Abstract: Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and tumor-derived cell lines showed that cytogenetic changes and allele loss on the short arm of chromosome 3 (3p) are most frequently involved in about 90% of small cell lung cancers and greater than 50% of non-small cell lung cancers. A group of recessive oncogenes, Fus1, 101F6, Gene 21 (NPRL2), Gene 26 (CACNA2D2), Luca 1 (HYAL1), Luca 2 (HYAL2), PL6, 123F2 (RaSSFI), SEM A3 and Beta* (BLU), as defined by homozygous deletions in lung cancers, have been located and isolated at 3p21.3.

Abstract: The present invention provides genetic markers, SOX5 and SPARC, for distant metastasis and poor prognosis of detection of the high risk potential for cancer patients. In addition, the present invention also provides a method to predict the risk potential for cancer patients with distant metastasis and poor prognosis. This method comprises obtaining a tissue sample from a patient; evaluating the expression levels of the SOX5 and/or SPARC genetic markers in the sample; and comparing the expression levels of genetic markers with those of non-cancerous tissues. The patient is determined to have the high risk of distant metastasis or poor prognosis when the expression level of SOX5 is higher, or when the expression level of SPARC is lower, than that of non-cancerous tissue.

Abstract: Methods of increasing the cellular pool of A-CoA and thus driving the metabolic pathways in the direction of A-CoA containing metabolites by overexpressing rate limiting enzymes in A-CoA synthesis. Methods of increasing intracellular levels of CoA and A-CoA through genetic engineering of bacterial strains in conjunction with supplementation with precursor molecules.

Abstract: Disclosed are a driving circuit for a single-phase SRM and a driving method thereof. The driving circuit for the single-phase SRM includes a switched reluctance motor, a voltage source which supplies energy to the switched reluctance motor, and an inverter circuit which is connected to the switched reluctance motor in parallel so as to temporarily store energy of the voltage source, and then supply the energy to the switched reluctance motor.

Abstract: Provided are screening assays for identifying and evaluating compounds with antioxidant and/or antiproliferative activities.

Abstract: A digital current-mode controller for a DC-DC converter is disclosed. The controller comprises a digital current reference; and a current loop compensator adapted to receive a digital current error signal derived from a digital current sample sensed from the DC-DC converter and the digital current reference and to generate a duty-cycle command, wherein the current loop compensator comprises a low-pass filter that is used in generating the duty-cycle command. A DC-DC regulator comprising a digital current-mode controller and a method of controlling a DC-DC converter are also disclosed.

Abstract: Methods, systems, and computer program products for performing real-time quadrature projection based FDOCT are disclosed. According to one method, a plurality of interferogram signals is phase shifted. A Fourier transform is applied to each of the plurality of interferogram signals. Depth dependence of the plurality of transformed interferogram signals is then removed. A real quadrature component and an imaginary quadrature component for each of the plurality of transformed interferogram signals are subsequently calculated. The real quadrature components of the transformed interferogram signals are combined to obtain a derived real component and the imaginary quadrature components of the transformed interferogram signals are combined to obtain a derived imaginary component. A full-range depth profile of the object is constructed by adding the derived real component to the product of the derived imaginary component and a scaling factor.

Abstract: The present invention provides a method for identifying inhibitors of protein kinases. Methods are also provided for inhibiting protein kinase activity. Specific non-peptide protein tyrosine kinase inhibitors are provided. The protein kinases produced using the method of the present invention may be used to treat a number of conditions in patients, including cancer, psoriasis, atherosclerosis, or immune system activity.

Abstract: Growth of SiGe on a significantly lattice mismatched substrate (e.g., Si) is provided by depositing a SiGe buffer layer at a growth temperature, then annealing the resulting structure at a temperature higher than the growth temperature. Additional buffer layers can be included following the same steps. The SiGe buffer is significantly lattice mismatched with respect to the substrate, and is preferably substantially lattice matched with a SiGe device to be grown on top of the buffer. The resulting buffer structure is relatively thin and provides low defect density, and low surface roughness. Disadvantages of thick graded buffer layers, such as high cost, high surface roughness, mechanical fragility, and CTE mismatch, are thereby avoided.

Abstract: Provided herein are methods for identifying a subject afflicted with chronic lymphocytic leukemia who is responsive to treatment with a chemotherapeutic agent by detecting the presence or absence of at least one APOE4 allele in the subject, the presence of an APOE4 allele identifying the subject as responsive to the treatment. Also provided are methods of treating a subject afflicted with chronic lymphocytic leukemia, including administering an estrogenic agent, an androgen withdrawal agent, an apoE4 peptide or mimetic thereof, and/or a chemotherapeutic agent in an amount effective to treat said chronic lymphocytic leukemia. Methods of determining a prognosis for a patient diagnosed with chronic lymphocytic leukemia are also provided. In addition, methods for stratifying a subject into a subgroup of a clinical trial and methods for identifying a patient in a clinical trial of a treatment for chronic lymphocytic leukemia are herein provided.

Abstract: A sensing system is provided that includes a transceiver. The transceiver includes a transmitter chain that transmits a double-sideband signal having first and second frequency components, and a receiving chain that receives the double-sideband signal after it is reflected by a target. The system further includes a baseband circuit for extracting information content from the received double-sideband signal. A separation between a first frequency of the first frequency component and a second frequency of the second frequency component causes a spike in a signal response generated by one sideband of the received double-sideband signal to substantially overlap a null point of a signal response generated by the other sideband of the received double-sideband signal.

Abstract: Inhibitors of protein kinase C (PKC)?, PKC? and PKC? are provided which are selective for those PKC isotypes. Combinatorial libraries for identifying protein kinases are also provided, as are methods of identifying protein kinases using those libraries. Additionally, methods of treating a mammal having a deleterious condition, where the condition is dependent on a protein kinase for induction or severity, are provided. Methods of inhibiting protein kinases are also provided.

Abstract: A method and computer program are provided for handing off a mobile device in communication with a first wireless system having a first network address to one or more other wireless systems within communication range of the mobile device. The method and computer program include periodically monitoring by the mobile device of communications from the first wireless system and the other wireless systems, calculating a signal strength associated with each of the monitored communications, selecting one of the other wireless systems, and transferring communication to the selected wireless system upon detection of a predetermined threshold of the signal strength associated with the first wireless system.

Abstract: Fourier domain a/LCI (faLCI) system and method which enables in vivo data acquisition at rapid rates using a single scan. Angle-resolved and depth-resolved spectra information is obtained with one scan. The reference arm can remain fixed with respect to the sample due to only one scan required. A reference signal and a reflected sample signal are cross-correlated and dispersed at a multitude of reflected angles off of the sample, thereby representing reflections from a multitude of points on the sample at the same time in parallel. Information about all depths of the sample at each of the multitude of different points on the sample can be obtained with one scan on the order of approximately 40 milliseconds. From the spatial, cross-correlated reference signal, structural (size) information can also be obtained using techniques that allow size information of scatterers to be obtained from angle-resolved data.

Abstract: A resonant power conversion apparatus includes a transformer T1 having a primary winding n1, a secondary winding n2, a tertiary winding n3, and a reset winding nR, a series circuit of switches S1 and S2, a capacitor Cr1 and diode D1 to the switch S1, a capacitor Cr2 and diode D2 to the switch S2, a series circuit of the winding n1 and a diode Dn1, a series circuit of the winding nR and a diode DR, a reactor Lr connected between a connection point of the switches S1 and S2 and a connection point of the windings n2 and n3, a switch S10 connected between the DC power source and the winding n2, a switch S20 connected between the DC power source and the winding n3, and a controller 10 configured to perform a zero-voltage switching operation of the switches S1 and S2.

Abstract: A secondary hybrid aqueous energy storage device includes an anode electrode, a cathode electrode which is capable of reversibly intercalating sodium cations, a separator, and a sodium cation containing aqueous electrolyte, wherein an initial active cathode electrode material comprises an alkali metal containing active cathode electrode material which deintercalates alkali metal ions during initial charging of the device.

Abstract: A navigation system or combination of navigation systems can be used to provide two or more navigation modalities to navigate a single instrument in a volume. For example, both an Electromagnetic (EM) and Electropotential (EP) navigation system can be used to navigate an instrument within the volume. Image data can also be illustrated relative to a tracked position of the instrument in the volume for navigation.

Abstract: Medical imaging often involves the collective use of information presented in multiple images of an individual, such as images generated through different imaging modalities (X-ray, CT, PET, etc.) The use of a composite of these images may involve image registration to adjust for the variable position and orientation discrepancies of the individual during imaging. However, registration may be complicated by soft tissue deformation between images, and implementations (particularly pure software implementations) of the mathematical models used in image registration may be computationally complex and may require up to several hours. Hardware architectures are presented that apply the mathematical techniques in an accelerated manner, thereby providing near-realtime image registration that may be of particular use for the short timeframe requirements of surgical environments.

Abstract: The invention provides an antifouling hydrogel comprising an effective amount of antifouling polymer modified with a compound containing catechol functional groups to yield a modified antifouling polymer comprising at least one catechol functional end group; and an effective amount of at least one oxidizing reagent, wherein the at least one oxidizing reagent reacts with the modified antifouling polymer to provide a modified antifouling polymer comprising at least one oxidized catechol end group, wherein an antifouling hydrogel is provided. Methods of synthesis, methods of use and kits of the antifouling hydrogel are also provided.

Abstract: A new and distinct lily plant substantially as shown and described, characterized by (1) stem thickness supported by flower crown without bending (10-11 mm in diameter); (2) straight stems with even leaf distribution from bottom to top (95-115 leaves per plant); (3) flower crown compact; (4) flower sizes (11 cm long 6 cm wide at open stage); (5) continuous blooms for two to four weeks; (6) coloration of leaves uniform from bottom to top; (7) height of plant around 40 cm; and (8) red to purple flowers.