Patents Assigned to Waseda University
  • Patent number: 8647613
    Abstract: The present invention has an object of providing a drug carrier capable of controlling in vivo pharmacokinetics. The present invention is directed to a drug carrier comprising a molecular assembly having a drug incorporated therein, and the above object can be achieved by a part of the amphiphilic molecules included in the molecular assembly being released from the molecular assembly by an external environmental change. The present invention utilizes a phenomenon that the hydrophilic-hydrophobic balance of the amphiphilic molecules is shifted toward hydrophilicity by an external environmental change and thus the amphiphilic molecules are freed from the molecular assembly.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: February 11, 2014
    Assignees: JCR Pharmaceuticals Co., Ltd., Waseda University
    Inventors: Shinji Takeoka, Yosuke Okamura, Hideo Kanazawa, Shuji Hisamoto, Kohei Kubota, Yosuke Obata
  • Publication number: 20140039236
    Abstract: A hydrotalcite-like substance capable of ion exchange with target anions, being of small crystal size that exhibits large basal spacing and excels at anion exchange performance; a process for producing the same; and a method of immobilizing hazardous substances. The hydrotalcite-like substance is produced by mixing an acidic solution containing aluminum and magnesium ions with an alkaline solution containing an alkali to synthesize a hydrotalcite-like substance, followed by, without ageing, water removal or neutralization. The molar ratio of aluminum ions and magnesium ions is preferably in the range of 1:5 to 1:2. Hazardous substances can be immobilized by pulverizing the hydrotalcite-like substance after synthesis and adding the powder to a subject, or adding a hydrotalcite-like substance in slurry form to a subject, or carrying out addition so as to cause the synthesis directly at the position of the subject.
    Type: Application
    Filed: October 11, 2013
    Publication date: February 6, 2014
    Applicants: JDC Corporation, Waseda University
    Inventors: Atsushi YAMAZAKI, Mai Takahashi
  • Patent number: 8636520
    Abstract: Disclosed is a method whereby a narrowed part similar to an actual lesioned blood vessel can be easily obtained. A mold (10) comprises first and second molded members (16, 17) having inner spaces (29, 40, 57) passing through in the axial direction and an axial member (18) detachably inserted through the individual inner spaces (29, 40, 57) of the individual molded members (16, 17). The molded members (16, 17) have tapered front parts (27, 27) respectively. In the state of facing the front ends (20) of the tapered front parts (27) to each other and thus forming a concave (12), the axial member (18) is attached. A first material (75) made of a mixed material comprising calcium carbonate or the like and silicone or the like is applied to the concave (12). A second material (76) such as silicone is applied to the entire outer periphery of the mold (10). After hardening the materials (75, 76), the mold (10) is withdrawn by detaching the axial member (18) and dividing the concave (12).
    Type: Grant
    Filed: January 28, 2009
    Date of Patent: January 28, 2014
    Assignee: Waseda University
    Inventors: Kiyotaka Iwasaki, Mitsuo Umezu, Takashi Tanaka
  • Patent number: 8625851
    Abstract: It is an object to measure a position of a feature around a road. An image memory unit stores images in which neighborhood of the road is captured. Further, a three-dimensional point cloud model memory unit 709 stores a point cloud showing three-dimensional coordinates obtained by laser measurement which is carried out simultaneously to the image-capturing of the images as a road surface shape model. Using an image point inputting unit 342, a pixel on a feature of a measurement target is specified by a user as a measurement image point. A neighborhood extracting unit 171 extracts a point which is located adjacent to the measurement image point and superimposed on the feature for the measurement target from the point cloud. A feature position calculating unit 174 outputs three-dimensional coordinates shown by the extracted point as three-dimensional coordinates of the feature for the measurement target.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: January 7, 2014
    Assignees: Mitsubishi Electric Corporation, Waseda University
    Inventors: Junichi Takiguchi, Naoyuki Kajiwara, Yoshihiro Shima, Ryujiro Kurosaki, Takumi Hashizume
  • Patent number: 8603162
    Abstract: An artificial mitral valve has a ring, an anterior cusp-side region, a posterior cusp-side region and a valve leaflet connected along an outer edge of the ring. The valve leaflet includes an anterior cusp forming member connected to the anterior cusp-side region and a posterior cusp forming member connected to the posterior cusp-side region. The anterior cusp forming member has an upper edge joined to the ring and a lower edge that forms a bifurcated portion. The upper edge is made up of a pair of right and left edges that incline inward and upward from the right and left sides, and a curved edge interposed between the inclined edges that curves along the anterior cusp-side region. The posterior cusp forming member has an upper edge joined to the ring and a lower edge that forms a bifurcated portion.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: December 10, 2013
    Assignee: Waseda University
    Inventors: Mitsuo Umezu, Hitoshi Kasegawa
  • Patent number: 8592807
    Abstract: Disclosed is a photoelectric element having an excellent conversion efficiency and provided with a hole transporting layer that is endowed with excellent hole transporting properties and a sufficiently large reaction interface. The photoelectric element of the invention has a pair of electrodes, an electron transporting layer and a hole transporting layer which are disposed between the electrodes, and an electrolyte solution. The hole transporting layer includes a first organic compound having a redox moiety capable of repeated oxidation and reduction. The electrolyte solution stabilizes a reduced state of the redox moiety. The organic compound and the electrolyte solution together form a first gel layer.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: November 26, 2013
    Assignees: Panasonic Corporation, Waseda University
    Inventors: Takashi Sekiguchi, Mitsuo Yaguchi, Takeyuki Yamaki, Hiroyuki Nishide, Kenichi Oyaizu, Fumiaki Kato, Michio Suzuka, Satoko Kambe
  • Patent number: 8571265
    Abstract: It is an object to measure a position of a feature around a road. An image memory unit stores images in which neighborhood of the road is captured. Further, a three-dimensional point cloud model memory unit 709 stores a point cloud showing three-dimensional coordinates obtained by laser measurement which is carried out simultaneously to the image-capturing of the images as a road surface shape model. Using an image point inputting unit 342, a pixel on a feature of a measurement target is specified by a user as a measurement image point. A neighborhood extracting unit 171 extracts a point which is located adjacent to the measurement image point and superimposed on the feature for the measurement target from the point cloud. A feature position calculating unit 174 outputs three-dimensional coordinates shown by the extracted point as three-dimensional coordinates of the feature for the measurement target.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: October 29, 2013
    Assignees: Mitsubishi Electric Corporation, Waseda University
    Inventors: Junichi Takiguchi, Naoyuki Kajiwara, Yoshihiro Shima, Ryujiro Kurosaki, Takumi Hashizume
  • Patent number: 8491308
    Abstract: It is intended to provide an endurance test apparatus whereby the behaviors of a vessel caused by a biomechanical burden can be simulated using a relatively simple constitution so that the endurance of a medical instrument (for example, a stent or an artificial vessel after anastomosis) can be tested in a similar state to an actual vessel, and an endurance test method therefor. Namely, an endurance test apparatus (10) comprises a simulated vessel (31) made of an elastic body, first and second holding members (32, 33) respectively supporting the both ends in the axial direction of the simulated vessel (31) and making the both ends relatively rotatable and interval-adjustable, and first and second motors (14, 15) operating these holding members (32, 33). The simulated vessel (31) is supported by the first and second holding members (32, 33) in a state stretched from its inherent length under a tensile force.
    Type: Grant
    Filed: February 29, 2008
    Date of Patent: July 23, 2013
    Assignee: Waseda University
    Inventors: Kiyotaka Iwasaki, Mitsuo Umezu, Akira Nishikohri, Shunsuke Tsubouchi
  • Patent number: 8483442
    Abstract: It is an object to measure a position of a feature around a road. An image memory unit stores images in which neighborhood of the road is captured. Further, a three-dimensional point cloud model memory unit 709 stores a point cloud showing three-dimensional coordinates obtained by laser measurement which is carried out simultaneously to the image-capturing of the images as a road surface shape model. A model projecting unit 172 projects a point cloud on the image, and an image displaying unit 341 displays the point cloud superimposed with the image on the displaying device. Using an image point inputting unit 342, a pixel on a feature of a measurement target is specified by a user as a measurement image point. A neighborhood extracting unit 171 extracts a point which is located adjacent to the measurement image point and superimposed on the feature for the measurement target from the point cloud.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: July 9, 2013
    Assignees: Mitsubishi Electric Corporation, Waseda University
    Inventors: Junichi Takiguchi, Naoyuki Kajiwara, Yoshihiro Shima, Ryujiro Kurosaki, Takumi Hashizume
  • Patent number: 8442678
    Abstract: A robotic device includes a first link portion, a second link portion that moves relative to the first link portion, a first contact load detecting portion that detects a contact load in a contact area of the first link portion, a second contact load detecting portion that detects a contact load in a contact area of the second link portion, and a first link portion control target setting portion that sets a control target for the first link portion. The first link portion control target setting portion sets the control target for the first link portion such that the difference between the detection value of the contact load of the first contact load detecting portion and the detection value of the contact load of the second contact load detecting portion decreases.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: May 14, 2013
    Assignees: Toyota Jidosha Kabushiki Kaisha, Waseda University
    Inventors: Kentaro Ichikawa, Shigeki Sugano, Kunihiro Iwamoto, Taisuke Sugaiwa, Hiroyasu Iwata
  • Patent number: 8438359
    Abstract: Provided is a method for managing a memory storage region used by a processor. The processor is connected to the memory that stores data accessed while a task is being executed. The memory management method including the steps of: dividing the memory area of the memory into blocks having a plurality of different sizes; selecting a block having a size matching a size of the data accessed while the task is being executed; and storing the data accessed while the task is being executed in the selected block.
    Type: Grant
    Filed: February 27, 2008
    Date of Patent: May 7, 2013
    Assignee: Waseda University
    Inventors: Hironori Kasahara, Keiji Kimura, Hirofumi Nakano, Takumi Nito, Takanori Maruyama, Tsuyoshi Miura, Tomohiro Tagawa
  • Patent number: 8422694
    Abstract: In a source sound separator, first and second target sound predominant spectra are generated respectively by first and second processing operations for linear combination for emphasizing the target sound, using received sound signals of two microphones arrayed at a distance from each other. A target sound suppressed spectrum is generated by processing for linear combination for suppression of the target sound, using the two received sound signals. Further, a phase signal containing a larger amount of signal components of the target sound and exhibiting directivity in the direction of the target sound is generated by processing of linear combination, using the two received sound signals. The target sound and the interfering sound are separated from each other using the first and second target sound predominant spectra, the target sound suppressed spectrum, and the phase signal.
    Type: Grant
    Filed: December 10, 2010
    Date of Patent: April 16, 2013
    Assignees: Oki Electric Industry Co., Ltd., Waseda University
    Inventors: Makoto Morito, Takashi Yazu, Kei Yamada, Tetsunori Kobayashi, Kenzo Akagiri, Tetsuji Ogawa
  • Patent number: 8414782
    Abstract: A process for producing a fluorocarbon microstructure capable of easily fabricating a three-dimensional fluorocarbon microstructure. The process for producing a fluorocarbon microstructure comprises a first processing step for forming, on a substrate (2), a film deposition portion with a given pattern made up of a through-hole figure by etching the substrate (2), a fabricating step for forming a fluorocarbon film (6) on an inner circumferential surface of a film deposition portion (9) to fabricate a fluorocarbon region surrounded by the fluorocarbon film (6), and a second processing step for fabricating the fluorocarbon microstructure protruding from a processing surface of the substrate (2) by etching a given region other than a fluorocarbon region on the substrate (2). Hence, the three-dimensional fluorocarbon microstructure can be fabricated which comprises a complicated structure that has conventionally been hard to fabricate.
    Type: Grant
    Filed: January 21, 2008
    Date of Patent: April 9, 2013
    Assignee: Waseda University
    Inventors: Takahiro Arakawa, Hiroyuki Kusakawa, Shuichi Shoji
  • Publication number: 20130011013
    Abstract: It is an object to measure a position of a feature around a road. An image memory unit stores images in which neighborhood of the road is captured. Further, a three-dimensional point cloud model memory unit 709 stores a point cloud showing three-dimensional coordinates obtained by laser measurement which is carried out simultaneously to the image-capturing of the images as a road surface shape model. Using an image point inputting unit 342, a pixel on a feature of a measurement target is specified by a user as a measurement image point. A neighborhood extracting unit 171 extracts a point which is located adjacent to the measurement image point and superimposed on the feature for the measurement target from the point cloud. A feature position calculating unit 174 outputs three-dimensional coordinates shown by the extracted point as three-dimensional coordinates of the feature for the measurement target.
    Type: Application
    Filed: July 12, 2012
    Publication date: January 10, 2013
    Applicants: Waseda University, MITSUBISHI ELECTRIC CORPORATION
    Inventors: Junichi TAKIGUCHI, Naoyuki Kajiwara, Yoshihiro Shima, Ryujiro Kurosaki, Takumi Hashizume
  • Publication number: 20130010074
    Abstract: It is an object to measure a position of a feature around a road. An image memory unit stores images in which neighborhood of the road is captured. Further, a three-dimensional point cloud model memory unit 709 stores a point cloud showing three-dimensional coordinates obtained by laser measurement which is carried out simultaneously to the image-capturing of the images as a road surface shape model. Using an image point inputting unit 342, a pixel on a feature of a measurement target is specified by a user as a measurement image point. A neighborhood extracting unit 171 extracts a point which is located adjacent to the measurement image point and superimposed on the feature for the measurement target from the point cloud. A feature position calculating unit 174 outputs three-dimensional coordinates shown by the extracted point as three-dimensional coordinates of the feature for the measurement target.
    Type: Application
    Filed: July 12, 2012
    Publication date: January 10, 2013
    Applicants: Waseda University, MITSUBISHI ELECTRIC CORPORATION
    Inventors: Junichi TAKIGUCHI, Naoyuki KAJIWARA, Yoshihiro SHIMA, Ryujiro KUROSAKI, Takumi HASHIZUME
  • Publication number: 20130005798
    Abstract: The object is to develop an antiprotozoal remedy having a novel mechanism of action. Provided is a compound represented by a chemical formula (1), a prodrug or a pharmaceutically acceptable salt thereof, wherein within the formula (1), R1 represents R10— of formula (4) or R20— of formula (5); R2 represents CHO—, etc.; R3 represents a hydrogen atom, CH3—C(?O)—, etc.; R4 represents a hydrogen atom, CH3—C(?O)—, etc.; each of R11 and R12 independently represents each a hydrogen atom, a methyl group, etc.; R13 represents —CH2—, —CH(—OH)— or —C(?O)—; each of R21 and R22 independently represents eaeh a hydrogen atom, a methyl group, etc.; R23 represents —CH2—, —CH(—OH)— or —C(?0)—; and R24 represents a hydrogen atom, a hydroxyl group, a methyl group, etc.
    Type: Application
    Filed: March 10, 2011
    Publication date: January 3, 2013
    Applicants: Obihiro University of Agriculture and Veterinary Medicine, Waseda University
    Inventors: Yoichi Nakao, Shintaro Ishigami, Yasuyuki Goto, Shin-ichiro Kawazu, Noboru Inoue
  • Patent number: 8338643
    Abstract: The present invention provides a reagent for introducing a protein or gene into a cell. The reagent of the present invention is, for example, a reagent for introducing a protein or gene into a cell, which comprises a composition comprising a cationic amino acid type lipid represented by the following formula (I)-1: (wherein in formula (I)-1: L is a single bond, —CONH—, or —S—S—; M1 is —(CH2)k— or —(CH2CH2O)k— (wherein k is an integer between 0 and 14); and m1 and m2 are each independently an integer between 11 and 21 (in this regard, when providing a reagent for introducing a gene into a cell, the case where both m1 and m2 are 15 is excluded)).
    Type: Grant
    Filed: November 26, 2007
    Date of Patent: December 25, 2012
    Assignee: Waseda University
    Inventors: Shinji Takeoka, Naoya Takeda, Hitoshi Kurumizaka, Isao Sakane, Namiko Ikegaya, Yosuke Obata, Syunsuke Saito
  • Patent number: 8332187
    Abstract: A controller of a cantilever evaluation system calculates a stream function value ?z(x, y; t+1) and vorticity ?z(x, y; t+1) at a subsequent time step t+1 using boundary conditions according to displacement h(z; t) of a cantilever and velocity ?h/?t(z; t), a stream function value ?z(x, y; t) and vorticity ?z(x, y; t) in two-dimensional planes. The controller uses the calculated stream function value ?z(x, y) and vorticity ?z(x, y) to calculate a fluid drag force acting on the cantilever. The controller substitutes the calculated fluid drag force into a displacement calculation equation to calculate the displacement h(z; t+1) of the one-dimensional beam at the subsequent time step t+1. The controller repeats such calculation for each grid point and further repeats it at each time step.
    Type: Grant
    Filed: October 22, 2008
    Date of Patent: December 11, 2012
    Assignees: Mizuho Information & Research Institute, Inc., Waseda University
    Inventors: Naoki Watanabe, Masaru Tsukada
  • Publication number: 20120282442
    Abstract: There are provided a mold manufacture method capable of easily manufacturing a mold having a nanosized fine structure, and a mold obtained using such method. The mold manufacture method includes: a step of forming a self-assembled film 2 on an inorganic thin film 1 having the fine structure, the self-assembled film 2 being composed of a silane coupling agent having a functional group including at least one of an amino group, a mercapto group, a thiol group, a disulfide group, a cyano group, a halogen group and a sulfonic acid group; a conductive layer formation step of forming a conductive layer 3 on the self-assembled film 2; and a step of forming a metal film 4 on the conductive layer 3 through electroplating.
    Type: Application
    Filed: June 28, 2012
    Publication date: November 8, 2012
    Applicant: Waseda University
    Inventors: Takayuki Homma, Mikiko Saito
  • Patent number: 8262796
    Abstract: A thin-film single crystal growing method includes preparing a substrate, irradiating an excitation beam on a metallic target made of a pure metal or an alloy in a predetermined atmosphere, and combining chemical species including any of atoms, molecules, and ions released from the metallic target by irradiation of the excitation beam with atoms contained in the predetermined atmosphere to form a thin film on the substrate.
    Type: Grant
    Filed: March 15, 2010
    Date of Patent: September 11, 2012
    Assignee: Waseda University
    Inventors: Noboru Ichinose, Kiyoshi Shimamura, Kazuo Aoki, Encarnacion Antonia Garcia Villora