Patents Assigned to Washington, University of
  • COMPOUNDS AND METHODS FOR TREATING CANCER, VIRAL INFECTIONS, AND ALLERGIC CONDITIONS
    Publication number: 20220380407
    Abstract: The present invention generally relates to compounds that are useful for inhibiting one or more trypsin-like S1 serine proteases, HGFA, matriptase, hepsin, KLK5 and/or TMPRSS2 as well as cysteine proteases including trypsin-like cysteine proteases (e.g. Cathepsin B). The present invention also relates to various methods of using the inhibitor compounds to treat or prevent viral infections, including those caused by coronaviruses and influenza, conditions associated with KLK5, various malignancies, pre-malignant conditions, and cancer.
    Type: Application
    Filed: June 25, 2020
    Publication date: December 1, 2022
    Applicant: Washington University
    Inventors: James W. Janetka, Vishnu Damalanka
  • TRANSGENIC MICROORGANISMS AND SYNTHESIS OF PIPERAZIC ACID, PIPERAZIC ACID CONTAINING PRODUCTS, AND DERIVATIVES THEREOF
    Publication number: 20220372533
    Abstract: Among the various aspects of the present disclosure is the provision of a biological and biochemical production of piperazic acid derived from the newly discovered production pathway for L-piperazic acid. One aspect of the present disclosure includes a transgenic microorganism (e.g., bacteria) engineered to accumulate piperazic acid and derivatives thereof, including a piperazic acid (Piz)-containing product. Another aspect of the present disclosure includes biochemical and biological methods for producing piperazic acid and derivatives thereof, including a piperazic acid (Piz)-containing product. Another aspect of the present disclosure includes compositions and methods of using isotopically labeled piperazic acid and derivatives thereof, including a piperazic acid (Piz)-containing product.
    Type: Application
    Filed: March 16, 2021
    Publication date: November 24, 2022
    Applicant: Washington University
    Inventors: Joshua Van Dyke-Blodgett, Yifei Hu
  • Sensors for Aromatic Compounds and Methods of Making and Using Same
    Publication number: 20220372585
    Abstract: Among the various aspects of the present disclosure is the provision of molecular sensors, microbial sensors, constructs, systems, and methods for selectively detecting aromatic compounds.
    Type: Application
    Filed: April 27, 2022
    Publication date: November 24, 2022
    Applicant: Washington University
    Inventors: Tae Seok Moon, Hyojeong Yi, Matthew Amrofell, Chenggang Xi, Austin Rottinghaus
  • Neurosteroids and enantiomers thereof for the prevention and treatment of neurodegenerative conditions
    Patent number: 11497754
    Abstract: The present disclosure is directed to a composition for prevention or treatment of neurodegenerative conditions. The composition comprises a neurosteroid, a synthetic enantiomer of a neurosteroid, or a combination thereof.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: November 15, 2022
    Assignee: Washington University
    Inventors: Douglas Covey, Charles Zorumski, Yukitoshi Izumi, Makoto Ishikawa
  • Systems for producing radionuclides using minimal target material
    Patent number: 11495365
    Abstract: Among the various aspects of the present disclosure is the provision of systems for producing radioisotopes and improving the specific activity of radioisotopes (e.g., Cu-64 chloride). As described herein, the system includes a target material area or target material shape that matches the proton beam strike area or proton beam strike shape, resulting in optimal thickness with less target material required.
    Type: Grant
    Filed: March 13, 2019
    Date of Patent: November 8, 2022
    Assignee: Washington University
    Inventor: Gregory Gaehle
  • Balloon encapsulation and isovolumetric suction thrombectomy catheter and methods thereof
    Patent number: 11490910
    Abstract: The disclosure provides for an adjustable catheter system with isovolumetric suction and restoration of fluid for the removal of a thrombus and a method of use thereof. The catheter system includes an inner catheter and an outer sheath surrounding at least a portion of the inner catheter. The inner catheter may include at least three lumina extending from the proximal end to the distal end of the inner catheter, at least one infusion fenestration along the infusion segment, and a distal encapsulation balloon at the distal end. The outer sheath may include at least three lumina extending from the proximal end to the distal end of the outer sheath and a proximal encapsulation balloon at the distal end. The catheter system may further include an agitator for mechanical morcellation of the thrombus.
    Type: Grant
    Filed: September 7, 2021
    Date of Patent: November 8, 2022
    Assignee: Washington University
    Inventors: Eric Leuthardt, Mohamed Zayed, Guy Genin, Joshua Osbun, Gayan De Silva, Sanghun A. Lee, Dillon Williams, Alexander Wirtz
  • SYSTEMS AND METHODS FOR REAL-TIME B0 FLUCTUATION COMPENSATION
    Publication number: 20220347492
    Abstract: Devices, systems, and methods for enhancing MRI image quality and tracking accuracy in MR-guided treatment systems are described.
    Type: Application
    Filed: May 3, 2022
    Publication date: November 3, 2022
    Applicant: Washington University
    Inventors: H. Michael Gach, Austen Curcuru, Taeho Kim, Umberto Villa
  • Interconnection network with adaptable router lines for chiplet-based manycore architecture
    Patent number: 11489788
    Abstract: An interconnection network for a processing unit having an array of cores. The interconnection network includes routers and adaptable links that selectively connect routers in the interconnection network. For example, each router may be electrically connected to one or more of the adaptable links via one or more multiplexers and a link controller may control the multiplexers to selectively connect routers via the adaptable links. In another example, adaptable links may be formed as part of an interposer and the link controller selectively connect routers via the adaptable links in the interposer using interposer switches. The adaptable links enable the interconnection network to be dynamically partitioned. Each of those partitions may be dynamically reconfigured to form a topology.
    Type: Grant
    Filed: October 30, 2020
    Date of Patent: November 1, 2022
    Assignee: The George Washington University
    Inventors: Hao Zheng, Ke Wang, Ahmed Louri
  • Compositions and methods for treatment of pre-cancerous skin lesions
    Patent number: 11478549
    Abstract: The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: October 25, 2022
    Assignee: Washington University
    Inventors: Lynn Cornelius, Shadmehr Demehri, Raphael Kopan
  • Triblock copolymer based anion exchange membranes (AEMs) as separators in electrochemical devices
    Patent number: 11482713
    Abstract: The present disclosure is directed to triblock copolymer based anion exchange membranes (AEMs) and methods for making same. The membranes are useful as separators in electrochemical devices, such as fuel cells, electrolyzers, water desalination systems, and redox flow batteries.
    Type: Grant
    Filed: December 7, 2020
    Date of Patent: October 25, 2022
    Assignee: Washington University
    Inventors: Zhongyang Wang, Javier Parrondo, Vijay K. Ramani
  • Systems and methods for approximate communication framework for network-on-chips
    Patent number: 11483256
    Abstract: Systems and methods are disclosed for reducing latency and power consumption of on-chip movement through an approximate communication framework for network-on-chips (“NoCs”). The technology leverages the fact that big data applications (e.g., recognition, mining, and synthesis) can tolerate modest error and transfers data with the necessary accuracy, thereby improving the energy-efficiency and performance of multi-core processors.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: October 25, 2022
    Assignee: The George Washington University
    Inventors: Ahmed Louri, Yuechen Chen
  • LIQUID BIOPSY TO DETECT CANCER EARLY AND SENSITIVELY IN PATIENTS WITH NEUROFIBROMATOSIS TYPE 1
    Publication number: 20220334121
    Abstract: Among the various aspects of the present disclosure is the provision of methods for detecting cancer in Neurofibromatosis Type 1 (NF1) patients.
    Type: Application
    Filed: January 27, 2022
    Publication date: October 20, 2022
    Applicants: Washington University, NATIONAL INSTITUTES OF HEALTH
    Inventors: Aadel Chaudhuri, Paul Jones, Jeffrey Szymanski, Angela Hirbe, Russell Sundby, John Shern
  • Biomedical patches with aligned fibers
    Patent number: 11471260
    Abstract: A multi-laminar electrospun nanofiber scaffold for use in repairing a defect in a tissue substrate is provided. The scaffold includes a first layer formed by a first plurality of electrospun polymeric fibers, and a second layer formed by a second plurality of electrospun polymeric fibers. The second layer is combined with the first layer. A first portion of the scaffold includes a higher density of fibers than a second portion of the scaffold, and the first portion has a higher tensile strength than the second portion. The scaffold is configured to degrade via hydrolysis after at least one of a predetermined time or an environmental condition. The scaffold is configured to be applied to the tissue substrate containing the defect, and is sufficiently flexible to facilitate application of the scaffold to uneven surfaces of the tissue substrate, and to enable movement of the scaffold by the tissue substrate.
    Type: Grant
    Filed: October 27, 2020
    Date of Patent: October 18, 2022
    Assignee: Washington University
    Inventors: Matthew R. MacEwan, Jingwei Xie, Zack Ray, Younan Xia
  • Isoxazole hydroxamic acids as histone deacetylase 6 inhibitors
    Patent number: 11472780
    Abstract: The present disclosure provides compounds represented by Formula (I): and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula (I) for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: October 18, 2022
    Assignees: The George Washington University, The Board of Trustees ofthe University of Illinois
    Inventors: Alejandro Villagra, Alan P. Kozikowski, Sida Shen
  • Single-impulse panoramic photoacoustic computed tomography (SIP-PACT)
    Patent number: 11471057
    Abstract: A single-impulse panoramic photoacoustic computed tomography (SIP-PACT) system for small-animal whole-body imaging is disclosed. In addition, a dual-speed of sound image universal back-projection reconstruction method is disclosed. Further, a PACT system for imaging a breast of a subject is disclosed.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: October 18, 2022
    Assignee: Washington University
    Inventors: Lihong Wang, Lei Li, Liren Zhu, Cheng Ma
  • Systems and methods for detecting embedded target elements using signal interference
    Patent number: 11464487
    Abstract: A sensor system includes a sensor module that is embedded in a target environment and a signal system. The sensor module includes an active sensor of a first type that detects a target element in the target environment and a reference sensor of the first type that prevents detection of target elements by the reference sensor. The active sensor and the reference sensor receive an ultrasonic signal and respectively generate a first response signal and a second response signal. The first response signal is at least partially as a function of the detected target element. The signal system includes an ultrasonic transducer that generates the ultrasonic signal and receives the first and second response signals, and a controller communicatively coupled to the ultrasonic transducer. The controller identifies the detected target element based at least partially on the first and second response signals.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: October 11, 2022
    Assignee: Washington University
    Inventors: Shantanu Chakrabartty, Yarub Alazzawi, Srikanth Signamaneni, Keng-Ku Liu, Mingquan Yuan
  • Modular micro-cathode arc thruster
    Patent number: 11465784
    Abstract: A modular micro-cathode arc thruster for use in satellites. An exemplary satellite has a plurality of stacked modular arc thrusters, each having an external anode, an internal cathode, and an insulator therebetween. The arc thrusters are situated in a housing, wherein the housing has an opening to eject exhausted thrusters. Once an arc thruster is expended, the push rod ejects that arc thruster and the next arc thruster takes its place.
    Type: Grant
    Filed: April 2, 2018
    Date of Patent: October 11, 2022
    Assignee: The George Washington University
    Inventors: Michael Keidar, George Teel, Samantha A. Hurley, Denis Borisovich Zolotukhin
  • Cloud simulation and validation system
    Patent number: 11461206
    Abstract: Cloud simulation or validation system allows for the simulation of a future node that may be deployed on a piece of hardware. The system may attempt to simulate the operating system for node-A on top of the hardware for node-A, including basic network connectivity. When a host is booted up with the simulated configuration, validation scripts may be run to verify that the site is correctly prepped for cloud deployment. With its pre-staged RAM-based OS temporarily loaded into the host's RAM memory, any set of OS-based scripts, tools or binaries, may be executed for simulation and validation based upon the intended role of the host onto which the cloud simulation or validation system configuration is loaded.
    Type: Grant
    Filed: April 22, 2021
    Date of Patent: October 4, 2022
    Assignees: AT&T Intellectual Property I, L.P., The George Washington University
    Inventors: Jonathan Roll, Edmund Barmettler, Traci Walton-Jerald
  • Model-based load balancing for network data plane
    Patent number: 11463511
    Abstract: Software-based data planes for network function virtualization may use a modular approach in which network functions are implemented as modules that can be composed into service chains. Infrastructures that allow these modules to share central processing unit resources are particularly appealing since they support multi-tenancy or diverse service chains applied to different traffic classes. Systems, methods, and apparatuses introduce schemes for load balancing considering central processing unit utilization of a next hop device when processing a packet that uses a service chain.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: October 4, 2022
    Assignees: AT&T Intellectual Property I, L.P., The George Washington University
    Inventors: Abhigyan, Wei Zhang, Timothy Wood
  • Systems and methods for hyperspectral analysis of cardiac tissue
    Patent number: 11457817
    Abstract: Systems and methods for hyperspectral analysis of cardiac tissue are provided. In some embodiments, a method for visualizing ablation lesions includes illuminating at one or more illumination wavelengths a surface of tissue having an ablation lesion; collecting a spectral data set comprising spectral images of the illuminated tissue acquired at multiple spectral bands each at one or more acquisition wavelengths; distinguishing between the ablation lesion and an unablated tissue based on one or more spectral differences between the ablation lesion and unablated tissue; and creating a composite image of the tissue showing the ablation lesion and the unablated tissue.
    Type: Grant
    Filed: June 13, 2019
    Date of Patent: October 4, 2022
    Assignee: The George Washington University
    Inventor: Narine Sarvazyan