Abstract: The composition for treating ocular effects of diabetes is a composition that contains an aldose reductase inhibitor in an ophthalmic gel for topical application to the eye. The composition includes a carrier having, by weight, about 0.4% carbomer, 4.0% sorbitol, 0.01% centrimide, 0.01% ethylenediaminetetraacetic acid (EDTA) and effective amounts of sodium chloride and sodium hydroxide for adjusting the pH of the topical carrier to about 7 and to achieve a desired viscosity, with the balance being water. The aldose reductase inhibitor (ARI) is mixed with the topical carrier at about 0.1%-6% by weight of the composition to form an ophthalmic gel. Preferably, the ARI is 2R,4S-6-fluoro-2-methyl-spiro[chroman-4,4?-imidazolidine]-2?,5?-dione, referred to as 2-methyl sorbinil, having the structure: or a pharmaceutically acceptable salt thereof. In use, the ophthalmic gel is preferably applied as an eye drop at a dosage of one drop per eye administered two to three times daily.

Abstract: An ophthalmic system for use in performing angular measurements in relation to a patient's eye. The ophthalmic system can include an optical angular measurement device that can provide angular indicia by, for example, projecting an image of an angular measurement reticle onto a patient's eye or by superimposing an image of an angular measurement reticle onto an image of the patient's eye. The ophthalmic system can include an optical refractive power measurement device for providing desired angular orientations for ocular implants or for incisions. The ophthalmic system can be used, for example, to align a toric intraocular lens to a desired angular orientation.

Abstract: The invention relates to a spectacle lens semi-finished or finished product with a front surface, a rear surface, a cylinder rim surface, a front edge surface with a front surface transition to the front surface and a front cylinder rim surface transition to the cylinder rim surface and/or a rear edge surface with a rear surface transition to the rear surface and a rear cylinder rim surface transition to the cylinder rim surface. The front surface transition is formed as a rounding and/or the rear surface transition is formed as a rounding.

Abstract: The present invention provides for an optical assembly using two ultra-thin optical pieces/parts defining the outer bound of the assembly with a solid or liquid core and methods of forming said assembly. In particular, the present in invention discloses the handling and arrangements of said ultra-thin optical pieces to prevent deformation and loss of optical quality of said ultra-thin optical pieces. The ultra-thin optical pieces can be from 25-200 microns and their structural integrity can be preserved through uninterrupted support throughout the encapsulation of one or more fluids, e.g., a saline solution and an oil solution, which can be used to form a liquid meniscus lens. In some embodiments, interlocking features included in the ultra-thin optical parts can be included in order to help create the seal and/or provide structural support to the liquid lens assembly.

Abstract: This invention discloses methods and apparatus to form organic semiconductor transistors upon three-dimensionally formed insert devices. In some embodiments, the present invention includes incorporating the three-dimensional surfaces with organic semiconductor-based thin film transistors, electrical interconnects, and energization elements into an insert for incorporation into ophthalmic lenses. In some embodiments, the formed insert may be directly used as an ophthalmic device or incorporated into an ophthalmic device.

Abstract: A high-volume gene therapy vector manufacturing process, entailing using a recombinant baculovirus to transform a producer cell, which producer cell in turn produces a recombinant gene therapy vector which is able to transform host cells even when they are not dividing.

Abstract: The present invention provides an eye surgery training simulator that can reduce learning cost and simulate the eyes in a more real way to allow surgery performers in practice to increase the success rate of surgery. The surgery training simulator compromise: a base with the accommodating tank, a hollow sphere inside said accommodating tank with a punched hole at the center of its top to simulate the eyeball rotation; a thin film covering the punched hole of said hollow sphere to simulate anterior capsule; a positioning sheet attached to the top surface of the hollow sphere with a hole corresponding to the punched hole; a positioning plug-in at the side of said punched hole that can limit the displacement of the capsulorhexis forceps; and at least an elastic component that can simulate eyeball muscle by pulling the hollow sphere and restore it after the rotation of the hollow sphere.

Abstract: Lacrimal inserts such as punctal plugs may be utilized for delivery of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured for controlled, pulsatile release into the eye.

Abstract: This invention is directed to a method of forming a patterned multi-piece insert for an ophthalmic lens. The method may include forming first insert front and back curve pieces. The method may further include depositing a conductive material onto one or both of the first insert front and back curve pieces and attaching an electronic component at least in part to the conductive material. The method may further include placing an adhesive material onto a surface of one or both of the first insert front and back curve pieces so that a first ophthalmic insert is sealed when the first insert front and back curve pieces are combined. The method may further include combining the first insert back and front curve pieces to form the first ophthalmic insert and applying a colorant to at least one surface of one or both of the first insert back and front curve pieces.

Abstract: An exercise apparatus includes a frame with a pair of vertical guides. A carriage is slidably carried on each of the guides. Each of the carriages has a locking mechanism to lock the carriage at a selected vertical position and a release to disengage the locking mechanism. A horizontal exercise bar is slidably carried on guide rods. First and second cables are coupled to a selectable exercise resistance, each of the cables having an end selectively coupled to either the respective carriage or to a respective bracket at the end of the exercise bar. Secondary brackets on the exercise bar are configured to engage respective ones of the carriage releases and grab the carriage so as to selectively engage and disengage the locking mechanisms upon axial rotation of the exercise bar and raise and lower the carriages with the exercise bar.

Abstract: A method and system for displaying images captured by an in vivo imaging device are disclosed. Embodiments according to the present invention display image sequence data in a first display area. When a first annotated image is displayed in the first display area, a first thumbnail image in a second display area corresponding to the first annotated image is replaced to indicate an occurring correspondence between the first annotated image and the first thumbnail image corresponding to the first annotated image being displayed. In one embodiment, the method further comprises displaying the first thumbnail image in the second display area when one other image of the image sequence data is displayed in the first display area after the first annotated image is displayed.

Abstract: Systems and methods for designing and implanting a customized intra-ocular lens (IOL) is disclosed. In one embodiment, a system includes an eye analysis module that analyzes a patient's eye and generates biometric information relating to the eye. The system also includes eye modeling and optimization modules to generate an optimized IOL model based upon the biometric information and other inputted parameters representative of patient preferences. The system further includes a manufacturing module configured manufacture the customized IOL based on the optimized IOL model. In addition, the system can include an intra-operative real time analyzer configured to measure and display topography and aberrometry information related to a patient's eye for assisting in proper implantation of the IOL.

Abstract: A method characterizes manufacturing imperfections in a camera and variations in its operating environment to allow images captured by the camera to be compensated for these defects. The method includes: (a) illuminating a field of view of the optical elements under a controlled condition; (b) exposing multiple images onto the image sensor under the controlled condition; (c) extracting from the multiple images parameter values for pixels of the image sensor; and (d) compensating images taken subsequently in the camera using the parameter values. The controlled condition includes an external light source for illumination, and the image sensor is sensitive to color components.

Abstract: The present invention relates to a formulation comprising a medium, one or more stabilizers, and one or more particles comprising nanoparticles included within a host material. In certain embodiments, a stabilizer comprises a HALS stabilizer. In certain embodiments, a stabilizer comprises a UVA stabilizer. In certain embodiments, the formulation includes a HALS stabilizer and a UVA stabilizer. In certain embodiments, nanoparticles have light-emissive properties. Other embodiments relate to a powder obtainable from a formulation of the invention, a composition including a powder of the invention, a coating comprising a formulation of the invention, and products and applications including a particle of the invention. In preferred embodiments, a nanoparticle comprises a semiconductor nanocrystal. In certain embodiments, a host material comprises a polymer. In certain embodiments, a host material comprises an inorganic material. A raw batch formulation and particle obtainable therefrom is also disclosed.

Abstract: An ophthalmic device includes a hydrogel lens and a media insert removably attached to the hydrogel lens. A method for removably attaching the media insert to the hydrogel lens includes receiving a first hydrogel lens including an annular opening, at least partially inserting a media insert into the annular opening of the first hydrogel lens, removing the media insert from the annular opening of the first hydrogel lens, receiving a second hydrogel lens including an annular opening, and at least partially inserting the removed media insert into the annular opening of the second hydrogel lens.

Abstract: An ophthalmic lens incorporating clearly identifiable, highly visible embedded labels that are not visible to the wearer or others when placed on the eye may be utilized to allow an individual to easily distinguish between the normal state of the lens and the inverted state of the lens as well as serve any number of functions, including acting as a brand label, a prescription label or as a cosmetic enhancer. The embedded label comprises holographic recordings revealed only in transmitted light.

Abstract: This invention discloses methods and apparatus for providing an ophthalmic lens with an energy source incorporated therein.

Abstract: A control device for controlling a plurality of sets of LEDs, especially for an automotive vehicle, the plurality of sets of LEDs comprising at least a first set that is associated with at least a first lighting and/or signaling function and a second set that is associated with at least a second and third function.

Abstract: The present inventions relate to optical components which include quantum confined semiconductor nanoparticles, wherein at least a portion of the nanoparticles include a ligand attached to a surface thereof, the ligand being represented by the formula X-Sp-Z, wherein: X represents: a primary amine group, a secondary amine group, a urea, a thiourea, an imidizole group, an amide group, a carboxylic acid or carboxylate group, a phosphonic or arsonic acid group, a phosphoric acid group, a phosphate group, a phosphite group, a phosphinic acid group, a phosphinate group, a phosphine oxide group, a phosphinite group, a phosphine group, an arsenic acid group, an arsenate group, an arsenous acid group, an arsenite group, an arsinic acid group, an arsine oxide group, or an arsine group; Sp represents a group capable of allowing a transfer of charge or an insulating group; and Z represents a multifunctional group including three or more functional groups capable of communicating a specific property or chemical reactivit