Patents Assigned to Zeneca
  • Disazo Compound
    Patent number: 5756693
    Abstract: A compound of the Formula (1) and salts thereof: ##STR1## wherein: A is optionally substituted phenyl or optionally substituted naphthyl;R.sup.1 is NR.sup.4 R.sup.5 ;R.sup.2 is H, halo, --COOH, --SO.sub.2 0H, optionally substituted alkyl, optionally substituted alkoxy, or optionally substituted alkylthio;R.sup.3, R.sup.4 & R.sup.5 are each independently H or optionally substituted alkyl;T is H or sulpho; andB is H, optionally substituted alkyl or optionally substituted phenyl;provided that the compound does not contain a piperazinyl group.The compound is suitable for use as a black colorant in ink jet printing inks especially for printing on plain paper.
    Type: Grant
    Filed: January 30, 1997
    Date of Patent: May 26, 1998
    Assignee: Zeneca Limited
    Inventors: Ronald Wynford Kenyon, Peter Gregory
  • Chemical compounds
    Patent number: 5756692
    Abstract: A bisazo compound of the Formula (1) and salts thereof: ##STR1## wherein the variables are as defined in the specification, the compounds of Formula (1) being free from fibre-reactive groups and any carboxyl substituents present in the compounds being attached in the form of one or more residue of the following formulae: ##STR2## Also claimed are ink compositions comprising the above compound; a precess for printing substrates with the ink compositions using an ink-jet printer; paper, project slides and textile materials printed with the ink compositions; and a process for coloration of textile materials with the ink compositions.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: May 26, 1998
    Assignee: Zeneca Limited
    Inventors: Peter Gregory, Ronald Wynford Kenyon, Paul Wight
  • Halogenated esters useful as intermediates for insecticides
    Patent number: 5756835
    Abstract: The invention provides novel compounds of formula:CF.sub.3 --CXCl--CH(OH)CH.sub.2 --C(CH.sub.3).sub.2 --CH.sub.2 --CO.sub.2 R(I)where X represents chloro or bromo and R represents hydrogen or alkyl of up to 4 carbon atoms, processes for preparing them and their use as intermediates in the preparation of insecticidal cyclopropane derivatives. Also provided are novel compounds of formula:BrCH.sub.2 --CH.sub.2 --C(CH.sub.3).sub.2 --CH.sub.2 --CO.sub.2 R(IV)wherein R represents alkyl of up to 4 carbon atoms, useful as intermediates in the preparation of the compounds of formula I.
    Type: Grant
    Filed: September 22, 1997
    Date of Patent: May 26, 1998
    Assignee: Zeneca Limited
    Inventor: Martin Charles Bowden
  • Antiarrhythmic peptide from venom of spider Grammostola spatulata
    Patent number: 5756663
    Abstract: The invention provides a novel peptide isolated from the venom of the spider Grammostola spatulata which peptide has antiarrhthymic activity. The invention also provides methods of treating arrhthymia comprising administering to a patient in need of such treatment an effective amount of the peptide. The invention further provides pharmaceutical compositions and methods of mediating hypotonic cell swelling induced calcium increase in cells.
    Type: Grant
    Filed: December 30, 1996
    Date of Patent: May 26, 1998
    Assignee: Zeneca Limited
    Inventors: Richard Alexander Lampe, Frederick Sachs
  • Monoazo dyes useful in ink compositions for printing on substrates by ink-jet printing
    Patent number: 5755862
    Abstract: An ink composition comprising(i) a medium comprising a mixture of water and one or more water-soluble organic solvent(s), an organic solvent, or a low melting point solid; and(ii) a dye of Formula (1) or salt thereof: ##STR1## wherein: each X.sup.1 independently is a labile or non-labile substituent;each T independently is --O--, --S-- or --NR.sup.1 --;each L.sup.1 independently is a divalent organic linker group;each V.sup.1 independently is a group which is capable of undergoing an addition reaction or an elimination and addition reaction;each R.sup.1 independently is H or optionally substituted alkyl;Z is the residue of a coupling component; andm and n are each independently 0 or 1.
    Type: Grant
    Filed: April 2, 1997
    Date of Patent: May 26, 1998
    Assignee: Zeneca Limited
    Inventors: Peter Gregory, Prakash Patel
  • Process
    Patent number: 5753022
    Abstract: A method of preparing a non-aqueous dispersion of CuPc which comprises milling crude CuPc in a high boiling liquid at a temperature from 50.degree. to 150.degree. C. in the presence of a polyester amine or polyesterammonium salt and a CuPc fluidising agent. Preferred polyesterammonium salt is obtainable by reacting polyhydroxystearic acid with 3-dimethylaminopropylamine quaternised with dimethylsulphate.
    Type: Grant
    Filed: February 5, 1996
    Date of Patent: May 19, 1998
    Assignee: Zeneca Limited
    Inventors: John David Schofield, Dean Thetford
  • Polyester composition
    Patent number: 5753782
    Abstract: Polyester composition comprising a biodegradable polyester and a plasticising quantity of at least one plasticiser selected from the group: high-boiling esters of polybasic acids; phosphoric acid derivatives; phosphorous acid derivatives; phosphonic acid derivatives; substituted fatty acids; high-boiling glycols, polyglycols, polyoxyalkylenes and glycerol each optionally substituted and optionally terminally esterified; pentaerythritols and derivatives; sulphonic acid derivatives; epoxy derivatives; chlorinated paraffins; polymeric esters; Wolflex-But*; provided that citrates does not include doubly esterified hydroxycarboxylic acids having at least 3 ester groups in its molecule and further provided that glycerols does not include glycerol triacetate and glycerol diacetate.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: May 19, 1998
    Assignee: Zeneca Limited
    Inventors: Timothy Hammond, John Jamieson Liggat, James Henry Montador, Andew Webb
  • Heterocyclic compouds
    Patent number: 5753659
    Abstract: A compound of the general formula(M.sup.1).sub.n --Q--(M.sup.2).sub.1-n --L--A Iwherein: n is 0 or 1;M.sup.1 is an amino group;Q is an aromatic heterocyclic group containing a basic nitrogen atom;M.sup.2 is an imino group;L is a template group; andA is an acidic group, or an ester or amide derivative thereof, or a sulphonamide group;and pharmaceutically acceptable salts and pro-drugs thereof, for use in the treatment of a disease in which platelet aggregation mediated by the binding of adhesion molecules to GPIIb-IIIa is involved. Novel compounds are also disclosed.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: May 19, 1998
    Assignee: Zeneca Limited
    Inventor: Stuart Dennett Mills
  • Process for the preparation of 4,6-dichloropyrimidine
    Patent number: 5750694
    Abstract: A process for preparing 4,6-dichloropyrimidine comprising treating 4,6-dihydroxy-pyrimidine with phosgene in the presence of a suitable base and optionally in the presence of a solvent.
    Type: Grant
    Filed: August 12, 1995
    Date of Patent: May 12, 1998
    Assignee: Zeneca Limited
    Inventors: John David Jones, Martin Charles Bowden, Stephen Martin Brown
  • Fungicide intermediates
    Patent number: 5750778
    Abstract: Certain fluoroalkanoic acids and derivatives, including 2-fluoroisobutyric acid and 2-fluoroisobutyryl chloride, useful as intermediates for fungicides, and methods of preparing them.
    Type: Grant
    Filed: August 10, 1993
    Date of Patent: May 12, 1998
    Assignee: Zeneca Limited
    Inventors: Patrick Jelf Crowley, Kevin Robert Lawson, Douglas John Smith, Donn Warwick Moseley
  • Process for preparing epoxides from carbonyl compounds using sulphonium or sulphoxonium ylides and intermediates useful therein
    Patent number: 5750740
    Abstract: A process for transforming a carbonyl compound into its corresponding epoxide, which comprises contacting the carbonyl compound with either trimethylsulphonium hydrogen sulphate and/or bis(trimethylsulphonium) sulphate or trimethylsulphoxonium hydrogen sulphate and/or bis(trimethylsulphoxonium) sulphate, in the presence of a base.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: May 12, 1998
    Assignee: Zeneca Limited
    Inventors: Raymond Vincent Heavon Jones, Elizabeth Shearer Currie Simpson
  • Antimicrobial proteins
    Patent number: 5750504
    Abstract: Antimicrobial proteins capable of isolation from seeds of Heuchera or Aesculus show a wide range of antifungal activity and some activity against Gram-positive bacteria. DNA encoding the proteins may be isolated and incorporated into vectors. Plants transformed with this DNA may be produced. The proteins find commercial application as antifungal or antibacterial agents; transformed plants will show increased disease-resistance.
    Type: Grant
    Filed: June 12, 1996
    Date of Patent: May 12, 1998
    Assignee: Zeneca Agrochemicals
    Inventors: Willem Frans Broekaert, Bruno Philippe Angelo Cammue, Rupert William Osborn, Sarah Bronwen Rees
  • Halogenated esters useful as intermediates for insecticides
    Patent number: 5750769
    Abstract: The invention provides novel compounds of formula:CF.sub.3 --CXCl--CH(OH)CH.sub.2 --C(CH.sub.3).sub.2 --CH.sub.2 --CO.sub.2 R(I)where X represents chloro or bromo and R represents hydrogen or alkyl of up to 4 carbon atoms, processes for preparing them and their use as intermediates in the preparation of insecticidal cyclopropane derivatives. Also provided are novel compounds of formula:BrCH.sub.2 --CH.sub.2 --C(CH.sub.3).sub.2 --CH.sub.2 --CO.sub.2 R(IV)wherein R represents alkyl of up to 4 carbon atoms, useful as intermediates in the preparation of the compounds of formula I.
    Type: Grant
    Filed: November 8, 1995
    Date of Patent: May 12, 1998
    Assignee: Zeneca Limited
    Inventor: Martin Charles Bowden
  • Process for modifying the production of carotenoids in plants, and DNA, constructs and cells therefor
    Patent number: 5750865
    Abstract: The gene of the construct pTOM5 is involved in the carotenoid pathway, which produces carotenes, lutein, xanthophylls, and pigments such as lycopene. The invention proposes to modify (inhibit or promote) the synthesis of such compounds in plants using novel DNA contructs comprising a DNA sequence homologous to some or all of the gene encoded by the clone pTOM5, preceded by a plant promoter. In particular, colour of plant parts, especially fruit, may be modified. Yellow tomatoes are disclosed.
    Type: Grant
    Filed: September 2, 1994
    Date of Patent: May 12, 1998
    Assignee: Zeneca Limited
    Inventors: Colin Roger Bird, Donald Grierson, Wolfgang Walter Schuch
  • Process for preparing 4,4,4-trichlorobutyl acetate
    Patent number: 5750773
    Abstract: A process for the preparation of 4,4,4-trichlorobutyl acetate comprising reacting allyl acetate with chloroform in the presence of a radical initiator, characterized by the incremental addition of the allyl acetate to the chloroform.
    Type: Grant
    Filed: July 11, 1996
    Date of Patent: May 12, 1998
    Assignee: Zeneca Limited
    Inventor: Martin Charles Bowden
  • Triphendioxazine compounds
    Patent number: 5750689
    Abstract: A compound of Formula (1) and salts thereof: ##STR1## wherein: W is Cl or Br;A is optionally substituted alkyl;each R independently is halogen, alkyl, alkoxy or carboxy;n is 0 or 1;a+b is 0 to 4;each X independently is O, S or NR.sup.1 wherein R.sup.1 is H or optionally substituted alkyl;B is a divalent organic linker group; andZ is an aromatic nitrogen ring heterocycle devoid of cellulose-reactive groups.
    Type: Grant
    Filed: May 8, 1996
    Date of Patent: May 12, 1998
    Assignee: Zeneca Limited
    Inventors: Gordon Alexander Thomson, Duncan Adrian Sidney Phillips
  • Heterocyclic compounds
    Patent number: 5750754
    Abstract: A compound of the general formula(M.sup.1).sub.n -Q-(M.sup.2).sub.1-n -L-A Iwherein: n is 0 or 1;M.sup.1 is an amino group;Q is an aromatic heterocyclic group containing a basic nitrogen atom;M.sup.2 is an imino group;L is a template group; andA is an acidic group, or an ester or amide derivative thereof, or a sulphonamide group;and pharmaceutically acceptable salts and pro-drugs thereof, for use in the treatment of a disease in which platelet aggregation mediated by the binding of adhesion molecules to GPIIb-IIIa is involved and the optically active compound (-)-(3R)-3-methyl-4-{4-?4-(4-pyridyl)-piperazin-1-yl!phenoxy}butyric acid is also disclosed.
    Type: Grant
    Filed: June 4, 1996
    Date of Patent: May 12, 1998
    Assignee: Zeneca Limited
    Inventor: Stuart D. Mills
  • Herbicidal compounds
    Patent number: 5744610
    Abstract: A compound of formula (I): ##STR1## or a salt, enamine or the like, acylate, sulphonate, carbamate or ether derivative thereof; wherein X, X.sup.1 and X.sup.2 are independently oxygen or sulphur, R.sup.1 is an optionally substituted heterocyclic or cycloalkyl group, and Y is an optionally substituted C.sub.2 -C.sub.4 alkylene group which is optionally interposed, by an oxygen atom, a group ##STR2## a group ##STR3## or an optionally mono-substituted nitrogen atom, wherein p is 0, 1 or 2, s is 0 or 1 and R.sup.b is alkyl or alkoxy; provided that when X, X.sup.1 and X.sup.2 are oxygen, R.sup.1 is not pyridyl or pyrimidinyl. Processes for the preparation of these compounds and herbicidal compositions containing them are also described and claimed.
    Type: Grant
    Filed: July 18, 1996
    Date of Patent: April 28, 1998
    Assignee: Zeneca Limited
    Inventors: John E. D. Barton, David Cartwright, John M. Cox, Glynn Mitchell, Charles G. Carter, David L. Lee, Francis H. Walker, Frank X. Woolard
  • PTOM36 constructs and tomato cells transformed therewith
    Patent number: 5744364
    Abstract: The invention relates to the clone pTOM36, comprising a gene encoding an enzyme involved in ripening related processes in tomato. Also described are DNA constructs comprising pTOM36 and a transcriptional intiation region operative in plants such that pTOM36 RNA is generated in plant cells, and tomato cells transformed with the DNA constructs.
    Type: Grant
    Filed: February 28, 1995
    Date of Patent: April 28, 1998
    Assignee: Zeneca Limited
    Inventors: Colin Roger Bird, Donald Grierson, John Anthony Ray, Wolfgang Walter Schuch
  • Pyridazion quinoline compounds
    Patent number: 5744471
    Abstract: The present invention relates to compounds, pharmaceutical compositions and methods of using compounds of formula (I) in the treatment and/or prevention of certain diseases or conditions. In formula (I), A is chosen from ortho substituted aryl or heteroaryl species, X is chosen from --OH, --SH, NHR and R.sup.1 or R.sup.2 is chosen from --(CH.sub.2).sub.n L wherein L may be selected from a variety of substituents including aryl, heteroaryl and heterocyclic groups. The compounds are useful in treating and/or preventing neurological disorders associated with excitatory amino acids.
    Type: Grant
    Filed: April 17, 1996
    Date of Patent: April 28, 1998
    Assignee: Zeneca Limited
    Inventors: Thomas Michael Bare, Timothy Wayne Davenport, James Roy Empfield, Jeffrey Alan McKinney, Richard Bruce Sparks