Patents Assigned to Zeneca
  • Quinazoline derivatives
    Patent number: 5942514
    Abstract: The invention concerns quinazoline derivatives of formula wherein n is 1, 2 or 3 and each R.sup.2 is independently halogeno; and R.sup.1 is 1-4C)alkoxy-(2-4C)alkylamino; or pharmaceutically-acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them, and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of proliferative disease such as cancer.
    Type: Grant
    Filed: September 26, 1997
    Date of Patent: August 24, 1999
    Assignee: Zeneca Limited
    Inventor: Andrew John Barker
  • Co-ordinated inhibition of plant gene expression
    Patent number: 5942657
    Abstract: Process for the inhibition of two or more target genes which comprises introducing into the plant a single control gene which has distinct DNA regions homologous to each of the target genes and a promoter operative in plants adapted to transcribe from such distinct regions RNA that inhibits expression of each of the target genes. Constructs suitable for use in the process, as well as cells and plants containing such constructs are disclosed. Specific examples relate to the pectinesterse and polygalacturonase genes.
    Type: Grant
    Filed: January 9, 1995
    Date of Patent: August 24, 1999
    Assignee: Zeneca Limited
    Inventors: Colin Roger Bird, Rupert George Fray, Donald Grierson, Wolfgang Walter Schuch, Graham Barron Seymour, Gregory Alan Tucker
  • Process for the preparation of 2-(pyrid-2-yloxymethyl)phenylacetates as pesticide intermediates
    Patent number: 5942623
    Abstract: The invention relates to a process for the preparation of 2-(pyrid-2-yloxymethyl)phenylacetates of formula (I) useful as intermediates for agricultural pesticides, which comprises reacting a 2-pyridine of formula (II), wherein L is a leaving group and A, D and m are as defined in the description with a compound MO--CH.sub.2 R where M is a metal atom and R is the residue of a metal salt of phenylacetic acid. It also includes the compounds MO--CH.sub.2 R, a process for their preparation and a "one-pot" process for the preparation of 2-(pyrid-2-yloxymethyl) phenylacetates from 3-isochromanone.
    Type: Grant
    Filed: February 19, 1998
    Date of Patent: August 24, 1999
    Assignee: ZENECA Limited
    Inventors: Alfred Glyn Williams, Gordon Richard Munns, Paul Anthony Worthington
  • O-methyloximes of benzopyran-3,4- and benzofuran-2,3-diones and methods for their preparation
    Patent number: 5939563
    Abstract: Compounds of formula (XXIII): ##STR1## wherein p is 0 or 1, and processes for making such compounds.
    Type: Grant
    Filed: March 30, 1998
    Date of Patent: August 17, 1999
    Assignee: ZENECA Limited
    Inventor: Ian Richard Matthews
  • Compatibility agent and method
    Patent number: 5939358
    Abstract: A compatibility agent comprising a block copolymer of ethylene oxide and propylene oxide comprising about 30-80% ethylene oxide and about 20-70% propylene oxide which has been found useful for making pesticidal compositions compatible when combined.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: August 17, 1999
    Assignee: ZENECA Limited
    Inventor: Dennis M. Hester
  • Yeast artificial chromosomes containing DNA encoding the cystic fibrosis (CFTR) gene
    Patent number: 5939255
    Abstract: Yeast Artificial Chromosomes (YACS) containing DNA encoding the cystic fibrosis (CFTR) gene are described. The YACs allow detailed analysis of the coding and non-coding regions of the gene and the determination of cystic fibrosis alleles in sample DNA from an individual or individuals.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: August 17, 1999
    Assignee: Zeneca Limited
    Inventors: Rakesh Anand, Alexander Fred Markham, John Craig Smith, Rashida Anwar, John Hamilton Riley, Donald James Ogilvie, Paul Elvin
  • Aralkyoxy alkoximino derivatives and their use as fungicides
    Patent number: 5935999
    Abstract: A compound of formula (I): ##STR1## wherein A is oxygen, W is CH.sub.3 O.CH.dbd.CCO.sub.2 CH.sub.3 and R.sup.1, R.sup.2, R.sup.3, X, Y and Z are as defined in the specification. The compounds are useful as plant fungicides and insecticides.
    Type: Grant
    Filed: July 31, 1995
    Date of Patent: August 10, 1999
    Assignee: Zeneca Limited
    Inventors: Paul Anthony Worthington, Ian Henry Aspinall
  • Process for the preparation of 1,2-benzisothiazolin-3-ones
    Patent number: 5936094
    Abstract: A process for making a 2-alkylbenzisothiazolinone which comprises reacting a bisamide of formula ##STR1## in water or an organic liquid containing water with a bisulphite or bisulphite release agent to form a Bunte salt and converting the Bunte salt under alkaline conditions to 2-alkyl-BIT. R is alkyl. Preferred substituents R are butyl, hexyl, 2-ethylbutyl and 2-ethylhexyl.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: August 10, 1999
    Assignee: Zeneca Limited
    Inventor: Mark Robert James
  • Microbiological process
    Patent number: 5935841
    Abstract: Filamentous microorganisms of improved properties, for example growth rate, may be obtained by culturing a sample of desired morphology until a substantial proportion of the culture diverges from that morphology, selecting an organism from the culture at that stage which exhibits the desired morphology and repeating the process with the selected microorganism. Furthermore, an isolated Fusarium graminearum having all of the characteristics of IMI 366464 and also possessing a greater morphological stability and growth rate than Fusarium graminearium strain IMI 145,425 is disclosed.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: August 10, 1999
    Assignee: Zeneca Limited
    Inventors: Anthony Peter Joseph Trinci, Geoffrey David Robson, Marilyn Gail Wiebe, Thomas William Naylor, Trevor Williamson
  • Quinazoline derivatives
    Patent number: 5932574
    Abstract: The invention concerns quinazoline derivatives of formula wherein n is 1, 2 or 3 and each R.sup.2 is independently halogeno; and R.sup.1 is di-?(1-4C)alkyl!amino-(2-4C)alkoxy, pryolidin-1-yl-(2-4C)alkoxy,piperidino-(2-4C)alkoxy, morpholino-(2-4C)alkoxy, piperazin-1-yl-(2-4C)alkoxy or 4-(1-4C)alkylpiperazin-1-yl-(2-4C)alkoxy; or pharmaceutically-acceptable salts thereof; processes for their preparation, pharmaceutical compositions containing them, and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of proliferative disease such as cancer.
    Type: Grant
    Filed: October 25, 1997
    Date of Patent: August 3, 1999
    Assignee: Zeneca Limited
    Inventor: Andrew John Baker
  • Chiral organometallic compounds
    Patent number: 5929266
    Abstract: A chiral, organometallic compound which, at a molecular level, has no C2 symmetry and comprises a carbon to carbon bond joining a chiral carbon atom to a carbon atom of a cyclopentadiene ring that is non-symmetrically substituted. Examples of such compounds include compounds of formula (I): ##STR1## wherein X.sup.1 and X.sup.2 are, independently, groups which are removable during a chemical reaction; M is titanium, zirconium or hafnium; and R.sup.1-8,11 are as specified in the description.
    Type: Grant
    Filed: November 3, 1997
    Date of Patent: July 27, 1999
    Assignee: Zeneca Limited
    Inventors: Raymond Vincent Heavon Jones, Michael Charles Henry Standen, Richard John Whitby, Jane Louise Bell
  • Arylindazoles and their use as herbicides
    Patent number: 5928998
    Abstract: Substituted arylindazoles of the formula: ##STR1## wherein X is CR.sup.14 and R.sup.14 is hydrogen, halogen, haloalkyl, cyano, nitro, alkylthio, alkylsulfonyl, alkylsulfinyl or alkoxy; and substituents R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 are as defined in the specification. Use of the compounds as herbicides and methods of making the compounds are also described.
    Type: Grant
    Filed: December 9, 1996
    Date of Patent: July 27, 1999
    Assignee: Zeneca Limited
    Inventors: Donald R. James, Don R. Baker, Steven D. Mielich, William J. Michaely, Steven Fitzjohn, Christopher G. Knudsen, Christopher Mathews, John M. Gerdes
  • Synergistic herbicidal combination
    Patent number: 5928994
    Abstract: Control of weeds in a rice crop is obtained by applying to the crop, the weeds, or the locus of either, a herbicidal composition containing molinate and oxyfluorfen in a weight ratio of from about 500:1 to about 30:1.
    Type: Grant
    Filed: September 2, 1998
    Date of Patent: July 27, 1999
    Assignee: Zeneca Limited
    Inventors: Richard L. Franz, Jee Mok Fua, Khosro Khodayari
  • Processes for the preparation of aryl-.beta.-diketones, arylpyrimidine ketones and crop protection intermediates
    Patent number: 5925795
    Abstract: This invention relates to processes for the preparation of aryl-.beta.-diketones and aryl-pyrimidine ketones. In addition, this invention relates to the preparation of aryl-.beta.-triketones and dimethyl aminomethylene .beta.-diketones, which are useful as crop protection intermediates.
    Type: Grant
    Filed: September 16, 1996
    Date of Patent: July 20, 1999
    Assignee: Zeneca Limited
    Inventors: Raymond A. Felix, Hsiao-Ling M. Chin, Frank X. Woolard, David L. Lee
  • Composition, compound and use
    Patent number: 5925487
    Abstract: A toner resin composition comprising a toner resin and the metal salt or complex of a carbocyclic hydroxy caboxylic acid containing at least one methylene group optionally substituted by hydroxy or amino such as 4-(N-methyl-N-2-hydroxyethyl)aminomethyl-3-hydroxy-2-naphthoic acid. Iron and zinc salts are preferred.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: July 20, 1999
    Assignee: Zeneca Limited
    Inventors: David Melville Fawkes, Peter Gregory, James Stanley Campbell
  • Phthalocyanine compounds
    Patent number: 5922116
    Abstract: A compound of the Formula (1) and salts thereof: ##STR1## wherein: M is a metal or hydrogen;Pc is a phthalocyanine nucleus;each R.sup.1,W.sup.1 and W.sup.2 independently is H or optionally substituted alkyl, aryl or aralkyl;each L.sup.1 independently is a divalent organic linking group;Z is an optionally substituted piperazinyl group;q is 1 or 2;x,y and t each independently have a value of 0.5 to 2.5; and(x+y+t)is 3 to 4.A process for making the compounds of Formula (1). The compounds of Formula (1) are useful as colorants for inks which are used in for example ink jet printing of substrates such as paper, plastics, textile materials, metal or glass.
    Type: Grant
    Filed: April 7, 1998
    Date of Patent: July 13, 1999
    Assignee: Zeneca Limited
    Inventors: Prahalad Manibhai Mistry, Ronald Wynford Kenyon
  • Bicyclic amines
    Patent number: 5922732
    Abstract: A compound of formula (I): ##STR1## wherein R.sup.1 represents a group of formula (A) where each of W, X, Y and Z and Z represents either a group CR or the nitrogen atom, provided that not more than two of W, X, Y and Z represent the nitrogen atom and where each R present is independently selected from hydrogen and halogen atoms and cyano, amino, hydrazino, acylamino, hydroxy, alkyl, hydroxyalkyl, alkoxy, haloalkyl, haloalkoxy, alkenyl, alkenyloxy, alkoxyalkenyl, alkynyl, carboxylic acyl, alkoxycarbonyl, aryl and heterocyclyl groups, said groups comprising up to 6 carbon atoms, and wherein R.sup.
    Type: Grant
    Filed: May 24, 1996
    Date of Patent: July 13, 1999
    Assignee: Zeneca Limited
    Inventors: Christopher John Urch, Roger Salmon, Terence Lewis, Christopher Richard Ayles Godfrey, Martin Stephen Clough
  • Triazole phosphonic acid derivatives and their use as herbicides
    Patent number: 5922644
    Abstract: A herbicidal compound of formula (I) ##STR1## or a salt, tautomer or cyclic derivative thereof; where R.sup.1 and R.sup.2 are hydrogen and A is an optionally substituted saturated or unsaturated chain or ring of three carbon atoms.Methods for preparing these compounds, intermediates used in the preparation and herbicidal compositions containing them are also described and claimed.
    Type: Grant
    Filed: September 28, 1994
    Date of Patent: July 13, 1999
    Assignee: Zeneca Limited
    Inventors: John Michael Cox, Peter Bellini, Roger Barrett, Russell Martin Ellis, Timothy Robert Hawkes
  • Transformed plants expressing antimicrobial proteins
    Patent number: 5919918
    Abstract: Antimicrobial proteins capable of isolation from seeds of Heuchera or Aesculus show a wide range of antifungal activity and some activity against Gram-positive bacteria. DNA encoding the proteins may be isolated and incorporated into vectors. Plants transformed with this DNA may be produced. The proteins find commercial application as antifungal or antibacterial agents; transformed plants will show increased disease-resistance.
    Type: Grant
    Filed: October 23, 1997
    Date of Patent: July 6, 1999
    Assignee: Zeneca Limited
    Inventors: Willem Frans Broekaert, Bruno Philippe Angelo Cammue, Rupert William Osborn, Sarah Bronwen Rees
  • Azo pyrazolone pigments
    Patent number: 5919915
    Abstract: An azo pyrazolone compound of the formula: ##STR1## wherein Z represents a substituent selected from Cl, Br, F, NO.sub.2, SO.sub.2 R, CO.sub.2 R, NHSO.sub.2 R.sup.1 and NHCOR.sup.1 in which R and R.sup.1 are hydrocarbyl groups and the sulphonic acid group in ring A is in the 3- or 4-position relative to the pyrazolyl group, said compound being in the form of a salt, and its use as a pigment.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: July 6, 1999
    Assignee: Zeneca Limited
    Inventors: Alan Patrick Chorlton, James Mason