Abstract: An integrated circuit multiplexes transmission data faster than by a system clock, and transfers a timing pulse Txclk for that multiplexing and a multiplexed signal Txdata from a transmitter chip 100 to a receiver chip 150 through communications by inductive coupling, respectively. Because of a transfer by inductive coupling being broadband, close-proximity wireless communications, the receiver chip 150 can faithfully obtain timing information on the timing pulse Txclk including jitter generated by a simple oscillator, and can thus accurately restore original data even by a high-speed transmission. This allows, in an integrated circuit that carries out communications by inductive coupling between chips to be stacked and mounted, carrying out communications between semiconductor chips with a small required area and faster than by a system clock.

Abstract: A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.

Abstract: An optical fiber for use in an immunoassay device having at least one microfluidic channel, the optical fiber being for transmitting excitation light to the microfluidic channel and for transmitting emitted fluorescence to a light detector.

Abstract: Multidrug resistance (MDR) is a major problem in cancer chemotherapy. The best characterized resistance mechanism is the one mediated by the over-expression of drug efflux transporters, permeability-glycoprotein (P-gp), which pump a variety of anticancer drugs out of the cells, resulting in lowered intracellular drug accumulation. A series of flavonoid dimers are developed in this invention, which are linked together by linker groups of various lengths. These flavonoid dimers are found to be efficient P-gp modulators that increase cytotoxicity of anticancer drugs in vitro and dramatically enhance their intracellular drug accumulation. It is found that the flavonoid dimers of this invention is also useful in reducing drug resistance in treating parasitic diseases.

Abstract: The invention relates to compositions, medicaments, methods for treating individuals with high plasma lipid levels, and methods for screening drug candidates useful in, for example, the treatment of hypercholesterolemia. Specifically, the invention relates to the discovery that MTP inhibition leads to increased accumulation in cellular free-cholesterol and is useful in the development of compositions, medicaments, methods of treatment and drug screening methods to treat high plasma lipid levels.

Abstract: The present invention is directed to a series of new compounds, combining the unique properties of fullerenes and bio-active amino acid residues, and to methods for making such compounds. The present invention is directed toward fullerene-based amino acids, and to amino acid residues, peptide chains, proteins, and polypeptides made from such fullerene-based amino acids. The present invention is further directed to amino acid residues, peptide chains, proteins, and polypeptides comprising such fullerene-based amino acids and into which such fullerene-based amino acids have been incorporated. Exemplary compounds have been prepared, and these compounds have been characterized and confirmed with infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), etc.

Abstract: This invention provides an improvement to methods of drug loading of ultrasound contrast agents. Echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof produced by the method of the invention wherein the echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof contain at least 10% more of a drug as compared to (1) echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof prepared by adding drug prior to emulsifying or (2) echogenic drug-loaded polymer microcapsules, nanocapsules, or mixtures thereof prepared by adding drug to lyophilized polymer microcapsules, nanocapsules, or mixtures thereof.

Abstract: Lithographically patterned nanowire electrodeposition (LPNE) combines attributes of photolithography with the versatility of bottom-up electrochemical synthesis. Photolithography is employed to define the position of a sacrificial nanoband electrode, preferably formed from a metal such as nickel, copper, silver, gold or the like, which is stripped using electrooxidation or a chemical etchant to advantageously recess the nanoband electrode between a substrate surface and the photoresist to form a trench defined by the substrate surface, the photoresist and the nanoband electrode. The trench acts as a “nanoform” to form an incipient nanowire during its electrodeposition. The width of the nanowire is determined by the electrodeposition duration while its height is determined by the height of the nanoband electrode.

Abstract: A fiber-optic sensor includes an optical fiber coil and a laser source optically coupled to the coil. Light from the source is transmitted to the coil as a first signal propagating along the coil in a first direction and a second signal propagating along the coil in a second direction opposite to the first direction. The optical paths of the first signal and the second signal are substantially reciprocal with one another and the first signal and the second signal are combined together after propagating through the coil to generate a third signal. The laser source is frequency-modulated or can have a coherence length longer than a length of the coil.

Abstract: Provided is a liposome comprising a hydrophobic lactone drug and a cyclodextrin, wherein the liposome has an intraliposomal pH and cyclodextrin concentration such that upon administration of the liposome to a subject, the liposome exhibits a uniform release profile of the hydrophobic lactone drug. Also provided is a method of administering a hydrophobic lactone drug to a subject in need thereof. The method comprises administering a liposome to the subject in need, wherein the liposome comprises the hydrophobic lactone drug and a cyclodextrin. The liposome has an intraliposomal pH and cyclodextrin concentration such that upon administration of the liposome to the subject, the liposome exhibits a uniform release profile of the hydrophobic lactone drug.

Abstract: Disclosed herein is a liposomal formulation that comprises a liposome and a liquid carrier. In the liposomal formulation, the liposome comprises a hydrophobic lactone drug and has an intraliposomal metal ion concentration higher than the metal ion concentration of the liquid carrier. Also disclosed herein is a method for active loading of a hydrophobic lactone drug into a liposome. The method includes preparing a liposome in the presence of a metal salt solution, an acid form of a counterion of the metal salt being membrane permeable, such that the liposome preparation contains entrapped metal ion. The method further includes forming a liposome with high intraliposomal pH by separating extravesicular metal salt solution from the liposome by exposing the liposome to a metal salt-free solution, resulting in diffusion of the acid form of the counterion out of the liposome and formation of an intraliposomal pH higher than that of the metal salt-free solution.

Abstract: An electron emission apparatus includes an insulating substrate, one or more grids located on the substrate, wherein the one or more grids includes: a first, second, third and fourth electrode that are located on the periphery of the gird, wherein the first and the second electrode are parallel to each other, and the third and fourth electrodes are parallel to each other; and one or more electron emission units located on the substrate. Each the electron unit includes at least one electron emitter, the electron emitter includes a first end, a second end and a gap; wherein the first end is electrically connected to one of the plurality of the first electrodes and the second end is electrically connected to one of the plurality of the third electrodes; two electron emission ends are located in the gap, and each electron emission end includes a plurality of electron emission tips.

Abstract: The invention provides a catalyst-coated nickel template including a) an open-cell nickel foam having within it pores defined by an internal nickel surface, the foam also having an external nickel surface not within the pores; and b) a layer of catalyst including Co and B on at least a portion of the internal nickel surface and at least a portion of the external nickel surface. The invention also provides a method of making a catalyst-coated nickel template that includes contacting a nickel template with a solution including a cobalt salt, a complexing agent, and a boron source selected from organoboranes and organoamine boranes under conditions sufficient to deposit boron and cobalt on a surface of the nickel template. Methods of generating H2 at a predetermined rate include contacting a NaBH4 solution with the catalyst-coated nickel template.

Abstract: A process for manufacturing esters from acid and alcohol and a system thereof are provided, wherein the system includes a reactive distillation column, a sidestream reactor packed with catalyst, and a decanter for conducting the method. The method is carried out by (a) extracting a first mixture of acid and alcohol from the reactive distillation column, for then feeding the first mixture to at least one sidestream reactor packed with catalyst to obtain a reaction product; (b) feeding the reaction product from the sidestream reactor to the reactive distillation column, allowing a second mixture of alcohol, ester and water to be separated from a top end of the reactive distillation column; (c) feeding the second mixture into the decanter to separate an organic phase from an aqueous phase; and (d) separating esters from the organic phase.

Abstract: A method for obtaining an image by parallel acquisition magnetic resonance imaging (MRI) is provided. Precessing nuclear spins are excited in a region of a subject. A plurality of response signals, representing magnetic resonance signals arising from the precessing nuclear spins, are simultaneously obtained from the region respectively with a plurality of RF reception coils, with each response signal representing a reduced data set of a totality of all of said response signals. Calibration data points are additionally obtained for each data set. A filter is synthesized using the calibration data points. The synthesizing filter is applied to the reduced data set to obtain a plurality of coupled simultaneous linear equations with a plurality of unknowns. The plurality of coupled simultaneously linear equations with the plurality of unknowns is solved to obtain a complete data set.

Abstract: Provided is an optical microscope system for detecting nanowires that is designed with a rotational polarizer and Fast Fourier Transform (FFT) to allow for use of an existing optical microscope in fabricating an electronic device having the nanowires. The optical microscope system includes: a light source for emitting light to provide the light to a nanowire sample; a rotational polarizer provided on a path of the light emitted from the light source for polarizing the light; an optical microscope for detecting a nanowire image using light that is polarized by the rotational polarizer and incident on the nanowire sample; a CCD camera provided in a region of the optical microscope for photographing and storing the nanowire image detected by the optical microscope; and a data processor for performing Fast Fourier Transform (FFT) on the nanowire image stored in the CCD camera.

Abstract: Disclosed is a method of micro/nano imprinting, which applies soft mold, pre-shaping sealing film, and soft holder arrangements to the micro/nano structure imprinting process of the curved substrates. The method of the present invention can prevent the curved surface from crumbling, which may result from high gas pressuring, and can obtain uniform imprinting pressure distribution throughout the whole curved substrate. Moreover, replicating micro/nano structures onto double-sided curve, both convex and concave, surfaces can also be achieved.

Abstract: The present invention relates to a method and a system for providing a local private broadcasting service with a mobile terminal. The system for providing a local private broadcasting service with the mobile terminal according to the present invention comprises a broadcasting mobile terminal; a viewing mobile terminal; and a broadcasting relay device which relays a broadcasting content to be streamed down in real time from the broadcasting mobile terminal to the viewing mobile terminal placed in a predetermined broadcasting service area centering on a position of the broadcasting mobile terminal based on a movement of the broadcasting mobile terminal. Thus, the present invention provides a method and a system for providing a local private, broadcasting service through which a mobile terminal user performs a private broadcasting and which has a limited, predetermined broadcasting transmission area based on a position of a broadcasting mobile terminal.

Abstract: An electron emission device includes a cathode device and a gate electrode. The gate electrode is separated and insulted from the cathode device. The gate electrode includes a carbon nanotube layer having a plurality of spaces. A display device includes a cathode device, an anode device spaced from the cathode electrode and a gate electrode. The gate electrode is disposed between the cathode device and the anode device. The cathode device, the anode device and the gate electrode are separated and insulted from each other. The gate electrode comprises a carbon nanotube layer having a plurality of spaces.

Abstract: An electron emission apparatus includes an insulating substrate, one or more grids located on the substrate, wherein the one or more grids includes: a first, second, third and fourth electrode that are located on the periphery of the gird, wherein the first and the second electrode are parallel to each other, and the third and fourth electrodes are parallel to each other; and one or more electron emission units located on the substrate. Each the electron unit includes at least one electron emitter, and the electron emitter includes a first end, a second end and a gap. At least one electron emission end is located in the gap.