Abstract: Compounds of Formula I and pharmaceutically acceptable salts thereof, are capable of blockading voltage-dependent sodium channels and are useful in particular, in treating glaucoma and multiple sclerosis.

Abstract: The presently disclosed subject matter provides methods for increasing perfusion in hypoxic regions of tissues in subjects. Also provided are methods for treating diseases and/or disorders associated with hypoxia in subjects, methods for increasing sensitivity of tumors to radiation and/or chemotherapy treatments, methods for delaying tumor growth in subjects, and methods for inhibiting tumor blood vessel growth in subjects. In some embodiments, the presently disclosed methods involve administering to subjects in need thereof a first composition selected from the group consisting of a nitrosylated hemoglobin and an agent that induces nitrosylation of endogenous hemoglobin in the subject and a second composition comprising a hyperoxic gas. In some embodiments, the presently disclosed methods also include treating a tumor with radiation therapy, chemotherapy, photodynamic therapy, immunotherapy, or combinations thereof. Also provided are inhalable gases that can be employed in the presently disclosed methods.

Abstract: A method of treating amyloidoses by administering an effective amount of a cystatin C composition. A method of preventing and inhibiting A? oligomerization by administering an effective amount of a cystatin C composition. A composition for inhibiting A? oligomerization including an effective amount of a cystatin C composition. A method of diagnosing disease by assaying for a biomarker comprising a cystatin C complex. A biomarker for disease including a cystatin C complex.

Abstract: Corrosion-inhibiting pigments based on manganese are described that contain a trivalent or tetravalent manganese/valence stabilizer complex. An inorganic or organic material is used to stabilize the trivalent or tetravalent manganese ion to form a compound that is sparingly soluble, exhibits low solubility, or is insoluble in water, depending upon the intended usage. Specific stabilizers are chosen to control the release rate of trivalent or tetravalent manganese during exposure to water and to tailor the compatibility of the powder when used as a pigment in a chosen binder system. Stabilizers may also modify the processing and handling characteristics of the formed powders. Manganese/valence stabilizer combinations are chosen based on the well-founded principles of manganese coordination chemistry. Many manganese-valence stabilizer combinations are presented that can equal the performance of conventional hexavalent chromium or tetravalent lead systems.

Abstract: A roulette gaming machine comprises a roulette board, a ball, a rotatable portion, ball receiving parts, numerals, a driving motor and a main control CPU. The rotatable portion is rotatably provided at a center portion of the roulette board. The ball receiving parts receives the ball and circularly arranged on an inner periphery side of the rotatable portion. The numerals are circularly arranged on an outer periphery side of the rotatable portion so as to be opposed to the ball receiving parts respectively. The driving motor rotates the rotatable portion in a certain direction. The main control CPU selects a drive control pattern. The main control CPU varies a constant speed rotation period for rotating the rotatable portion at a certain rotation speed according to the drive control pattern, and controls the driving unit according to the constant speed rotation period and the certain rotation speed.

Abstract: Temperature-adjustable pore size molecular sieves comprise a plurality of metal clusters bound with a plurality of amphiphilic ligands, each ligand comprising a functionalized hydrophobic moiety and a functionalized hydrophilic moiety, and wherein the metal clusters and amphiphilic ligand hydrophilic moieties form a metal cluster layer, the metal cluster layer forming at least one hydrophilic pore. On each side of the metal cluster layer, a plurality of associated amphiphilic ligand hydrophobic moieties cooperate with the metal cluster layer to form a tri-layer and a plurality of tri-layers are held in proximity with each other to form at least one hydrophobic chamber.

Abstract: A system includes a plurality of scanning devices and light receivers, enabling a plurality of images of a site to be displayed using output signals produced in response to light from the light receivers. To avoid crosstalk caused by light receivers receiving light emitted by a plurality of scanning devices, different wavebands of light can be applied to different scanning devices, the received light can be filtered, or the light can be supplied to one scanning device at a time to multiplex either frame-by-frame, or pixel-by-pixel, or the light supplied to each scanning device can be modulated and the received light demodulated so that an image is produced in response to light from a single scanning device. Expensive components such as laser light sources, optical detectors, a controller, and processor can be shared by multiple imaging devices to minimize the cost of the imaging system.

Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.

Abstract: The invention provides methods for identifying a compound that inhibits cytochrome c synthesis. This invention further provides a method for the high throughput screening of compounds that inhibit cytochrome c synthesis.

Abstract: A method of eliminating an ectoparasite infestation is disclosed that may include steps of defining a target area on an animal having an ectoparasite infestation, heating a volume of air to a temperature to form heated air, applying the heated air to the target area with an airflow such that the heated air impinges directly on substantially all ectoparasites located within the target area, and maintaining the heated air at the target area for a period of time sufficient to affect an ectoparasite mortality rate of at least 50%.

Abstract: The current invention provides for methods of immunotherapy using a combination of epitope-specific and cytokine or anticytokine immunotherapy. The method provides for modulation of pathogenic immune responses and includes the identification of molecules comprising specific epitopes involved in a particular disease state of interest, administration of the epitope-specific molecule in conjunction with the cytokine or anticytokine, and downstream modification of the administration of the cytokine/anticytokine relative to the administration of the epitope-specific molecule.

Abstract: A bi-directional software development process simulation model is described. The model simulates the stages of a software development process, using equations relating to defect injection and detection and parameters describing detection and injection rates. With forward development process simulation, predictions can be made for process outcomes. By simulating in the reverse direction, defect detection requirements can be found for each stage of the model to achieve a desired performance result. Outcome-based control levels are utilized with the model to better detect whether a process is out of control. By going between the forward and reverse simulation directions, control of the process can be fine-tuned as defect detection data is obtained during process execution. In addition to quality as measured by defects, other metrics can be simulated, including cost, time, and features; similarly other product development scenarios, such as hardware or systems engineering can also be modeled and simulated.

Abstract: A gas-fed hollow cathode keeper can reduce ion bombardment erosion by expelling gas through the keeper faceplate. The expelled gas effectively creates a high-pressure “shield” around the keeper such that bombarding ions suffer energy-reducing collisions before impacting the keeper. If the bombarding ion energy is reduced enough, the erosion is eliminated since sputtering is a threshold phenomenon.

Abstract: A method is provided for electrochemically depositing a polymer with spatial selectivity. A substrate having a substrate surface is contacted with an aqueous solution containing a selectively insolubilizable polysaccharide, such as chitosan, which is subjected to electrochemically treatment to deposit, with spatial selectivity, the selectively insolubilizable polysaccharide on a patterned electrically conductive portion of the substrate surface.

Abstract: A distributed monitoring and control system includes a plurality of nodes forming a redundant communication network. Each of the nodes includes a processor, a memory and a transceiver. At least one of the nodes includes a sensor for acquiring information. At least one of the nodes includes an actuator. At least one of the processors is programmed with a control algorithm to receive information acquired from the sensors, calculate a control command and communicate the control command to the actuators for execution.

Abstract: A method for controlling access to a system of finite resources with excess demand employs a two stage admission process. Subscribers are first admitted based on an initial bid price and resource availability. The market price is determined by the highest bid price among the rejected arrivals in the current batch. Admitted subscribers are then given the option to secure continued access to the resource by accepting a fee-based reservation. The fee for the reservation is determined in a manner which is fair to the reserving subscriber, as well as all other subscribers, in that the reservation fee is priced to provide access at a cost which prevents arbitraging opportunities. If the current market price exceeds a non-reserved subscriber's bid price, that non-reserved subscriber is displaced. If the current market price exceeds a reserved subscriber's bid price, that reserved subscriber's reservation is activated and access to the resource continues.

Abstract: Amplifier circuits and methods are implemented using a variety of different embodiments. According to one such embodiment, a method is implemented using a field-effect transistor (FET) having a gate node, a source node and a drain node. A first circuit state is implemented in which the gate node, the source node and the drain node are connected to inputs that generate a stored charge at the gate node, the amount of stored charge at the gate node being responsive to a first voltage level. A second circuit state is implemented in which the drain node is connected to a voltage source, the source node is connected to a load, and while charge at the gate node is preserved, current between the drain node to the source node drives a voltage level of the load to a proportionally amplified version of the first voltage level.

Abstract: Described herein are ultra wide-band distributed RF (UWB-DRF) front-end receivers comprising composite cells distributed along transmission lines, where each composite cell comprises a low-noise amplifier (LNA) merged with a mixer. By merging the LNA and the mixer in each composite cell, the power consumption and chip area of the RF front-end is reduced. Further, the distributed architecture of the RF front-end allows it to operate over a wide bandwidth by absorbing the parasitic capacitances of the composite cells into the transmission lines of the RF-front end. Embodiments of the RF front-end provide wideband flat gain, low noise figure (NF), wideband linearity, and wideband matching at the inputs of the RF front-end. In an embodiment, a programmable resistance at the termination of the RF transmission line allows the RF front-end to trade off a few decibels of mismatch at the RF input for higher gain and lower NF.

Abstract: This invention permits retinal images to be acquired at high speed and with unprecedented resolution in three dimensions (4×4×6 ?m). The instrument achieves high lateral resolution by using adaptive optics to correct optical aberrations of the human eye in real time. High axial resolution and high speed are made possible by the use of Fourier-domain optical coherence tomography. Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.

Abstract: The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.