Patents Assigned to Viacyte, Inc.
  • Hepatocyte lineage cells
    Patent number: 8574905
    Abstract: Disclosed herein are methods for producing liver precursor cells as well as hepatocyte cells form pluripotent and/or multipotent cells. Also disclosed herein are methods of enriching isolating and/or purifying liver precursor cells and/or hepatocyte cells. Further disclosed are compositions comprising cell cultures and cell populations that are enriched for liver precursor cells or hepatocyte cells.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: November 5, 2013
    Assignee: ViaCyte, Inc.
    Inventors: Kevin D'Amour, Emmanuel E. Baetge
  • AGENTS AND METHODS FOR INHIBITING HUMAN PLURIPOTENT STEM CELL GROWTH
    Publication number: 20130280802
    Abstract: The present invention relates to compositions and methods for inhibiting or suppressing undifferentiated or pluripotent stem cell growth and proliferation in a differentiated or differentiating cell population or culture.
    Type: Application
    Filed: December 8, 2010
    Publication date: October 24, 2013
    Applicant: ViaCyte, Inc
    Inventors: Thomas Schulz, Allan Robins
  • ENCAPSULATION OF PANCREATIC CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS
    Publication number: 20130209425
    Abstract: The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.
    Type: Application
    Filed: March 26, 2013
    Publication date: August 15, 2013
    Applicant: VIACYTE, INC.
    Inventor: VIACYTE, INC.
  • CELL COMPOSITIONS DERIVED FROM DEDIFFERENTIATED REPROGRAMMED CELLS
    Publication number: 20130164787
    Abstract: Disclosed herein are cell culture compositions, for example, pancreatic cell culture compositions, derived from dedifferentiated human reprogrammed pluripotent stem cells, such as induced pluripotent stem (iPS) cells, and methods for producing and using such cell culture compositions.
    Type: Application
    Filed: February 6, 2013
    Publication date: June 27, 2013
    Applicant: VIACYTE, INC.
    Inventor: ViaCyte, Inc.
  • Stem cell aggregate suspension compositions and methods of differentiation thereof
    Patent number: 8445273
    Abstract: The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.
    Type: Grant
    Filed: August 29, 2011
    Date of Patent: May 21, 2013
    Assignee: ViaCyte, Inc.
    Inventors: Chad Green, Xiaojie Yu, Anne Bang, Eugene Brandon, Olivia Kelly, Alan D Agulnick, E Edward Baetge, Kevin A D'Amour, Thomas C Schulz, Allan J Robins
  • METHODS FOR PURIFYING ENDODERM AND PANCREATIC ENDODERM CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS
    Publication number: 20130122520
    Abstract: The present disclosure relates to compositions and methods comprising cell surface markers for hES-derived cells, in particular, endoderm lineage cells including pancreatic endoderm-type cells, derived from hES cells.
    Type: Application
    Filed: December 21, 2012
    Publication date: May 16, 2013
    Applicant: VIACYTE, INC.
    Inventor: ViaCyte, Inc.
  • SCALABLE PRIMATE PLURIPOTENT STEM CELL AGGREGATE SUSPENSION CULTURE AND DIFFERENTIATION THEREOF
    Publication number: 20130115695
    Abstract: The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.
    Type: Application
    Filed: November 8, 2012
    Publication date: May 9, 2013
    Applicant: VIACYTE, INC.
    Inventor: ViaCyte, Inc.
  • Encapsulation of pancreatic cells derived from human pluripotent stem cells
    Patent number: 8425928
    Abstract: The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.
    Type: Grant
    Filed: July 22, 2011
    Date of Patent: April 23, 2013
    Assignee: ViaCyte, Inc.
    Inventors: Laura Martinson, Chad Green, Evert Kroon, Alan Agulnick, Olivia Kelly, Emmanuel E. Baetge
  • Compositions and methods useful for culturing differentiable cells
    Patent number: 8415158
    Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: April 9, 2013
    Assignee: ViaCyte, Inc.
    Inventors: Allan J Robins, Thomas C Schulz
  • Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
    Patent number: 8338170
    Abstract: The present disclosure relates to compositions and methods comprising cell surface markers for hES-derived cells, in particular, endoderm lineage cells including pancreatic endoderm-type cells, derived from hES cells.
    Type: Grant
    Filed: April 21, 2008
    Date of Patent: December 25, 2012
    Assignee: Viacyte, Inc.
    Inventors: Olivia Kelly, Anne Bang
  • Methods and compositions for feeder-free pluripotent stem cell media containing human serum
    Patent number: 8334138
    Abstract: The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.
    Type: Grant
    Filed: August 15, 2010
    Date of Patent: December 18, 2012
    Assignee: ViaCyte, Inc.
    Inventors: Allan J Robins, Thomas C Schulz
  • Encapsulation of pancreatic cells derived from human pluripotent stem cells
    Patent number: 8278106
    Abstract: The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: October 2, 2012
    Assignee: Viacyte, Inc.
    Inventors: Laura Martinson, Chad Green, Evert Kroon, Alan Agulnick, Olivia Kelly, Emmanuel E. Baetge
  • COMPOSITIONS AND METHODS USEFUL FOR CULTURING DIFFERENTIABLE CELLS
    Publication number: 20120214237
    Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
    Type: Application
    Filed: February 29, 2012
    Publication date: August 23, 2012
    Applicant: VIACYTE, INC.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • Methods for identifying factors for differentiating definitive endoderm
    Patent number: 8216836
    Abstract: Disclosed herein are methods of identifying one or more differentiation factors that are useful for differentiating cells in a cell population comprising definitive endoderm cells into cells which are capable of forming tissues and/or organs that are derived from the gut tube.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: July 10, 2012
    Assignee: Viacyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Susan Eliazer, Emmanuel E. Baetge
  • Methods for culturing pluripotent stem cells in suspension using ERBB3 ligands
    Patent number: 8211699
    Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: July 3, 2012
    Assignee: ViaCyte, Inc.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors
    Patent number: 8187878
    Abstract: The present invention provides compositions and methods for the production of differentiated mammalian cells. More particularly, the present invention provides cellular differentiation methods employing culturing the cells on a feeder layer or under feeder-free conditions in cell culture and further contacting the cells with an inhibitor of the PI3-kinase pathway and a member of the TGFb family for the generation of differentiated mammalian cells from pluripotent mammalian stem cells. Preferably, the differentiated cell is selected from the group consisting of a mesendodermal cell, a mesodermal cell, and an endodermal cell.
    Type: Grant
    Filed: August 15, 2005
    Date of Patent: May 29, 2012
    Assignees: University of Georgia Research Foundation, Inc., ViaCyte, Inc.
    Inventors: Stephen Dalton, Allan Sheppard, Karen Jones, E. Edward Baetge, Kevin A. D'Amour, Alan D. Agulnick
  • Compositions and methods useful for culturing differentiable cells
    Patent number: 8153429
    Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: April 10, 2012
    Assignee: ViaCyte, Inc.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
    Patent number: 8129182
    Abstract: Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell populations.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: March 6, 2012
    Assignee: Viacyte, Inc.
    Inventors: Kevin A. D'Amour, Anne Bang, Emmanuel E. Baetge
  • STEM CELL AGGREGATE SUSPENSION COMPOSITIONS AND METHODS OF DIFFERENTIATION THEREOF
    Publication number: 20120045830
    Abstract: The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.
    Type: Application
    Filed: August 29, 2011
    Publication date: February 23, 2012
    Applicant: VIACYTE, INC.
    Inventors: Chad Green, Xiaojie Yu, Anne Bang, Eugene Brandon, Olivia Kelly, Alan D. Agulnick, E. Edward Baetge, Kevin A. D'Amour, Thomas C. Schulz, Allan J. Robins
  • SMALL MOLECULES SUPPORTING PLURIPOTENT CELL GROWTH AND METHODS THEREOF
    Publication number: 20120021513
    Abstract: The present invention relates to compositions and methods for maintaining undifferentiated pluripotent stem cell cultures.
    Type: Application
    Filed: April 27, 2010
    Publication date: January 26, 2012
    Applicant: VIACYTE, INC.
    Inventors: Thomas C. Schulz, Allan J. Robins