Abstract: Systems and methods for performing bosonic quantum error correction (QEC) using Gottesman-Kitaev-Preskill (GKP) states are provided. An ancilla quantum mechanical oscillator is used to probe Gaussian noise experienced by a data quantum mechanical oscillator without disturbing the state of the data quantum mechanical oscillator. The ancilla quantum mechanical oscillator is initialized with a GKP state and entangled with the state of a data quantum mechanical oscillator to correlate any noise experienced by the data state with the state of the ancilla quantum mechanical oscillator. The states are then disentangled, and momentum and position quadrature operators of the ancilla quantum mechanical oscillator are measured and used to perform QEC on the information stored in the data quantum mechanical oscillator.

Abstract: The present invention provides methods and compositions for treating a cancer, methods for increasing an immune response against a tumor, methods for treating an autoimmune disease, and methods for decreasing an inflammation response in a subject in need thereof by modulating the expression and/or activity of Siglec 15 and/or its binding ligands.

Abstract: Techniques for implementing a QRAM by routing quantum information through multiple modes of a bosonic system are described. According to some aspects, a single bosonic system may be configured to maintain quantum information in a large number of independent modes at the same time. Suitable operations upon these modes may allow a quantum address value to be routed to modes associated with respective bits such that the only modes altered by the operations are those associated with the addresses being accessed. These modes may be operated upon based on the stored values then extracted to obtain the desired correlated superposition of the stored bit values in the addresses. The bits stored at the address locations may be classical bits, or may be qubits.

Abstract: In some aspects, the invention provides a method of treating atherosclerosis in a subject. The method comprises administering to the subject an agent that increases the activity or level of a let-7 miRNA or an agent that decreases activity or level of a TGF? signaling polypeptide in an endothelial cell in the subject. In some embodiments, the subject is administered an additional agent comprising a therapeutically effective amount of rapamycin or any derivative thereof. In some embodiments, the agent is a let-7 miRNA. In some other aspects, the invention provides a pharmaceutical composition comprising a let-7 miRNA. In some embodiments, the let-7 miRNA is encapsulated in a nanoparticle formulated for selective delivery to an endothelial cell.

Abstract: A method for magnetic resonance imaging uses an electromagnet [304], which may have open geometry, to generate a spatially nonuniform magnetic field within an imaging region [306]. The current through the electromagnet is controlled to repeatedly cycle the nonuniform magnetic field between a high strength for polarizing spins and a low strength for spatial encoding and readout. Using RF coils [308], excitation pulses are generated at a frequency that selects a non-planar isofield slice for imaging. The RF coils are also used to generate refocusing pulses for imaging and to generate spatial encoding pulses, which may be nonlinear. Magnetic resonance signals originating from the selected non-planar isofield slice of the nonuniform magnetic field in the imaging region [306] are detected using the RF coils [308] in parallel receive mode. MRI images are reconstructed from the parallel received magnetic resonance signals, e.g., using algebraic reconstruction.

Abstract: The present invention provides compositions and methods for inhibiting PTPN22 for restoring human central B-cell tolerance or for treating or preventing an autoimmune disease or disorder.

Abstract: Described herein are improved methods for the detection of endometriosis. Generally, the methods include, but are not limited to, applying machine learning algorithm to miRNA levels in order to detect, predict, diagnose, or monitor the presence or absence of endometriosis.

Abstract: The present invention provides methods and compositions for treating and preventing lung injuries due to or associated with coronavirus infections that cause Severe Acute Respiratory Syndrome, including COVID-19. More specifically the present invention provides methods for treating or preventing the lung injuries associated with SARS-CoV-2 infections, such as acute lung injury (ALI), lung fibrosis, and acute respiratory distress syndrome (ARDS). The methods comprise administering a therapeutically effective amount of a pharmaceutical composition comprising a protein kinase inhibitor compound having MAP3K2/MAP3K3 inhibition activity, such as pazopanib or nintedanib, or a pharmaceutically acceptable salt, solvate, or prodrug thereof, to a patient in need thereof. The present invention also provides devices for administering the compositions.

Abstract: The invention relates to the identification of secretory antibody-bound bacteria in the microbiota in a subject that influence the development and progression of inflammatory diseases and disorders. Thus, the invention relates to compositions and methods for detecting and identifying the constituents of a subject's microbiota, methods of modifying the constituents of the microbiota, and methods for treating inflammatory diseases and disorders in a subject in need thereof.

Abstract: Parametrically pumped four-wave mixing is a key building block for many developments in the field of superconducting quantum information processing. However, undesired frequency shifts such as Kerr, cross-Ken and Stark shifts inherent with four-wave mixing, lead to difficulties in tuning up the desired parametric processes and, for certain applications, severely limit the fidelities of the resulting operations. Some embodiments include a Josephson four-wave mixing device consisting of a SQUID transmon coupled to a half-flux biased SNAIL transmon, a.k.a. capacitively shunted flux qubit. When the two transmon have matching frequencies, an interference effect cancels the negative Kerr of the SQUID transmon with the positive Kerr of the SNAIL transmon while preserving parametric four-wave mixing capabilities.

Abstract: The invention features a composition comprising an immuno-stimulatory compound and a pHLIP® peptide, e.g., an immunostimulatory compound that comprises a cyclic purine dinucleotide, which binds to a stimulator of interferon genes (STING) such as a cGAMP cyclic compound inside a cell.

Abstract: A wireless Josephson-junction-based amplifier is described that provides improved tunability and increased control over both a quality factor Q and participation ratio p of the amplifier. The device may be fabricated on a chip and mounted in a waveguide. No wire bonding between the amplifier and coaxial cables or a printed circuit board is needed. At least one antenna on the chip may be used to couple energy between the waveguide and wireless JBA. The amplifier is capable of gains greater than 25 dB.

Abstract: The invention features a compositions and methods for inducing an immune response to targeted cells. The compositions induce targeting of a cell by positioning carbohydrate epitopes on the surface of the cell by conjugation of the epitope to a pH-triggered membrane peptide (pHLIP®).

Abstract: The present invention includes compositions and methods for treating disease and disorders associated with pathological calcification or pathological ossification by modulating the level or activity of NPP1 or a mutant thereof, or a mutant NPP4 modified to exhibit ATP hydrolase activity similar to the hydrolase activity of NPP1.

Abstract: The present invention relates to the discovery that inhibition of Dickkopf2 (DKK2) increases CD8+ cytotoxic T lymphocyte (CTL) activity, attenuates tumor, and hence suppresses tumor formation. Thus, in various embodiments described herein, the methods of the invention relate to methods of treating cancer by administering to a patient an effective amount of a humanized anti-DKK2 antibody, methods for providing anti-tumor immunity in a subject, methods of stimulating a T cell mediated immune response to a cell population or a tissue and suppressing tumor in a subject. Additionally, the current invention includes methods of diagnosing a cancer or a predisposition of developing a cancer or a metastasis and methods for determining the use of immunotherapy treatment or cancer vaccine for treating cancer. Furthermore, the invention encompasses a pharmaceutical composition for treating cancer as well as a kit for carrying out the aforementioned methods.

Abstract: Techniques are described in which a qubit is far off-resonantly, or dispersively, coupled to a quantum mechanical oscillator. In particular, a dispersive coupling between a physical qubit and a quantum mechanical oscillator may be selected such that control of the combined qubit-oscillator system can be realized. The physical qubit may be driven with an electromagnetic pulse (e.g., a microwave pulse) and the quantum mechanical oscillator simultaneously driven with another electromagnetic pulse, the combination of which results in a change in state of the qubit-oscillator system.

Abstract: The present invention relates to a system, device, and method for the high throughput multiplexed detection of a wide number of compounds. The invention comprises of a microwell array coupled to a capture agent array to form a plurality of interfaces between a microwell and a set of immobilized capture agents. The set of capture agents comprises a plurality of distinguishable features, with each feature corresponding to the detection of a particular compound of interest. In certain embodiments, each microwell is configured to contain a single cell. The invention is therefore capable of performing a high throughput analysis of single cell profiles, including profiles of secreted compounds.

Abstract: One aspect of the invention provides a method of continuously scanning with a localization microscope. The method includes: modifying a position of a sample relative to a field of view (FOV) of the localization microscope to capture a plurality of image frames of the sample, each captured image frame having a limited FOV; acquiring image frames with the localization microscope during at least one position modification; determining a set of localization position coordinates for at least one localizable object in the sample within at least one image frame of the plurality of image frames; determining one or more field of view (FOV) position coordinates for the at least one image frame; and modifying the set of localization position coordinates based on the one or more FOV position coordinates to produce a collection of coordinates covering a larger spatial region than the at least one image frame.

Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions (e.g., kits) for the identification of subjects with misfolded proteins in their urine. For example, methods and compositions for determining that a urine sample from a pregnant woman contains or does not contain misfolded are provided. In some embodiments, the presence of misfolded proteins in a urine sample from a pregnant woman is an indication of preeclampsia.

Abstract: An environmentally sensitive membrane binding polypeptide, pH (low)-sensitive membrane peptide (pHLIP) has improved insertion kinetics balanced with solubility to selectively target acidic tissues.