Abstract: The use of chemically modified dicarboxy polysaccharides for the topical treatment of the eyeball are described. The modified polysaccharides provide a carrier in solutions for the treatment of the eyeball to obtain a timed release.
Type:
Grant
Filed:
May 10, 2005
Date of Patent:
August 4, 2009
Assignee:
Board of Trustees of Michigan State University
Abstract: This invention relates to a compact cavity ring down spectrometer for detection and measurement of trace species in a sample gas using a tunable solid-state continuous-wave mid-infrared PPLN OPO laser or a tunable low-power solid-state continuous wave near-infrared diode laser with an algorithm for reducing the periodic noise in the voltage decay signal which subjects the data to cluster analysis or by averaging of the interquartile range of the data.
Abstract: In an X-ray computerized tomography scanner, a correction phantom embedding an X-ray absorbing object is put on or around a non-vertical rotary axis between an X-ray source and a two-dimensional X-ray detector, and two dimensional imaging data of the phantom is acquired. Then a locus of the X-ray absorbing material is determined in the two-dimensional imaging data, and based on the locus an ideal locus is obtained in the direction of the rotary axis. Next, a difference between the calculated position of the ideal locus and a measured position is determined in the direction of the rotary axis. The difference is used to correct deviation in the direction of the rotary axis.
Type:
Grant
Filed:
July 19, 2004
Date of Patent:
August 4, 2009
Assignees:
J. Morita Manufacturing Corporation, Nihon University
Abstract: Apparatus for control of physiological functions, including physiological functions of the urinary tract, using at least one electrode sized and configured to be located on, in, or near a targeted component of the pudendal nerve, and/or its branch(es), and/or its spinal root(s). The apparatus includes a controller coupled to the electrode to apply an electrical signal having an amplitude to the electrode at a selected frequency to stimulate the targeted component. The controller operates in a first mode to apply a first frequency or range of frequencies without substantially changing the amplitude for achieving a first physiologic response (e.g., controlling urinary continence) and the controller operates in a second mode to apply a second frequency or range of frequencies, different than the first frequency, for achieving a second physiologic response different than the first physiologic response (e.g., controlling micturition).
Type:
Grant
Filed:
April 11, 2006
Date of Patent:
August 4, 2009
Assignee:
Case Western Reserve University
Inventors:
Joseph W. Boggs, II, Brian J. Wenzel, Kenneth J. Gustafson, Warren M. Grill
Abstract: The present invention relates to a new family of structurally and functionally related nucleic acids and proteins, designed the CATERPILLER family, which is characterized by landmark structural motifs including a nucleotide binding domain and leucine-rich repeat domains.
Type:
Grant
Filed:
April 30, 2003
Date of Patent:
August 4, 2009
Assignee:
The University of North Carolina at Chapel Hill
Inventors:
Jenny P.-Y Ting, Michael W. Linhoff, Jonathan A. Harton, Christopher B. Moore
Abstract: A method for manufacturing a thermal interface material includes the steps of: (a) forming an array of carbon nanotubes on a substrate; (b) submerging the carbon nanotubes in a liquid macromolecular material; (c) solidifying the liquid macromolecular material; and (d) cutting the solidified liquid macromolecular material, to obtain the thermal interface material with the carbon nanotubes secured therein.
Type:
Grant
Filed:
November 3, 2006
Date of Patent:
August 4, 2009
Assignees:
Tsinghua University, Hon Hai Precision Industry Co., Ltd.
Inventors:
Hua Huang, Chang-Hong Liu, Shou-Shan Fan
Abstract: An antenna whose resonance and electromagnetic radiation properties can be modified by environmental conditions, acoustic conditions, and the like. The reconfiguring antenna acts to facilitate wireless transmission of information about the local environment without the need for local power.
Type:
Grant
Filed:
March 15, 2006
Date of Patent:
August 4, 2009
Assignee:
The Regents of the University of California
Abstract: A display device for compensating for degradation of a threshold voltage of a driving thin-film transistor (“TFT”) and method for driving the display device includes a light-emitting element, wherein the light-emitting element emits light by a driving current applied thereto, a driving TFT controlling the magnitude of the driving current directed to the light-emitting element, a capacitor which charges a voltage which varies depending on a data voltage and a threshold voltage of the driving TFT and maintains a voltage corresponding to a difference between the data voltage and a gate voltage of the driving TFT, a first switching unit supplying the data voltage to the capacitor in response to a scan signal, and a second switching unit which is diode-connected and supplies the driving TFT with a light emitting signal.
Type:
Grant
Filed:
November 16, 2006
Date of Patent:
August 4, 2009
Assignees:
Samsung Electronics Co., Ltd., Seoul National University Industry Foundation
Abstract: A thickness shear mode (TSM) sensor having a visco-elastic polymer coating and a fundamental frequency greater than 20 MHz useful for organic vapor or gas detection. The TSM quartz resonators at a fundamental frequency of 96 MHz were evaluated for their performance in organic vapor sensing applications and results were compared with the performance of 10 and 20 MHz resonators. These devices were produced by chemical milling of AT-cut quartz. Seven test organic vapors were utilized at concentrations ranging from 0.2 volume percent to 13.7 volume percent in the vapor phase. In all cases, the rubbery polymer polyisobutylene was used as a sensing layer. Detailed results for various sensor parameters such as sensitivity, baseline noise and drift, limit of detection, response and recovery times, dynamic range, and repeatability for the 96 MHz device were compared with those for 10 and 20 MHz devices. The test case of benzene/polyisobutylene was chosen to make these detailed comparisons.
Type:
Grant
Filed:
July 28, 2006
Date of Patent:
August 4, 2009
Assignee:
University of South Florida
Inventors:
Venkat R. Bhethanabotla, Randolph D. Williams
Abstract: The present invention provides mass tag complexes that permit simultaneously obtaining information of a plurality of biological molecules. The biological molecules may be RNA or protein, and the information includes both level of expression as well as spatial disposition within a cell or tissue. The mass tag comprise a core structure, a target binding structure (e.g., nucleic acid or peptide binding structure), a cleavable linker and a mass tag that exhibits a unique mass spectroscopy signal.
Abstract: The present invention relates to a process for the preparation of a carbon nanotubes reinforced polymer. The process comprises the following steps: a) contacting carbon nanotubes in an aqueous medium with a water-soluble component, comprising either a water-soluble first polymer or a water-soluble surfactant; b) mixing the resulting product from step A) with either an aqueous latex of a second polymer, or with (a) water-soluble precursor(s) of a second polymer; c) removing water from the so obtained mixture; d) heating the product from step C) to a temperature at which the second polymer flows or where the second polymer is formed from out of its precursor(s); and e) processing and/or solidifying the product of step D) into a desired form. As a result the carbon nanotubes retain essentially their original aspect ratio. As a result, mechanical and conductivity properties are improved.
Type:
Grant
Filed:
February 12, 2004
Date of Patent:
August 4, 2009
Assignees:
Stichting Dutch Polymer Institute, Ben-Gurion University of the Negev Research and Development Authority
Inventors:
Cornelis E. Koning, Oren Regev, Joachim Loos
Abstract: Administration of antisense oligodeoxynucleotides (ODN) targeted against the testosterone-repressed prostate message-2 (TRPM-2) gene can reduce the amount of TRPM-2 in renal cell cancer (RCC) cells and other cancer cells, and as a result enhance chemosensitivity of these cells to chemotherapy agents and radiation. Thus, for example, the sensitivity of renal cell cancer cells to a chemotherapeutic agent can be increased by exposing renal cell cancer cells to a chemotherapeutic agent and an agent which reduces the amount of TRPM-2 in the renal cell cancer cells. This provides an improved method for treatment of renal cell cancer, which is generally resistant to treatment with known chemotherapy agents.
Type:
Grant
Filed:
September 28, 2001
Date of Patent:
August 4, 2009
Assignee:
The University of British Columbia
Inventors:
Martin Gleave, Paul S. Rennie, Hikeaki Miyake, Colleen Nelson, Tobias Zellweger
Abstract: A nanoarray template utilizing coordination chemistry or metal ion binding to control the site-isolation and orientation of virus particles is provided. The nanoarray template is generated by lithography including Dip Pen Nanolithography. The surface chemistry that is inherent in many viruses, metal-ion based or inorganic coordination chemistry is used to immobilize individual virus particles without the need for their genetic modification. Single particle control enables a wide variety of studies involving viruses that are not possible with microarrays, including single particle, single cell infectivity studies, exploration of such structures as templates in materials synthesis and molecular electronics, and studies aimed at understanding how surface presentation influences their bioactivity. This is an example of such control at the single-particle level, and therefore, commercial use of nanoarrays in biological systems.
Type:
Grant
Filed:
August 18, 2006
Date of Patent:
August 4, 2009
Assignee:
Northwestern University
Inventors:
Chad A. Mirkin, Rafael A. Vega, Daniel Maspoch, Khalid Salaita
Abstract: Methods and apparatus for processing corn into one or more corn products. Oil is extracted from corn or corn products or by-products with a solvent. The corn-solvent mixture is separated into streams, one of which preferably includes an extract containing at least oil and solvent, and another containing de-oiled corn solids and adsorbed solvent. The solvent is separated from oil, and the de-oiled, desolventized corn solids are processed to provide one or more corn products.
Type:
Grant
Filed:
January 6, 2006
Date of Patent:
August 4, 2009
Assignee:
The Board of Trustees of the University of Illinois
Abstract: In accordance with aspects of the invention methods of using rhodium hydroquinone catalysts for the conjugate addition of boronic acids are disclosed.
Type:
Grant
Filed:
June 15, 2006
Date of Patent:
August 4, 2009
Assignee:
Brown University
Inventors:
William C. Trenkle, Julia L. Barkin, Seung Uk Son, Dwight A. Sweigart, Marcus D. Faust, Jr.
Abstract: Methods for the reduction of gaseous carbon dioxide emissions from combustion or oxidation reactions are provided. The various methods involve the formation of carbon suboxides and/or polymerized carbon suboxides (PCS), preferentially over gaseous carbon oxides to thereby reduce gaseous carbon dioxide emissions. The various methods can be employed for efficient generation of energy and/or hydrogen. In addition, various methods for the use of polymerized carbon suboxide are disclosed.
Type:
Grant
Filed:
February 21, 2007
Date of Patent:
August 4, 2009
Assignee:
Drexel University
Inventors:
Alexander Fridman, Alexander F. Gutsol, Young I. Cho
Abstract: A solid electrolyte fuel cell component is formed by tape casting an electrolyte layer and electrode layers to form a green tape which can be manipulated. The green tape is coiled into a form having an S-shaped central portion having oppositely-directed loops, so as to provide a first longitudinal channel presenting an anode surface and a second longitudinal channel presenting a cathode surface. After coiling, the assembly is fired to produce a solid, sintered product.
Type:
Grant
Filed:
October 18, 2002
Date of Patent:
August 4, 2009
Assignee:
The University Court of The University of St. Andrews
Inventors:
John Thomas Sirr Irvine, Frances Gwyneth Elaine Jones, Paul Alexander Connor
Abstract: The present invention provides transgenic plants which after harvest degrade the lignin and cellulose therein to fermentable sugars which can further be fermented to ethanol or other products. In particular, the transgenic plants comprise ligninase and cellulase genes from microbes operably linked to a DNA encoding a signal peptide which targets the fusion polypeptide produced therefrom to an organelle of the plant, in particular the chloroplasts. When the transgenic plants are harvested, the plants are ground to release the ligninase and cellulase which then degrade the lignin and cellulose of the transgenic plants to produce the fermentable sugars.
Type:
Grant
Filed:
May 5, 2008
Date of Patent:
August 4, 2009
Assignee:
Board of Trustees of Michigan State University
Inventors:
Masomeh B. Sticklen, Bruce E. Dale, Shahina B. Maqbool
Abstract: The present invention relates to a communications environment comprising a digital marketplace arrangement which enables user to have dynamic access to a variety of network operators and service operators which are registered with the marketplace. The users can communicate with the digital marketplace via a logical market channel enabling user, service providers and network operators to interact in real time and negotiate for appropriate communication links and quality of service. Each communications environment may comprise more than one digital marketplace.
Type:
Grant
Filed:
April 17, 2001
Date of Patent:
August 4, 2009
Assignee:
University of Strathclyde
Inventors:
John Dunlop, Demessie Girma, James Menzies Irvine, Gwenael Le Bodic
Abstract: Small, polybasic peptides are disclosed that are effective as furin inhibitors, e.g. hexa- to nona-peptides having L-Arg or L-Lys in most positions. Removing the peptide terminating groups can improve inhibition of furin. High inhibition was seen in a series of non-amidated and non-acetylated polyarginines. The most potent inhibitor identified to date, nona-L-arginine, had a Ki against furin of 40 nM. Non-acetylated, poly-D-arginine-derived molecules are preferred furin inhibitors for therapeutic uses, such as inhibiting certain bacterial infections, viral infections, and cancers. Due to their relatively small size, these peptides should be non-immunogenic. These peptides are efficiently transported across cell membranes.
Type:
Grant
Filed:
April 21, 2006
Date of Patent:
August 4, 2009
Assignees:
Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Torrey Pines Institute for Molecular Studies
Inventors:
Iris Lindberg, Angus Cameron, Richard A. Houghten, Jon Richard Appel