Patents Assigned to Yale University
  • MANIPULATION OF MENINGEAL LYMPHATIC VASCULATURE FOR BRAIN AND CNS TUMOR THERAPY
    Publication number: 20220008510
    Abstract: A method of inducing lymphangiogenesis in the brain or central nervous system of a subject is provided in which an effective amount of a lymphangiogenesis inducer is administered. A method of inducing lymphangiogenesis in a tumor in the brain or central nervous system of a subject is provided in which an effective amount of a lymphangiogenesis inducer is administered. A method of treating a cancer of the brain or central nervous system is also provided in which an effective amount of a lymphangiogenesis inducer is administered. An example of a lymphangiogenesis inducer is VEGFC. The lymphangiogenesis inducer can be in the form of a protein or a polynucleotide encoding the protein, such as an mRNA or AAV. The lymphangiogenesis inducer can be administered to the cistemamagna or directly into the lymphatic system. An immunotherapeutic agent, such as a checkpoint inhibitor, may also be administered.
    Type: Application
    Filed: November 15, 2019
    Publication date: January 13, 2022
    Applicant: Yale University
    Inventors: Akiko IWASAKI, Jean-Leon THOMAS, Eric SONG
  • Imide-based modulators of proteolysis and associated methods of use
    Patent number: 11220515
    Abstract: The description relates to imide-based compounds, including bifunctional compounds comprising the same, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the description provides compounds, which contain on one end a ligand which binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. Compounds can be synthesized that exhibit a broad range of pharmacological activities consistent with the degradation/inhibition of targeted polypeptides of nearly any type.
    Type: Grant
    Filed: January 26, 2019
    Date of Patent: January 11, 2022
    Assignee: Yale University
    Inventors: Craig M. Crews, George Burslem, Philipp M. Cromm, Saul Jaime-Figueroa, Momar Toure
  • MicroRNAs as biomarkers for endometriosis
    Patent number: 11220713
    Abstract: Disclosed herein are compositions and methods useful for the diagnosis, assessment, and characterization of endometriosis in a subject in need thereof, based upon the expression level of at least one miRNA that is associated with endometriosis.
    Type: Grant
    Filed: February 25, 2021
    Date of Patent: January 11, 2022
    Assignee: Yale University
    Inventor: Hugh Taylor
  • Inductively-shunted transmon qubit for superconducting circuits
    Patent number: 11223355
    Abstract: Techniques for modifying the Josephson potential of a transmon qubit by shunting the transmon with an inductance are described. The inclusion of this inductance may increase the confined potential of the qubit system compared with the conventional transmon, which may lead to a transmon qubit that is stable at much higher drive energies. The inductive shunt may serve the purpose of blocking some or all phase-slips between the electrodes of the qubit. As a result, the inductively shunted transmon may offer an advantage over conventional devices when used for applications involving high energy drives, whilst offering few to no drawbacks in comparison to conventional devices when used at lower drive energies.
    Type: Grant
    Filed: December 11, 2019
    Date of Patent: January 11, 2022
    Assignee: Yale University
    Inventors: W. Clarke Smith, Jayameenakshi Venkatraman, Xu Xiao, Lucas Verney, Luigi Frunzio, Shyam Shankar, Mazyar Mirrahimi, Michel Devoret
  • Magnetic resonance gradient accessory providing tailored gradients for diffusion encoding
    Patent number: 11202583
    Abstract: A system includes a magnetic resonance gradient accessory within an MRI system. The MRI system includes a magnet housing, a superconducting magnet generating a magnet field B0 to which a patient is subjected, shim coils, RF coils, receiver coils, magnetic gradient coils, and a patient table. The magnetic resonance gradient accessory creates local magnetic gradient fields critical to image generation and provides for diffusion encoding of a specific body region.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: December 21, 2021
    Assignee: Yale University
    Inventors: Gigi Galiana Stadtler, Robert Todd Constable
  • QUANTUM INFORMATION PROCESSING WITH AN ASYMMETRIC ERROR CHANNEL
    Publication number: 20210390444
    Abstract: Techniques for performing quantum information processing using an asymmetric error channel are provided. According to some aspects, a quantum information processing includes a data qubit and an ancilla qubit, the ancilla qubit having an asymmetric error channel. The data qubit is coupled to the ancilla qubit. The ancilla qubit may be driven with a stabilizing microwave field to create the asymmetric error channel.
    Type: Application
    Filed: June 28, 2019
    Publication date: December 16, 2021
    Applicant: Yale University
    Inventors: Shruti Puri, Alexander Grimm, Philippe Campagne-lbarcq, Steven M. Girvin, Michel Devoret
  • HIGH-SPEED ULTRATHIN SILICON-ON-INSULATOR INFRARED BOLOMETERS AND IMAGERS
    Publication number: 20210389183
    Abstract: In one aspect, the invention provides a nanobolometer cell including a base layer, a dielectric spacer layer above and adjacent to the base layer, an ultrathin silicon film above and adjacent to the spacer layer, and at least one plasmonic optical antenna resonator above and adjacent to the silicon film.
    Type: Application
    Filed: November 8, 2019
    Publication date: December 16, 2021
    Applicants: Yale University, Wisconsin Alumni Research Foundation
    Inventors: Qiushi Guo, Cheng Li, Fengnian Xia, Zhenqiang Ma, Dong Liu, Zhenyang Xia
  • Compositions and methods for grafts modified with a non-thrombogenic and pro-migratory cell-derived extracellular matrix
    Patent number: 11191872
    Abstract: The present invention relates to novel compositions and methods for reducing or eliminating the thrombogenicity of a graft by modifying the graft with a cell-derived extracellular matrix lacking thrombospondin-2 (TSP2-null ECM) to render it non-thrombogenic when transplanted to a subject in need thereof. The invention also provides a method for improving the biocompatibility of a medical device or an implant by modifying the medical device or implant with a cell-derived TSP2-null ECM, whereby the medical device or implant is rendered non-thrombogenic and pro-migratory.
    Type: Grant
    Filed: April 25, 2017
    Date of Patent: December 7, 2021
    Assignee: Yale University
    Inventors: Themis Kyriakides, Nina Kristofik
  • COMPOSITIONS AND METHODS FOR TREATING LUNG INJURIES ASSOCIATED WITH SARS-COV-2 INFECTIONS
    Publication number: 20210361650
    Abstract: The present invention provides methods and compositions for treating and preventing lung injuries due to or associated with coronavirus infections that cause Severe Acute Respiratory Syndrome, including COVID-19. More specifically the present invention provides methods for treating or preventing the lung injuries associated with SARS-CoV-2 infections, such as acute lung injury (ALI), lung fibrosis, and acute respiratory distress syndrome (ARDS). The methods comprise administering a therapeutically effective amount of a pharmaceutical composition comprising a protein kinase inhibitor compound having MAP3K2/MAP3K3 inhibition activity, such as pazopanib or nintedanib, or a pharmaceutically acceptable salt, solvate, or prodrug thereof, to a patient in need thereof. The present invention also provides devices for administering the compositions.
    Type: Application
    Filed: May 20, 2021
    Publication date: November 25, 2021
    Applicants: Qx Therapeutics Inc., Yale University
    Inventors: Dianqing Wu, Ho Yin Lo
  • Method for obtaining globally activated monocytes
    Patent number: 11179417
    Abstract: The present invention relates to methods for producing immuno-stimulatory autologous dendritic cells. The present invention further relates to the use of such cells for treating patients suffering from hyper-proliferative disease such as cancer.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: November 23, 2021
    Assignees: Transimmune AG, Yale University
    Inventors: Gunter Bauer, Justin Duckworth, Robert Tigelaar, Richard Edelson, Michael Girardi, Karsten Henco, Adrian Hayday
  • Techniques for manipulation of two-qubit quantum states and related systems and methods
    Patent number: 11184006
    Abstract: According to some aspects, a method is provided of operating a system that includes a multi-level quantum system dispersively coupled to a first quantum mechanical oscillator and dispersively coupled to a second quantum mechanical oscillator, the method comprising applying a first drive waveform to the multi-level quantum system, applying one or more second drive waveforms to the first quantum mechanical oscillator, and applying one or more third drive waveforms to the second quantum mechanical oscillator.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: November 23, 2021
    Assignee: Yale University
    Inventors: Chen Wang, Yvonne Gao, Luigi Frunzio, Michel Devoret, Robert J. Schoelkopf, III
  • DERMATOLOGIC TOPICAL APPLICATIONS OF ROR GAMMA AND ROR GAMMA-T INHIBITORS FOR THE PREVENTION OF SKIN CANCER DEVELOPMENT
    Publication number: 20210353568
    Abstract: Described herein are methods and compositions useful to reduce (partially/inhibit or completely—prevent) skin cancer development in an individual in need thereof.
    Type: Application
    Filed: September 17, 2019
    Publication date: November 18, 2021
    Applicant: Yale University
    Inventors: Michael Girardi, Julia Lewis
  • Nanolipogel vehicles for controlled delivery of different pharmaceutical agents
    Patent number: 11173119
    Abstract: A “nanolipogel” is a delivery vehicle including one or more lipid layer surrounding a hydrogel core, which may include an absorbent such as a cyclodextrin or ion-exchange resin. Nanolipogels can be constructed so as to incorporate a variety of different chemical entities that can subsequently be released in a controlled fashion. These different incorporated chemical entities can differ dramatically with respect to size and composition. Nanolipogels have been constructed to contain co-encapsulated proteins as well as small hydrophobic drugs within the interior of the lipid bilayer. Agents incorporated within nanolipogels can be released into the milieu in a controlled fashion, for example, nanolipogels provide a means of achieving simultaneous sustained release of agents that differ widely in chemical composition and molecular weight. Additionally, nanolipogels can favorably modulate biodistribution.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: November 16, 2021
    Assignee: Yale University
    Inventors: Tarek M. Fahmy, Eric Stern, Richard A. Flavell, Jason Park, Alyssa Siefert, Stephen H. Wrzesinski
  • Tuned oscillator atomic force microscopy methods and apparatus
    Patent number: 11162977
    Abstract: Techniques for operating an atomic force microscope, the atomic force microscope comprising a cantilever and configured to image a surface of a sample using a probe tip coupled to the cantilever, the techniques comprising using a controller to perform: obtaining, based on at least one intrinsic parameter of the cantilever, a first quality factor and a first free oscillation amplitude, wherein the cantilever exhibits only one stable oscillation state when oscillating at the first free oscillation amplitude and operating at the first quality factor; and controlling the cantilever to exhibit the only one stable oscillation state by controlling the cantilever to oscillate at a fixed frequency at or near a resonance frequency of the cantilever, oscillate at the first free oscillation amplitude, and operate at the first quality factor.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: November 2, 2021
    Assignee: Yale University
    Inventors: Udo Schwarz, Eric Altman, Hendrik Hölscher, Omur Erdinc Dagdeviren
  • Oxytocin and opioid antagonists for treatment of social dysfunction disorder
    Patent number: 11160843
    Abstract: The present invention relates to the discovery that co-administration of both oxytocin (OT) and at least one opioid antagonist can increase social function in a subject. In certain embodiments, the co-administration can be used to treat one or more social dysfunction disorders in a subject, including, but not limited to autism, schizophrenia, anxiety disorders and post-traumatic stress disorder (PTSD). In other embodiments, the OT and the opioid antagonist can be co-administered to a subject as an aerosolized pharmaceutical composition.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: November 2, 2021
    Assignee: Yale University
    Inventors: Wohn Chui Chang, Olga Dal Monte, Matthew Piva
  • Modified proteins and methods of use thereof
    Patent number: 11155580
    Abstract: This invention is generally related to small proteins, such as miniature proteins, including avian pancreatic polypeptide (aPP), modified so that the small proteins reach the cytosol. In some embodiments, the modified protein molecules deliver an associated cargo molecule to the cytosol. Other embodiments of the invention relate to modified protein fusion molecules that reach the cytosol.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: October 26, 2021
    Assignee: Yale University
    Inventors: Alanna Schepartz Shrader, Jacob S. Applebaum, Jonathan R. LaRochelle
  • Assessing risk of reading and language impairment
    Patent number: 11155871
    Abstract: Described herein are the association BV677278 (READ1) with reading disability and language impairment, as well as the synergistic interaction of DCDC2 risk haplotypes or alleles with KIAA0319 risk allele.
    Type: Grant
    Filed: November 7, 2013
    Date of Patent: October 26, 2021
    Assignee: Yale University
    Inventors: Jeffrey R. Gruen, Natalie R. Powers
  • TELESCOPES AND IMAGERS INCLUDING TILTABLY MOUNTED NARROWBAND INTERFERENCE FILTERS
    Publication number: 20210325586
    Abstract: One aspect of the invention provides a telescope including: at least one lens or mirror arranged to receive collimated light defining an optical axis at a first end and form an image at a last end; and a narrowband interference filter positioned along the optical axis prior to the first end. The narrowband interference filter is tiltably mounted with respect to the optical axis. Another aspect of the invention provides an imager including: an optical collimator; a plurality of lenses or mirrors arranged relative to the optical collimator to receive collimated light from the optical collimator defining an optical axis at a first end and form an image at a second end; and a narrowband interference filter positioned along the optical axis between the optical collimator and the first end. The narrowband interference filter is tiltably mounted with respect to the optical axis.
    Type: Application
    Filed: April 15, 2021
    Publication date: October 21, 2021
    Applicant: Yale University
    Inventors: Pieter Van Dokkum, Roberto Abraham, Deborah Lokhorst
  • CD4 T cells provide antibody access to immunoprivileged tissue
    Patent number: 11147862
    Abstract: The present disclosure relates to compositions and methods for treating or preventing a disease or disorder of immunoprivileged tissue. It is described herein that an immunogenic composition which induces production of memory CD4 T cells allows for the access of a therapeutic antibody to the immunoprivileged tissue.
    Type: Grant
    Filed: May 16, 2017
    Date of Patent: October 19, 2021
    Assignee: Yale University
    Inventors: Norifumi Iijima, Akiko Iwasaki
  • METHODS FOR TREATING AORTIC ANEURYSM DISEASE
    Publication number: 20210318336
    Abstract: This present disclosure relates to the use of one or more biomarkers for diagnosis, screening, or monitoring aortic aneurysm disease (e.g., ascending aortic aneurysm, descending thoracic aortic aneurysm, abdominal aortic aneurysm and Marfan syndrome) in a biological sample (e.g., a blood sample) of a subject. Accordingly, this disclosure provides methods and kits for determining the presence of one or more biomarkers for aortic aneurysm disease in a biological sample of a subject; methods for using the presence of such biomarkers to predict or diagnose aortic aneurysm disease in a subject; and methods to select or modify a therapeutic regimen (e.g., a beta-blocker treatment) for a subject based on the use of such biomarkers.
    Type: Application
    Filed: April 9, 2021
    Publication date: October 14, 2021
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Yale University
    Inventor: Prashanth Vallabhajosyula