Abstract: The present invention, as described above and as further defined by the claims below, provides methods for creating an Ophthalmic Lens with Stabilizing Features and a Rigid Insert, where the Stabilizing Features may orient the Ophthalmic Lens when placed on an eye. In some embodiment, the Stabilizing Features may be included as a unique Reactive Monomer Mixture with separate properties than the encapsulating RMM. Other embodiments may include Stabilizing Features comprising separate insert pieces. In alternate embodiments, the Rigid Insert may include the Stabilizing Features, such as, for example, through thermoforming techniques.

Abstract: A camera for enhanced color imaging in a low light environment including: one or more illuminators for illuminating a R, a G, and a B light at different time periods; an image sensor for capturing R G and B image frames; and a processor configured to generate an intermediate color frame from each of the R, G and B image frames; determine moving pixels in the each of the intermediate color frames; determine a true color for the moving pixels in each intermediate color frame; generate a true color frame for each intermediate color frame by substituting color of the moving pixels with respective true colors of the moving pixels, in intermediate color frame; calculate scene color metrics from the true color frame or intermediate color frame; and adaptively adjust illumination of one or more of the R, G, and B lights to enhance a next frame.

Abstract: A computerized system mountable on a vehicle operable to detect an object by processing first image frames from a first camera and second image frames from a second camera. A first range is determined to said detected object using the first image frames. An image location is projected of the detected object in the first image frames onto an image location in the second image frames. A second range is determined to the detected object based on both the first and second image frames. The detected object is tracked in both the first and second image frames When the detected object leaves a field of view of the first camera, a third range is determined responsive to the second range and the second image frames.

Abstract: Image transforming vision enhancement device that enhances vision by transforming images provided by one or more cameras into modified images projected on one or more displays. The system may be embedded in glasses, contact lenses, binoculars, or other vision devices, in computer screens, or in components of moving vehicles. Image transformations may include modifying colors to assist colorblind users or to highlight color ranges, mapping invisible frequencies into visible colors, adding labels or graphics, and generating time-varying images with flashing or changing features. Images from multiple cameras may be combined, providing users with panoramic vision from a single device. Low light vision may be enhanced, and excessive glare may be attenuated. The system may magnify images with a variable magnification. User interfaces may be provided to configure and customize the image transformations.

Abstract: Provided is an optical device including an object-side body portion to and from which an eyepiece-side support member supporting an eyepiece system optical component can be attached and removed; an objective system optical component supported on the object-side body portion; a housing section that houses at least a portion of the eyepiece-side support member; a manipulation member by which a rotation manipulation is performed on the housing section; a following member that is driven and displaced by the manipulation member being rotated; and a gripping member that has at least a portion thereof arranged inside the housing section and grips the eyepiece-side support member when the following member is displaced. The manipulation member rotates freely relative to the following member when a gripping force exerted on the eyepiece-side support member by the gripping member reaches a prescribed value.

Abstract: The invention relates to a spectacle lens semi-finished or finished product with a front surface, a rear surface, a cylinder rim surface, a front edge surface with a front surface transition to the front surface and a front cylinder rim surface transition to the cylinder rim surface and/or a rear edge surface with a rear surface transition to the rear surface and a rear cylinder rim surface transition to the cylinder rim surface. The front surface transition is formed as a rounding and/or the rear surface transition is formed as a rounding.

Abstract: This invention discloses methods and apparatus to form organic semiconductor transistors upon three-dimensionally formed insert devices. In some embodiments, the present invention includes incorporating the three-dimensional surfaces with organic semiconductor-based thin film transistors, electrical interconnects, and energization elements into an insert for incorporation into ophthalmic lenses. In some embodiments, the formed insert may be directly used as an ophthalmic device or incorporated into an ophthalmic device.

Abstract: The present invention provides for an optical assembly using two ultra-thin optical pieces/parts defining the outer bound of the assembly with a solid or liquid core and methods of forming said assembly. In particular, the present in invention discloses the handling and arrangements of said ultra-thin optical pieces to prevent deformation and loss of optical quality of said ultra-thin optical pieces. The ultra-thin optical pieces can be from 25-200 microns and their structural integrity can be preserved through uninterrupted support throughout the encapsulation of one or more fluids, e.g., a saline solution and an oil solution, which can be used to form a liquid meniscus lens. In some embodiments, interlocking features included in the ultra-thin optical parts can be included in order to help create the seal and/or provide structural support to the liquid lens assembly.

Abstract: The composition for treating ocular effects of diabetes is a composition that contains an aldose reductase inhibitor in an ophthalmic gel for topical application to the eye. The composition includes a carrier having, by weight, about 0.4% carbomer, 4.0% sorbitol, 0.01% centrimide, 0.01% ethylenediaminetetraacetic acid (EDTA) and effective amounts of sodium chloride and sodium hydroxide for adjusting the pH of the topical carrier to about 7 and to achieve a desired viscosity, with the balance being water. The aldose reductase inhibitor (ARI) is mixed with the topical carrier at about 0.1%-6% by weight of the composition to form an ophthalmic gel. Preferably, the ARI is 2R,4S-6-fluoro-2-methyl-spiro[chroman-4,4?-imidazolidine]-2?,5?-dione, referred to as 2-methyl sorbinil, having the structure: or a pharmaceutically acceptable salt thereof. In use, the ophthalmic gel is preferably applied as an eye drop at a dosage of one drop per eye administered two to three times daily.

Abstract: An ophthalmic system for use in performing angular measurements in relation to a patient's eye. The ophthalmic system can include an optical angular measurement device that can provide angular indicia by, for example, projecting an image of an angular measurement reticle onto a patient's eye or by superimposing an image of an angular measurement reticle onto an image of the patient's eye. The ophthalmic system can include an optical refractive power measurement device for providing desired angular orientations for ocular implants or for incisions. The ophthalmic system can be used, for example, to align a toric intraocular lens to a desired angular orientation.

Abstract: The present invention provides an eye surgery training simulator that can reduce learning cost and simulate the eyes in a more real way to allow surgery performers in practice to increase the success rate of surgery. The surgery training simulator compromise: a base with the accommodating tank, a hollow sphere inside said accommodating tank with a punched hole at the center of its top to simulate the eyeball rotation; a thin film covering the punched hole of said hollow sphere to simulate anterior capsule; a positioning sheet attached to the top surface of the hollow sphere with a hole corresponding to the punched hole; a positioning plug-in at the side of said punched hole that can limit the displacement of the capsulorhexis forceps; and at least an elastic component that can simulate eyeball muscle by pulling the hollow sphere and restore it after the rotation of the hollow sphere.

Abstract: A high-volume gene therapy vector manufacturing process, entailing using a recombinant baculovirus to transform a producer cell, which producer cell in turn produces a recombinant gene therapy vector which is able to transform host cells even when they are not dividing.

Abstract: This invention is directed to a method of forming a patterned multi-piece insert for an ophthalmic lens. The method may include forming first insert front and back curve pieces. The method may further include depositing a conductive material onto one or both of the first insert front and back curve pieces and attaching an electronic component at least in part to the conductive material. The method may further include placing an adhesive material onto a surface of one or both of the first insert front and back curve pieces so that a first ophthalmic insert is sealed when the first insert front and back curve pieces are combined. The method may further include combining the first insert back and front curve pieces to form the first ophthalmic insert and applying a colorant to at least one surface of one or both of the first insert back and front curve pieces.

Abstract: An exercise apparatus includes a frame with a pair of vertical guides. A carriage is slidably carried on each of the guides. Each of the carriages has a locking mechanism to lock the carriage at a selected vertical position and a release to disengage the locking mechanism. A horizontal exercise bar is slidably carried on guide rods. First and second cables are coupled to a selectable exercise resistance, each of the cables having an end selectively coupled to either the respective carriage or to a respective bracket at the end of the exercise bar. Secondary brackets on the exercise bar are configured to engage respective ones of the carriage releases and grab the carriage so as to selectively engage and disengage the locking mechanisms upon axial rotation of the exercise bar and raise and lower the carriages with the exercise bar.

Abstract: The present invention relates to a formulation comprising a medium, one or more stabilizers, and one or more particles comprising nanoparticles included within a host material. In certain embodiments, a stabilizer comprises a HALS stabilizer. In certain embodiments, a stabilizer comprises a UVA stabilizer. In certain embodiments, the formulation includes a HALS stabilizer and a UVA stabilizer. In certain embodiments, nanoparticles have light-emissive properties. Other embodiments relate to a powder obtainable from a formulation of the invention, a composition including a powder of the invention, a coating comprising a formulation of the invention, and products and applications including a particle of the invention. In preferred embodiments, a nanoparticle comprises a semiconductor nanocrystal. In certain embodiments, a host material comprises a polymer. In certain embodiments, a host material comprises an inorganic material. A raw batch formulation and particle obtainable therefrom is also disclosed.

Abstract: An ophthalmic lens incorporating clearly identifiable, highly visible embedded labels that are not visible to the wearer or others when placed on the eye may be utilized to allow an individual to easily distinguish between the normal state of the lens and the inverted state of the lens as well as serve any number of functions, including acting as a brand label, a prescription label or as a cosmetic enhancer. The embedded label comprises holographic recordings revealed only in transmitted light.

Abstract: Lacrimal inserts such as punctal plugs may be utilized for delivery of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured for controlled, pulsatile release into the eye.

Abstract: An ophthalmic device includes a hydrogel lens and a media insert removably attached to the hydrogel lens. A method for removably attaching the media insert to the hydrogel lens includes receiving a first hydrogel lens including an annular opening, at least partially inserting a media insert into the annular opening of the first hydrogel lens, removing the media insert from the annular opening of the first hydrogel lens, receiving a second hydrogel lens including an annular opening, and at least partially inserting the removed media insert into the annular opening of the second hydrogel lens.