Patents Assigned to William H. Rorer, Inc.
  • Method of lowering blood pressure
    Patent number: 4279928
    Abstract: Multiple daily dosing with amidinoureas of the formula ##STR1## produces a significant and sustained decrease in blood pressure in humans.
    Type: Grant
    Filed: April 2, 1979
    Date of Patent: July 21, 1981
    Assignee: William H. Rorer, Inc.
    Inventors: Richard L. Riley, George H. Douglas, John Yelnosky
  • Process for producing ethynylbenzenes
    Patent number: 4267388
    Abstract: There is disclosed a novel process for preparing anti-inflammatory ethynylbenzene derivatives represented by the general formula I: ##STR1## wherein Y is hydrogen, halogen or loweralkyl of 1 to 3 carbon atoms; R represents a ring having the structure: ##STR2## wherein x is 1 to 3, or a ring of the structure: ##STR3## wherein Y' is hydrogen, halogen, loweralkyl of 1 to 3 carbon atoms and loweralkoxy of 1 to 3 carbon atoms; Y" is hydrogen or halogen; and Y"' is hydrogen or halogen, provided Y, Y', Y" and Y"' are not all hydrogen at the same time, by reacting a benzyl alcohol of formula V: ##STR4## with a sulfonyl chloride, reducing the sulfonate VI of the formula: ##STR5## and dehydrohalogenating the formed .beta.
    Type: Grant
    Filed: July 12, 1979
    Date of Patent: May 12, 1981
    Assignee: William H. Rorer, Inc.
    Inventors: Paul R. Darkes, Henry F. Campbell, George H. Douglas
  • Ethynylbenzene compounds and derivatives thereof to treat inflammation, pain or fever
    Patent number: 4264627
    Abstract: A method of treating patients by administering an effective amount of a compound which is a hydroxy, alkoxy or acyloxy ethynylbenzene, and the pharmaceutical preparation thereof.
    Type: Grant
    Filed: January 11, 1977
    Date of Patent: April 28, 1981
    Assignee: William H. Rorer, Inc.
    Inventor: Julius Diamond
  • Triazinones
    Patent number: 4246409
    Abstract: Novel s-triazine compounds are prepared as derivatives of the corresponding amidinourea and amidinothiourea compounds by reacting with an activated form of an acid amide to give substituted s-triazinones and thiones respectively, of the formula ##STR1## The s-triazinones and thiones are useful derivatives in analyzing for the corresponding amidinourea or amidino thiourea precursors and also have useful pharmacological properties which make them suitable for a variety of medicinal purposes including use as antidiarrheal agents.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: January 20, 1981
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, William L. Studt, Chong M. Won, Stuart A. Dodson, Jerome J. Zalipsky
  • Method for treatment of diarrheal disease conditions or symptons in mammals
    Patent number: 4242337
    Abstract: A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: December 30, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, William L. Studt, Stuart A. Dodson
  • Method for treatment of gastrointestinal secretory and ulcerogenic disease conditions or symptoms in mammals
    Patent number: 4242338
    Abstract: A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: December 30, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, William L. Studt, Stuart A. Dodson
  • Method for the treatment of diarrheal disease conditions and symptoms in mammals
    Patent number: 4242340
    Abstract: A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: December 30, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, William L. Studt, Stuart A. Dodson
  • Method for treatment of gastrointestinal spasmodic disease conditions or symptoms in mammals
    Patent number: 4242339
    Abstract: A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: December 30, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, William L. Studt, Stuart A. Dodson
  • Dysmenorrhea treatment
    Patent number: 4241087
    Abstract: Amidinoureas of the formula: ##STR1## when administered to females who suffer dysmenorrhea relieve discomfort and pain and prevent damage caused by abnormal uterine muscle spasms incident to dysmenorrhea.
    Type: Grant
    Filed: April 2, 1979
    Date of Patent: December 23, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: Ghulam N. Mir, Jacqueline B. Krebs, William L. Studt
  • Method of treatment
    Patent number: 4235929
    Abstract: This invention describes a method of treating inflammation in warm blooded animals by topically administering an effective amount of benzylideneaniline or its derivatives.
    Type: Grant
    Filed: March 2, 1979
    Date of Patent: November 25, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George W. Nuss, Jr., Norman J. Santora, George H. Douglas
  • Compositions and method of treatment
    Patent number: 4230727
    Abstract: Compositions for inhibiting cellular proliferation in mammals containing as the active ingredient N-benzylideneaniline and its derivatives, and the method therefor.
    Type: Grant
    Filed: April 2, 1979
    Date of Patent: October 28, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George W. Nuss, Jr., Norman J. Santora, George H. Douglas
  • Triazinones from amidinoureas
    Patent number: 4225315
    Abstract: Novel s-triazine compounds are prepared as derivatives of the corresponding amidinourea and amidinothiourea compounds by reacting with an activated form of an acid amide to give substituted s-triazinones and thiones respectively, of the formula ##STR1## The s-triazinones and thiones are useful derivatives in analyzing for the corresponding amidinourea or amidino thiourea precursors and also have useful pharmacological properties which make them suitable for a variety of medicinal purposes including use as antidiarrheal agents.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: September 30, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: Chong M. Won, Jerome J. Zalipsky, Dahyabhai M. Patel
  • Anti-inflammatory compositions containing .alpha.-phenyl-N-phenylnitrone compounds
    Patent number: 4224340
    Abstract: This invention relates to novel compositions containing .alpha.-phenyl-n-phenylnitrone compounds which are useful for the topical treatment of inflammation in warm-blooded animals.
    Type: Grant
    Filed: March 15, 1979
    Date of Patent: September 23, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: Henry F. Campbell, Norman F. Santora, George H. Douglas
  • Treatment of hypertension with amidinoureas
    Patent number: 4220658
    Abstract: Novel phenylamidinourea compounds and processes for their preparation are described. These compounds have an effective degree of anti-hypertensive properties and exert activities on the cardiovascular system. A method for the treatment of hypertensive disorders is also described.
    Type: Grant
    Filed: July 17, 1978
    Date of Patent: September 2, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, Julius Diamond
  • Amidinoureas for lowering blood pressure
    Patent number: 4219567
    Abstract: This invention describes novel chemical compounds which are 1-amidino-3-phenylureas. The method of preparing these compounds and their pharmaceutical uses is also disclosed.
    Type: Grant
    Filed: April 24, 1978
    Date of Patent: August 26, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: Julius Diamond, Jerome J. Zalipsky
  • Heterocyclic phenyl azo hydroxybenzenes
    Patent number: 4219474
    Abstract: The following novel azo compounds, pharmaceutically acceptable salts and process for preparing the same are disclosed: 2-[(p-(2-pyridylsulfamoyl)phenyl)azo]hydroxybenzene; 3-[(p-(2-pyridylsulfamoyl)phenyl)azo]salicylic acid; and 5-[(p-(4-(2-pyridylanilino))-N-phenyl)azo]salicylic acid.
    Type: Grant
    Filed: March 20, 1978
    Date of Patent: August 26, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: Jerome J. Zalipsky, Dahyabhai M. Patel
  • Method for treatment of gastrointestinal spasmodic disease conditions or symptoms in mammals
    Patent number: 4218450
    Abstract: A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: August 19, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: George H. Douglas, William L. Studt, Stuart A. Dodson
  • Method for alleviating hypertension with amidinoureas
    Patent number: 4216230
    Abstract: This invention describes novel chemical compounds which are 1-amidino-3-phenylureas. The method of preparing these compounds and their pharmaceutical uses is also disclosed.
    Type: Grant
    Filed: July 19, 1978
    Date of Patent: August 5, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: Julius Diamond, Jerome J. Zalipsky
  • Method for treating gastrointestinal hyperacidity or ulceration with amidinoureas
    Patent number: 4216229
    Abstract: This invention describes novel chemical compounds which are 1-amidino-3-phenylureas. The method of preparing these compounds and their pharmaceutical uses is also disclosed.
    Type: Grant
    Filed: July 19, 1978
    Date of Patent: August 5, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: Julius Diamond, Jerome J. Zalipsky
  • Method of treatment
    Patent number: 4214003
    Abstract: This invention describes a method of treating inflammation in warm-blooded animals by topically administering an effective amount of .alpha.-phenyl-N-phenylnitrone and derivatives thereof.
    Type: Grant
    Filed: October 3, 1978
    Date of Patent: July 22, 1980
    Assignee: William H. Rorer, Inc.
    Inventors: Henry F. Campbell, Norman J. Santora, George H. Douglas