Abstract: A pulse generator circuit may include a diode configured to operate as an opening switch, a tank circuit in series with the diode having an admittance that is switchable from a first value to a second value that is different from the first value, and a switching system configured to cause the tank circuit to switch between the first value and the second value. The diode may saturate in less than 100 nanoseconds. A saturable core transformer may operate as a switch that controls the opening of the diode. The pulse generator may generate a plurality of pulses, each having a length of no more than 3 nanoseconds and an amplitude of at least 1 kilovolt. Electrodes may be connected to the pulse generator to deliver the plurality of pulses to biological cells.

Abstract: A limiting amplifier with an input stage with dc offset cancellation, identical gain stages, an output buffer and a feedback filter. The input stage receives a differential input signal and outputs a first intermediate differential signal. The gain stages are cascaded to amplify the first intermediate differential signal and generate a second intermediate differential signal, amplified by the output buffer to produce an output signal. The feedback filter provides a dc offset voltage of the output signal to the input stage for the dc offset cancellation. The input stage comprises a resistor network coupled between a pair of input nodes and a power line and comprising a common resistor, a pair of load resistors and a shunt resistor. The load resistors share a common terminal connected to the common resistor that is connected to the power line. The shunt resistor has two terminals respectively connected to the load resistors.

Abstract: A liposome contains an active agent and has a gel-phase lipid bilayer membrane comprising phospholipid and a surface active agent. The phospholipids are the primary lipid source for the lipid bilayer membrane and the surface active agent is contained in the bilayer membrane in an amount sufficient to increase the percentage of active agent released at the phase transition temperature of the lipid bilayer, compared to that which would occur in the absence of the surface active agent. The surface active agent is present in the lipid bilayer membrane so as to not destabilize the membrane in the gel phase.

Abstract: T cells are profiled with respect to their expression of antigen receptor. The cells are arrayed on a planar or three-dimensional substrate through binding to immobilized or partially diffused MHC-antigen complexes. The cells may further be characterized with respect to their ability to respond to external stimulus in the microenvironment. External stimuli include cell-cell interactions, response to factors, and the like.

Abstract: The water rocket launch system is an automated system for launching multiple water rockets simultaneously with additional visual and auditory effects. The water rocket launch system includes a platform, with at least one launching base slidably mounted on an upper surface thereof. The at least one launching base is selectively and controllably driven to slide on the platform. At least one water rocket storage chamber is mounted on the platform, with the at least one water rocket storage chamber having an open interior region for receiving and storing a plurality of water rockets, and further having an open bottom end. A plurality of launching assemblies are mounted on the at least one launching base, so that the plurality of water rockets stored within the at least one water rocket storage chamber may be released thereon, with each launching assembly engaging and releasably supporting a respective one of the water rockets.

Abstract: A structure for high performance light emitting electrochemical cells comprises at least two active layers of mixed ionic/electronic conducting materials, at least one of which is electroluminescent. The active layers are sandwiched between ion blocking electrodes, typically metal and/or transparent conducting oxide, that are electrically but not ionically conductive. Application of bias to the electrodes results in the polarization of ions at the electrodes thereby generating a field to drive the injection of electronic carriers into the active layer. The injected electron and holes recombine within the active layers to emit light. The ability to balance electron and hole injection in the design of such devices provides for optimal light emission efficiency.

Abstract: In one embodiment of the present invention, a power IC device is disclosed containing a power MOS transistor with a low ON resistance and a surface channel MOS transistor with a high operation speed. There is also provided a method of manufacturing such a device. A chip has a surface of which the planar direction is not less than ?8° and not more than +8° off a silicon crystal face. The p-channel trench power MOS transistor includes a trench formed vertically from the surface of the chip, a gate region in the trench, an inversion channel region on a side wall of the trench, a source region in a surface layer of the chip, and a drain region in a back surface layer of the chip. The surface channel MOS transistor has an inversion channel region fabricated so that an inversion channel current flows in a direction not less than ?8° and not more than +8° off the silicon crystal direction.

Abstract: An electric machine includes a rotor having at least one pole pair, the at least one pole pair including a first magnetic pole and a second magnetic pole having opposite polarities. The first magnetic pole may include a first inner radial permanent-magnet layer and a first outer radial permanent-magnet layer. The second magnetic pole may include a second inner radial permanent-magnet layer and a second outer radial permanent-magnet layer. An outer end of the first inner radial permanent-magnet layer and an outer end of the second inner radial permanent-magnet layer may be separated by an angle of between about 27 and about 55 electrical degrees. The electric machine may also include a stator having a stator core with an odd number of stator slots per pole pair of the rotor.

Abstract: A liquid crystal device comprises ferroelectric particles suspended in a liquid crystal material. A method for fabricating a light-modulating device is also disclosed. The method comprises the steps of providing a pair of substrates with a cell gap therebetween, wherein electrodes are disposed on the facing surfaces of the substrates, and permanently disposing a suspension of ferroelectric particles in a liquid crystal material into said cell gap. A method of generating an image comprises providing a pair of substrates with a cell gap therebetween, providing transparent electrodes on each of said substrates adjacent to the cell gap, permanently disposing a suspension of ferroelectric particles in a liquid crystal material within the cell gap, and applying an electric field across the electrodes.

Abstract: Antibodies that bind to a 40 kDa protein which is expressed on tumors, but is not expressed on normal adult hemopoietic cells are disclosed. Also disclosed are methods for production and the use of such antibodies.

Abstract: A method and system to provide improved accuracies in multi jointed robots through kinematic robot model parameters determination are disclosed. The present invention calibrates multi-jointed robots by using the chain rule for differentiation in the Jacobian derivation for variations in calculated poses of reference points of a reference object as a function of variations in robot model parameters. The present invention also uses two such reference objects and the known distance therebetween to establish a length scale, thus avoiding the need to know one link length of the robot. In addition, the present invention makes use of iterative methods to find the optimum solution for improved accuracy of the resultant model parameters. Furthermore, the present invention provides for determination of the end joint parameters of the robot, including parameters defining the tool attachment mechanism frame, which allows for interchange of tools without subsequent calibration.

Abstract: Organic light emitting devices are disclosed which are comprised of a heterostructure for producing electroluminescence wherein the heterostructure is comprised of an emissive layer containing a phosphorescent dopant compound.

Abstract: The present invention provides methods for diagnosing, providing a prognosis, and staging thyroid cancer, using panels of molecular markers that are differentially expressed in thyroid cancer. Also provided are methods to identify compounds that are useful for the treatment or prevention of thyroid cancer.

Abstract: Disclosed are compositions and methods for the sensitive and selective detection of ions using nucleic acid enzymes.

Abstract: The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering proteins, peptides or siRNAs transdermally to an animal subject. The nanoparticles are composed of positively charged chitosan substrate, negatively charged core substrate complexed with chitosan, and encapsulated bioactive agents.

Abstract: Disclosed are peptides that inhibit the enzymatic activity of tyrosinase, as well as formulations and methods for their use in the reduction of skin pigmentation, and methods of administering the inhibitory peptides in a topical formulation. Peptide sequences disclosed include KFEKKFEK and YRSRKYSSWY.

Abstract: The present invention discloses a method for modulating the production of a protein from a polynucleotide in a CHO cell by replacing at least one codon of the polynucleotide with a synonymous codon that has a higher or lower translation efficiency in the CHO cell than the codon it replaces, or by introducing into the CHO cell a polynucleotide that codes for an iso-tRNA which limits the rate of production of the polypeptide and which corresponds to a codon of the first polynucleotide. The present invention also discloses the use of a protein-encoding polynucleotide whose codon composition has been modified for enhanced production of the protein in CHO cells.

Abstract: The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides new derivatives and analogs of trihydroxy polyunsaturated eicosanoids that can be prepared according to these methods. The invention also provides compositions and methods using trihydroxy polyunsaturated eicosanoid derivatives for the prevention, amelioration and treatment of a variety of diseases or conditions associated with inflammation or inflammatory response, autoimmune diseases, rheumatoid arthritis, cardiovascular diseases, or abnormal cell proliferation or cancer.

Abstract: The present invention relates to compounds having estrogenic activity selected from the group consisting of Loliolide, (4S,6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one, (4R,6S)-4-Hydroxy-6-nonadecyl-tetrahydro-pyran-2-one and analogues thereof. The compounds of the present invention are selective estrogen receptor modulator, which can selectively activate ER? and simultaneously express high estrogenic activity, and also can be applied as medical or food compositions to improve estrogen deficiency-related symptoms.

Abstract: An exemplary method for computer based collaboration between a plurality of participants communicating over a data network comprises steps of receiving communications data with the computer, using a text analysis tool to identify at least a plurality of k-words from the communications data and a plurality of relations linking at least a portion of the plurality of k-words, and displaying the k-words and relations to the plurality of participants over the computer network.