fan
  • Safe device for iontophoretic delivery of drugs
    Patent number: 9555238
    Abstract: Provided is a device for iontophoretic delivery of a drug to or into a tissue, including an arrangement that prevents operation of the device at a current density that is higher than a predetermined value, the arrangement including first means responsive to a first data item, indicative of the surface area through which the current is to pass, as to set the maximal current allowed at the surface area indicated by the data item. Also provided is a method for iontophorectivally administering drug to or into a tissue, including determining a maximal allowed level of current density and preventing application of current density above the maximal allowed level.
    Type: Grant
    Filed: January 15, 2014
    Date of Patent: January 31, 2017
    Assignees: Hadasit Medical Research Services & Development Limited, Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Abraham J. Domb, Joseph Frucht-Pery, Mervyn Shapiro
  • Genetically modified mice and engraftment
    Patent number: 9554563
    Abstract: A mouse with a humanization of the mIL-3 gene and the mGM-CSF gene, a knockout of a mRAG gene, and a knockout of a mIl2rg subunit gene; and optionally a humanization of the TPO gene is described. A RAG/Il2rg KO/hTPO knock-in mouse is described. A mouse engrafted with human hematopoietic stem cells (HSCs) that maintains a human immune cell (HIC) population derived from the HSCs and that is infectable by a human pathogen, e.g., S. typhi or M. tuberculosis is described. A mouse that models a human pathogen infection that is poorly modeled in mice is described, e.g., a mouse that models a human mycobacterial infection, wherein the mouse develops one or more granulomas comprising human immune cells. A mouse that comprises a human hematopoietic malignancy that originates from an early human hematopoietic cells is described, e.g., a myeloid leukemia or a myeloproliferative neoplasia.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: January 31, 2017
    Assignees: Regeneron Pharmaceuticals, Inc., Yale University, Institute for Research in Biomedicine (IRB)
    Inventors: Sean Stevens, Andrew J. Murphy, Richard Flavell, Elizabeth Eynon, Jorge Galan, Tim Willinger, Markus Manz, Anthony Rongvaux, George D. Yancopoulos
  • Blind extraction of target signals
    Patent number: 9560447
    Abstract: A system and method allow for extracting target signals from the overall measurement data without knowing how and where these data are collected, the locations and characteristics of target sources as well as those of random background noise sources. In essence, it uses an innovative and advanced signal processing technique to reveal certain critical information from a mixture of data that is hard to obtain otherwise. In particular, it allows for denoising the measured data that have been contaminated by various interfering and background noise, making it possible to extract certain target information that may be otherwise difficult to observe. The only assumption made in this method is that the target signal is incoherent with respect to all interfering signals and background noise. The more information about a target signal is available, the more complete the extracted signal becomes.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: January 31, 2017
    Assignee: WAYNE STATE UNIVERSITY
    Inventor: Sean F Wu
  • Method and system for providing a game theory based global routing
    Patent number: 9558313
    Abstract: A system and method for global routing that includes receiving nets that need to be routed and capacity constraints, ordering, using processing circuitry, the nets, routing, using the processing circuitry, the nets based on a maze routing with framing method, determining, using the processing circuitry, whether the routing is congestion free, selecting, using the processing circuitry, a subset of the nets based on a game theory method when the routing is not congestion free, applying a rip-up and re-route process on the subset of the nets, and repeating the selecting and applying steps until the routing is congestion free.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: January 31, 2017
    Assignee: King Fahd University of Petroleum and Minerals
    Inventors: Umair Farooq Siddiqi, Sadiq M. Sait
  • Communication device and method for designing multi-antenna system thereof
    Patent number: 9559422
    Abstract: The disclosure provides a communication device. The communication device includes a ground conductor portion and a multi-antenna system. The multi-antenna system includes at least a first and a second resonant portion, each of which is disposed on the corresponding radiating edge of the ground conductor portion. Each of the resonant portions may have a loop resonant structure or may have an open-slot resonant structure, and has a resonant path. The electrically coupling portion makes the length of the resonant path less than or equal to 0.18 times the wavelength of the lowest operating frequency of the multi-antenna system, and thereby excites the corresponding radiating edge and forms a strong surface current distribution, and generates an effective radiating energy and at least one resonant mode, in which the effective radiating energy has a corresponding strongest radiation direction.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: January 31, 2017
    Assignees: Industrial Technology Research Institute, National Sun Yat-sen University
    Inventors: Kin-Lu Wong, Yeh-Chun Kao, Po-Wei Lin, Wei-Yu Li
  • Compositions and methods for quadricyclane modification of biomolecules
    Patent number: 9556195
    Abstract: The present disclosure features a strain-promoted [2+2+2] reaction that can be carried out under physiological conditions. In general, the reaction involves reacting a pi-electrophile with a low lying LUMO with a quadricyclane on a biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo and in vitro. The reaction is compatible with modification of living cells. In certain embodiments, the pi-electrophile can comprise a molecule of interest that is desired for delivery to a quadricyclane-containing biomolecule via [2+2+2] reaction.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: January 31, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Ellen May Sletten, Carolyn Ruth Bertozzi
  • Solid ion conductor, solid electrolyte including the same, lithium battery including the solid electrolyte, and method of manufacturing the solid ion conductor
    Patent number: 9559396
    Abstract: A solid ion conductor including a garnet oxide represented by Formula 1: L5+x+2y(Dy,E3-y)(Mez,M2-z)Od??Formula 1 wherein L is at least one of a monovalent cation or a divalent cation, D is a monovalent cation, E is a trivalent cation, Me and M are each independently a trivalent, tetravalent, pentavalent, or a hexavalent cation, 0<x+2y?3, 0?y?0.5, 0?z<2, and 0<d?12, wherein O is partially or totally substituted with at least one of a pentavalent anion, a hexavalent anion, or a heptavalent anion; and B2O3.
    Type: Grant
    Filed: July 30, 2013
    Date of Patent: January 31, 2017
    Assignees: SAMSUNG ELECTRONICS CO., LTD., KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Jae-myung Lee, Tae-young Kim, Young-sin Park, Seung-wook Baek, Jong-heun Lee, Jee-hyun Ahn
  • Nanoparticle catalyst capable of forming aromatic hydrocarbons from COand H
    Patent number: 9555405
    Abstract: Nanocatalysts and methods of using the same to obtain aromatic hydrocarbon compounds from a source of carbon atoms and a source of hydrogen atoms in a single reaction step is provided. The catalyst comprises an Fe/Fe3O4 nanocatalyst that may be supported on a non-reactive support material such as a zeolite or alumina CO2 and H2 are preferred sources of carbon and hydrogen atoms for the reaction. The aromatic hydrocarbon compounds produced are suitable for direct usage as fuel without need for further refining.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: January 31, 2017
    Assignee: Kansas State University Research Foundation
    Inventors: Hongwang Wang, Stefan H. Bossmann, Donghai Wang, Deryl L. Troyer, Tej Shrestha
  • Synthesis of hyperbranched amphiphilic polyester and theranostic nanoparticles thereof
    Patent number: 9555008
    Abstract: A method of making a hyperbranched amphiphilic polyester compound includes drying under vacuum a mixture of 2-(4-hydroxybutyl)-malonic acid and p-toluene sulphonic acid as catalyst. The vacuum is then released with a dry inert gas after drying. The dried mixture is heated under the inert gas at a temperature sufficient for polymerization. The inert gas is evacuated while continuing to heat the mixture. The formed polymer is then dissolved in dimethylformamide and precipitated out by adding methanol. Modifications of the method yield nanoparticles of polyesters having properties suited for coencapsulating fluorescent dyes together with therapeutic drugs, resulting in theranostic nanoparticles, that is, nanoparticles useful in both therapeutic treatments and diagnostic methods.
    Type: Grant
    Filed: February 22, 2016
    Date of Patent: January 31, 2017
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: J. Manuel Perez, Santimukul Santra
  • Nanostructured antibacterial and remineralizing dental bonding agents and dental bonding systems
    Patent number: 9554971
    Abstract: The present invention provides dental bonding agents and dental bonding systems comprising the dental bonding agents. The dental bonding agents of the invention are characterized by having antibacterial properties, and in some aspects of the invention, remineralizing properties.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: January 31, 2017
    Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
    Inventors: Huakun Xu, Michael Weir
  • Nanofluids for thermal management systems
    Patent number: 9556375
    Abstract: A nanofluid is generally provided for use in a heat transfer system. The nanofluid can include nanoparticles suspended in a base liquid at a nanoparticle concentration in the nanofluid of about 0.01% to about 5% by volume. The nanoparticles can include zinc-oxide nanoparticles. The nanofluid for use in a heat transfer system can, in one embodiment, further include a surfactant. Thermal management systems configured to cool a computer having integrated circuits that generate heat during use are also provided. The thermal management system can include a zinc-oxide nanofluid circulated through a series of tubes via a pump such that heat produced by electronic components of the computer can be captured by the circulating nanofluid and then removed from the nanofluid by a radiator.
    Type: Grant
    Filed: March 15, 2011
    Date of Patent: January 31, 2017
    Assignee: University of South Carolina
    Inventors: Dale A. McCants, Andrew M. Hayes
  • Method and tool to reverse the charges in anti-reflection films used for solar cell applications
    Patent number: 9559222
    Abstract: A method is provided for making a solar cell. The method includes providing a stack including a substrate, a barrier layer disposed on the substrate, and an anti-reflective layer disposed on the barrier layer, where the anti-reflective layer has charge centers. The method also includes generating a corona with a charging tool and contacting the anti-reflective layer with the corona thereby injecting charge into at least some of the charge centers in the anti-reflective layer. Ultra-violet illumination and temperature-based annealing may be used to modify the charge of the anti-reflective layer.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: January 31, 2017
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Vivek Sharma, Clarence Tracy
  • Tension and compression tester for fracture stress test of compact pipe sample
    Patent number: 9557256
    Abstract: A tension and compression tester for a fracture stress test of a compact pipe sample having a crack portion formed thereon, comprises: a pair of holders each of which is configured to surround both ends of the compact pipe sample respectively such that the crack portion is interposed between both ends of the compact pipe; fixing portions each of which is disposed between the compact pipe sample and the holder to enhance fastening between the compact pipe sample and the holder; levers each of which is connected with the fixing portion and the holder to deliver tension or bending to the compact pipe sample; and separation preventing portions for fixing both ends of the holder and the lever with each other to prevent separation of the lever and the holder. Accordingly, the tester can conduct both tension and compression tests, while easily applying loads on the sample during the test.
    Type: Grant
    Filed: June 30, 2015
    Date of Patent: January 31, 2017
    Assignee: Research & Business Foundation SUNGKYUNKWAN UNIVERSITY
    Inventors: Changsung Seok, Suk Woo Hong
  • Germanium-based glass polyalkenoate cement
    Patent number: 9555156
    Abstract: Disclosed herein are compositions and methods for making germanium-based glass polyalkenoate cements. Also disclosed are methods for their use as bone cements for bone augmentation procedures.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: January 31, 2017
    Assignee: DALHOUSIE UNIVERSITY
    Inventors: Victoria Dickinson, Daniel Boyd, Brett Dickey, Sharon Kehoe
  • Devices and methods for percutaneous access, hemostasis, and closure
    Patent number: 9554787
    Abstract: The present invention provides methods and devices for obtaining percutaneous access, maintaining hemostasis, and providing closure of openings in tissues of the body. In particular, the present invention provides methods and devices for maintaining hemostasis and providing closure surgical incisions of the left ventricular apex of the heart.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: January 31, 2017
    Assignee: Northwestern University
    Inventors: Patrick M. McCarthy, Swaminadhan Gnanashanmugam, Usha Periyanayagam, Ingrid Lin, Leah Ralph, Christopher Lubeck
  • Modification of recombinant adenovirus with immunogenic plasmodium circumsporozoite protein epitopes
    Patent number: 9555089
    Abstract: The present disclosure relates to adenovirus protein modifications to augment immune response to a transgene of a recombinant adenovirus and to circumvent pre-existing anti-adenovirus immunity. Some embodiments are directed to a recombinant adenovirus derived from a recombinant adenovirus plasmid vector, wherein the recombinant adenovirus plasmid vector comprises a nucleotide sequence encoding a Plasmodium circumsporozoite protein, or antigenic portion thereof, operably linked to a heterologous promoter and a modified capsid or core protein, wherein an immunogenic epitope of Plasmodium circumsporozoite is inserted into or replaces at least part of a capsid or core protein. Other embodiments are directed to a pharmaceutical composition or a malaria vaccine composition comprising a recombinant adenovirus according to the above embodiments.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: January 31, 2017
    Assignee: THE ROCKEFELLER UNIVERSITY
    Inventors: Takayuki Shiratsuchi, Moriya Tsuji
  • Ordering block copolymers
    Patent number: 9557640
    Abstract: A method for ordering block copolymers including forming a first layer having a first preference mode; and providing a reactive agent in selected regions of the first layer that modifies the selected regions to a second preference mode, wherein the selected regions define other regions of the first layer retaining the first preference mode thereby forming an alignment layer for block copolymers.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: January 31, 2017
    Assignee: Board of Regents, University of Texas System
    Inventors: C. Grant Willson, Christopher Ellison, Michael Maher, Christopher Bates, Dustin Janes
  • Methods for hybrid GPU/CPU data processing
    Patent number: 9558748
    Abstract: The present invention describes methods for performing large-scale graph traversal calculations on parallel processor platforms. The invention describes methods for on-the-fly hypothesis rescoring that utilizes graphic processing units (GPUs) in combination with utilizing central processing units (CPUs) of computing devices. The invention is described in one embodiment as applied to the task of large vocabulary continuous speech recognition.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: January 31, 2017
    Assignee: CARNEGIE MELLON UNIVERSITY
    Inventors: Ian Lane, Jike Chong, Jungsuk Kim