Abstract: Disclosed herein are implantable 3-dimensional large capacity device assemblies, specifically, large capacity device assemblies for encapsulating pancreatic progenitor cells for treatment of diabetes.
Type:
Application
Filed:
March 7, 2014
Publication date:
September 11, 2014
Applicant:
ViaCyte, Inc.
Inventors:
Vincent So, Laura Martinson, Chad Green, Michael Scott
Abstract: Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying PDX1-positive endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of endoderm cells, such as PDX1-positive foregut endoderm cells and PDX1-negative definitive endoderm cells, are also disclosed.
Type:
Application
Filed:
January 2, 2014
Publication date:
July 10, 2014
Applicant:
VIACYTE, INC.
Inventors:
Kevin Allen D'Amour, Alan D. Agulnick, Susan Eliazer, Emmanuel E. Baetge
Abstract: Disclosed herein are cell cultures comprising expanded definitive endoderm cells as well as methods for expanding definitive endoderm cells in culture.
Type:
Application
Filed:
January 15, 2014
Publication date:
July 10, 2014
Applicant:
ViaCyte, Inc.
Inventors:
Olivia Kelly, Emmanuel E. Baetge, Melissa Carpenter
Abstract: Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell populations.
Type:
Application
Filed:
November 5, 2013
Publication date:
June 5, 2014
Applicant:
ViaCyte, Inc.
Inventors:
Kevin A. D'Amour, Anne Bang, Emmanuel E. Baetge
Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
Abstract: Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.
Type:
Application
Filed:
November 5, 2013
Publication date:
May 15, 2014
Applicant:
VIACYTE, INC.
Inventors:
Kevin Allen D'Amour, Alan D. Agulnick, Emmanuel E. Baetge
Abstract: Disclosed herein are reagent-cell complexes comprising one or more definitive endoderm cells. Also described herein are compositions for detecting definitive endoderm. Method of enriching, isolating and/or purifying definitive endoderm cells are also disclosed.
Type:
Application
Filed:
October 29, 2013
Publication date:
May 15, 2014
Applicant:
ViaCyte, Inc.
Inventors:
Kevin Allen D'Amour, Alan D. Agulnick, Emmanuel Edward Baetge
Abstract: The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.
Abstract: Disclosed herein are cell cultures comprising expanded definitive endoderm cells as well as methods for expanding definitive endoderm cells in culture.
Type:
Grant
Filed:
October 20, 2009
Date of Patent:
February 25, 2014
Assignee:
ViaCyte, Inc.
Inventors:
Olivia Kelly, Emmanuel E. Baetge, Melissa Carpenter
Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
Abstract: Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying PDX1-positive endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of endoderm cells, such as PDX1-positive foregut endoderm cells and PDX1-negative definitive endoderm cells, are also disclosed.
Type:
Grant
Filed:
April 26, 2005
Date of Patent:
February 11, 2014
Assignee:
ViaCyte, Inc.
Inventors:
Kevin Allen D'Amour, Alan D. Agulnick, Susan Eliazer, Emmanuel E. Baetge
Abstract: Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying PDX1-positive endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of endoderm cells, such as PDX1-positive foregut endoderm cells and PDX1-negative definitive endoderm cells, are also disclosed.
Type:
Grant
Filed:
February 28, 2008
Date of Patent:
January 21, 2014
Assignee:
ViaCyte, Inc.
Inventors:
Kevin Allen D'Amour, Alan D. Agulnick, Susan Eliazer, Emmanuel E. Baetge
Abstract: Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.
Type:
Grant
Filed:
March 30, 2009
Date of Patent:
January 7, 2014
Assignee:
Viacyte, Inc.
Inventors:
Kevin Allen D'Amour, Alan D. Agulnick, Emmanuel E. Baetge
Abstract: The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.
Abstract: Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell populations.
Type:
Grant
Filed:
October 17, 2011
Date of Patent:
December 10, 2013
Assignee:
ViaCyte, Inc.
Inventors:
Kevin A. D'Amour, Anne Bang, Emmanuel E. Baetge
Abstract: Disclosed herein are cell cultures comprising dorsal and/or ventral PDX1-positive foregut endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified dorsal and/or ventral PDX1-positive foregut endoderm cells as well as methods for enriching, isolating and purifying dorsal and/or ventral PDX1-positive foregut endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of dorsal and/or ventral PDX1-positive foregut endoderm cells, are also disclosed.
Type:
Application
Filed:
August 9, 2013
Publication date:
November 28, 2013
Applicant:
ViaCyte, Inc.
Inventors:
Kevin Allen D'Amour, Alan D. Agulnick, Susan Eliazer, Emmanuel E. Baetge
Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
Abstract: Disclosed herein are reagent-cell complexes comprising one or more definitive endoderm cells. Also described herein are compositions for detecting definitive endoderm. Method of enriching, isolating and/or purifying definitive endoderm cells are also disclosed.
Type:
Grant
Filed:
November 13, 2006
Date of Patent:
November 19, 2013
Assignee:
ViaCyte, Inc.
Inventors:
Kevin Allen D'Amour, Alan D Agulnick, Emmanuel Edward Baetge