Patents Assigned to Zeneca
  • Patent number: 5712322
    Abstract: A composition of matter useful in the production of photoinitiator compositions, said compositions of matter comprising 100 parts by weight of camphorquinone and from 1 to 50 parts by weight of an anthraquinone compound having in the 2-position a substituent of the formula:--X--COR.sup.1 (1)wherein R.sup.1 represents an optionally substituted hydrocarbyl radical and X represents ##STR1## wherein R.sup.2 represents hydrogen or an optionally substituted hydrocarbyl radical.
    Type: Grant
    Filed: October 6, 1995
    Date of Patent: January 27, 1998
    Assignee: Zeneca Limited
    Inventors: Pushpito Kumar Ghosh, Iain Andrew Weddell, John Edward Yates
  • Patent number: 5710169
    Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, Q.sup.4, and Q.sup.5 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of SP and NKA are useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
    Type: Grant
    Filed: October 24, 1995
    Date of Patent: January 20, 1998
    Assignee: Zeneca Limited
    Inventor: Keith Russell
  • Patent number: 5710283
    Abstract: A process for preparing a compound of formula IIa or IIb: ##STR1## wherein R.sup.2, R.sup.3, R.sup.4 and R.sup.5 independently represent hydrogen or C.sub.1 -C.sub.4 alkyl; andA is an optionally substituted aromatic or heteroaromatic ring system; the process comprising the steps of:(a) reacting a racemic mixture of a compound of formula II: ##STR2## wherein R.sup.2, R.sup.3, R.sup.4, R.sup.5 and A are as defined for formulae IIa and IIb; with a sterically hindered chiral esterifying agent to form enantiomers of formulae IIIa and IIIb: ##STR3## wherein R.sup.2, R.sup.3, R.sup.4, R.sup.5 and A are as defined for formulae IIa and IIb and R.sup.15 is a chiral sterically hindered residue;b) separating the diastereoisomers of formulae IIIa and IIIb; and(c) converting the diastereoisomers of formulae IIIa and IIIb separately to compounds of formulae IIa and IIb respectively by acid or base hydrolysis. If required, the unwanted enantiomer of formula IIa or IIb may be inverted to give the preferred isomer.
    Type: Grant
    Filed: November 21, 1996
    Date of Patent: January 20, 1998
    Assignee: Zeneca Limited
    Inventors: Glynn Mitchell, Shaheen Khatoon Vohra
  • Patent number: 5707930
    Abstract: Herbicidal 4-cycloalkyl-5-substituted pyrimidine compounds of the formula ##STR1## are described. Herbicidal compositions containing such substituted-pyrimidinyl compounds and methods of controlling undesirable vegetation employing these compounds are also disclosed. The compounds in which XR, is hydroxyl are also useful as intermediates for producing the disclosed substituted-pyrimidinyl derivatives.
    Type: Grant
    Filed: September 16, 1996
    Date of Patent: January 13, 1998
    Assignee: Zeneca Limited
    Inventors: Raymond A. Felix, Hsiao-Ling M. Chin, Frank X. Woolard, David L. Lee, David B. Kanne
  • Patent number: 5705691
    Abstract: A process for the preparation of an N-(alkylsulphonyl)amide, the process comprising reacting a primary amide with a sulphonyl halide in the presence of a base which is sufficiently strong to cause at least partial deprotonation of the amide.
    Type: Grant
    Filed: July 8, 1996
    Date of Patent: January 6, 1998
    Assignee: Zeneca Limited
    Inventors: Stephen M. Brown, James P. Muxworthy, Gareth DeBoos
  • Patent number: 5705505
    Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
    Type: Grant
    Filed: September 26, 1996
    Date of Patent: January 6, 1998
    Assignee: Zeneca Limited
    Inventors: Ashokkumar Bhikkappa Shenvi, Robert Toms Jacobs, Scott Carson Miller, Cyrus John Ohnmacht, Jr., Chris Allan Veale
  • Patent number: 5705516
    Abstract: A compound having the formula R--S(O).sub.n CH.sub.2 CH.sub.2 CH.dbd.CF.sub.
    Type: Grant
    Filed: March 8, 1995
    Date of Patent: January 6, 1998
    Assignee: Zeneca Limited
    Inventors: Michael Drysdale Turnbull, Alison Mary Smith, Roger Salmon
  • Patent number: 5705456
    Abstract: Compounds of formula I: ##STR1## where n is 0 or an integer from 1 to 5; X is halogen, nitro or cyano, or C.sub.1-10 hydrocarbyl or C.sub.1-10 hydrocarbyloxy, either of which may be substituted with one or more halogen atoms;Y is CH.sub.2, O or S; andR.sup.1 and R.sup.2 independently represent hydrogen, C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl or halogen;Processes for the preparation of compounds of formula I, herbicidal compositions and methods utilising them are also disclosed.
    Type: Grant
    Filed: November 29, 1996
    Date of Patent: January 6, 1998
    Assignee: Zeneca Limited
    Inventors: Glynn Mitchell, Stephen Christopher Smith
  • Patent number: 5703246
    Abstract: A process for the preparation of an oxirane, aziridine or cyclopropane of formula (I) wherein, X is oxygen, NR.sup.4 or CHR.sup.5 ; R.sup.1 is hydrogen, alkyl, aryl, heteroaromatic, heterocyclic or cycloalkyl; R.sup.2 is hydrogen, alkyl, aryl, heteroaromatic, CO.sub.2 R.sup.8, CHR.sup.14 NHR.sup.13, heterocyclic or cycloalkyl; or R.sup.1 and R.sup.2 join together to form a cycloalkyl ring; R.sup.3 is hydrogen, alkyl, aryl, heteroaromatic, CO.sub.2 R.sup.8, R.sup.8.sub.3 Sn, CONR.sup.8 R.sup.9 or trimethylsilyl; R.sup.4 and R.sup.5 are, independently, alkyl, cycloalkyl, aryl, heteroaromatic, SO.sub.2 R.sup.8, SO.sub.3 R.sup.8, COR.sup.8, CO.sub.2 R.sup.8, CONR.sup.8 R.sup.9 or CN, or R.sup.4 can also be P(O)(aryl).sub.2 ; R.sup.8 and R.sup.9 are independently alkyl, aryl or arylalkyl; R.sup.13 and R.sup.14 are independently hydrogen, alkyl or aryl; the process comprising reacting a mixture of a compound of formula (II), wherein R.sup.1, R.sup.2 and X are as defined above, and a sulphide of formula SR.sup.6 R.
    Type: Grant
    Filed: March 15, 1996
    Date of Patent: December 30, 1997
    Assignee: Zeneca Limited
    Inventors: Varinder Kumar Aggarwal, Hesham Nimer Hasan Abdel-Rahman, Hee Yoon Lee
  • Patent number: 5703215
    Abstract: A process for the coloration of a substrate, especially a textile, comprising the steps of:(a) applying to the substrate a mixture comprising an aqueous solvent and a water-soluble dye comprising molecules which contain a nucleophilic group and an electrophilic group; and(b) heating or basifying or heating and basifying the dye thereby causing molecules of the dye to join together.Also claimed are dyes, polymers and oligomers.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: December 30, 1997
    Assignee: Zeneca Limited
    Inventors: Andrew Hunter Morris Renfrew, Andrew Paul Shawcross
  • Patent number: 5700742
    Abstract: Antimicrobial treatment of textile material with an oligomeric or polymeric biguanide and a strong organic acid having a pK value below 4.5. Acid protects treated material against yellowing the presence of chlorine bleaches and loss of antimicrobial activity on laundering. The preferred biguanide is poly(hexamethylene biguanide) hydrochloride.
    Type: Grant
    Filed: April 18, 1996
    Date of Patent: December 23, 1997
    Assignee: Zeneca Limited
    Inventor: John David Payne
  • Patent number: 5700798
    Abstract: Compounds of formula I ##STR1## wherein X.sup.a, X.sup.b, R, R.sup.1 and R.sup.2 have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful as potassium channel openers for the treatment of urinary incontinence. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
    Type: Grant
    Filed: October 10, 1995
    Date of Patent: December 23, 1997
    Assignee: Zeneca Limited
    Inventors: Frederick Jeffrey Brown, Keith Russell, Paul James Warwick, Jr.
  • Patent number: 5700395
    Abstract: A dispersant comprising a polyethyleneimine residue carrying polyester chains derived from a caprolactone and at least one other specified lactone or hydroxycarboxylic acid.
    Type: Grant
    Filed: September 25, 1995
    Date of Patent: December 23, 1997
    Assignee: Zeneca Limited
    Inventors: Dean Thetford, John David Schofield
  • Patent number: 5698493
    Abstract: A synergistic herbicidal composition comprising atrazine and either NMSC (i.e., 2-(2'-nitro-4'-methylsulfonylbenzoyl)-1,3-cyclohexanedione), or NMSOC (i.e., 2-(2'-nitro-4'-methylsulfonyloxybenzoyl)-1,3-cyclohexanedione): ##STR1## Also disclosed is a method of controlling undesirable vegetation by applying an effective amount of such composition to the locus of the vegetation to be controlled.
    Type: Grant
    Filed: September 23, 1996
    Date of Patent: December 16, 1997
    Assignee: Zeneca Limited
    Inventors: Byron H. Lake, Trevor J. Purnell
  • Patent number: 5698495
    Abstract: Herbicidal compositions containing substituted pyrazole compounds and derivatives thereof of the formula: ##STR1## wherein Y is O or S and Z is a carbon-carbon single bond, O, S, C.dbd.O or C.dbd.N. Methods of controlling undesirable vegetation using these compounds and derivatives are also disclosed. Herbicidal compounds wherein Z is a carbon-carbon single bond, S, C.dbd.O or C.dbd.N are also described.
    Type: Grant
    Filed: October 31, 1996
    Date of Patent: December 16, 1997
    Assignee: Zeneca Limited
    Inventors: Christopher John Mathews, Don Robert Baker
  • Patent number: 5693766
    Abstract: A thermal transfer sheet comprising a substrate having a coating comprising a dye of Formula (1): ##STR1## wherein: Y is --H, alkyl, alkoxy, --NHCOalkyl, NHCOaryl, --NHSO.sub.2 alkyl or --NHSO.sub.2 aryl;Ring A is unsubstituted apart from the --N.dbd.N--, --Y and --N< groups or may be substituted by from 1 to 3 substituent groups;R.sup.1 and R.sup.2 each independently is alkyl;R.sup.3 is --H, alkyl, aryl, --SO.sub.2 alkyl, --Salkyl, --Saryl, halogen, pyridyl or R.sup.6 O(CH.sub.2).sub.n -- in which R.sup.6 is alkyl, acyl, aryl and n is from 1 to 10;R.sup.4 is --CN, --NO.sub.2, --SCN or --COOalkyl; andR.sup.5 is a group of Formula (2): ##STR2## in which: Z is --H, alkyl, alkoxy, --NHCOalkyl, --NHCOaryl, --NHSO.sub.2 alkyl or --NHSO.sub.2 aryl;Ring B is unsubstituted apart from the --N.dbd.N--, --Z and --N< groups or may be substituted by from 1 to 3 substituent groups;R.sup.7 and R.sup.8 each independently is --H or alkyl;R.sup.9 independently is any of the groups defined for R.sup.4 ;R.sup.
    Type: Grant
    Filed: December 18, 1995
    Date of Patent: December 2, 1997
    Assignee: Zeneca Limited
    Inventor: Roy Bradbury
  • Patent number: 5693639
    Abstract: Compounds of formula I ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and A-B have any of the meanings given in the specification, and their pharmaceutically acceptable salts are useful in the treatment of urinery incontinence. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
    Type: Grant
    Filed: February 20, 1996
    Date of Patent: December 2, 1997
    Assignee: Zeneca Limited
    Inventors: James Roy Empfield, Daniel Ray Mayhugh, Keith Russell
  • Patent number: 5693389
    Abstract: A polyester composition comprises at least one first semi-crystalline or crystallizable polyhydroxyalkanoate (PHA-X) and at least one second polyhydroxyalkanoate (PHA-Y) in semi-crystalline or crystalline form and having a higher crystalline melting point than said PHA-X. The PHA-Y is prepared by an annealing treatment in which the crystalline melting point is raised preferably by at least 5.degree. C. compared to the PHA-X and preferably by at least 3.degree. C. compared to the PHA-Y prior to the annealing treatment. The PHA-X and PHA-Y are preferably selected from polyhydroxybutyrate and polyhydroxybutyrate-co-valerate.
    Type: Grant
    Filed: April 17, 1996
    Date of Patent: December 2, 1997
    Assignee: Zeneca Limited
    Inventor: John Jamieson Liggat
  • Patent number: 5691400
    Abstract: A composition comprising water and the following components:(a) an epoxy compound comprising at least one epoxy group and at least one hydrolysable silyl group; and(b) a hydroxy functional polymer having carboxy and/or sulpho groups.The compositions are generally water-based and may be used for making films and coatings having good mechanical and physical properties.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: November 25, 1997
    Assignee: Zeneca Limited
    Inventors: John Gerard Carey, John Christopher Padget, David Alan Pears
  • Patent number: 5691349
    Abstract: Quinuclidine derivatives of formula, and their pharmaceutically acceptable salts, in which: R.sup.1 is hydrogen or hydroxy; R.sup.2 is hydrogen; pr R.sup.1 and R.sup.2 are joined together so that CR.sup.1 -CR.sup.2 is a double bond; X is selected from --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --C.dbd.C--, --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 NH--, NHCH.sub.2 --, --CH.sub.2 CO--, --COCH.sub.2 --, --CH.sub.2 S(O).sub.n -- and --S(O).sub.n CH.sub.2 -- wherein n is 0, 1 or 2; and AR is phenyl which may be optionally unsubstituted or substituted by one or more substituents such as halogeno, hydroxy, amino, nitro, cyano, carboxy, carbamoyl, alkyl, alkenyl, alkynyl, alkoxy, alkylamino, dialkylamino, N-alkylcarbamoyl, N,N-di-alkylcarbamoyl, alkoxycarbonyl, alkythio, alkylsulphinyl, alkylsulphonyl, halogeno alkyl, alkanoylamino, alkylenedioxy, alkanoyl and oxime derivatives thereof and O-alkyl ethers of said oximes; provided that when X is selected from --OCH.sub.2 --, --NHCH.sub.2 --, and SCH.sub.2 --, R.sup.
    Type: Grant
    Filed: June 23, 1995
    Date of Patent: November 25, 1997
    Assignee: Zeneca Limited
    Inventors: Keith Blakeney Mallion, George Robert Brown, Paul Robert Owen