Abstract: The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.

Abstract: Monocyclic chlorine based inductively coupled plasma deep etching processes for the rapid micromachining of titanium substrates and titanium devices so produced are disclosed. The method parameters are adjustable to simultaneously vary etch rate, mask selectivity, and surface roughness and can be applied to titanium substrates having a wide variety of thicknesses to produce high aspect ratio features, smooth sidewalls, and smooth surfaces. The titanium microdevices so produced exhibit beneficially high fracture toughness, biocompatibility and are robust and able to withstand harsh environments making them useful in a wide variety of applications including microelectronics, micromechanical devices, MEMS, and biological devices that may be used in vivo.

Abstract: This invention provides compound having a structure of Formula I or Formula II Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.

Abstract: Conventional block ciphers that traffic in 128-bit block sizes are ill-suited for operating in small domains like credit card numbers. Some embodiments relate to techniques for constructing and speeding up practical and provably secure schemes for deterministically enciphering data from a small domain like credit card numbers using a conventional block cipher or other pseudorandom function.

Abstract: A nanoplasmonic resonator (NPR) comprising a metallic nanodisk with alternating shielding layer(s), having a tagged biomolecule conjugated or tethered to the surface of the nanoplasmonic resonator for highly sensitive measurement of enzymatic activity. NPRs enhance Raman signals in a highly reproducible manner, enabling fast detection of protease and enzyme activity, such as Prostate Specific Antigen (paPSA), in real-time, at picomolar sensitivity levels. Experiments on extracellular fluid (ECF) from paPSA-positive cells demonstrate specific detection in a complex bio-fluid background in real-time single-step detection in very small sample volumes.

Abstract: An image diagnostic processing device includes peripheral region specifying means which specifies a peripheral region connecting to an abnormal candidate region included in an image representing the inside of a subject, and judging means which judges whether the abnormal candidate region is an anatomic abnormal region or not, based on a first feature quantity of the abnormal candidate region and a second feature quantity of the peripheral region.

Abstract: Methods and apparatus are provided herein for time-resolved analysis of the effect of a perturbation (e.g., a light or voltage pulse) on a sample. By operating in the time domain, the provided method enables sub-microsecond time-resolved measurement of transient, or time-varying, forces acting on a cantilever.

Abstract: A radio repeater system is provided that utilizes miniaturized antennas and a meta-material channel isolator. The radio repeater is comprised of: a receive antenna configured to receive a signal at a desired channel frequency; a transmit antenna configured to transmit the signal at the channel frequency; an amplifier electrically connected between the receive antenna and the transmit antenna; and an array of resonating circuits disposed spatially between the receive antenna and the transmit antenna. Each resonating circuit is designed to resonant at the channel frequency and thereby suppress propagation of surface waves between the antennas.

Abstract: A new fractionation device shows desirable features for exploratory screening and biomarker discovery. The constituent MSCs may be tailored for desired pore sizes and surface properties and for the sequestration and enrichment of extremely low abundant protein and peptides in desired ranges of the mass/charge spectrum. The MSCs are effective in yielding reproducible extracts from complex biological samples as small as 10 ?l in a time as short as 30 minutes. They are inexpensive to manufacture, and allow for scaled up production to attain the simultaneous processing of a large number of samples. The MSCs are multiplexed, label-free diagnostic tools with the potential of biological recognition moiety modification for enhanced specificity. The MSCs may store, protect and stabilize biological fluids, enabling the simplified and cost-effective collection and transportation of clinical samples.

Abstract: A light emitting diode structure of (Al,Ga,In)N thin films grown on a gallium nitride (GaN) semipolar substrate by metal organic chemical vapor deposition (MOCVD) that exhibits reduced droop. The device structure includes a quantum well (QW) active region of two or more periods, n-type superlattice layers (n-SLs) located below the QW active region, and p-type superlattice layers (p-SLs) above the QW active region. The present invention also encompasses a method of fabricating such a device.

Abstract: An organic light emitting diode (OLED) uses a ?-conjugated polymer emissive layer (MEH-PPV) sandwiched between two semitransparent electrodes. The preferred embodiment utilizes an optically thin gold film anode, whereas the cathode was in the form of an optically thick aluminum (Al) film with patterned periodic subwavelength 2D hole array that showed anomalous transmission in the spectral range of the polymer photoluminescence band. At similar current densities we obtained a seven-fold electroluminescence efficiency enhancement with the patterned Al device compared with a control device based on unperforated Al electrode.

Abstract: The invention is directed to a cervical spine protection apparatus one or more composite bands attached to provide restraint of one or more motions of the cervical spine of a wearer. The apparatus is designed to protect a wearer from incurring cervical spinal injuries, and/or to reduce the severity of cervical spine injuries without substantially compromising the normal functional range of motion of the wearer's cervical spine.

Abstract: Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.

Abstract: Methods and therapeutic strategies utilizing proteinacious channels in lipid membranes of mammalian cells. The methods entail administering a pharmaceutical to a lipid membrane of a mammalian cell, and then determining the effect of the pharmaceutical on the electrophysiology of at least one proteinacious channel of the lipid membrane, wherein the proteinacious channel is a Kv7 potassium channel and/or a L-type calcium channel of an airway smooth muscle cell (ASMC). The method can be used to identify pharmaceuticals that may be used to treat asthmatic and other bronchospastic conditions that can lead to airway obstruction, or to perform drug screening to assess potential risk of pharmaceuticals.

Abstract: A semiconductor apparatus and a design method for the semiconductor apparatus allow debugging or repairs by using a spare cell. The semiconductor apparatus includes a plurality of metal layers. At least one repair block performs a predetermined function. A spare block is capable of substituting for a function of the repair block. And at least one of the plurality of metal layers is predetermined to be a repair layer for error revision. At least one pin of the repair block is connected to the repair layer through a first pin extension, and at least one pin of the spare block is capable of extending to the repair layer. When the repair block is to be repaired, the pin extension of the repair layer and the repair block is disconnected, and at least one pin of the spare block is connected to the repair layer through a second pin extension.

Abstract: The present invention relates to systems and methods for dehumidifying air by establishing humidity gradients in one or more dehumidification units. Water vapor from relatively humid atmospheric air entering the dehumidification units is extracted by the dehumidification units without substantial condensation into low pressure water vapor vacuum volumes. The water vapor is extracted through water vapor permeable membranes of the dehumidification units into the low pressure water vapor vacuum volumes. The air exiting the dehumidification units is less humid than the air entering the dehumidification units. The low pressure water vapor extracted from the air is compressed to a slightly higher pressure, condensed, and removed from the system at ambient conditions. In addition, each of the dehumidification units may be associated with one or more evaporative cooling units through which the air will be directed, with the evaporative cooling units being upstream and/or downstream of the dehumidification units.

Abstract: Methods, systems, and devices using an algorithm that consists of scoring the bits in the data stream with a periodicity of N, where N is the word-length in bits, and then selecting as the most significant bit the one which receives the highest score after some large number of samples are disclosed. The condition under which bit bk receives a point depends on the binary format.

Abstract: Embodiments of a product such as a stimuli-responsive product can comprise a shape memory component and a nanofiber component that forms a fibrous microstructure or network. The resulting product can be responsive to stimuli, such as electrical stimuli, in a manner that cause the product to deform, deflect, and rebound. In one embodiment, the product can comprise an epoxy and a continuous non-woven nanofiber, the combination of which provides a product with enhanced actuation speed.

Abstract: Highly sensitive Surface Enhanced Raman Spectroscopy (SERS) sensors are described in the form of a optical resonator and a metal nanostructure deposited on surface of the optical resonator. In one embodiment the optical resonator is in the form of a photonic crystal, but other optical resonators are contemplated. Examples are described in which the resonant near-fields of a large-area replica molded photonic crystal efficiently couples light from a laser to dielectric-metal “post-cap” nanostructures deposited on the photonic crystal surface by a glancing angle evaporation technique, achieving a high SERS enhancement factor. Other constructions are also contemplated a metal nanostructure formed on a dielectric support deposited on the photonic crystal, including a metallic film deposited over close-packed surface of nanospheres, arrays of metallic nanotriangles, metallic nanorods, metallic nanohelices, arrays of metallic nanospheres, and roughened metal surfaces.

Abstract: The present invention discloses SNP markers associated with PCOS and provides probes, chips, primers, kits and methods for detecting the SNP markers. Furthermore, the present invention relates to the use of SNPs in predicting or diagnosing the risk of PCOS.