Abstract: The present invention is directed to syntheses of cyclolinear networks. Two novel cyclic siloxanes were used as starting materials. The cyclic siloxanes are self-condensed and co-condensed with silanol-terminated polydimethylsiloxane to vinyl-terminated cyclolinear polymers. Cyclolinear networks can be synthesized by hydrosilylation of vinyl-terminated cyclolinear polyorganosiloxanes with a copolymer of dimethylsiloxane and methylhydrosiloxane.

Abstract: A method of calculating an electron resonance spectra data value for each of one or more chemical constituents. In one embodiment, one or more potential electron capture orbitals is identified for each of the one or more chemical constituents; an electron orbital wavefunction is determined for each of the one or more potential electron capture Orbitals; and a theoretical electron resonance spectra data value is generated for each of the one or more chemical constituents. In another embodiment, a theoretical electron resonance spectra data value may be used to identify an unknown chemical constituent.

Abstract: The present invention provides the use of IFN-?, an agent that increases the expression of IFN-?, or a polynucleotide which is capable of expressing IFN-? or said agent for the manufacture of a medicament for the treatment of rhinovirus-induced exacerbation of a respiratory disease selected from asthma and chronic obstructive pulmonary disease, wherein said treatment is by airway delivery of said medicament, e.g. by use of an aerosol nebuliser. Also provided is IFN-? for the same purpose.

Abstract: A composite material includes an elastomer matrix, a set of first capsules containing a polymerizer, and a set of second capsules containing a corresponding activator for the polymerizer. The polymerizer may be a polymerizer for an elastomer. The composite material may be prepared by combining a first set of capsules containing a polymerizer, a second set of capsules containing a corresponding activator for the polymerizer, and a matrix precursor, and then solidifying the matrix precursor to form an elastomeric matrix.

Abstract: The mechanism of the UV light-induced reaction between the indole moiety of tryptophan and chloroform, and the structure of the modified tryptophan and polypeptides including such modified tryptophan residues. The excited indole moiety, which is formed upon UV light irradiation, emits a solvated electron which initiates a series of events that yield fluorescent derivatives that have CHO group covalently bound to the indole moiety. These derivatives are herein referred to as formyltryptophan, and are relatively stable. Similar reactions are observed when 5-hydroxytryptophan, 5-fluorotryptophan, or N-methylindolacetate are used in place of tryptophan, or when other haloalkanes, such as trichloracetic acid, trichlorethanol, trichlorethane, bromoform, and iodoactetate are used in place of chloroform. The derivatives can be used in a variety of applications in fluorescence spectroscopy, and for nuclear magnetic resonance, X-ray crystallography, infra-red spectroscopy, circular dicroism and mass spectroscopy.

Abstract: A cantilever control device is provided that can prevent, in an atomic force microscope, self-excited oscillation of a cantilever from stopping and prevent a probe of the cantilever from coming into contact with a measurement object. In the atomic force microscope, a cantilever control device 1 is constituted from a cantilever 10 having a probe 12, an actuator 20 that causes self-excited oscillation in the cantilever 10, an oscillation velocity detector 30 that detects the oscillation velocity of the cantilever 10, a displacement calculator 32 that calculates the oscillation displacement of the cantilever 10, and a controller 40 that generates a signal for driving the actuator 20. A feedback control signal S is represented as (K?G·x2)·dx/dt, where x is the oscillation displacement of the cantilever 10, dx/dt is the oscillation velocity of the cantilever 10, and both K and G are feedback gains of a positive value.

Abstract: A new class of diketo acids constructed on nucleobase scaffolds, designed as inhibitors of HIV replication through inhibition of HIV integrase, is described. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS and ARC, either as the compounds, or as pharmaceutically acceptable salts, with pharmaceutically acceptable carriers, used alone or in combination with antivirals, immunomodulators, antibiotics, vaccines, and other therapeutic agents. Methods of treating AIDS and ARC and methods of treating or preventing infection by HIV are also described.

Abstract: The present invention discloses the existence of two novel proteins UspA1 and UspA2, and their respective genes uspA1 and uspA2. Each protein encompasses a region that is conserved between the two proteins and comprises an epitope that is recognized by the MAb 17C7. One or more than one of these species may aggregate to form the very high molecular weight form (i.e. greater than 200 kDa) of the UspA antigen. Compositions and both diagnostic and therapeutic methods for the treatment and study of M. catarrhalis are disclosed.

Abstract: A membrane electrode assembly for use with a direct organic fuel cell containing a formic acid fuel includes a solid polymer electrolyte having first and second surfaces, an anode on the first surface and a cathode on the second surface and electrically linked to the anode. The solid polymer electrolyte has a thickness t: t ? n f ? D f ? C f ? K f ? j f c where Cf is the formic acid fuel concentration over the anode, Df is the effective diffusivity of the fuel in the solid polymer electrolyte, Kf is the equilibrium constant for partition coefficient for the fuel into the solid polymer electrolyte membrane, ? is Faraday's constant nf is the number of electrons released when 1 molecule of the fuel is oxidized, and jfc is an empirically determined crossover rate of fuel above which the fuel cell does not operate.

Abstract: This document relates to methods and materials involved in diagnosing SLE. For example, this document relates to methods and materials involved in diagnosing SLE, diagnosing severe SLE, and assessing a mammal's susceptibility to develop severe SLE. For example, this document provides nucleic acid arrays that can be used to diagnose SLE in a mammal. Such arrays can allow clinicians to diagnose SLE based on a simultaneous determination of the expression levels of many genes that are differentially expressed in SLE patients as compared to healthy controls. In addition, methods and materials for assessing SLE activity, determining the likelihood of experiencing active SLE, and detecting SLE treatment effectiveness are provided herein.

Abstract: A source of multipotent amniotic fluid/fetal stem cells (MAFSCs) is disclosed. MAFSC are of fetal origin and have a normal diploid karyotype. These cells are characterized by the following cell surface markers: SSEA3, SSEA4, Tra-1-60, Tra-1-81, Tra-2-54, HLA class I, CD13, CD44, CD49b, CD105 and are distinguished by the absence of the antigen markers CD34, CD45, and HLA Class II, but are distinguished from mouse embryonic stem cells in that these cells do not express the cell surface marker SSEA1. MAFSC express the stem cell transcription factor Oct-4. MAFSC cells can be propagated for an indefinite period of time in continuous culture in an undifferentiated state. The MAFSCs have the ability to differentiate in culture in a regulated manner, into three or more subphenotypes. Cells can then be differentiated into endodermal, mesodermal and ectodermal derived tissues in vitro and in vivo. A method for isolating, identifying, expanding and differentiating MAFSCs is disclosed.

Abstract: Methods of delivering a desired polypeptide to an individual are disclosed. The methods comprise administering to the individual an immunogenic vector comprising a nucleic acid encoding the desired polypeptide operably linked to regulatory elements in combination with one or more of gD protein, a function fragment of gD protein, a nucleic acid encoding gD protein operably linked to regulatory elements, or a nucleic acid encoding a functional fragment of gD protein operably linked to regulatory elements. Compositions comprising an immunogenic vector that comprises a nucleic acid encoding the desired polypeptide operably linked to regulatory elements; and one or more of gD protein, a function fragment of gD protein, a nucleic acid encoding gD protein operably linked to regulatory elements, or a nucleic acid encoding a functional fragment of gD protein operably linked to regulatory elements are disclosed. Methods for inhibiting an undesirable immune response in an individual are disclosed.

Abstract: An engine management apparatus for an internal combustion engine of a vehicle includes a microprocessor that is operable on adjustment mechanisms of the vehicle. The vehicle has a torque sensor for sensing torque generated by the engine and the adjustment mechanisms adjust parametric values related to the torque. Memory circuitry is accessible by the microprocessor. The memory circuitry stores data representing at least one set of parametric values and a range of torque values corresponding to respective parametric values in the set. A set of instructions are executable by the microprocessor so that the microprocessor cyclically retrieves a real time torque value from the torque sensor and updates the memory if the retrieved torque value is higher than a stored torque value corresponding to a current parametric value. The microprocessor adjusts the current parametric value if the retrieved torque value is lower than the stored torque value.

Abstract: The method and system for vehicular guidance comprises an imaging device for collecting color image data to facilitate distinguishing crop image data (e.g., crop rows) from background data. A definer defines a series of scan line segments generally perpendicular to a transverse axis of the vehicle or of the imaging device. An image parameter evaluator determines scan line image parameter data for each of the scan line segments. An alignment detector (e.g., search engine) identifies a preferential heading of the vehicle that is generally aligned with respect to a crop feature, associated with the crop image data, based on the determined scan line image parameter meeting or exceeding a maximum value or minimum threshold value. A reliability estimator estimates a reliability of the vehicle heading based on compliance with a criteria for scan line image parameter data associated with one or more crop rows.

Abstract: A method for manufacturing the DP-bioglass to use in dental fracture repair via the carbon dioxide laser, the method comprises the steps: mixing and co-dissolving silicon and phosphoric acid raw material into ethanol; sequentially adding nitric acid, calcium and sodium raw material and stirring; standing, drying, triturating and heating the composition to obtain a glass powder material consisting of Na2O—CaO—SiO2—P2O5 and drying the oxide material mixing with a phosphoric acid to react the DP-bioglass.

Abstract: A nanostructure is used to generate a highly localized nanoscale optical field. The field is excited using surface plasmon amplification by stimulated emission of radiation (SPASER). The SPASER radiation consists of surface plasmons that undergo stimulated emission, but in contrast to photons can be localized within a nanoscale region. A SPASER can incorporate an active medium formed by two-level emitters, excited by an energy source, such as an optical, electrical, or chemical energy source. The active medium may be quantum dots, which transfer excitation energy by radiationless transitions to a resonant nanosystem that can play the same role as a laser cavity in a conventional laser. The transitions are stimulated by the surface plasmons in the nanostructure, causing the buildup of a macroscopic number of surface plasmons in a single mode.

Abstract: The invention provides a lithographic method referred to as “dip pen” nanolithography (DPN). DPN utilizes a scanning probe microscope (SPM) tip (e.g., an atomic force microscope (AFM) tip) as a “pen,” a solid-state substrate (e.g., gold) as “paper,” and molecules with a chemical affinity for the solid-state substrate as “ink.” Capillary transport of molecules from the SPM tip to the solid substrate is used in DPN to directly write patterns consisting of a relatively small collection of molecules in submicrometer dimensions, making DPN useful in the fabrication of a variety of microscale and nanoscale devices. The invention also provides substrates patterned by DPN and kits for performing DPN. The invention further provides a method of performing AFM imaging in air. The method comprises coating an AFM tip with a hydrophobic compound, the hydrophobic compound being selected so that AFM imaging performed using the coated AFM tip is improved compared to AFM imaging performed using an uncoated AFM tip.

Abstract: An optical lithography method is disclosed that uses double exposure of a reusable template mask and a trim mask to fabricate regularly-placed rectangular contacts in standard cells of application-specific integrated circuits (ASICs). A first exposure of the reusable template mask with periodic patterns forms periodic dark lines on a wafer and a second exposure of an application-specific trim mask remove the unwanted part of the dark lines and the small cuts of the dark lines left form the rectangular regularly-placed contacts. All contacts are placed regularly in one direction while unrestrictedly in the perpendicular direction. The regular placement of patterns on the template mask enable more effective use of resolution enhancement technologies, which in turn allows a decrease in manufacturing cost and the minimum contact size and pitch.

Abstract: An integrated transformer structure includes a first coil element associated with a transverse axis, the first coil element having at least one turn. The first coil element includes a first portion provided on a first lateral level, and a second portion provided on a second lateral level. The first and second lateral levels being mutually spaced apart along said transverse axis. The first and second portions being displaced laterally from said axis by different respective distances. At least one crossover portion of the first coil element, in which the first coil element being configured to provide a conducting path through at least a portion of the first portion of the first coil element to the crossover portion, through the crossover portion and subsequently through at least a portion of the second portion of the first coil element, in which any change of flow direction along said path is less than 90° in a lateral direction.

Abstract: The invention relates to a walker having a main supporting frame, a superstructure frame and a body support means. The superstructure frame is operatively arranged for vertical adjustment relative to the main supporting frame and includes an adjustable interior opening for accommodating a user and an entrance gate operatively arranged to provide access to the adjustable interior opening. The body support means is secured to the superstructure frame and operatively arranged to support the user. Furthermore, the walker may include four wheels, each of which may include a directional locking apparatus and/or braking system, and the walker may include at least one arm support operatively arranged for supporting the user. The walker may also include at least one handle operatively arranged for transmission of the walker.