Abstract: The present invention provides a mutant oligonucleotide composition encoding a cellular c-Src tyrosine kinase oncogene. Methods for isolating, expressing and characterizing recombinant Src mutant polypeptide are also provided. The invention further relates to methods for utilizing such oligonucleotides, polypeptides, agonists and antagonists for applications, which relate to research, diagnostics, and clinical arts. More specifically, this invention provides methods of diagnosing, treating, immunizing, and creating transgenic animals based on use of such mutant Src.

Abstract: The present invention provides in one of the embodiments for either a continuous wave (cw) or pulsed alkali laser having an optical cavity resonant at a wavelength defined by an atomic transition, a van der Waals complex within the optical cavity, the van der Waals complex is formed from an alkali vapor joined with a polarizable gas, and a pump laser for optically pumping the van der Waals complex outside of the Lorentzian spectral wings wherein the van der Waals complex is excited to form an exciplex that dissociates forming an excited alkali vapor, generating laser emission output at the wavelength of the lasing transition.

Abstract: The present invention includes compositions and methods for making and using an isolated cyanobacterium that includes a portion of an exogenous bacterial cellulose operon sufficient to express bacterial cellulose, whereby the cyanobacterium produces extracellular glucose. The compositions and methods of the present invention may be used as a new global crop for the manufacture of cellulose, CO2 fixation, for the production of alternative sources of conventional cellulose as well as a biofuel and precursors thereof.

Abstract: Methods and systems are disclosed for signal processing. A method includes receiving a plurality of digitized coefficients determining a best-fit distribution of a general family of distributions for the plurality of digitized coefficients, and providing a characterization of the digitized coefficients based upon the determined best-fit distribution. The system includes a memory for storing computer program instructions and a processor in communication with the memory. The processor is operable to execute the computer program instructions to receive a plurality of digitized coefficients, determine a best-fit distribution of a general family of distributions for the plurality of digitized coefficients, and provide a characterization of the digitized coefficients based upon the determined best-fit distribution.

Abstract: A microfluidic fluid flow system (100) is disclosed having a fluid chamber or channel (150) with inlet and outlet ports (104, 106), allowing the fluid channel to be filled with a fluid. One or more flow obstructions or perturbances, such as cylinders (152), are provided in the channel. An oscillatory boundary condition is applied, for example, with a piezoelectric driver (130), that is selected to induce a conservative, low-intensity steady streaming flow in the channel. The low-intensity streaming flow produces distinct eddies that can be utilized, for example, for fluid-dynamically trapping or retaining particles (90) such as cells (92) at well defined locations in the channel. The system may be used to trap and study individual cells or for concentrating or filtering particles in a fluid.

Abstract: The invention is directed to a polypeptide derived from domain IV of the extracellular matrix protein perlecan that can selectively adhere cells, nucleic acids encoding the inventive polypeptide, vectors comprising the nucleic acids, devices comprising a scaffold coated with the inventive polypeptide, and methods of adhering cells to a scaffold using the inventive polypeptide.

Abstract: ?v?3 Integrin receptor targeting liposomes comprise a cationic amphiphile such as a cationic lipid, a neutral lipid, and a targeting lipid. The targeting lipid includes a non-peptidic ?v?3 integrin antagonist.

Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.

Abstract: A first and a second static-pressure gas bearings supporting a rod at two locations in the axial direction in the non-contact manner are provided, in which the first static-pressure gas bearing is fixedly supported by a bearing housing, while the second static-pressure gas bearing is supported capable of displacement through a movable support mechanism. And this movable support mechanism has an actuator and suppresses contact of the rod with the static-pressure gas bearings by displacing the shaft center of the second static-pressure gas bearing with respect to the first static-pressure gas bearing by this actuator according to a load acting on the rod.

Abstract: A high-power thyristor module includes a housing configured with an inner receiving space, and a thyristor unit disposed in the inner receiving space in the housing and including a mounting frame, and a plurality of high-power thyristors mounted on the mounting frame. Each thyristor has a gate. The mounting frame includes a dielectric top plate disposed on a top side of the housing, and a plurality of electrodes mounted on the top plate so that the electrodes are exposed outwardly of the housing, and coupled respectively to the gates of the thyristors. Cooling oil is contained in the inner receiving space so that the thyristors are submerged thereby.

Abstract: A communication method and apparatus using the IP address of a gateway for an MN in a VPN are provided. When the MN is to access the VPN, the gateway acting an FA in the VPN performs a Mobile IP registration on behalf of the MN and is allocated a HoA for the MN from an HA. Therefore, the number of addresses required for the Mobile IP registration of the MN is reduced and overlap between an IP-in-IP tunnel for Mobile Internet and an IPsec tunnel for the VPN is avoided. As a result, packet transmission overhead is reduced.

Abstract: A method of embedding useful data in a digital music file in a way that maintains compatibility with existing digital music formats and players and has no effect on the size of the digital music file or sound quality. A digital music file is analyzed to determine a list of start and end locations of at least n consecutive zeros, defining a list of record locations, where n is an integer greater than two. The file store locations are written in initial record locations of the list of record locations and the data and a start key is written remaining record locations of the list of record locations. A process of retrieving the embedded data is also disclosed.

Abstract: A method for receiving multicast service data by a terminal in a communication system. The method includes receiving a pilot from a base station, measuring channel state information using the received pilot, and transmitting the channel state information to the base station; receiving a frame from the base station, and determining whether there is an error in the received frame; when no error has occurred in the received frame, determining whether the number of frames consecutively received without error is greater than or equal to a predetermined number; and when the number of frames consecutively received without error is greater than or equal to the predetermined number, transitioning to a non-feedback state where the terminal transmits no channel state information to the base station. The frame includes multicast service data.

Abstract: Disclosed herein is a high-throughput assay to measure intracellular polyglutamine protein aggregation using fluorescence resonance energy transfer (FRET). Three libraries of over 3000 biologically active small molecules were screened for inhibitory activity, and a lead compound was characterized in detail. Y-27632, an inhibitor of the Rho-associated kinase p160ROCK, diminished polyglutamine protein aggregation at micromolar concentrations, and reduced neurodegeneration in a Drosophila model of polyglutamine disease.

Abstract: A server is arranged to distribute at least one stream of audio data corresponding to an audio signal to two or more speakers across a network. Each speaker includes a respective clock for regenerating the audio signal from the audio data. For each speaker, the server determines a relative rate of the speaker clock to a real time rate; and for each stream of data provided to a speaker, the server determines from a respective relative rate, respective samples of the audio signal to be altered in accordance with said relative rate. The streams are altered accordingly and transmitted across the network.

Abstract: Methods, apparatus and systems for an up-converter resonant cavity light emitting diode device includes a semiconductor light source, an up-converter to form the light emitter with up-converting materials and an electrical source coupled with the semiconductor light source for providing electrical energy to the semiconductor light source to provide a desired wavelength emitted light. The semiconductor light source is a resonant cavity light emitting diode or laser that emits an approximately 975 nm wavelength to provide electrical and optical confinement to the semiconductor light source to form a resonant cavity up-converting light emitting diode (UC/RCLED). Rows and columns of electrodes provide active matrix addressing of plural sets of UC/RCLEDs for display devices.

Abstract: A 3D scanning apparatus configured to image a physical entity comprises a radiation projector for projecting a plurality of radiation stripes onto the physical entity, a detector for detecting striped radiation received from the physical entity; and a data storage device for storing the received radiation as a pixellated bitmap image, the apparatus characterised in that the physical entity, the radiation projector and the detector are geometrically arranged to constrain the number of times that each received stripe is permitted to occur in a given pixel row of the bitmap, the geometrica) constraint determining a stored occlusion classification comprising a plurality of types of occlusions and the apparatus additionally comprising an occlusion type processing means configured to utilise the classification for detecting the various types of occlusions in said received image data.

Abstract: The invention provides a general “signal-on” architecture for oligonucleotide-based detectors that leads to order of magnitude increases in signal gain and sensitivity as compared to prior art detectors. The detectors of the invention rely on base pairing between two oligonucleotide strands, the sensor strand and the blocker strand. In the ‘off’ position of the detector, i.e., in the absence of target, the blocker strand and sensor strand are base-paired. As shown in FIG. 1, the formation of comparatively rigid, duplex DNA prevents the redox moiety from approaching the electrode surface, thereby suppressing Faradaic currents. When target is added to the system, the target displaces the blocker strand, binds to the sensor strand, liberating the end of the redox-labeled oligonucleotide to produce a flexible element. This, in turn, allows the redox moiety to collide with the electrode surface, producing a readily detectable Faradaic current.

Abstract: A pharmaceutical for promoting neogenesis or regeneration of pancreatic ? cells which produces and secretes insulin and for promoting insulin production in ? cells, comprising ghrelin or a derivative thereof as an effective component.

Abstract: This invention is directed to a method for preparation of a biological sample for measurement of protein epitopes that allows for the preservation of intracellular protein epitopes and detection of signal transduction pathways based on the ability to capture transient activation states of the epitopes. The method provided by the invention allows for the rapid fixation of biological samples containing red blood cells, to ensure that epitopes of signal transduction molecules and other intracellular protein epitopes are preserved in the active state. The method of the invention further allows for lysis of red blood cells, thereby making it a useful method for cytometric analysis of biological samples, including, for example, whole blood, bone marrow aspirates, peritoneal fluids, and other red blood cell containing samples. The invention also provides a method to recover or “unmask” epitopes on intracellular antigens that have been made inaccessible by the cross linking fixative necessary to fix the sample.