Patents Assigned to Viacyte, Inc.
  • Stem cell aggregate suspension compositions and methods of differentiation thereof
    Patent number: 8008075
    Abstract: The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.
    Type: Grant
    Filed: November 4, 2008
    Date of Patent: August 30, 2011
    Assignee: ViaCyte, Inc.
    Inventors: Chad Green, Xiaojie Yu, Anne Bang, Eugene Brandon, Olivia Kelly, Alan D. Agulnick, E. Edward Baetge, Kevin A. D'Amour, Thomas C. Schulz, Allan J. Robins
  • Methods for increasing definitive endoderm production
    Patent number: 7993916
    Abstract: Disclosed herein are methods for increasing the production of definitive endoderm cells from pluripotent stem cells. Also disclosed herein are agents capable of increasing definitive endoderm cell production.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: August 9, 2011
    Assignee: Viacyte, Inc.
    Inventors: Alan Agulnick, Kevin D'Amour, Emmanuel Edward Baetge
  • Methods of producing pancreatic hormones
    Patent number: 7993920
    Abstract: Disclosed herein are methods of producing pancreatic hormone-expressing cells by first differentiating pluripotent cells in cell culture so as to produce endodermal cells, the endodermal cells being competent to further differentiate into hormone-expressing cells capable of secreting at least one pancreatic hormone in response to a physiological signal, and then, transplanting the cultured endodermal cells into an organism, such as an organism in need of an endocrine cell therapy.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: August 9, 2011
    Assignee: Viacyte, Inc.
    Inventors: Laura Martinson, Evert Kroon, Kevin D'Amour, Emmanuel Edward Baetge
  • Hepatocyte lineage cells
    Patent number: 7989204
    Abstract: Disclosed herein are methods for producing liver precursor cells as well as hepatocyte cells form pluripotent and/or multipotent cells. Also disclosed herein are methods of enriching isolating and/or purifying liver precursor cells and/or hepatocyte cells. Further disclosed are compositions comprising cell cultures and cell populations that are enriched for liver precursor cells or hepatocyte cells.
    Type: Grant
    Filed: April 27, 2007
    Date of Patent: August 2, 2011
    Assignee: Viacyte, Inc.
    Inventors: Kevin D'Amour, Emmanuel E. Baetge
  • Preprimitive streak and mesendoderm cells
    Patent number: 7985585
    Abstract: This disclosure relates to compositions comprising human preprimitive streak cells and/or human mesendoderm cells as well as methods for their production. Additionally, disclosed herein are methods of identifying factors useful in the further differentiation of preprimitive streak and mesendoderm cell types.
    Type: Grant
    Filed: June 23, 2006
    Date of Patent: July 26, 2011
    Assignee: Viacyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Emmanuel E. Baetge
  • METHODS AND COMPOSITIONS FOR FEEDER-FREE PLURIPOTENT STEM CELL MEDIA CONTAINING HUMAN SERUM
    Publication number: 20100311164
    Abstract: The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.
    Type: Application
    Filed: August 15, 2010
    Publication date: December 9, 2010
    Applicant: VIACYTE, INC.
    Inventors: Allan J. Robins, Thomas C. Schulz