Abstract: The present invention provides compositions and methods of use thereof to prevent and/or treat pathogenic infection. In particular, the present invention provides the use of kinase inhibitors to inhibit kinases that involve in pathogen-host cell interactions that are associated with or cause pathogenic infections, therefore, to effectively prevent and/or treat pathogenic infections with far less likely to engender resistance as compared to conventional antibiotics and anti-viral drugs. The present invention further provides the use of kinase inhibitors for the treatment of acute pathogenic infections for a short period of time to avoid toxicities that may caused by long term use of these kinase inhibitors.

Abstract: A method for detecting an electromagnetic wave includes: providing a carbon nanotube structure including a plurality of carbon nanotubes arranged along a same direction. The carbon nanotube structure is irradiated by an electromagnetic wave to be measured. The resistance of the carbon nanotube structure irradiated by the electromagnetic wave is measured.

Abstract: The present invention concerns methods and compositions involving inhibitors and enhancers of RAD51, a protein involved in homologous recombination. In some embodiments, the present invention concerns methods for stimulating homologous recombination, which has a number of significant research and clinical applications. In certain other embodiments, there are methods for protecting cells using a compound that enhances RAD51 activity. Such enhancers may also be employed to prevent or reduce damage to cells that may be caused by DNA damaging agents. In other embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 enhancer or inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.

Abstract: According to one embodiment of the invention, an engine system comprises a housing, an outer gerotor, an inner gerotor, a tip inlet port, a face inlet port, and a tip outlet port. The housing has a first sidewall, a second sidewall, a first endwall, and a second endwall. The outer gerotor is at least partially disposed in the housing and at least partially defines an outer gerotor chamber. The inner gerotor is at least partially disposed within the outer gerotor chamber. The tip inlet port is formed in the first sidewall and allows fluid to enter the outer gerotor chamber. The face inlet port is formed in the first endwall and allows fluid to enter the outer gerotor chamber. The tip outlet port is formed in the second sidewall and allows fluid to exit the outer gerotor chamber.

Abstract: A first device is provided. The device includes a print head. The print head further includes a first nozzle hermetically sealed to a first source of gas. The first nozzle has an aperture having a smallest dimension of 0.5 to 500 microns in a direction perpendicular to a flow direction of the first nozzle. At a distance from the aperture into the first nozzle that is 5 times the smallest dimension of the aperture of the first nozzle, the smallest dimension perpendicular to the flow direction is at least twice the smallest dimension of the aperture of the first nozzle.

Abstract: A sputter ion pump includes one vacuum chamber, two parallel anode poles and one cold cathode electron emitter. The vacuum chamber includes at least one aperture located in an outer wall thereof. The two parallel anode poles are positioned in the vacuum chamber and arranged in a symmetrical configuration about a center axis of the vacuum chamber. The cold cathode electron emission device is located on or proximate the outer wall of the vacuum chamber and faces a corresponding aperture. The cold cathode electron emission device is thus configured for injecting electrons through the corresponding aperture and into the vacuum chamber. The sputter ion pump produces a saddle-shaped electrostatic field and is free of a magnetic field. The sputter ion pump has a simplified structure and a low power consumption.

Abstract: Disclosed is a compound represented by the formula (I) below as a dihydronaphthalene compound having a chemical structure which is excellent in production efficiency when compared with lasofoxifene and nafoxidine. This compound is useful as a proteasome inhibitor and/or an antitumor agent.

Abstract: The present invention provides a micromixer biochip, comprising: a substrate having a surface; a fluidic channel layer disposed above the surface of the substrate, including a mixing chamber and a single-opening fluidic channel, wherein one end of the single-opening fluidic channel is closed and the other end of the single-opening fluidic channel connects to the mixing chamber, and a top portion of the single-opening fluidic channel is made of a flexible material; and an air chamber layer disposed above the top portion of the fluidic channel layer, including an air pore, at least one chamber, and an air channel connecting the chamber and the air pore, wherein the number and position of the air chamber correspond to the number and position of the single-opening fluidic channel of the fluidic channel layer

Abstract: A system for encryption, and subsequent decryption, of encoded data allows for transcoding of the encrypted data. The data is encoded in such a way that different packets have different importance levels, so that some or all of the packets at the lower importance levels can be discarded or truncated in order to reduce the data rate. This is achieved by introducing dependencies into the encoding process. The packets at the highest importance level are encoded with reference only to other packets at the highest importance level, while the encoding of packets at lower importance levels also depend on the encoding of the packets at the highest importance level. The encoded data is then encrypted in such a way that the encryption process has dependencies that correspond to the dependencies in the encoding process.

Abstract: Provided are an antenna apparatus for linearly polarized diversity antennas in a radio frequency identification (RFID) reader, and a method of controlling the antenna apparatus. The antenna apparatus includes: a plurality of linearly polarized diversity antennas disposed to have different directions to one another; a switching unit connecting the linearly polarized diversity antennas to the RFID reader; and a controller controlling the switching unit to selectively activate the linearly polarized diversity antennas.

Abstract: The present invention relates to the discovery, identification and characterization of a receptor protein, referred to herein as T1R3, which is expressed in taste receptor cells and associated with the perception of bitter and sweet taste. The invention encompasses transgenic animals and cells that do not express functional T1R3 protein, particularly knock-out animals and cells, and transgenic animals and cells that express a non-native T1R3 protein. Experimental model systems based on these animals and cells can be used to study T1R3-mediated taste transduction and responses of the components of the T1R3 signal transduction pathway to various tastants, furthering our understanding of the molecular biology and biochemistry of taste. Such model systems would also be useful for screening for novel tastants and taste modulators, such as enhancers of desirable flavors, and blockers of undesirable flavors.

Abstract: A differential signal driven direct-current voltage generating device is proposed, which is designed for use with a PLL (phase-locked loop) circuit or a DLL (delay-locked loop) circuit system for generating an output of a direct-current (DC) voltage in response to a pair of differential signals, such as phase-difference signals; and which is characterized by the utilization of a capacitor-switched voltage doubler for doubling the output voltage of a charge pump so that the doubled voltage can be used as a control voltage for a PLL-VCO (voltage-controlled oscillation) or a DLL-VCDL (voltage-controlled delay line) circuit for generation of an output oscillating signal with a wider frequency range.

Abstract: An electro-catalyst for the oxidation of ammonia in alkaline media; the electrocatalyst being a noble metal co-deposited on a support with one or more other metals that are active to ammonia oxidation. In some embodiments, the support is platinum, gold, tantalum, or iridium. In some embodiments, the support has a layer of Raney metal deposited thereon prior to the deposition of the catalyst. Also provided are electrodes having the electro-catalyst deposited thereon, ammonia electrolytic cells, ammonia fuel cells, ammonia sensors, and a method for removing ammonia contaminants from a contaminated effluent.

Abstract: The present invention concerns ink for printing on ceramic surfaces such as glass, which contains glass frits for silica nanoparticles and optionally a pigment, and is suitable for ink jet printing.

Abstract: A scanning device processes a multi-point simultaneous acquisition. The acquisition is processed for an infra-red diffuse optical tomography. An intensity modulated light is used with a frequency domain analysis theorem to obtain a reconstructed scanning image. The fibers are capable of a vertical movement and a radial movement. Thus, a precise image showing optical-information data is obtained with a low cost, even through scanning at a minimal angle.

Abstract: The present invention comprises pharmaceutical compositions comprising a co-crystal of an API and a co-crystal former, and methods of making and using the same.

Abstract: The present invention provides novel nucleic acid and protein sequences for methods and compositions for treating, screening, and diagnosing cardiovascular disease and methods for using these genes and gene products for prevention of cardiac cell death and prevention of cardiac tissue damage resulting from ischemic events in cardiac tissue, as well as other tissue that is subject to damage resulting from an ischemic event. The genes, gene products and agents of the invention are also useful for treating other related clinical or coronary events such as angina, myocardial infarct (MI), and stroke, for monitoring the effectiveness of their treatment, and for drug development. The genes, gene products and agents of the present invention are also provided as pharmaceutical compositions for treatment of cardiovascular disease, ischemic heart disease, myocardial infarct and related conditions. Kits are also provided for the diagnosis, treatment and prognosis of cardiac diseases and related conditions.

Abstract: The present invention provides compounds of Formula I: wherein: R1 is a label (e.g., a detectable groups; an anti-tumor agent)s; L is present or absent and when present is a linking group; and x represents an integer from 1 to 10; or a pharmaceutically acceptable salt thereof. the compounds are useful for, among other things, identifying cysteine sulfenic acids in proteins and monitoring oxidative damage in proteins and cells.

Abstract: A filter comprises at least one filtration unit with a filtration passage having an inlet and an outlet, wherein the filtration unit includes at least one groove formed in an inlet side surface of the filtration unit, said at least one groove extending to the inlet and dimensioned to hold back substances which may clog the filtration passage, by means of upper edges of said at least one groove. According to the present invention, by forming at least one groove in an inlet side surface of the filtration unit, the filtration passages of the filter can be effectively prevented from being clogged.

Abstract: A system and method for determining bubble shell properties using optical scattering. One or more ultrasound contrast agent (UCA) bubbles is placed in an imaging volume and illuminated with a laser. The UCA is exposed to pressure variations (e.g., using pulses of imaging or therapeutic ultrasound), while optical scattering data are collected and processed. The scattering intensity is related to the radius of the UCA. Thus, changes in the radius due to varying pressure conditions results in variations in the scattering intensity. The collected data are processed to provide a radius versus time (RT) relationship. The RT relationship is fit to one or more conventional dynamic models. The fitted empirical data can be used to determine one or more UCA parameters, such as shear modulus and shell viscosity.