Patents Assigned to Wake Forest University
  • Pharmaceutical compositions for high-capacity targeted delivery
    Patent number: 9486533
    Abstract: Provided herein are aptamers and pharmaceutical compositions comprising the same. In some embodiments, the aptamer selectively binds a protein of interest such as an extracellular receptor protein of interest (e.g., a cancer cell extracellular receptor protein, which may be differentially expressed in some embodiments). In some embodiments, the aptamer is directly linked by covalent bonding (e.g., via a geminal diamine linkage) to from 2 to 10 toxin compounds. Also provided herein is a method of selecting an aptamer that specifically binds to a protein expressed by a cell of interest, wherein in some embodiments the aptamer comprises at least one binding site for one or more active compounds. In some embodiments, primer regions flanking the variable region of the aptamers in the pool contains from 1 to 10 mismatches with respect to said forward or reverse primer.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: November 8, 2016
    Assignee: Wake Forest University Health Sciences
    Inventor: William H. Gmeiner
  • Compositions, methods, and kits for identifying candidate molecules from encoded chemical libraries
    Patent number: 9487774
    Abstract: The subject matter relates to relates to a one-bead-one-sequence composition, a library of tagged chemicals comprising a plurality of one-bead-one-sequence compositions, a method for identifying a candidate molecule from a library of tagged chemicals, and a composition produced by a process, all as described herein.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: November 8, 2016
    Assignee: Wake Forest University
    Inventors: Martin Guthold, Jed C. Macosko
  • Vessel encoded arterial spin labeling using fourier encoding suitable for vascular territory mapping
    Patent number: 9468394
    Abstract: Methods, systems, computer programs, circuits and workstations are configured to generate at least one two-dimensional color blood flow map that combines X and Y encoded primary and secondary peak data of 1-dimensional Inverse Fourier Transform images to visually indicate (i) anterior/posterior and right/left directional components of respective feeding arteries using defined colors and (ii) brightness to indicate an amount of blood flow associated with each voxel, with increased brightness associated with increased blood flow.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: October 18, 2016
    Assignee: Wake Forest University Health Sciences
    Inventor: Youngkyoo Jung
  • Methods for detecting risk of fatal prostate cancer using serum calcium
    Patent number: 9470697
    Abstract: A method of screening for increased risk of fatal prostate cancer in a subject comprises providing a blood sample collected from the subject, and then detecting the presence or absence of an increased level of serum calcium in the sample. An increased level of serum calcium indicates the subject is at increased risk of fatal prostate cancer.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: October 18, 2016
    Assignee: Wake Forest University Health Services
    Inventors: Gary G. Schwartz, Halcyon G. Skinner
  • Topical wound treatment method and composition
    Patent number: 9445989
    Abstract: A topical wound treatment composition comprises a hydrogen peroxide generator; alkaline powder; not more than 5 percent by weight of water; additional topical active agent if desired, and emollient (preferably hygroscopic emollient) to balance. When topically applied to a wound and water from the surrounding environment diffuses into the composition, the hydrogen peroxide generator and/or the alkaline compound diffuse into one another, causing a chemical reaction that generates treatment-effective amounts of oxygen to occur. The oxygen can then diffuse out of the composition and aid in wound treatment or healing.
    Type: Grant
    Filed: March 1, 2013
    Date of Patent: September 20, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Benjamin S. Harrison, Steve J. Hodges
  • Medical tools for small incision eye surgery
    Patent number: 9433495
    Abstract: Systems, devices and methods for performing small incision DLEK include providing a corneal transplantation donor tissue graft; then forming the tissue graft into an implantable configuration using the flexible substrate. Related medical kits and tools for forming a compact or rolled donor tissue graft are also described.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: September 6, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Keith Andrew Walter, Kurt Weber
  • Aligned scaffolding system for skeletal muscle regeneration
    Patent number: 9421305
    Abstract: Provided herein are anisotropic muscle implants that have a biodegradable scaffold comprising a plurality of fibers oriented along a longitudinal axis. The implants may include mammalian muscle cells seeded and/or fused into myotubes on the scaffold. Methods of forming the muscle implants are provided, as are methods of treating a subject in need of skeletal muscle reconstruction.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: August 23, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Sang Jin Lee, James J. Yoo, Anthony Atala
  • Muscle tissue regeneration using muscle fiber fragments
    Patent number: 9415076
    Abstract: The invention is directed to methods and compositions for obtaining uniform sized muscle fiber fragments for transplantation. These muscle fiber fragments are able to reconstitute into long fibers that are oriented along native muscle. The implanted muscle cells integrate with native vascular and neural network, as confirmed by histology and immunohistochemistry. This invention is particularly advantageous because autologous muscle can be harvested from a donor site, processed and injected into target sites in the operating room. The fragmented muscle fibers can be readily integrated within the host.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: August 16, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Anthony Atala, James Yoo, In Kap Ko
  • Systemic gene replacement therapy for treatment of X-linked MyoTubular Myopathy (XLMTM)
    Patent number: 9415120
    Abstract: The present invention provides compositions and methods for treating a myopathy. In certain embodiments, the invention provides compositions and methods for treating, improving muscle function, and prolonging survival in a subject with X-linked myotubular myopathy (XLMTM). The present invention provides a method comprising systemic administration of a composition that induces the increased expression of myotubularin in the muscle of a subject. The invention provides sustained regional and global increases in muscle function.
    Type: Grant
    Filed: January 13, 2015
    Date of Patent: August 16, 2016
    Assignees: Wake Forest University Health Sciences, Genethon, Children's Medical Center Corporation
    Inventors: Martin K. Childers, Alan H. Beggs, Ana Maria Buj Bello
  • Implantable connector systems having magnetic portions thereon and related methods
    Patent number: 9409036
    Abstract: A connecting system includes an implantable base unit having an implantable housing with an externally accessible magnetic portion and an implantable unit connecting member. The implantable base unit is configured to be at least partially implanted in a subject such that the externally accessible magnetic portion is accessible from an external region of the subject. An interface unit is releasably coupled to the implantable base unit. The interface unit has an interface housing with an interface magnetic portion and an interface unit connecting member. The interface magnetic portion is configured to engage the externally accessible magnetic portion of the implantable base unit to mechanically couple the implantable unit connecting member and the interface unit connecting member.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: August 9, 2016
    Assignee: Wake Forest University Health Sciences
    Inventor: David Klorg
  • Co-encapsulation of live cells with oxygen-generating particles
    Patent number: 9393272
    Abstract: Microcapsules are described that comprise (a) a liquid aqueous or hydrogel core; (b) a semipermeable membrane surrounding said core; (c) live animal cells (e.g., pancreatic cells) in the core; and (d) oxygen-generating particles in said core, said oxygen-generating particles included in said microcapsules in an amount sufficient to lengthen the duration of viability of said animal cells in said microcapsules. Compositions comprising such microcapsules and uses thereof, such as in treating diabetes, are also described.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: July 19, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Emmanuel C. Opara, Benjamin S. Harrison
  • Treatment of specific cardiovascular conditions with nitrite
    Patent number: 9387224
    Abstract: It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension. This discovery provides useful treatments to regulate a subject's blood pressure and blood flow, for example, by the administration of nitrite salts. Provided herein are methods of administering a pharmaceutically-acceptable nitrite salt to a subject, for treating, preventing or ameliorating a condition selected from: (a) ischemia-reperfusion injury (e.g., hepatic or cardiac or brain ischemia-reperfusion injury); (b) pulmonary hypertension (e.g., neonatal pulmonary hypertension); or (c) cerebral artery vasospasm.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: July 12, 2016
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Wake Forest University, Loma Linda University
    Inventors: Mark T. Gladwin, Alan N. Schechter, Christian J. Hunter, Gordon G. Power, Daniel B. Kim-Shapiro, Richard O. Cannon, III
  • Prosthetic penile implants with tethered rear tip extenders and related methods
    Patent number: 9375314
    Abstract: Rear tip extenders include a tether attached to a collar that can be mounted onto a respective cylinder forward of a fluid line (that communicates with a scrotal pump) to prevent full separation or detachment from the cylinder during a revision procedure.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: June 28, 2016
    Assignee: Wake Forest University Health Sciences
    Inventor: Ryan P. Terlecki
  • Surgical staplers with tissue protection and related methods
    Patent number: 9370362
    Abstract: Surgical staplers include: (a) a stapler head having opposed first and second elongate jaws with opposing proximal and distal end portions; (b) a staple cartridge held in at least one of the first and second jaws, the stapler cartridge configured to concurrently deliver a plurality of parallel rows of staples; and (c) a tissue protection segment held in a proximal portion of at least one of the first and second jaws. The jaws are configured to close against target tissue and, at stapler firing, staples are delivered to a subset of tissue held inside the jaws so that tissue held by the tissue protection segment adjacent the proximal end portion of the stapler is not stapled.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: June 21, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: John K. Petty, Lucas P. Neff
  • Reprogramming Mesenchymal Stromal Cells Into Hematopoietic Cells
    Publication number: 20160130554
    Abstract: Method for reprogramming of stromal cells into hematopoietic cells are provided. Also provided are mesenchymal stromal cells that can be reprogrammed into hematopoietic cells. In addition, hematopoietic cells reprogrammed from mesenchymal stromal cells are provided. Reprogramming stromal cells into hematopoietic cells is effected through a vector encoding a transcription factor that controls hematopoietic cell differentiation. Methods of treating subjects having diminished hematopoietic cell populations are provided as well.
    Type: Application
    Filed: November 4, 2015
    Publication date: May 12, 2016
    Applicant: Wake Forest University Health Sciences
    Inventors: Maria Graca N.D. Almeida-Porada, Christopher D. Porada, Colin E. Bishop
  • Field induced polymer electroluminescent (FIPEL) device
    Patent number: 9318721
    Abstract: In one aspect, optoelectronic devices are described herein. In some embodiments, an optoelectronic device described herein includes a radiation transmissive first electrode, a second electrode, a light emitting organic layer disposed between the first electrode and the second electrode, a dielectric layer disposed between the light emitting organic layer and the first electrode and/or second electrode, and a phosphor layer disposed in an optical path of the light emitting organic layer, wherein the light emitting organic layer includes a singlet emitter phase and a triplet emitter phase.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: April 19, 2016
    Assignee: Wake Forest University
    Inventor: David L. Carroll
  • Inkjet printing of tissues and cells
    Patent number: 9301925
    Abstract: Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.
    Type: Grant
    Filed: March 11, 2015
    Date of Patent: April 5, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Tao Xu, James J. Yoo, Anthony Atala
  • IL-13 receptor binding peptides
    Patent number: 9296785
    Abstract: A targeting peptide that specifically binds to an IL13 receptor (e.g., wherein said targeting peptide is not an IL13 fragment) is described. The targeting peptide is optionally conjugated to at least one effector molecule. In some embodiments, the peptide specifically binds to the IL13R?2 protein.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: March 29, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Waldemar Debinski, Hetal Pandya, Denise Gibo
  • Molecular signature of cancer
    Patent number: 9290558
    Abstract: The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: March 22, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Waldemar Debinski, Jill Wykosky, Denise Mazess Herpai
  • Apparatus and method for cardiac tissue modulation by topical application of vacuum to minimize cell death and damage
    Patent number: 9289193
    Abstract: A method and apparatus are provided for treating cardiac tissue to modulate ischemic heart tissue with topical sub-atmospheric pressure to minimize cell death and damage.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: March 22, 2016
    Assignee: Wake Forest University Health Sciences
    Inventors: Louis C. Argenta, David L. Carroll, James E. Jordan, Nicole H. Levi, Jie Liu, Michael J. Morykwas, William D. Wagner