Abstract: Disclosed is the surprising discovery that aminophospholipids, such as phosphatidyserine and phosphatidylethanolamine, are specific, accessible and stable markers of the luminal surface of tumor blood vessels. The present invention thus provides aminophospholipid-targeted diagnostic and therapeutic constructs for use in tumor intervention. Antibody-therapeutic agent conjugates and constructs that bind to aminophospholipids are particularly provided, as are methods of specifically delivering therapeutic agents, including toxins and coagulants, to the stably-expressed aminophospholipids of tumor blood vessels, thereby inducing thrombosis, necrosis and tumor regression.

Abstract: A system (10) for monitoring PLC impedance of a phase conductor 12.1 of a high voltage overhead power transmission line (OHTL) 12 comprises a hybrid 40 comprising a first port (40), a second port (40.2) and a third port (40.3). The hybrid is configured to divide power received at the first port between the second and third ports, at least partially to isolate the second port from power received at the third port and at least partially to isolate the third port from power received at the second port. The isolation is a function of an impedance connected to the first port 40.1. The first port is connected to the phase conductor. The second port is connected to be driven by an alternating signal source (14). The second and third ports are connected to a monitoring logging device (42) for monitoring signals at the second and third ports, thereby to monitor the isolation at second and third ports and hence impedance at the first port.

Abstract: A time to digital converter having a hierarchical structure is provided. The time to digital converter includes: a plurality of delay stages for sequentially delaying a first signal for a specific delay time; a plurality of flip-flops for comparing delay signals of the first signal delayed by the delay stages with a second signal, and generating different outputs before and after a phase difference between the delay signals of the first signal and the second signal becomes smaller than a resolution of the phase detector; a selection signal generator for generating a selection signal for selecting a signal most similar to the second signal among the delay signals of the first signal from the outputs of the flip-flops; and a Multiplexer (MUX) for receiving the delay signals of the first signal and the selection signal, and outputting the signal most similar to the second signal among the delay signals of the first signal.

Abstract: A method of forming, in or on a Si substrate, planar micro-coils with coil windings of high aspect ratio (>3) and a wide variety of geometric shapes. The micro-coils may be formed on a Si substrate and be embedded in a dielectric, or they may be formed in trenches within a Si substrate. The micro-coils may have field enhancing ferromagnetic pillars rising above the micro-coil plane, formed at positions of maximum magnetic field strength and the micro-coils may also include magnetic layers formed beneath the substrate and contacting the pillars to form a substantially closed pathway for the magnetic flux. The substrate may be thinned to membrane proportions. These micro-coils produce strong magnetic fields with strong field gradients and can be used in a wide variety of processes that involve the exertion of strong magnetic forces at small distances or the creation of magnetic wells for trapping and manipulating small particles.

Abstract: The present invention provides nucleic acid sequences encoding a modified leukotoxin protein, wherein the modification comprises the removal of nucleic acid sequences encoding amino acids within hydrophobic transmembrane domains of full length leukotoxin protein, preferably from Mannheimia haemolytica. The modified leukotoxin proteins are useful in vaccine compositions effective against Mannheimia haemolytica in animals.

Abstract: Methods and systems for removing copper from ferrous scrap are described. Some amounts of copper in ferrous scrap are removed by oxidation and subsequent mechanical impact of the oxidized scrap. Further removal of copper from the solid scrap can be achieved by fluxing the copper oxide below the melting point of ferrous scrap using CaO—SiO2—B2O3— and Na2O—SiO2—B2O3-based slags. Using the invention, copper can be removed from ferrous scrap in a natural, cost-effective, and environmental-friendly manner.

Abstract: A gas sensor includes an in-fiber resonant wavelength device provided in a fiber core at a first location. The fiber propagates a sensing light and a power light. A layer of a material is attached to the fiber at the first location. The material is able to absorb the gas at a temperature dependent gas absorption rate. The power light is used to heat the material and increases the gas absorption rate, thereby increasing sensor performance, especially at low temperatures. Further, a method is described of flash heating the gas sensor to absorb more of the gas, allowing the sensor to cool, thereby locking in the gas content of the sensor material, and taking the difference between the starting and ending resonant wavelengths as an indication of the concentration of the gas in the ambient atmosphere.

Abstract: The present invention provides digital imaging architectures comprising detectors coupled to readout circuitry. The readout circuitry functions in particular modes, the use of which can depend on characteristics of the input signals transferred to the readout circuitry from the detectors, or can depend on the characteristics of the output signal required from the readout circuitry. When the input signal has a particular magnitude the readout circuitry can function in a first mode in which the input signal can be amplified to a measurable level, and when the input signal has another magnitude, the readout circuitry can function in an alternate mode in which the input signal can be read out with a different or no amplification. Thus, the present invention can provide a large dynamic range of detection that can amplify sensitive input signals from a detector as well as read larger signals with little or no amplification.

Abstract: Provided are forward-imaging optical coherence tomography (OCT) systems and probes.

Abstract: The application is directed toward a method of treating a brain tumor in a patient comprising systemically administering a monoclonal antibody.

Abstract: A metamaterial microwave lens having an array of electronic inductive capacitive cells in which each cell has an electrically conductive pattern which corresponds to incident electromagnetic radiation as a resonator. At least one cell has a first and second electrical sections insulated from each other and each which section has at least two legs. A static capacitor is electrically connected between one leg of the first section of the cell and one leg of the second section of the cell. A MEMS device is electrically disposed between the other legs of the first and second sections of the cell. The MEMS device is movable between at least two positions in response to an electrical bias between the first and second sections of the cell to vary the index of refraction and resonant frequency of The cell.

Abstract: A harmful gas treatment apparatus and a water treatment apparatus uses an electrochemical device provided with a solid electrolyte membrane having ion conductivity. A first electrochemical device provided with an anode on one surface of a hydrogen ion conductive electrolyte membrane and a cathode on the other surface thereof is combined with a second electrochemical device provided with an anode on one surface of a hydroxyl ion conductive electrolyte membrane and a cathode on the other surface thereof. Both cathodes are disposed so as to face each other within an electrochemical reaction tank. Each of the cathodes is provided with TiO2 as a metal oxide and Pt as a platinum group supported on a porous body having functions to occlude, concentrate and reduce harmful substances as a reducing catalyst. Thus, a water vapor partial pressure and an oxygen partial pressure on the both cathodes is reduced, making it possible to enhance hydrogen generation efficiency at the normal temperature and constant current.

Abstract: A logic gate is adapted to implement logical expressions. The logic gate includes at least one input that is adapted to receive an input signal and at least one control signal. At least one of the input signal and the control signal is a noise signal. At least one output is adapted to produce an output signal. A nonlinear updater operates as a dynamically configurable element and produces multiple different logic gates as selected by the control signal based at least in part on the noise signal. The nonlinear updater is electrically coupled to the input and is also electrically coupled to the output. The nonlinear updates is configured to apply a nonlinear function to the input signal in response to the control signal to produce the output signal representing a logical expression being implemented by one of the multiple different logic gates on the input signal.

Abstract: The invention provides materials and methods for the identification of cells exhibiting a cell proliferative disorder that are amenable to treatment with a herpes simplex virus that does not express an approximately wild-type level of ICP34.5. Also provided are methods of treating cell proliferative diseases, disorders or conditions, such as cancers, rheumatoid arthritis and macular degeneration, using these HSVs. Further provided are methods for preventing such cell proliferative disorders by administering the HSVs as well as methods for ameliorating a symptom associated with a cell proliferative disorder by administering such HSVs.

Abstract: A system including: (i) a methodology for targeted cellular ablation in zebrafish; (ii) a methodology for regional cellular ablation in zebrafish. These methodologies are used to identify genetic components that regulate cellular regeneration and to identify drug compounds that influence cellular regeneration for the purpose of developing therapies for degenerative conditions. Transgenic zebrafish disclosed herein contain transgenic constructs composed of: (i) cell and/or tissue-type specific regulatory elements (e.g.

Abstract: This invention provides methods for extracting platelets, compositions obtained therefore, and methods for using the same.

Abstract: A dual-power-supply system uses both a fuel cell and a chargeable secondary battery. A differential voltage adding unit adds a differential voltage between the voltage of the fuel cell and a necessary target output voltage to the voltage of the fuel cell by using the secondary battery, thereby obtaining an output voltage of the dual-power-supply system. A control unit detects the output voltage, and controls the differential voltage adding unit such that the output voltage is equal to the target output voltage.

Abstract: A logic gate implements logical expressions. A least one logic gate input receives at least one input logic gate signal and at least one control signal. At least one output for produces a logic gate output signal. A nonlinear updater operates as a dynamically configurable element to produce a plurality of different logic gates as selected by the control signal. The nonlinear updater includes a nonlinear updater output. The nonlinear updater is configured to apply a nonlinear function to the input logic gate signal to produce the nonlinear updater output signal representing a logical expression being implemented by one of the plurality of different logic gates on the input logic gate signal. A comparator includes a comparator input that is adapted to receive a reference threshold value for producing the logical gate output signal based on a comparison of the nonlinear output signal to the reference threshold value.

Abstract: Systems and methods for increasing the efficiency of data storage processes for high performance, high core number computing systems. In one embodiment, the systems of the present invention perform sequential I/O whenever possible. To achieve a high degree of sequentiality, the block allocation scheme is determined by the next available block on the next available disk. This simple, non-deterministic data placement method is extremely effective for providing sequential data streams to the spindle by minimizing costly seeks. The sequentiality of the allocation scheme is not affected by the number of clients, the degree of randomization within the incoming data streams, the logical byte addresses of incoming request's file extents, or the RAID attributes (i.e., parity position) of the block.

Abstract: Apparatus and methods for rotation test stimulus and analysis methods overcome many of the limitations of traditional clinical tests of peripheral vestibular function. An embodiment includes a rotational stimuli applied to the rotational motion for testing that includes two separate components, a bias component and a probe component. The bias component for rotational motion is designed to temporarily turn off vestibular responses in one ear while the responsiveness in the opposite ear is simultaneously evaluated using the probe component of the stimulus. Responses from application of these stimuli are analyzed by isolating and separating the bias response from the probe response. The bias and probe component responses are parameterized by applying curve fits of mathematical functions to the isolated bias and probe component responses. These parameters characterize the patient's vestibular function.