Abstract: Antimicrobial proteins capable of isolation from seeds of Allium show a wide range of antifungal activity and some activity against Gram-positive bacteria. DNA encoding the proteins may be isolated and incorporated into vectors. Plants transformed with this DNA may be produced. The proteins find commercial application as antifungal or antibacterial agents; transformed plants will show increased disease resistance.

Abstract: A bisazo compound of the Formula (1) and salts thereof: ##STR1## wherein Ar.sup.1, Ar.sup.2, each J, each X, L, R.sup.1 and R.sup.2 are as defined in the description, provided that L comprises the residue ##STR2## and/or L.sup.1 is--NH--A--NR.sup.9 R.sup.10wherein L.sup.1, A, R.sup.9 and R.sup.10 are as defined in the description, the compounds of Formula (1) being free from fiber-reactive groups and any carboxyl substituents present in the compounds being attached in the form of one or more residue of the following formulae: ##STR3## Also disclosed are ink compositions comprising the above compound; a process for printing substrates with the ink compositions using an ink-jet printer; paper, project slides and textile materials printed with the ink compositions; and a process for coloration of textile materials with the ink compositions.

Abstract: The present invention provides a conjugate of a solution stable G-CSF derivative and a water soluble polymer which is an acid stable physiologically active substance derived from naturally occurring G-CSF.

Abstract: The invention concerns quinazoline derivatives of the formula I ##STR1## wherein n is 1, 2 or 3 and each R.sup.2 is independently halogeno, trifluoromethyl or (1-4C)alkyl;R.sup.3 is (1-4C)alkoxy; andR.sup.1 is di-?(1-4C)alkyl!amino-(2-4C)alkoxy, pyrrolidin-1-yl-(2-4C)alkoxy, piperidino-(2-4C)alkoxy, morpholino-(2-4C)alkoxy, piperazin-1-yl-(2-4C)alkoxy, 4-(1-4C)alkylpiperazin-1-yl-(2-4C)alkoxy, imidazol-1-yl-(2-4C)alkoxy, di-?(1-4C)alkoxy-(2-4C)alkyl!amino-(2-4C)alkoxy, thiamorpholino-(2-4C)alkoxy, 1-oxothiamorpholino-(2-4C)alkoxy or 1,1-dioxothiamorpholino-(2-4C)alkoxy, and wherein any of the above-mentioned R.sup.1 substituents comprising a CH.sub.2 (methylene) group which is not attached to a N or O atom optionally bears on said CH.sub.

Abstract: A compound for effecting molecular weight control in polymerisation is a CoII chelate of formula, wherein each group R is an organic cyclic group which, independently, is a monovalent group which comprises a cyclic structure or taken together as two adjacent groups provides a divalent group, and wherein further at least one of the groups R includes at least one heteroatom selected from 0, N, S, P, halogen and Si, which heteroatom provides a substituent group or part of a substituent group on the cyclic structure, or a heteroatom of a heterocyclic ring of the cyclic structure; and wherein each group Q is independently selected from F, Cl, Br, OH, C.sub.1-12 alkoxy and C.sub.1-12 alkyl; or being a CoIII analogue of the cobalt II chelate of formula in which the Co atom is additionally covalently bonded to H, a halide or other anion, or a homolytically dissociable organic group. Free-radical polymerication of at least one ethylenically unsaturated monomer is carried out in the presence of such a compound.

Abstract: The invention concerns quinazoline derivatives of the formula I ##STR1## wherein n is 1,2 or 3 and each R.sup.2 is independently halogeno, trifluoromethyl or (1-4C)alkyl;R.sup.1 is (1-4C)alkoxy;A is (1-4C)alkylene; andQ is a saturated, monocyclic 4-, 5-, 6- or 7-membered heterocyclic ring containing one or two oxygen heteroatoms, which ring optionally bears up to four (1-4C)alkyl substituents; or a pharmaceutically-acceptable salt thereof;processes for their preparation, pharmaceutical compositions containing them and the use of their receptor tyrosine kinase inhibitory properties in the treatment of proliferative disease such as cancer.

Abstract: Compounds having the formula (I): ##STR1## and stereoisomers thereof, wherein A is hydrogen, halo, hydroxy, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-4 haloalkyl, C.sub.1-4 haloalkoxy, C.sub.1-4 alkylcarbonyl, C.sub.1-4 alkoxycarbonyl, phenoxy, nitro or cyano; R.sup.1 and R.sup.2, which may be the same or different, are hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclylalkyl, optionally substituted cycloalkylalkyl, optionally substituted aralkyl, optionally substituted heteroarylalkyl, optionally substituted aryloxyalkyl, optionally substituted heteroaryloxyalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted aryloxy, optionally substituted heteroaryloxy, nitro, halo, cyano, --NR.sup.3 R.sup.4, --Co.sub.2 R.sup.3, --CONR.sup.3 R.sup.4, --COR.sup.3, --S(O).sub.n R.sup.3 wherein n is 0, 1 or 2, (CH.sub.2).sub.m PO(OR.

Abstract: Herbicidal 3-substituted pyridine compounds and derivatives thereof of the formula: ##STR1## wherein Ar is a substituted or unsubstituted 5- or 6-membered heteroaryl group having 1, 2 or 3 ring nitrogen atoms with the remainder of the ring atoms being carbon; a substituted or unsubstituted 5-membered heteroaryl group having a ring heteroatom of oxygen or sulfur with the remainder of the ring atoms being carbon; or a substituted or unsubstituted 5-membered heteroaryl group having one ring nitrogen atom and either an oxygen or sulfur ring heteroatom with the remainder of the ring atoms being carbon. Herbicidal compositions containing such 3-substituted pyridine compounds and derivatives thereof and methods of controlling undesirable vegetation employing these compounds and derivatives are also disclosed. The compounds in which XR is hydroxyl are also useful as intermediates for producing the disclosed 3-substituted pyridine derivatives.

Abstract: A method for the preparation of a 2-hydroxyarylaldehyde which comprises reacting a magnesium bis-hydrocarbyloxide, derived at least in part from a hydroxyaromatic compound having at least one free position ortho to the hydroxyl group, with formaldehyde or a formaldehyde-liberating compound under substantially anhydrous conditions at a pressure of from 50 to 700 mm Hg absolute.

Abstract: The invention relates to toxins from venom of Australian funnel web spider species. Eight toxins are specifically exemplified. The toxins have a molecular weight of approximately 4000 amu., containing 36-37 amino acids, and are capable of forming 3 intrachain disulphide bridges. Polynucleotides which encode the toxins, insect viruses and plants which express the toxins and variants of the toxins are also included.

Abstract: A monoazo compound of the Formula (1) and salts thereof: ##STR1## wherein each of R.sup.1 and R.sup.2, independently, represents H, halogen, alkyl, alkoxy or acylamino; each of R.sup.3, R.sup.4 and R.sup.5, independently, represents H or optionally substituted hydrocarbyl other than groups comprising the residue --A'NR.sup.7 R.sup.8 wherein A represents an optionally substituted alkylene group containing 2 or more carbon atoms and each of R.sup.7 and R.sup.8, independently, represents H or optionally substituted hydrocarbyl or R.sup.7 and R.sup.8 together with the attached nitrogen atom form a 5- or 6-membered ring and R.sup.6 represents an optionally substituted hydrocarbyl group not comprising the residue --A--NR.sup.7 R.sup.8 wherein A, R.sup.7 and R.sup.8 are as defined above; or R.sup.3 and R.sup.4 together with the attached nitrogen atom and/or R.sup.5 and R.sup.

Abstract: A granular composition comprising a pesticidally active amount of a fungal biological control agent said agent being present in the form of blastospores.

Abstract: A process for colouring a synthetic textile material or fibre blend thereof which comprises applying to the synthetic textile material a compound of Formula (1): ##STR1## wherein: Ring A and Ring D are optionally substituted and at least one of Ring A or Ring D carries at least one --SO.sub.2 F groupexcept for2-?(9,10-dihydro-9,10-dioxo-1-anthracenyl)amino!ethanesulphonylfluoride,2-?(9,10-dihydro-9,10-dioxo-2-anthracenyl)amino!ethanesulphonylfluoride,2,2'-?(9,10-dihydro-9,10-dioxo-1,4-anthracenediyl)diimino!bisethane sulphonylfluoride,2,2'-?(9,10-dihydro-9,10-dioxo-1,5-anthracenediyl)diimino!bisethane sulphonylfluoride,2,2'-?(9,10-dihydro-2-methoxy-9,10-dioxo-1,4-anthracenediyl)diimino) bisethanesulphonylfluoride,2-?(4-(benzoylamino)-9,10-dihydro-9,10-dioxo-1-anthracenyl!amino!ethanesulp honylfluoride,2-?(9,10-dihydro-4-(methylamino)-9,10-dioxo-1-anthracenyl!amino!ethane sulphonylfluoride.

Abstract: The invention concerns acid derivatives of formula IR.sup.1 --CON(R.sup.2)--N(R.sup.3)CO--X.sup.1 --Q--X.sup.2 --G(I)and pharmaceutically acceptable metabolically labile esters or amides thereof, and pharmaceutically acceptable salts thereof, in which R.sup.1, R.sup.2, R.sup.3, X.sup.1, Q, X.sup.2 and G have the meanings given in the specification. The invention also concerns processes for the preparation of the acid derivatives of formula I, pharmaceutical compositions containing them their use as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa.

Abstract: Compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, acetoxy or acyl, and processes for preparing the same.

Abstract: A process for coloring a synthetic textile material or fiber blend thereof which comprises applying to the synthetic textile material a dye, which is free from water solubilizing groups, carrying at least one --SO.sub.2 F group provided that the dye is not an azo, bisazo or anthraquinone dye.

Abstract: An ink composition comprising a dye containing at least one group of the Formula (1): ##STR1## wherein: W.sup.1 is --F, --OR.sup.1, --SR.sup.1 or --NR.sup.1 R.sup.2 in which R.sub.1 and R.sup.2 each independently is H, optionally substituted alkyl, cycloalkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted aralkyl or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a 5 or 6 membered ring; and a medium comprising at least one of a low melting point solid, an organic solvent and a mixture of water and one more water-soluble organic solvent(s).Also claimed is a process for ink jet printing using the inks, a process for ink jet printing of textiles using the inks and a toner containing a dye with at least one group of Formula (1).

Abstract: The invention provides the novel compound 4,4,4-trichlorobutyl methanesufonate, useful as an intermediate in the production of certain agricultural pesticides, and a process for its manufacture.

Abstract: This invention is concerned with an improved process for the synthesis of hydroxysulfone, which is a key intermediate in the synthesis of carbonic anhydrase inhibitors, especially dorzolamide. Carbonic anhydrase inhibitors are known to be effective in treating elevated intraocular pressure or glaucoma.

Abstract: A method of controlling the growth of plants comprising applying to the locus of such plants an herbicidally effective amount of a compound exhibiting an IC.sub.50 value of less than about 300 nM in the inhibition of farnesyl pyrophosphate synthase in daffodil chromoplasts.