Patents Assigned to Washington, University of
  • GENOME SEQUENCING AS AN ALTERNATIVE TO CYTOGENETIC ANALYSIS
    Publication number: 20220301656
    Abstract: A computer-implemented method for the identification of clinically relevant structural variants in a subject with AML or MDS from whole genome sequencing data is disclosed that includes providing a whole-genome sequencing dataset, performing a structural variant analysis on the whole-genome sequencing dataset and producing a report that includes clinically relevant CNAs, SVs, and gene-level variants identified by the structural variant analysis.
    Type: Application
    Filed: March 18, 2022
    Publication date: September 22, 2022
    Applicant: Washington University
    Inventors: Eric Duncavage, David Spencer
  • Enzyme-dependent fluorescence recovery of NADH after photobleaching to assess dehydrogenase activity of living tissues
    Patent number: 11445950
    Abstract: The invention provides for a system for in vivo real time measurement of NADH recovery kinetics, comprising: 1) a specific pulse sequence to non-destructively, yet effectively, photobleach NADH for measurement of NADH recovery kinetics; 2) illumination light parameters to acquire NADH fluorescence before and after photobleaching, without causing fluorescence bleaching artifacts, for measurement of NADH recovery kinetics; and 3) configurations for devices capable of photobleaching NADH by at least 10% within tissues for effective measurement of NADH recovery kinetics in tissues within a living subject or excised tissues and organs.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: September 20, 2022
    Assignee: The George Washington University
    Inventors: Matthew Kay, Angel Moreno, Rafael Jaimes
  • Automated Interpretation of Protein Capillary Electrophoresis Data
    Publication number: 20220293211
    Abstract: Serum protein electrophoresis (SPEP) analysis systems and methods for automatically generating appropriate clinical interpretations of SPEP data are disclosed.
    Type: Application
    Filed: March 15, 2022
    Publication date: September 15, 2022
    Applicant: Washington University
    Inventors: Andrew Hughes, Ann Gronowski, Christopher Farnsworth
  • Atlas registration for resting state network mapping in patients with brain tumors
    Patent number: 11443429
    Abstract: A method for mapping brain function of a subject includes generating a lesion mask using a search light algorithm based on a plurality of anatomical images of the subject. The plurality of anatomical images are registered with atlas images by nonlinear atlas registration using the generated lesion mask to generate a warping map. A plurality of functional images of the subject are resampled using the warping map to generate a functional map, functional connectivity is computed using the functional map and a multi-layer perceptron.
    Type: Grant
    Filed: June 1, 2020
    Date of Patent: September 13, 2022
    Assignee: Washington University
    Inventors: Ki Yun Park, Abraham Snyder, Eric Leuthardt
  • Methods of characterizing and treating hidradenitis suppurativa
    Patent number: 11441187
    Abstract: Disclosures herein encompass methods of treating a subject with moderate to severe hidradenitis suppurativa (HS) encompassing the determination of differential gene expression to characterize HS severity followed by administration of a treatment specific for the stage of HS severity characterized in the subject.
    Type: Grant
    Filed: October 4, 2019
    Date of Patent: September 13, 2022
    Assignee: The George Washington University
    Inventors: Victoria Shanmugam, Derek Jones
  • METHODS OF ESTIMATION-BASED SEGMENTATION AND TRANSMISSION-LESS ATTENUATION AND SCATTER COMPENSATION IN NUCLEAR MEDICINE IMAGING
    Publication number: 20220284643
    Abstract: Among the various aspects of the present disclosure is the provision of methods for estimation-based segmentation of nuclear medicine images, as well as methods of transmission-less attenuation and scatter compensation of nuclear medicine images.
    Type: Application
    Filed: February 26, 2021
    Publication date: September 8, 2022
    Applicant: Washington University
    Inventors: Abhinav Kumar Jha, Ziping Liu, Hae Sol Moon, Zitong Yu, Md Ashequr Rahman
  • Treatment for Wolfram syndrome and other endoplasmic reticulum stress disorders
    Patent number: 11426415
    Abstract: The present invention generally relates to compositions and methods for treating or preventing an endoplasmic reticulum stress disorder in subjects, including compositions and methods for treating or preventing Wolfram syndrome. The present invention also relates to methods for treating symptoms of neurodegenerative diseases.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: August 30, 2022
    Assignees: Washington University, The United States of America, As Represented by the Secretary, Department of Health and Human Services
    Inventors: Fumihiko Urano, Jana Mahadevan, Amy Clark, Ajit Jadhav, David Maloney, Brandon Harvey, Shyh-ming Yang, Mark Henderson
  • Imaging nerve function and pathologies using diffusion basis spectrum imaging
    Patent number: 11426073
    Abstract: Repetitive electrical activity produces microstructural alteration in myelinated axons. These transient microstructural changes can be non-invasively visualized via two different magnetic-resonance-based approaches: diffusion fMRI and dynamic T2 spectroscopy in the ex vivo perfused bullfrog sciatic nerves. Non-invasive diffusion fMRI, based on standard diffusion tensor imaging (DTI), clearly localized the sites of axonal conduction blockage as might be encountered in neurotrauma or other lesion types. Diffusion fMRI response was graded in proportion to the total number of electrical impulses carried through a given locus. Diffusion basis spectrum imaging (DBSI) method revealed a reversible shift of tissue water into a restricted isotropic diffusion signal component, consistent with sub-myelinic vacuole formation.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: August 30, 2022
    Assignee: Washington University
    Inventors: Sheng-Kwei Song, William M. Spees, Tsen-Hsuan Lin, Peng Sun, Chunyu Song
  • BARBED ROD FOR LINEAR TISSUE CLOSURE AND APPROXIMATION
    Publication number: 20220257240
    Abstract: A barbed rod device is provided for tissue closure and approximation. The device includes two or more subassemblies. Each subassembly includes a receiver having a central opening and centerline axis, a plurality of barbs extending radially outward from the receiver, and a linking rod extending from the receiver along the centerline axis of the receiver. The linking rod includes a locking end opposite the receiver. The locking end of a first subassembly is configured to engage the receiver of a second subassembly.
    Type: Application
    Filed: February 14, 2022
    Publication date: August 18, 2022
    Applicant: Washington University
    Inventor: John Felder
  • Oxygen and nitrogen functionalized carbonaceous supports with improved nanoparticle dispersion, and methods of making and uses of the same
    Patent number: 11413603
    Abstract: Metal nanoparticle-bearing carbonaceous supports, or solid-supported metal-catalysts, can be formed by incipient wetness, wet impregnation and ethylene glycol reduction methods. The solid-supported metal-catalysts can be used a heterogeneous catalysts in various catalytic reactions such as hydrodeoxygenation reactions, catalyze hydrodehalogenation reactions, N—N hydrogenolysis reactions and oxidation reactions. The solid-supported metal-catalysts are easy to handle, are easily separable from reaction media, are stable in various types of reaction media, and are recyclable.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: August 16, 2022
    Assignee: The George Washington University
    Inventors: Danmeng Shuai, Tao Ye
  • Compounds having RD targeting motifs and methods of use thereof
    Patent number: 11413359
    Abstract: The present invention provides compounds that have motifs that target the compounds to cells that express integrins. In particular, the compounds have peptides with one or more RD motifs conjugated to an agent selected from an imaging agent and a targeting agent. The compounds may be used to detect, monitor and treat a variety of disorders mediated by integrins.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: August 16, 2022
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Samuel Achilefu, Kexian Liang, Rui Tang
  • Non-invasive imaging and treatment system for cardiac arrhythmias
    Patent number: 11406845
    Abstract: Disclosed are systems and methods for the treatment of cardiac arrhythmias.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: August 9, 2022
    Assignee: Washington University
    Inventors: Clifford G. Robinson, Phillip S. Cuculich
  • Dichromic fluorescent compounds
    Patent number: 11406719
    Abstract: The present invention provides dichromic fluorescent compounds, as well as processes for making and methods for using the dichromic fluorescent compounds.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: August 9, 2022
    Assignee: Washington University
    Inventors: Samuel Achilefu, Zongren Zhang, Mikhail Berezin
  • Mitogen-activated protein kinase inhibitors, methods of making, and methods of use thereof
    Patent number: 11407771
    Abstract: Compounds that inhibit mitogen-activated protein kinases (MAPKs) are disclosed. Some inhibitor compounds specifically target a single MAPK such as MAPK13, while others target multiple MAPKs such as MAPK13 and MAPK12. The compounds can be used therapeutically for a variety of diseases, including cancer and respiratory diseases. Methods of synthesis of the compounds are also disclosed.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: August 9, 2022
    Assignee: Washington University
    Inventors: Michael J. Holtzman, Arthur G. Romero, Benjamin J. Gerovac, Zhenfu Han, Shamus P. Keeler, Kangyun Wu
  • SWELL1-LRRC8 COMPLEX MODULATORS
    Publication number: 20220242812
    Abstract: The present invention is directed to various polycyclic compounds and methods of using these compounds to treat a variety of diseases including metabolic diseases such as obesity, diabetes, nonalcoholic fatty liver disease; cardiovascular diseases such as hypertension and stroke; neurological diseases, male infertility, muscular disorders, and immune disorders.
    Type: Application
    Filed: June 10, 2020
    Publication date: August 4, 2022
    Applicants: Washington University, University of Iowa
    Inventors: Rajan Sah, Robert Kerns, Pratik Chheda
  • PAN-NEURAMINIDASE INHIBITING ANTIBODIES
    Publication number: 20220242935
    Abstract: The present invention relates to antibodies against influenza neuraminidase, compositions containing the antibodies and methods of using the antibodies.
    Type: Application
    Filed: May 29, 2020
    Publication date: August 4, 2022
    Applicants: Washington University, Icahn School of Medicine at Mount Sinai, The Scripps Research Institute
    Inventors: Ali Ellebedy, Florian Krammer, Ian Wilson
  • Methods of treating based on site-specific tau phosphorylation
    Patent number: 11402392
    Abstract: The present disclosure provides methods to quantify tau phosphorylation at specific amino acid residues to predict time to onset of mild cognitive impairment due to Alzheimer's disease, stage Alzheimer's disease, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions.
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: August 2, 2022
    Assignee: Washington University
    Inventors: Nicolas Barthelemy, Randall Bateman, Eric McDade
  • Deep learning-assisted image reconstruction for tomographic imaging
    Patent number: 11403792
    Abstract: Systems and methods for reconstructing an image of a subject or object based on a plurality of measured signals representing the subject or object obtained by an imaging device are disclosed. The systems and methods reconstruct the image of the subject or object by performing an iterative reconstruction method to produce a plurality of intermediate images and the image of the subject, and transforming at least one selected intermediate image from the plurality of intermediate images using a quasi-projection operator. The quasi-projection operator includes a deep-learning model configured to map the at least one selected intermediate image to at least one regularized intermediate image. In addition, systems and methods for training the deep-learning model using a training data set that includes a plurality of training images and a plurality of corresponding training object images is disclosed.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: August 2, 2022
    Assignee: Washington University
    Inventors: Mark Anastasio, Thomas Matthews, Brendan Kelly
  • Treatment for bacterial infections with salicylic acid analogs
    Patent number: 11400102
    Abstract: Methods and compositions are provided for the reduction in virulence of a bacterium by interfering with the biosynthesis of yersiniabactin using salicylic acid or an analog thereof. Also provided are methods of treating a bacterial infection in a subject in need thereof.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: August 2, 2022
    Assignee: Washington University
    Inventor: Jeffrey P. Henderson
  • Biocompatible smart biomaterials with tunable shape changing and enhanced cytocompatibility properties
    Patent number: 11400185
    Abstract: The present application relates to biocompatible polymers that exhibit a shape-memory effect, devices made using the materials and methods of producing such materials and devices.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: August 2, 2022
    Assignee: The George Washington University a Congressionally Chartered Not-for-Profit Corporation
    Inventors: Shida Miao, Wei Zhu, Nathan J. Castro, Lijie G. Zhang