Patents Assigned to Washington, University of
  • OPTICAL WHISPERING GALLERY MODE BARCODES FOR HIGH-PRECISION AND WIDE-RANGE MEASUREMENTS
    Publication number: 20230010794
    Abstract: Systems and methods for measuring a temperature using an optical whispering gallery mode (WGM) resonator are disclosed. The system includes a WGM resonator operatively coupled to a tunable laser source and a detector, as well as a computing device. The computing device is configured to transform a transmission spectrum from the detector into a measured barcode that includes a matrix of values indicative of at least one characteristic of the transmission spectrum. The computing device is further configured to transform the measured barcode into a temperature based on a relative collective shift of the measured barcode from a reference barcode selected from a predetermined library of reference barcodes.
    Type: Application
    Filed: July 7, 2022
    Publication date: January 12, 2023
    Applicant: Washington University
    Inventors: Lan Yang, Jie Liao
  • Synthesis of aerosol gels comprising macro-aggregates in a buoyancy-opposed flame reactor by a diffusion-limiting cluster aggregating process
    Patent number: 11548793
    Abstract: A process for gas-phase synthesis of titanium dioxide aerosol gels with controlled monomer size and crystalline phase using a diffusion flame aerosol reactor operated in a buoyancy-opposed configuration is disclosed. The process includes introducing a precursor stream into a diffusion flame aerosol reactor, introducing a fuel stream into the reactor, combusting the precursor stream and the fuel stream in a flame to form at least one nanoparticle, and operating the reactor in a down-fired buoyancy-opposed configuration to produce the aerosol gel.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: January 10, 2023
    Assignee: Washington University
    Inventors: Rajan K. Chakrabarty, Pai Liu
  • Real time monitoring and prediction of motion in MRI
    Patent number: 11543483
    Abstract: Methods, computer-readable storage devices, and systems are described for reducing movement of a patient undergoing a magnetic resonance imaging (MRI) scan by aligning MRI data, the method implemented on a Framewise Integrated Real-time MRI Monitoring (“FIRMM”) computing device including at least one processor in communication with at least one memory device. Aspects of the method comprise receiving a data frame from the MRI system, aligning the received data frame to a preceding data frame, calculating motion of a body part between the received data frame and the preceding data frame, calculating total frame displacement, and excluding data frames with a cutoff above a pre-identified threshold of the total frame displacement.
    Type: Grant
    Filed: October 20, 2021
    Date of Patent: January 3, 2023
    Assignees: Washington University, Oregon Health & Science University
    Inventors: Nico Dosenbach, Jonathan Koller, Andrew Van, Abraham Snyder, Amy Mirro, Damien Fair, Eric Earl, Rachel Klein, Oscar Miranda Dominguez, Anders Perrone
  • Micro-cathode matrix arc thrusters
    Patent number: 11542042
    Abstract: A matrix thruster that may be used to reposition and/or stabilize a CubeSAT satellite. The matrix thruster includes a conductive plate with an opening, a plurality of wires within the opening, a power supply electrically connected to the conductive plate or each of the plurality of wires via an inductor, and an electrical switch. The electrical switch creates a current change that creates an electric potential spike across the inductor. The electric potential spike across the inductor initiates an arc discharge between one of the wires and the conductive plate, which forms plasma that ejects cathode particles from the matrix thruster. Using multiple wires (e.g., four titanium wires) extends the lifetime of the thruster, as each wire restores an inter-electrode film needed for the other wires to continue generating plasma.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: January 3, 2023
    Assignee: The George Washington University
    Inventors: Keir Daniels, Zachary Switzer, Dimitris Kiaoulias, Michael Keidar
  • Preparative electrophoretic method for targeted purification of genomic DNA fragments
    Patent number: 11542495
    Abstract: A sample containing particles having high-molecular-weight (HMW) DNA is entrapped in a gel matrix, and the gel matrix is exposed to a lysis reagent configured to release the HMW DNA from the particles. The HMW DNA may be purified by subjecting the gel matrix to an electrophoretic field that removes the HMW DNA from the particles, lysis reagents, and/or other sample constituents, from the gel matrix such that the HMW DNA remains. The gel matrix may be subjected with DNA cleavase reagents configured to cleave at specific DNA sequences within the HMW DNA to liberate defined segments of the DNA as fragments of reduced size. The gel matrix may also be subjected to an electrophoretic field, which moves and separates the DNA fragments from uncleaved DNA of the HMW DNA, which remains substantially immobile. The electrophoretically separated DNA fragments may be isolated from the gel matrix.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: January 3, 2023
    Assignees: Sage Science, Inc., Washington University
    Inventors: Robi David Mitra, Jeffrey Milbrandt, Ezra Solomon Abrams, Todd J. Barbera, T. Christian Boles
  • Methods and compositions for improving exercise endurance, performance, or tolerance
    Patent number: 11534423
    Abstract: Among the various aspects of the present disclosure is the provision of methods and compositions for improving exercise endurance, performance, or tolerance using an S1P inhibiting agent.
    Type: Grant
    Filed: January 2, 2020
    Date of Patent: December 27, 2022
    Assignee: Washington University
    Inventors: Rita Brookheart, Brian Finck
  • Heparanase Inhibitor as Anti-Viral and Immunomodulatory Therapy
    Publication number: 20220401468
    Abstract: A method of treating an RNA virus infection in a subject in need that includes administering a therapeutically effective amount of a heparanase inhibitor. The RNA virus includes SARS-CoV-1, SARS-CoV-2, HTLV-1, HIV-1, and any combination thereof. The heparanase inhibitor includes heparin, a heparin mimetic, or any combination thereof. In some aspects, the heparanase inhibitor is Roneparstat. In some aspects, the administration of the therapeutically effective amount of the heparanase inhibitor results in the inhibition of infection by the RNA virus and associated inflammatory cytokine production.
    Type: Application
    Filed: June 15, 2022
    Publication date: December 22, 2022
    Applicant: Washington University
    Inventors: Katherine Weilbaecher, Jingyu Xiang
  • Split intein mediated polymerization and production of mussel foot adhesive protein materials
    Patent number: 11530245
    Abstract: Mussels strongly adhere to a variety of surfaces by secreting byssal threads that contain mussel foot proteins (Mfps). Recombinant production of Mfps presents an attractive route for preparing advanced adhesive materials. Using synthetic biology strategies, Mfp5 together with Mfp5 oligomers containing two or three consecutive, covalently-linked Mfp5 sequences (named Mfp52 and Mfp53) were synthesized. Positive correlations were found between Mfp5 molecular weight and underwater adhesive properties, including adhesion force, adhesion work, protein layer thickness, and recovery distance. Dopa-modified Mfp53 displayed a high adhesion force (201±36 nN ?m?1) and a high adhesion work (68±21 fJ ?m?1) for 200 s cure times, higher than previously reported Mfp-mimetic adhesives. Results disclosed herein highlight the power of synthetic biology in producing biocompatible and highly adhesive Mfp-based materials.
    Type: Grant
    Filed: August 28, 2019
    Date of Patent: December 20, 2022
    Assignee: Washington University
    Inventors: Fuzhong Zhang, Eugene Kim
  • Methods and apparatus for improving the image resolution and sensitivity of whole-body positron emission tomography (PET) imaging
    Patent number: 11529108
    Abstract: A positron emission tomography (PET) technique that can enhance the image resolution and system sensitivity of a clinical PET/CT scanner for imaging a whole body or a target region of a subject is provided. The system includes a detector array and a detector panel. The detector array includes an array of gamma ray detectors defining a field of view of a scanner and configured to detect at least one coincidence event. The detector panel includes an array of gamma ray detectors having a higher intrinsic spatial resolution than the detector array and positioned in closer proximity to a patient table than the detector array. The detector panel is positioned outside the field of view defined by the detector array during at least a portion of scanning by the PET system. The detector panel is configured to detect at least one coincidence event in cooperation with the detector array.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: December 20, 2022
    Assignee: Washington University
    Inventors: Yuan-Chuan Tai, Joseph O'Sullivan, Ke Li, Qiang Wang
  • COMPOSITIONS AND METHODS FOR INCREASING CELL SURFACE OXYTOCIN RECEPTOR (OXTR)
    Publication number: 20220395511
    Abstract: Among the various aspects of the present disclosure is the provision of OXTR chaperones and methods of use thereof. An aspect of the present disclosure provides for a method of increasing the display of oxytocin receptor (OXTR) on a plasma membrane in a cell of a subject comprising: administering an OXTR chaperone, wherein the OXTR chaperone increases OXTR on a cell surface. Another aspect of the present disclosure provides for a method of increasing or restoring oxytocin sensitivity in a subject comprising: administering an OXTR chaperone, wherein the OXTR chaperone increases OXTR on a cell surface. Yet another aspect of the present disclosure provides for a method of increasing the efficacy of oxytocin or synthetic oxytocin in a subject comprising: administering an OXTR chaperone, wherein the OXTR chaperone increases OXTR on a cell surface.
    Type: Application
    Filed: June 10, 2022
    Publication date: December 15, 2022
    Applicant: Washington University
    Inventors: Sarah England, Manasi Malik, Princess Imoukhuede, Yingye Fang
  • NMDAR INHIBITING AGENTS AND GABAAR POTENTIATING AGENTS AND USES THEREOF
    Publication number: 20220396597
    Abstract: N-methyl-d-aspartate receptors (NMDAR) and/or potentiating y-aminobutyric acid receptors (GABAAR) agents and uses thereof are described. Uses of these agents include methods of treating or preventing various psychiatric diseases, disorders, or conditions and methods of treating or preventing alcohol use disorder in a subject in need thereof.
    Type: Application
    Filed: October 16, 2020
    Publication date: December 15, 2022
    Applicant: Washington University
    Inventors: Douglas Covey, Steven Mennerick
  • Smart sensor for online situational awareness in power grids
    Patent number: 11527891
    Abstract: Waveforms in power grids typically reveal a certain pattern with specific features and peculiarities driven by the system operating conditions, internal and external uncertainties, etc. This prompts an observation of different types of waveforms at the measurement points (substations). An innovative next-generation smart sensor technology includes a measurement unit embedded with sophisticated analytics for power grid online surveillance and situational awareness. The smart sensor brings additional levels of smartness into the existing phasor measurement units (PMUs) and intelligent electronic devices (IEDs). It unlocks the full potential of advanced signal processing and machine learning for online power grid monitoring in a distributed paradigm.
    Type: Grant
    Filed: November 30, 2019
    Date of Patent: December 13, 2022
    Assignee: The George Washington University
    Inventors: Payman Dehghanian, Shiyuan Wang
  • LIPOSOME COMPOSITIONS AND METHODS OF TREATMENT TARGETED TO TUMOR ENDOTHELIUM
    Publication number: 20220387460
    Abstract: Compositions and methods of treatment for multiple myeloma (MM) are disclosed that include a liposome with a lipid bilayer shell enclosing a fluid-filled center, a targeting moiety coupled to the outer surface of the shell, a treatment compound disposed within the lipid bilayer shell or within the fluid-filled center, and an efficacy-enhancing compound disposed within the lipid bilayer shell or within the fluid-filled center. In some embodiments, the targeting moiety is PSGL-1, the proteasome-inhibiting compound is bortezomib, and the BMME-disrupting agent is a CXCR4 inhibitor or ROCK inhibitor.
    Type: Application
    Filed: November 11, 2020
    Publication date: December 8, 2022
    Applicant: Washington University
    Inventors: Abdel Kareem Azab, Cinzia Federico
  • SYSTEMS AND METHODS FOR INTEGRATED ANALYSIS OF BLOOD AND SURGICAL DRAIN FLUID BIOMARKERS
    Publication number: 20220389520
    Abstract: A method for detecting at least one systemic condition and at least one locoproximal condition within a surgical site of a subject following a surgery is disclosed. The method includes obtaining a surgical drainage fluid sample from the surgical site and a blood sample from the subject, isolating analyte-containing portions from the surgical drainage fluid sample and the blood sample, and detecting and quantifying at least a portion of the analytes within the analyte-containing portions to produce at least one assay result, wherein the at least one assay result is indicative of the at least one systemic condition and the at least one locoproximal condition within a surgical site of a subject. At least one assay result may be provided to a practitioner and used to select at least one additional treatment.
    Type: Application
    Filed: June 7, 2022
    Publication date: December 8, 2022
    Applicant: Washington University
    Inventors: Jose Zevallos, Aadel Chaudhuri
  • SYSTEMS AND METHODS FOR MULTIMODAL ANALYSIS OF SURGICAL DRAIN FLUID USING INTERCHANGEABLE AND CUSTOMIZABLE NUCLEIC ACID BASED TESTS
    Publication number: 20220389510
    Abstract: A method for detecting at least one surgery-related condition within a surgical site of a subject following a surgery is disclosed. The method includes providing at least one modular nucleic acid assay, obtaining a surgical drainage sample from the surgical site of the subject, isolating a nucleic acid-containing portion from the sample, and detecting and quantifying at least a portion of the amount of nucleic acids within the nucleic acid-containing portion using the at least one nucleic acid assay to produce at least one assay result. At least one assay result may be provided to a practitioner and used to select at least one additional treatment. The modular nucleic acid assays may be used in any combination with a single surgical drainage sample to assess minimal residual cancer, local immune environment, infection, transplant organ rejection, and/or free flap failure.
    Type: Application
    Filed: June 2, 2022
    Publication date: December 8, 2022
    Applicant: Washington University
    Inventors: Jose Zevallos, Aadel Chaudhuri
  • TWO-DIMENSIONAL HIGH-ENTROPY TRANSITION METAL DICHALCOGENIDES FOR CARBON DIOXIDE ELECTROCATALYSIS
    Publication number: 20220389600
    Abstract: Two-dimensional (2D) high-entropy transition metal dichalcogenide (TMDC) alloy compositions, methods of synthesizing the TMDC alloys, physical/chemical properties of the TMDC alloys, and uses of the TMDC alloys as catalysts in electrochemical reactions are disclosed.
    Type: Application
    Filed: June 8, 2022
    Publication date: December 8, 2022
    Applicant: Washington University
    Inventors: Rohan Mishra, John Cavin
  • Adaptive and self-adaptive plasma cancer therapeutic platform
    Patent number: 11517366
    Abstract: A method and system of adaptive cold atmospheric based treatment for diseased tissues, such as an area with cancerous cells, is disclosed. A plasma device generates a cold atmospheric plasma jet directed at the area having cancerous cells. A sensor is operable to sense the viability of the cancerous cells in the area. A controller is coupled to the plasma device and sensor. The controller is operative to control an initial plasma jet generated by the plasma device. The controller receives a sensor signal from the sensor to determine cell viability of the selected cells from the initial plasma jet. The controller adjusts the plasma jet based on the viability of the cancerous cells.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: December 6, 2022
    Assignee: The George Washington University
    Inventor: Michael Keidar
  • CDPK1 inhibitors, compositions, and methods related thereto
    Patent number: 11518761
    Abstract: The invention relates to inhibitors of calcium-dependent protein kinase 1 (CDPK1) and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, P. falciparum, C. hominis, or C. parvum infections, using the novel inhibitors of the invention.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: December 6, 2022
    Assignees: Vyera Pharmaceuticals, LLC, Washington University
    Inventors: Allen T. Hopper, L. David Sibley, James W. Janetka, Jon Helander
  • Label-free detection of renal cancer
    Patent number: 11519907
    Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: December 6, 2022
    Assignee: Washington University
    Inventors: Srikanth Singamaneni, Evan Kharasch, Jeremiah Morrissey, Chang Hee Lee
  • Label-free detection of renal cancer
    Patent number: 11519906
    Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: December 6, 2022
    Assignee: Washington University
    Inventors: Srikanth Singamaneni, Evan Kharasch, Jeremiah Morrissey, Chang Hee Lee