Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.

Abstract: The invention relates to quinazoline derivatives of the formula: ##STR1## ?wherein: Y.sup.1 represents --O--, --S--, --CH.sub.2 --, --SO--, --SO.sub.2 --, --NR.sup.5 CO--, --CONR.sup.6 -, --SO.sub.2 NR.sup.7 -, --NR.sup.8 SO.sub.2 -- or --NR.sup.9 - (wherein R.sup.5, R.sup.6, R.sup.7, R.sup.8 and R.sup.9 each independently represents hydrogen, alkyl or alkoxyalkyl);R.sup.1 represents hydrogen, hydroxy, halogeno, nitro, trifluoromethyl, cyano, alkyl, alkoxy, alkylthio, amino or alkylamino.R.sup.2 represents hydrogen, hydroxy, halogeno, alkyl, alkoxy, trifluoromethyl, cyano, amino or nitro;m is an integer from 1 to 5;R.sup.3 represents hydroxy, halogeno, alkyl, alkoxy, alkanoyloxy, trifluoromethyl, cyano, amino or nitro;R.sup.

Abstract: A compound of formula (I), wherein A is C.sub.1-6 alkyl, --O--C.sub.1-6 alkyl, --O--phenyl or phenyl, optionally substituted by C.sub.1-3 alkyl or halogen; n is an integer of from 0 to 3; W is a group of formula (i), (ii) or (iii) where R is hydrogen or C.sub.1-4 alkyl, x is --O--, --S--, --NH--, or --CH.sub.2 --, Y is oxygen or sulphur and the chiral centre * in formula (i) or (ii) is in its (S) or (R) form or is a mixture thereof in any proportions; and Z is a group of formula (iv) --HC.sub.2 CH.sub.2 NR.sup.1 R.sup.2 (v) or (vi) where R.sup.1 and R.sup.2 are independently selected from hydrogen and C.sub.1-4 alkyl and R.sup.3 is hydrogen or C.sub.1-4 alkyl; and salts, solvates and physiologically functional derivatives thereof.

Abstract: Process for making organic solvent-free aqueous crosslinkable polymer composition comprising: a) preparing an aqueous solution of an acid-functional oligomer with Tg 10 to 125.degree. C. and having crosslinker functional groups; b) conducting an aqueous emulsion polymerization to make an aqueous emulsion of an olefinic hydrophobic polymer in the presence of the aqueous oligomer solution, the hydrophobic polymer having Tg at least 25.degree. C. below that of the oligomer and optionally crosslinker functional groups, and c) combining with a crosslinking agent reactable with the crosslinker groups of the oligomer and polymer, said composition having Koenig hardness of .gtoreq.40 sec and minimum film forming temperature (MFFT) .ltoreq.55.degree. C. Also the aqueous composition so formed and its use in various applications. The aqueous composition has excellent properties and in particular an advantageous balance of MFFT and Koenig hardness.

Abstract: Process for the free-radical polymerisation of olefinically unsaturated monomer(s) using a free-radical initiator, the polymerisation being performed in the presence of a compound for effecting molecular weight control, wherein the molecular weight control compound is a Co Il chelate of the following formula I ##STR1## wherein each group X, independently in each ring and in different rings, is a substituent selected from alkyl of 1 to 14 carbon atoms and cycloalkyl of 6 to 14 carbon atoms; n, independently in each ring, is 0 to 5 provided that in at least one ring, n is 1 to 5; Z, independently on each boron atom, is selected from F, Cl, Br, OH, alkoxy of 1 to 12 carbon atoms, aryloxy of 6 to 12 carbon atoms, alkyl of 1 to 12 carbon atoms, and aryl of 6 to 12 carbon atoms; or two Z groups taken together provide on one or both boron atoms a group --O--(Q)--O-- where Q is a divalent aryl or alicyclic linking group or an alkylene linking group, or two Z groups taken together on one or both boron atoms provide a

Abstract: A novel human signal-transduction kinase polypeptide is described which is expressed at a particularly high level in tissues of the human immune system. A full length cDNA which encodes the novel signal transduction serine/threonine kinase polypeptide is disclosed as well as the interior structural region and the amino acid residue sequence of the native biological molecule. Methods are provided to identify compounds that modulate the biological activity of the human Ste20-like serine/threonine signal transduction kinase.

Abstract: The invention relates to insect viruses and plants which express an exogenous polypeptide derived from spiders of the genus Atrax or Hadronyche, which polypeptide is toxic to insects. The polypeptide has a molecular weight of approximately 4000 amu,) containing 36-37 Gino acids, and is capable of forming three intrachain disulfide bridges. Polyiucleotides which encode the polypeptide, insectidoidal compositions and methods of controlling insect infestation of crops are also included.

Abstract: Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalyzed reactions.

Abstract: A compound of formula (I): ##STR1## or a salt, enamine or the like, acylate, sulphonate, carbamate or ether derivative thereof; wherein X, X.sup.1 and X.sup.2 are independently oxygen or sulphur, R.sup.1 is an optionally substituted heterocyclic or cycloalkyl group, and Y is an optionally substituted C.sub.2 -C.sub.4 alkylene group which is optionally interposed by an oxygen atom, a group ##STR2## a group ##STR3## or an optionally mono-substituted nitrogen atom, wherein p is 0, 1 or 2, s is 0 or 1 and R.sup.b is alkyl or alkoxy; provided that when X, X.sup.1 and X.sup.2 are oxygen, R.sup.1 is not pyridyl or pyrimidinyl. Processes for the preparation of these compounds and herbicidal compositions containing them are also described and claimed.

Abstract: The invention relates to quinazoline derivatives or pharceutically-acceptable salts thereof, which possess anti-tumor activity; to processes for their manufacture; and to pharmaceutical compositions containing them.The invention provides a quinazoline of the formula: ##STR1## wherein R.sup.1 is (1-4C)alkyl; the quinazoline ring may optionally bear one or two further substituents selected from halogeno, (1-4C)alkyl and (1-4C)alkoxy;R.sup.2 is hydrogen or (1-4C)alkyl;R.sup.3 includes hydrogen and (1-4C)alkyl; andAr is optionally substituted phenylene or heterocyclene;or a pharmaceutically-acceptable salt or ester thereof.

Abstract: A composition of copper phthalocyanines containing, on average, from 0.1 to 3 methyl groups per phthalocyanine nucleus. The composition is suitable for the coloration of paints and plastics materials.

Abstract: The invention concerns 4-anilinoquinazoline derivatives of the formula I ##STR1## wherein m is 1 or 2; each R.sup.1 includes hydrogen, halogeno, (1-4C)alkyl and (1-4C)alkoxy;n is 1, 2 or 3;each R.sup.2 includes hydrogen, hydroxy, halogeno and (1-4C)alkyl; and Ar is a 5- or 9-membered nitrogen-linked heteroaryl moiety containing up to four nitrogen heteroatoms, or Ar is a 5-, 6-, 9- or 10-membered nitrogen-linked unsaturated heterocyclic moiety containing up to three nitrogen heteroatoms which bears one or two substituents selected from oxo and thioxo such as 2-oxo-4-imidazolin-1-yl;or a pharmaceutically-acceptable salt thereof;processes for their preparation, pharmaceutical compositions containing them, and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of proliferative disease such as cancer.

Abstract: The trimethylsulphonium salt of N-phosphonomethylglycine is prepared by reacting N-phosphonomethylglycine, preferably in the form of a solid, with an aqueous solution of trimethylsulphonium carbonate or trimethylsulphonium bicarbonate or a mixture thereof. The trimethylsulphonium carbonate or trimethylsulphonium bicarbonate may be prepared by bubbling carbon dioxide through an aqueous solution of trimethylsulphonium hydroxide. It is possible to manufacture trimethylsulphonium carbonate or bicarbonate at one site and then transport them to a different site for local manufacture of N-phosphonomethylglycine in a relatively unsophisticated plant which produces minimal effluent.

Abstract: Control of weeds in a rice crop is obtained by applying to the crop, the weeds, or the locus of either or both, a herbicidal composition containing molinate and acetochlor in a weight ratio of from about 250:1.5 to about 5:1.

Abstract: The invention concerns the quinazoline derivative 6-(2-methoxyethylamino)-7-methoxy-4-(3'-methylanilino)quinazoline, or a pharmaceutically-acceptable salt thereof, processes for its preparation, pharmaceutical compositions containing the compound and the use of the receptor tyrosine kinase inhibitory properties of the compound in the treatments of proliferative disease such as cancer.

Abstract: A compound of formula (I),R--S(O).sub.n CH.sub.2 CH.sub.2 CH.dbd.CF.sub.2or a salt thereof, wherein n is 0, 1 or 2; and R is a group of formula (V) or (VII) ##STR1## wherein: at least one of R.sup.2, R.sup.3, R.sup.4 or R.sup.5 is a S(O)nCH.sub.2 CH.sub.2 CH.dbd.CF.sub.2 group; and the remainder of R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are each independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, alkynyl, cycloalkyl, alkylcycloalkyl, alkoxy, alkenyloxy, alkynyloxy, hydroxyalkyl, alkoxyalkyl, optionally substituted aryl, optionally substituted arylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted aryloxy, optionally substituted arylalkoxy, optionally substituted aryloxyalkyl, optionally substituted heteroaryloxy, optionally substituted heteroarylalkoxy, optionally substituted heteroaryloxyalkyl, haloalkyl, haloalkenyl, haloalkynyl, haloalkoxy, haloalkenyloxy, haloalkynyloxy, halogen, hydroxy, cyano, nitro, --NR.sup.7 R.sup.

Abstract: A process for the nitration of an aromatic or heteroaromatic compound with a nitrating agent comprising nitric acid or a mixture of nitric and sulphuric acids, characterised in that nitration is performed in a solvent comprising at least 50% v/v of a C.sub.1 -C.sub.6 alkyl ester of a C.sub.1 -C.sub.4 carboxylic acid. The process is of particular use for the nitration of diphenyl ethers to give compounds which are useful as herbicides or as intermediates in the synthesis of herbicides.

Abstract: The invention relates to sustained release formulations comprising 11-?4-?2-(2-hydroxyethoxy)ethyl!-1-piperazinyl!dibenzo?b,f! ?1,4!thiazepine or a pharmaceutically acceptable salt thereof, to methods of treating psychotic states and hyperactivity utilizing the sustained release formulations and to a process for preparing the sustained release formulations.

Abstract: Fungicidal compounds having the formula (I): ##STR1## in which any two of K, L and M are nitrogen and the other is CA wherein A is H, halogen, C.sub.1-4 alkyl, cyano, nitro or trifluoromethyl; X is a linking group other than oxygen; T is oxygen or sulphur; and Z is an optionally substituted carbocyclic or heterocyclic ring.

Abstract: Biocidal proteins isolated from Mirabilis have been characterized. The proteins show a wide range of antifungal activity and are active against gram-positive bacteria. DNA encoding the proteins has been isolated and incorporated into vectors. Plants transformed with this DNA have been produced. The proteins find commercial application as antifungal or antibacterial agents; transformed plants will show increased disease-resistance.