Abstract: The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders.

Abstract: The present disclosure provides methods of treating a disease in a non-rodent mammal comprising administering to the cerebrospinal fluid (CSF) of the non-rodent mammal an rAAV2 particle containing a vector comprising a nucleic acid encoding a therapeutic protein inserted between a pair of AAV inverted terminal repeats in a manner effective to infect an ependymal cell in the non-rodent mammal, wherein the ependymal cell secretes the therapeutic protein so as to treat the disease.

Abstract: A stress evaluation apparatus, a stress evaluation method, and a program for evaluating stress received by an operator during when an in-vehicle device is operated by an upper limb are provided. The apparatus includes a detection sensor, a calculation process portion and an evaluation portion. The detection sensor detects a muscle potential of a measuring object muscle of the operator. The calculation process portion receives time series information of the muscle potential to calculate strength information. The evaluation portion compares the strength information with an evaluation standard to make an evaluation of stress of the operator. The method includes detecting a muscle potential of a measuring object muscle, receiving time series information of the muscle potential to calculate strength information, and comparing the strength information with an evaluation standard to evaluate stress.

Abstract: A method for treating a mammalian subject afflicted with prostate cancer comprising i) an oligonucleotide which reduces clusterin expression and ii) an androgen receptor antagonist having the structure or a pharmaceutically acceptable salt thereof, each in an amount that when in combination with the other is effective to treat the mammalian subject.

Abstract: In one embodiment according to the invention, there is provided a method of sensing a response of a living cell or virus to a change in conditions. The method comprises applying an essentially constant external electromotive force that causes oscillation of an acoustic wave device at essentially constant amplitude and frequency under steady state conditions. The acoustic wave device has attached at least one living cell or virus. A combined oscillating system including the acoustic wave device and the living cell or virus exhibits a fundamental frequency and at least one harmonic frequency of the combined oscillating system.

Abstract: A system and method for transferring agricultural material from a transferring vehicle to a storage portion of a receiving vehicle, and detecting and filling void areas of the agricultural material is disclosed. A transferring vehicle having a spout transfers agricultural material to a storage portion of a receiving vehicle. An imaging device associated with the transferring vehicle and facing towards the storage portion of the receiving vehicle collects imaging data. An image processing module is operable to, based on the imaging data, estimate fill levels of agricultural material within the storage portion; identify an area of the storage portion as targeted to fill; and identify a first void within the targeted area. A controller in communication with the image processing module is configured to command the spout to a position to direct agricultural material to the first void.

Abstract: A cathode composite material includes a cathode active material and a coating layer coated on a surface of the cathode active material. The cathode active material includes a spinel type lithium nickel manganese oxide. The coating layer includes a lithium metal oxide having a crystal structure belonging to C2/c space group of the monoclinic crystal system. The present disclosure also relates to a lithium ion battery including the cathode composite material.

Abstract: Methods, devices and systems for performing digital measurements are provided.

Abstract: The present disclosure provides a new and improved intravitreal injection device, which is capable of locating the injection site with precision and reproducibility, ensuring the smooth delivery of medications or other treatments, and reducing potential need contaminations. In various embodiments, the device comprises a head unit and a hollow stem extending orthogonally from a bottom of the head unit. The device additionally includes a locating foot slidingly disposed on a distal end of the stem and a biasing device structured to bias the locating foot toward an extended position.

Abstract: A cathode composite material includes a cathode active material and a coating layer coated on a surface of the cathode active material. The cathode active material includes a layered type lithium nickel cobalt manganese oxide. The coating layer comprises a lithium metal oxide having a crystal structure belonging to C2/c space group of the monoclinic crystal system. The present disclosure also relates to a lithium ion battery including the cathode composite material.

Abstract: A gas sensor comprises a layered structure with an ionic conductive film and a high gas-permeability interlayer film, a first catalyst electrode and a second catalyst electrode, a conductivity promotion structure, a high-k layer and a current detecting unit. The ionic conductive film includes a material with ionic conductivity ranging from 0.02 to 1000 S/cm. The first catalyst electrode and second catalyst electrode are located on the layered structure and spaced by a predetermined distance for ionizing gas and converting the ionized gas into gas. The conductivity promotion structure includes a material with electronic conductivity ranging from 10?5 to 105 S/cm, and provides wanted electrons for reaction with the gas. The high-k layer is interposed between the conductivity promotion structure and layered structure. The current detecting unit is coupled the first catalyst electrode and second catalyst electrode to sense a detecting current with respect to the ionized gas.

Abstract: Disclosed are biomolecule based bioprobes that exhibit improved water solubility and monolayer-forming properties with substantially little or no aggregation that can appreciably interfere with binding of the bioprobes to a target nucleotide. The bioprobes may be used in conjunction with a suitable reporter system to detect very small quantities of biological markers. The bio-probes comprise a nucleobase sequence capable of hybridizing to a target nucleotide; and at least one charged functional group attached to said nucleobase sequence. Also disclosed are biosensors, and sensing devices that comprise the bio-probe. Further disclosed are suitable electrochemical reporter systems for use with bioprobes. Methods of use of these devices and probes, including for the detection of target biomarkers, including biomarkers for cancer cells or pathogens, are also included.

Abstract: An embodiment in accordance with the present invention provides an automatic external defibrillator including an anterior pad designed such that it can be used during an endoscopic or surgical procedure that may generate electromagnetic interference. The anterior pad has a first arm adhered longitudinally along and substantially parallel to a left side of a sternum of the subject and a second arm adhered along a 5th intercostal space of the subject. The device also includes a posterior pad. Both the anterior and posterior pads include electrodes for delivering a shock to the subject. The device can also include a wearable component containing sensing electrodes for measuring heart rhythms and a transmitting them to a monitor. The monitor monitors these heart rhythms and alerts the subject or medical care providers to irregularities in the rhythms.

Abstract: The present invention aims to elucidate a miRNA involved in cellular senescence and to provide a method of use thereof. The senescence marker of the present invention comprises a gene transcript of miR-22. Further, the method for evaluating a senescence inhibitor of the present invention comprises the step of measuring the expression level of a gene transcript of miR-22 in a sample in the presence of a test compound and in the absence of the test compound; and the step of comparing the expression level of the gene transcript of miR-22 in the sample in the presence of the test compound with the expression level of the gene transcript of miR-22 in the sample in the absence of the test compound. Further, the cancer inhibitor of the present invention comprises as an effective component a gene transcript of miR-22, which cancer inhibitor promotes cellular senescence and inhibits invasion and/or metastasis of cancer.

Abstract: Methods and compositions for treating a mental condition in a subject in need thereof, includes administering to a subject in need thereof an effective amount of a CDD-102A compound [5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine], or a pharmaceutically acceptable salt or hydrate thereof pharmaceutically acceptable salt or hydrate thereof.

Abstract: A laser device includes a seed laser, a polarizer, a pseudorandom bit sequence (PRBS) pattern generator, and a phase modulator. The polarizer may be optically coupled to receive an output of the seed laser and may generate a polarization filtered output. The PRBS pattern generator may be configured to generate a PRBS pattern. The phase modulator may be configured to apply a PRBS modulation scheme to the polarization filtered output based on the PRBS pattern. The PRBS pattern may be generated to have a length above a first threshold for avoiding an occurrence of backward propagation being in phase with forward propagation in an active fiber receiving an output of the phase modulator when the pattern repeats and below a second threshold for phase mismatch in the active fiber.

Abstract: The present invention concerns antibodies that react immunologically with an epitope comprising VDKSRWQQG (SEQ ID NO: 1), including those that bind to cancer cells, and methods relating thereto. In particular, the antibodies that react immunologically with a particular epitope found in anti-tumor antigen antibodies are not only indicative of favorable therapy using the anti-tumor antigen antibodies, but are therapeutic in and of themselves.

Abstract: The present invention relates to compounds according to Formula I: and salts thereof, wherein R1, R2, R3, R4, Ar, and n are as defined herein. Methods for preparing compounds of Formula I are also provided. The present invention further includes methods of treating cellular proliferative disorders, such as cancer, with the compounds of Formula I.

Abstract: A composite comprising a conducting polymer and a graphene-based material is provided. The composite includes a graphene-based material doped with nitrogen or having a nitrogen-containing species grafted thereon, and a conducting polymer arranged on the graphene-based material. Methods of preparing the composite, and electrodes formed from the composite are also provided.

Abstract: The invention provides methods for reducing growth and/or metastasis of androgen-independent (castration resistant) prostate cancer in a tissue in an animal. In one embodiment the method comprises administering to the animal a therapeutically effective amount of a compound that reduces the number of B cells, and/or the function of B cells, in the tissue. In yet another embodiment, the invention provides methods for reducing androgen-induced growth of prostate epithelial cells in prostate tissue in an animal. In one embodiment, the method comprises administering to the animal a therapeutically effective amount of a compound that reduces the number of B cells, and/or the function of B cells, in the tissue.