Abstract: A coating material is blended preferably in an amount of 60 to 90% by mass relative to paint film forming components thereby to form a curable solvent-based topcoating material. The coating material includes an oleophilic polyrotaxane which includes a cyclic molecule, a linear molecule including the cyclic molecule with piercing through the cyclic molecule, and blocking groups which are placed at both end terminals of the linear molecule to prevent the cyclic molecule from leaving from the linear molecule, at least one of the above-mentioned liner molecule and the cyclic molecule having hydrophobic modification group.

Abstract: A lidar and digital camera system collect data and generate a three-dimensional image. A lidar generates a laser beam to form a lidar shot and to receive a reflected laser beam to provide range data. A digital camera includes an array of pixels to receive optical radiation and provide electro-optical data. An optical bench passes the laser beam, reflected laser beam, and optical radiation and is positioned to align each pixel to known positions within the lidar shot. Pixels are matched to form a lidar point-cloud which is used to generate an image.

Abstract: A phosphoprotein detection reagent that selectively binds phosphoamino acids. Methods of generating and employing the reagent are also provided, as are methods of detecting modulation of protein phosphorylation are disclosed. Methods of detecting a change in state of a cell are also disclosed. Additionally, a kit for the detection of phosphoproteins is also disclosed.

Abstract: Methods, systems, apparatus and devices for using a modified PDH technique to measure the FSR of an etalon with one part per 104 precision.

Abstract: The invention provides for an apparatus (1) for growing aquatic animals comprising at least two securing members (3, 6) adapted to be removably fixed together such that a feed substrate (7) can be reversibly sandwiched between the securing members. The invention also provides for modular assemblies of the apparatus, and further provides methods of culturing aquatic animals and methods of increasing roe content of aquatic animals.

Abstract: The invention provides methods for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell. The invention also provides methods for preventing tumor progression in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization. Furthermore, the invention provides methods for inhibiting tumor cell growth in an animal comprising inhibiting FoxM1B activity, expression, or nuclear localization in tumor cells in the animal.

Abstract: A nucleic acid molecule encoding the gilvocarcin V gene cluster and subunits thereof. Recombinant vectors and host cells comprising a nucleic acid compound encoding the gilvocarcin V gene cluster or subunits thereof. Host cells comprising recombinant vectors encoding the gilvocarcin polyketide synthase and gilvocarcin post-PKS modifying enzymes from Streptomyces griseoflavus can be used to produce gilvocarcin and functional gilvocarcin mutants, analogs and derivatives thereof with application as antibiotics, anticancer agents, immunosuppressants, antivirals, and neuroprotective agents.

Abstract: A system to form and store an electrocardiogram (ECG) signal derived from a cardiac electrical signal that includes an apparatus having a pair of the electrodes to connect to a patient to detect the cardiac electrical signal. A signal sampler samples the cardiac electrical signal to form the ECG signal. A data storage device stores the ECG signal. A computer communicates with the data storage device to retrieve the ECG signal for analysis by software stored in the memory of the computer. The software analyzes a morphology of the amplitude of a plurality of R-wave peaks contained within the ECG signal and/or analyzes a morphology of the area of a plurality of QRS complex pulses contained within the ECG signal.

Abstract: Here, the inventors disclose the treatment of imatinib mesylate resistant chronic myelogenous leukemia cells with a cotreatment of vorinostat (SAHA, suberoylanilide hydroxamic acid) and dasatinib, a dual Abl/Src kinase (TK) inhibitor. Combined treatment of cultured human CML and BaF3 cells with vorinostat and dasatinib induced more apoptosis than either agent alone, as well as synergistically induced loss of clonogenic survival, which was associated with greater depletion of Bcr-Abl, p-CrkL and p-STAT5 levels. Co-treatment with dasatinib and vorinostat also attenuated the levels of Bcr-AblE255K and Bcr-AblT315I and induced apoptosis of BaF3 cells with ectopic expression of the mutant forms of Bcr-Abl. Finally, co-treatment of the primary CML cells with vorinostat and dasatinib induced more loss of cell viability and depleted Bcr-Abl or Bcr-AblT315I, p-STAT5 and p-CrkL levels than either agent alone.

Abstract: Cellular physiology workstations for automated data acquisition and perfusion control are described. The cellular physiology workstation may be used for physiological and electrophysiological experiments. Methods for employing such cellular physiology workstations in physiological and electrophysiological experiments are also disclosed. The cellular physiology workstations comprise one or more recording chambers each for holding one or more cells to be measured. One or more cells are place in each recording chamber. Perfusions means, such as an automatic perfusion system is connected to the recording chamber to perfuse the cells with a plurality of solutions containing different concentration of one or more agents to be tested. Biosensors, such as patch clamps, electrodes, or microscopes are positioned to detect a response from the cell. The cellular physiology workstation may optionally comprise injecting means for introducing an injection solution into the cell before and during analysis.

Abstract: A process for the preparation of a nucleophilic addition product of an aziridine and a nucleophile, the process comprising treating the arizidine with the nucleophile in the presence of a biaryl phosphoric acid catalyst.

Abstract: A method of making a compound of Formula I? comprises reacting a compound of the formula DLCHO, with a compound of the formula to produce the compound of Formula I?. Methods of using the compounds are also described, particularly as intermediates for the synthesis of porphyrin rods, which porphyrin rods are in turn useful for (among other things) the production of molecular memory devices.

Abstract: A system for constructing image slices through a selected object, the system comprising an identifiable fiducial reference in a fixed position relative to the selected object, wherein the fiducial reference comprises at least two identifiable reference markers. A source of radiation is provided for irradiating the selected object and the fiducial reference to form a projected image of the selected object and the fiducial reference which is recorded by a recording medium.

Abstract: A convex parimutuel call auction implemented at a central market organizer computer includes receiving orders from market participants, calculating a quantity of accepted bids for each of the orders, and communicating to the participants the calculated quantity of accepted bids for each of the orders. Each order includes a specification by a participant of contingent claims on outcomes of a future event, a limit bid price, and a limit bid quantity. The calculation involves maximizing an objective function given by an approximate profit to the market organizer plus a weighted logarithmic penalty function. Because the formulation is convex, the solution may be computed in polynomial time using standard techniques, such as a path-following algorithm.

Abstract: The present invention provides for a proteomic approach to grading gliomas, and for predicting patient survival. In addition to employing global protein expression patterns, such as by mass spectrometry, particular target proteins whose expression is altered in various gliomas can be used to predict the stage/classification of a glioma, as well as to indicate whether a given patient will be a short- or long-term survivor.

Abstract: A method, medium, and system of rendering image data, including receiving three-dimensional space data for each pixel forming the image data, the three-dimensional space data including depth and color information values for each pixel, determining an order of rendering for a plurality of surfaces forming the image data in an order of the distance between a rendering viewpoint and the surface forming the image data, generating splat depth information values for each splat included in the surface forming the image data, according to the rendering order, and determining whether the splat included in the surface forming the image data is required to be blended and accordingly selectively performing a blending on the splat.

Abstract: An electrochromic mirror includes an electrochromic film, an electrically conductive reflective film formed at one thickness direction side of the electrochromic film, an electrically conductive film provided at one thickness direction side of the electrochromic film and at a side of the electrically conductive reflective film that is opposite from the electrochromic film, an electrolytic solution containing lithium ions and enclosed between the electrically conductive reflective film and the electrically conductive film, and a reduction reaction compensation unit. In the electrolytic solution, due to applying a voltage such that the electrically conductive film is made positive and electrically conductive reflective film is made negative, the lithium ions move toward the side of the electrochromic film and are provided to a reduction reaction of the electrochromic film. The reduction reaction compensation unit compensates the reduction reaction.

Abstract: The present invention relates to a magnesium-based composite material includes a magnesium-based metallic material, and at least one nanoscale reinforcement film disposed therein. The present invention also relates to a method for fabricating the above-described a magnesium-based composite material, the method includes the steps of: (a) providing at least two magnesium-based plates; (b) providing at least one nanoscale reinforcement film; (c) sandwiching the at least one nanoscale reinforcement film between the at least two magnesium-based plates to form a preform; and (d) hot rolling the preform to achieve the magnesium-based composite material.

Abstract: The invention provides tandem single nucleotide polymorphisms and methods for their use, for example, in diagnosing Down Syndrome.

Abstract: The present invention provides thermal detectors having an optical cavity that is optimized to couple light into a sensor. Light that is on resonance is coupled with the sensor with as high as 100% efficiency, while light off resonance is substantially reflected away. Light that strikes the sensor from the sides (i.e. not on the optical cavity axis) only interacts minimally with sensor because of the reduced absorption characteristics of the sensor. Narrowband sensors in accordance with the present invention can gain as much as 100% of the signal from one direction and spectral band, while receiving only a fraction of the normal radiation noise, which originates from all spectral bands and directions.