Patents Assigned to University
  • Patent number: 7803289
    Abstract: The invention provides a process for preparing an overvoltage protection material comprising: (i) preparing a mixture comprising a polymer binder precursor and a conductive material; and (ii) heating the mixture to cause reaction of the polymer binder precursor and generate a polymer matrix having conductive material dispersed therein, wherein the polymer binder precursor is chosen such that substantially no solvent is generated during the reaction.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: September 28, 2010
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Chi-Ming Chan, Kai-Mo Ng, Catherine Yuen Chien Wong, Ying Kit Cheung
  • Patent number: 7803392
    Abstract: The present invention relates to pH-sensitive mucoadhesive film-forming gels and wax-film composites suitable for topical and mucosal delivery of molecules of interest, namely active pharmaceuticals. The gels comprise a pharmaceutically acceptable pH-sensitive polymer that responds to a lowering of pH by precipitating into films when in contact with the skin or mucosal surface. The films also comprise an adhesive polymer that allows the film to remain in contact with the tissue for an extended period of time. The wax-film composites comprise a bi-layer film having both the said pH-sensitive mucoadhesive layer to promote strong adherence to the skin and mucosal surfaces as well as a specially bonded wax layer intended to extend the adherence of the film to tissues for a prolonged period of time.
    Type: Grant
    Filed: December 27, 2000
    Date of Patent: September 28, 2010
    Assignee: University of Kentucky Research Foundation
    Inventors: Russell Mumper, Michael Jay
  • Patent number: 7803551
    Abstract: Methods are provided for nucleic acid analysis wherein a target nucleic acid that is at least partially double stranded is mixed with a dsDNA binding dye having a percent saturation of at least 50% to form a mixture. In one embodiment, the nucleic acid is amplified in the presence of the dsDNA binding dye, and in another embodiment a melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye as the mixture is heated. Dyes for use in nucleic acid analysis and methods for making dyes are also provided.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: September 28, 2010
    Assignees: University of Utah Research Foundation, Idaho Technology, Inc.
    Inventors: Carl T. Wittwer, Virginie Dujols
  • Patent number: 7803919
    Abstract: A quantitative trait locus (QTL) affecting milk fat and protein concentration was localized to a 4cM confidence interval on chromosome 6 centered on the microsatellite BM143. The genes and sequence variation in this region were characterized, and common haplotypes spanning five polymorphic sites in the genes IBSP, SPP1, PKD2, and ABCG2 for two sires heterozygous for this QTL were localized. Expression of SPP1 and ABCG2 in the bovine mammary gland increased from parturition through lactation. SPP1 was sequenced, and all the coding exons of ABCG2 and PKD2 were sequenced for these two sires. The single nucleotide change capable of encoding a substitution of tyrosine-581 to serine (Y581S) in the ABCG2 transporter was the only polymorphism corresponding to the segregation status of all three heterozygous and 15 homozygous sires for the QTL in the Israeli and US Holstein populations.
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: September 28, 2010
    Assignee: The Board of Trustees of The University of Illinois
    Inventors: Eyal Seroussi, Harris A. Lewin, Mark R. Band, Miri Cohen-Zinder, James K. Drackley, Denis M. Larkin, Juan J. Loor, Micha Ron, Moshe Shani, Joel Ira Weller
  • Patent number: 7803566
    Abstract: The present invention relates to the identification of gene sequences and proteins involved in vaccinia virus dominant T cell epitopes. Two vaccinia virus CD8+ T cell epitopes restricted by the most common human MHC class I allele, HLA-A0201 have been identified. Both epitopes are highly conserved in vaccinia and variola viruses. The induction of the T cell responses following primary vaccination is demonstrated by the kinetics of epitope specific CD8+ T cells in 3 HLA-A0201 individuals. This information will be useful for the design and analyses of the immunogenicity of experimental vaccinia vaccines, and for basic studies of human T cell memory.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: September 28, 2010
    Assignee: The University of Massachusetts
    Inventors: Masanori Terajima, John Cruz, Francis A. Ennis
  • Patent number: 7804409
    Abstract: A system for monitoring compliance with handwashing protocols by a plurality of workers, each worker carrying a wireless tag having a worker identifier, the monitoring being performed in a facility having a plurality of areas, the system comprising a plurality of wireless tag reader/transmitters each having an area identifier, at least one wireless tag reader/transmitter being positioned in each of the areas and each wireless tag reader/transmitter being capable of reading the worker identifier stored in the wireless tag when the worker is within range of the wireless tag reader/transmitter and further capable of transmitting the worker and area identifiers to at least one computing device; and at least one of said wireless tag reader/transmitters being disposed at a handwashing station; wherein the at least one wireless tag reader/transmitter reads the worker identifier when the worker manipulates a device at the handwashing station dispensing a washing substance and transmits the worker and area identifiers
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: September 28, 2010
    Assignee: Duke University
    Inventors: Andrew D. Munro, Robert G. Munro
  • Patent number: 7802477
    Abstract: A probe is inserted at a predetermined speed into a food to be measured, and vibrations created by the insertion are acquired by a piezoelectric element. The vibrations are displayed, and the pulse number per unit time on the basis of the insertion speed of the probe is calculated so that the oral sensation of the food is quantitatively specified with the pulse number.
    Type: Grant
    Filed: February 18, 2005
    Date of Patent: September 28, 2010
    Assignee: Hiroshima University
    Inventor: Naoki Sakurai
  • Patent number: 7803784
    Abstract: MicroRNAs (miRNAs) are a diverse and abundant class of ˜22-nucleotide (nt) endogenous regulatory RNAs that play a variety of roles in animal cells by controlling gene expression at the posttranscriptional level. Increased miR-181a expression in mature T cells is shown to cause a marked increase in T cell activation and augments T cell sensitivity to peptide antigens. Moreover, T cell blasts with higher miR-181a expression become reactive to antagonists. The effects of miR-181a on antigen discrimination are in part achieved by dampening the expression of multiple negative regulators in the T cell receptor (TCR) signaling pathway, including PTPN22 and the dual specificity phosphatases DUSP5 and DUSP6. This results in a reduction in the TCR signaling threshold, thus quantitatively and qualitatively enhancing T cell sensitivity to antigens.
    Type: Grant
    Filed: October 24, 2007
    Date of Patent: September 28, 2010
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Qi-Jing Li, Chang-Zheng Chen, Mark M. Davis, Jacqueline Chau
  • Patent number: 7803796
    Abstract: Provided is a homopiperazine compound for inhibiting ribosomal frameshifting by binding to an RNA pseudoknot structure of SARS coronavirus. Particularly, the present invention provides a pharmaceutical composition for inhibiting synthesis of protein induced by ?1 frameshifting by binding to an RNA pseudoknot structure specifically existing in SARS coronavirus. The composition includes a therapeutically effective amount of homopiperazine compound of following chemical formula 1 or a pharmaceutically accepted salt thereof, and a pharmaceutically accepted carrier or excipient.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: September 28, 2010
    Assignee: Sungkyunkwan University Foundation For Corporate Collaboration
    Inventors: Hyun-Ju Park, So-Jung Park, Yang-Gyun Kim
  • Patent number: 7804571
    Abstract: Structures, devices, systems and methods of using multi-domain vertical alignment liquid crystal displays with high transmittance, high contrast ratio and wide view angle in which at least one of the electrode substrates has circular or ring-shaped openings, such as holes or slits. Circular or ring-shaped patterns for openings and electrodes have not been used in the construction of a liquid crystal display. The new multi-domain vertical alignment (MDVA) liquid crystal display is particularly suitable for liquid crystal display television and computer monitor applications.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: September 28, 2010
    Assignees: University of Central Florida Research Foundation, Inc., Toppoly Optoelectronics Corp.
    Inventors: Ruibo Lu, Qi Hong, Shin-Tson Wu, Thomas X. Wu
  • Patent number: 7803531
    Abstract: The disclosure describes methods for inducing apoptosis of a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Included are methods for inducing apoptosis of cancer cells. Also described are compounds and compositions for use in methods of thiamin depletion and treating diseases such as cancer, and methods for identifying thiamin-depleting agents and for preparing pharmaceutical compositions.
    Type: Grant
    Filed: January 13, 2003
    Date of Patent: September 28, 2010
    Assignee: Brandeis University
    Inventors: Chandler Fulton, Elaine Y. Lai
  • Patent number: 7803622
    Abstract: The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.
    Type: Grant
    Filed: February 15, 2005
    Date of Patent: September 28, 2010
    Assignee: University of Iowa Research Foundation
    Inventors: John F. Engelhardt, Dongsheng Duan
  • Patent number: 7804468
    Abstract: A data driver and a method of driving the same. The data driver includes a shift register for generating sampling signals; sampling latches for sampling digital data applied to output channels, respectively, in accordance with the sampling signals; holding latch units for receiving the sampled digital data of the channels from the sampling latches to hold the digital data for a first period; first digital-to-analog converters for receiving the held digital data of the channels from the holding latch units to generate currents corresponding to the digital data; a second digital-to-analog converter commonly connected to the channels and the first digital-to-analog converters to receive the digital data provided from the holding latch units for a second period and to generate correction currents for the data currents; and output stages for sampling, correcting, and driving final currents using the data currents and the correction currents.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: September 28, 2010
    Assignees: Samsung Mobile Display Co., Ltd., IUCF-HYU (Industry-University Cooperation Foundation Hanyang University)
    Inventors: Yong Sung Park, Oh Kyong Kwon, Han Jin Bae, Joon Ho Bae, Byong Deok Choi
  • Patent number: 7804977
    Abstract: We propose methods for generating a halftone image, in which each pixel takes one of two tone values. The generated image contains hidden data, which is present at data storage pixels chosen using a pseudo-random number generator. In a first case, the data is hidden within an existing halftone image by reversing the tone value at certain of the data storage pixels, and at pixels neighboring the data storage pixels. In a second case, the halftone image is generated from a grey-scale image, and data is hidden during this conversion process.
    Type: Grant
    Filed: August 22, 2006
    Date of Patent: September 28, 2010
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Oscar Chi-Lim Au, Ming Sun Fu
  • Patent number: 7803393
    Abstract: An implant for use in biological/biomedical applications may be prepared by subjecting a substrate to a gas-plasma treatment. The substrate may be a biocompatible material, including metals, ceramics, and polymers. More specifically, the substrate may be a bioresorbable polymer. The gas-plasma treatment may include subjecting the substrate to a plasma formed by a reactive gas. The gas-plasma treatment may be performed for a chosen duration at a radio frequency within a temperature range, a pressure range, and a supplied energy range. The substrate may be exposed to living cells, such that some of the living cells become coupled to the substrate. Gas-plasma treatment parameters may be chosen such that the living cells coupled to the treated substrate produce more of a cellular product than living cells coupled to an untreated substrate.
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: September 28, 2010
    Assignee: Board of Regents, The University of Texas System
    Inventors: C. Mauli Agrawal, Steven R. Bailey, Jodie L. Polan
  • Patent number: 7803361
    Abstract: Interleukin-2 (IL-2) mutants having reduced toxicity, which include full-length IL-2, truncated forms of IL-2 and forms of IL-2 that are linked to another molecule are disclosed herein. Particular substitutions within IL-2, particularly within the permeability enhancing peptide region of IL-2 achieve substantial reduction of vasopermeability activity as compared to a wildytpe form of the mutant IL-2 while retaining many of the immune activating properties of IL-2. Invention IL-2 mutants can be used to stimulate the immune system of an animal and may be used in the treatment of various disorders and conditions.
    Type: Grant
    Filed: April 7, 2009
    Date of Patent: September 28, 2010
    Assignee: University of Southern California
    Inventors: Alan L. Epstein, Peisheng Hu
  • Patent number: 7803362
    Abstract: The invention relates to interferon-? molecules having certain O-linked oligosaccharide structures.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: September 28, 2010
    Assignees: Synageva BioPharma Corp., University of GA Research Foundation
    Inventors: Robert D. Ivarie, Alex J. Harvey, Julie A. Morris, Guodong Liu, Jeffrey C. Rapp
  • Patent number: 7803382
    Abstract: The invention provides methods, compositions and kits for inducing and/or enhancing an immune response in a subject. The invention in some aspects includes polypeptide and nucleic acid molecules that induce and/or enhance an immune response. In some aspects of the invention, the polypeptide and/or nucleic acid molecules of the invention are useful to induce and/or enhance an immune response in a subject who has or is suspected of having cancer.
    Type: Grant
    Filed: September 9, 2004
    Date of Patent: September 28, 2010
    Assignees: Ludwig Institute for Cancer Research Ltd., Chancelors Masters and Scholars of the University of Oxford
    Inventors: Lloyd J. Old, Sacha Gnjatic, Djordje Atanackovic, Vincenzo Cerundolo, Khoon-Lin Ling
  • Patent number: 7804764
    Abstract: The transmitter of one embodiment of the present invention includes: a S/P section for converting original serial data to parallel data which will correspond to a plurality of subcarriers; and a second IFFT section for converting the parallel data from the frequency domain to the time domain. The transmitter includes, between the S/P section and the second IFFT section, a first IFFT section for modulating the plurality of subcarriers using elements of a matrix derived from an expression for Inverse Discrete Fourier Transform involving time domain signal levels and frequency domain signal levels. The configuration enables CI and PO-CI to be implemented on transmitters and receivers with a simple configuration.
    Type: Grant
    Filed: August 1, 2006
    Date of Patent: September 28, 2010
    Assignees: National University Corporation Nara Institute of Science and Technology, Sky Perfect JSAT Corporation
    Inventors: Takao Hara, Anwar Khoirul, Kiyotake Ando
  • Patent number: 7805477
    Abstract: The present invention relates to computing circuits and method for running an MPEG-2 AAC or MPEG-4 AAC algorithm efficiently, which is used as an audio compression algorithm in multi-channel high-quality audio systems, on programmable processors. In accordance with the present invention, the IMDCT process which takes large part of the amount of the operations in implementation of an MPEG-2/4 AAC algorithm can be performed in efficient. In addition, while the architecture of the existing digital signal processor is still used, the performance can be improved by means of the addition of the architecture of the address generator, Huffman decoder, and bit processing architecture. After all, to design and change the programmable processor is facilitated.
    Type: Grant
    Filed: January 30, 2006
    Date of Patent: September 28, 2010
    Assignees: Pulsus Technologies, Ajou University Industry-Academic Cooperation Foundation
    Inventors: Jong Hoon Oh, Myung Hoon Sunwoo, Jong Ha Moon