Patents Assigned to Viacyte, Inc.
  • In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
    Patent number: 8859286
    Abstract: A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described. Immature beta cells co-express INS and NKX6.1 and are uni-potent and thereby develop into mature beta cells when implanted in vivo. The mature beta cells in vivo are capable of producing insulin in response to glucose stimulation.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: October 14, 2014
    Assignee: ViaCyte, Inc.
    Inventor: Alan D. Agulnick
  • IN VITRO DIFFERENTIATION OF PLURIPOTENT STEM CELLS TO PANCREATIC ENDODERM CELLS (PEC) AND ENDOCRINE CELLS
    Publication number: 20140271566
    Abstract: A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described. Immature beta cells co-express INS and NKX6.1 and are uni-potent and thereby develop into mature beta cells when implanted in vivo. The mature beta cells in vivo are capable of producing insulin in response to glucose stimulation.
    Type: Application
    Filed: December 13, 2013
    Publication date: September 18, 2014
    Applicant: ViaCyte, Inc.
    Inventor: Alan D. Agulnick
  • 3-DIMENSIONAL LARGE CAPACITY CELL ENCAPSULATION DEVICE ASSEMBLY
    Publication number: 20140257515
    Abstract: Disclosed herein are implantable 3-dimensional large capacity device assemblies, specifically, large capacity device assemblies for encapsulating pancreatic progenitor cells for treatment of diabetes.
    Type: Application
    Filed: March 7, 2014
    Publication date: September 11, 2014
    Applicant: ViaCyte, Inc.
    Inventors: Vincent So, Laura Martinson, Chad Green, Michael Scott
  • PDX1 EXPRESSING ENDODERM
    Publication number: 20140193904
    Abstract: Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying PDX1-positive endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of endoderm cells, such as PDX1-positive foregut endoderm cells and PDX1-negative definitive endoderm cells, are also disclosed.
    Type: Application
    Filed: January 2, 2014
    Publication date: July 10, 2014
    Applicant: VIACYTE, INC.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Susan Eliazer, Emmanuel E. Baetge
  • EXPANSION OF DEFINITIVE ENDODERM CELLS
    Publication number: 20140193905
    Abstract: Disclosed herein are cell cultures comprising expanded definitive endoderm cells as well as methods for expanding definitive endoderm cells in culture.
    Type: Application
    Filed: January 15, 2014
    Publication date: July 10, 2014
    Applicant: ViaCyte, Inc.
    Inventors: Olivia Kelly, Emmanuel E. Baetge, Melissa Carpenter
  • SMALL MOLECULES SUPPORTING PLURIPOTENT CELL GROWTH AND METHODS THEREOF
    Publication number: 20140186948
    Abstract: The present invention relates to compositions and methods for maintaining undifferentiated pluripotent stem cell cultures.
    Type: Application
    Filed: January 22, 2014
    Publication date: July 3, 2014
    Applicant: ViaCyte, Inc.
    Inventors: Thomas C Schulz, Allan J Robins
  • ENDOCRINE PRECURSOR CELLS, PANCREATIV HORMONE-EXPRESSING CELLS AND METHOS OF PRODUCTION
    Publication number: 20140154801
    Abstract: Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell populations.
    Type: Application
    Filed: November 5, 2013
    Publication date: June 5, 2014
    Applicant: ViaCyte, Inc.
    Inventors: Kevin A. D'Amour, Anne Bang, Emmanuel E. Baetge
  • Compositions and Methods Useful for Culturing Differentiable Cells
    Publication number: 20140154802
    Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
    Type: Application
    Filed: February 10, 2014
    Publication date: June 5, 2014
    Applicant: Viacyte, Inc.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • MARKERS OF DEFINITIVE ENDODERM
    Publication number: 20140134726
    Abstract: Disclosed herein are reagent-cell complexes comprising one or more definitive endoderm cells. Also described herein are compositions for detecting definitive endoderm. Method of enriching, isolating and/or purifying definitive endoderm cells are also disclosed.
    Type: Application
    Filed: October 29, 2013
    Publication date: May 15, 2014
    Applicant: ViaCyte, Inc.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Emmanuel Edward Baetge
  • DEFINITIVE ENDODERM
    Publication number: 20140134727
    Abstract: Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.
    Type: Application
    Filed: November 5, 2013
    Publication date: May 15, 2014
    Applicant: VIACYTE, INC.
    Inventors: Kevin Allen D'Amour, Alan D. Agulnick, Emmanuel E. Baetge
  • METHODS AND COMPOSITIONS FOR FEEDER-FREE PLURIPOTENT STEM CELL MEDIA CONTAINING HUMAN SERUM
    Publication number: 20140099713
    Abstract: The present invention provides compositions and methods for the culture and maintenance of pluripotent stem cells. More particularly, the present invention provides for compositions and methods for culturing, maintaining, growing and stabilizing primate pluripotent stem cells in a feeder-free defined media further comprising human serum, or a soluble attachment component of the human serum, for promoting cell attachment.
    Type: Application
    Filed: December 10, 2013
    Publication date: April 10, 2014
    Applicant: ViaCyte, Inc.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • Small molecules supporting pluripotent cell growth and methods thereof
    Patent number: 8685726
    Abstract: The present invention relates to compositions and methods for maintaining undifferentiated pluripotent stem cell cultures.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: April 1, 2014
    Assignee: Viacyte, Inc.
    Inventors: Thomas C Schulz, Allan J Robins
  • Compositions and methods useful for culturing differentiable cells
    Patent number: 8658352
    Abstract: The present invention relates to cell culture methods and compositions that are essentially serum-free and comprise a basal salt nutrient solution and an ErbB3 ligand.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: February 25, 2014
    Assignee: ViaCyte, Inc.
    Inventors: Allan J. Robins, Thomas C. Schulz
  • Expansion of definitive endoderm cells
    Patent number: 8658151
    Abstract: Disclosed herein are cell cultures comprising expanded definitive endoderm cells as well as methods for expanding definitive endoderm cells in culture.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: February 25, 2014
    Assignee: ViaCyte, Inc.
    Inventors: Olivia Kelly, Emmanuel E. Baetge, Melissa Carpenter
  • 3-dimensional large capacity cell encapsulation device
    Patent number: D714956
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: October 7, 2014
    Assignee: ViaCyte, Inc.
    Inventors: Vincent So, Laura Martinson, Chad Green, Michael Scott
  • 3-Dimensional large capacity cell encapsulation device
    Patent number: D718466
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: November 25, 2014
    Assignee: ViaCyte, Inc.
    Inventors: Vincent So, Laura Martinson, Chad Green, Michael Scott
  • 3-dimensional large capacity cell encapsulation device
    Patent number: D718467
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: November 25, 2014
    Assignee: ViaCyte, Inc.
    Inventors: Vincent So, Laura Martinson, Chad Green, Michael Scott
  • 3-dimensional large capacity cell encapsulation device
    Patent number: D718468
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: November 25, 2014
    Assignee: ViaCyte, Inc.
    Inventors: Vincent So, Laura Martinson, Chad Green, Michael Scott
  • 3-dimensional large capacity cell encapsulation device
    Patent number: D718469
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: November 25, 2014
    Assignee: ViaCyte, Inc.
    Inventors: Vincent So, Laura Martinson, Chad Green, Michael Scott
  • 3-dimensional large capacity cell encapsulation device
    Patent number: D718472
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: November 25, 2014
    Assignee: ViaCyte, Inc.
    Inventors: Vincent So, Laura Martinson, Chad Green, Michael Scott