Patents Assigned to Zeneca
  • Maize chlorotic dwarf virus resistant maize and the production thereof
    Patent number: 5563316
    Abstract: The present invention provides a maize plant, method of making and using the same, which is resistant to Maize Chlorotic Dwarf Virus (MCDV). More particularly the invention relates to the introgression into elite maize lines genetic material identified by map loci which is capable of causing the plant and hybrid produced therefrom to be resistant to MCDV.
    Type: Grant
    Filed: August 31, 1994
    Date of Patent: October 8, 1996
    Assignee: Zeneca Limited
    Inventors: George K. Rufener, II, Albert J. Balducchi, Ronald P. Mowers, Richard C. Pratt, Raymond Louie, Michael McMullen, John Knoke
  • Heterocyclic compounds
    Patent number: 5563141
    Abstract: A compound of the general formula(M.sup.1).sub.n --Q--(M.sup.2).sub.1-n --L--A Iwherein:n is 0 or 1;M.sup.1 is an amino group;Q is an aromatic heterocyclic group containing a basic nitrogen atom;M.sup.2 is an imino group;L is a template group; andA is an acidic group, or an ester or amide derivative thereof, or a sulphonamide group;and pharmaceutically acceptable salts and pro-drugs thereof, for use in the treatment of a disease in which platelet aggregation mediated by the binding of adhesion molecules to GPIIb-IIIa is involved. Novel compounds are also disclosed.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: October 8, 1996
    Assignee: Zeneca Limited
    Inventors: Michael G. Wayne, Michael J. Smithers, John W. Rayner, Alan W. Faull, Robert J. Pearce, Andrew G. Brewster, Richard E. Shute, Stuart D. Mills, Peter W. R. Caulkett
  • Herbicidal compounds
    Patent number: 5563115
    Abstract: A compound of formula (I): ##STR1## or a salt, enamine or the like, acylate, sulphonate, carbamate or ether derivative thereof; wherein X, X.sup.1 and X.sup.2 are independently oxygen or sulphur, R.sup.1 is an optionally substituted heterocyclic or cycloalkyl group, and Y is an optionally substituted C.sub.2 -C.sub.4 alkylene group which is optionally interposed by an oxygen atom, a group ##STR2## a group ##STR3## or an optionally mono-substituted nitrogen atom, wherein p is 0, 1 or 2, s is 0 or 1 and R.sup.b is alkyl or alkoxy; provided that when X, X.sup.1 and X.sup.2 are oxygen, R.sup.1 is not pyridyl or pyrimidinyl. Processes for the preparation of these compounds and herbicidal compositions containing them are also described and claimed.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: October 8, 1996
    Assignee: Zeneca Limited
    Inventors: John E. D. Barton, David Cartwright, John M. Cox, Glynn Mitchell, Charles G. Carter, David L. Lee, Francis H. Walker, Frank X. Woolard
  • Corn lethal necrosis resistant maize and the production thereof
    Patent number: 5563318
    Abstract: Maize which has improved resistance to MDMV.sub.B and/or CLN selected by reference to RFLP data for certain chromosome regions associated with the resistance. The method for introgressing the identified chromosomal regions into high yielding inbred lines which are resistant.
    Type: Grant
    Filed: March 31, 1994
    Date of Patent: October 8, 1996
    Assignee: Zeneca Limited
    Inventors: Albert J. Balducchi, George K. Rufener, II, Ronald P. Mowers
  • Impregnated porous granules and a polyurethane matrix held within the pores thereof and holding a liquid material for controlled release of liquid material and process therefor
    Patent number: 5562914
    Abstract: A composition of matter having a clay porous granule and a polyurethane matrix formed from the polymerization of a polyol and a polyisocyanate and held within the pores of the granule and having uniformly distributed throughout the polyurethane matrix a liquid material, for example, a pesticide and a method for loading a porous granule with the polyurethane and the liquid material by:(a) spraying a porous granule with a liquid composition comprising a polyol, a polyisocyanate and a liquid material to be retained in the porous granule, and(b) polymerizing the polyol and the polyisocyanate to form a polyurethane matrix polymer which has the liquid materials uniformly distributed throughout the polyurethane matrix.
    Type: Grant
    Filed: December 6, 1990
    Date of Patent: October 8, 1996
    Assignee: Zeneca Inc.
    Inventors: Herbert B. Scher, Marius Rodson
  • Structure having controlled water resistance
    Patent number: 5560962
    Abstract: A structure of controlled water resistance comprises a core of material having mechanical strength when dry but not when water-wet and a coating comprising biodegradable water resistant polymer. The polymer is preferably applied to the core by electrostatic coating of dry fine particles as laid down in microorganism cells or as clusters of such particles. The structure is useful in the form of disposable biodisintegrable articles.
    Type: Grant
    Filed: August 10, 1994
    Date of Patent: October 1, 1996
    Assignee: Zeneca Limited
    Inventors: Peter M. Brunger, David J. Kemmish
  • Carboxamide derivatives for treating asthma
    Patent number: 5559131
    Abstract: The present invention concerns novel carboxamide derivatives of formula I, set out hereinbelow which antagonize the pharmacological actions of one of the endogenous neuropeptide tachykinins at the neurokinin 2 (NK2) receptor, making them useful whenever such antagonism is desired, such as in the treatment of asthma and related conditions. The invention also provides pharmaceutical compositions containing the novel carboxamide derivatives for use in such treatment, methods for their use, and processes and intermediates for the manufacture of the novel carboxamide derivatives.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: September 24, 1996
    Assignee: Zeneca Limited
    Inventor: Scott C. Miller
  • Stable liquid compositions and their use
    Patent number: 5558816
    Abstract: Stable composition of 1,2-benzisothiazolin-3-one (BIT) in dipropylene glycol having lower pH and lower viscosity than known compositions. The BIT is present as an alkali metal salt obtained by reacting 0.75 to 1.07 moles alkali metal hydroxide with one mole BIT.
    Type: Grant
    Filed: July 19, 1995
    Date of Patent: September 24, 1996
    Assignee: Zeneca Limited
    Inventor: John D. Payne
  • Carboxamide derivatives for treating asthma
    Patent number: 5559132
    Abstract: The present invention concerns novel carboxamide derivatives of formula I, set out hereinbelow which antagonize the pharmacological actions of one of the endogenous neuropeptide tachykinins at the neurokinin 2 (NK2) receptor, making them useful whenever such antagonism is desired, such as in the treatment of asthma and related conditions. The invention also provides pharmaceutical compositions containing the novel carboxamide derivatives for use in such treatment, methods for their use, and processes and intermediates for the manufacture of the novel carboxamide derivatives.
    Type: Grant
    Filed: February 21, 1995
    Date of Patent: September 24, 1996
    Assignee: Zeneca Limited
    Inventor: Scott C. Miller
  • Heterocyclic derivatives
    Patent number: 5556977
    Abstract: Compounds of formula I ##STR1## and metabolically labile esters and amides thereof, and pharmaceutically acceptable salts thereof, in which R.sup.13, M.sup.2, X.sup.1, Z.sup.1, Z.sup.1a, X.sup.2 and A.sup.1 have the meanings given in the specification. The compounds are useful as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa. Intermediates are also disclosed.
    Type: Grant
    Filed: March 28, 1994
    Date of Patent: September 17, 1996
    Assignee: Zeneca Limited
    Inventors: Michael G. Wayne, Michael J. Smithers, John W. Rayner, Alan W. Faull, Robert J. Pearce, Andrew G. Brewster, Richard E. Shute, Sturat D. Mills, Peter W. R. Caulkett
  • Alkylphenoxy substituted bis (thio phosphoryl) amines
    Patent number: 5557003
    Abstract: A process for extracting metal values especially zinc values from aqueous solutions of metal salts which comprises contacting the aqueous solution with an organic phase comprising a compound of the formula: ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4, independently, represents an optionally substituted hydrocarbyl or hydrocarbyloxy group or R.sup.1 and R.sup.2 together with the attached phosphorus atom and/or R.sup.3 and R.sup.4 together with the attached phosphorus atom form a 5- to 8-membered heterocyclic ring.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: September 17, 1996
    Assignee: Zeneca Limited
    Inventors: John Campbell, Raymond F. Dalton, Peter M. Quan
  • Heterocyclic derivatives
    Patent number: 5554613
    Abstract: Quinuclidine derivatives of formula I, and their pharmaceutically acceptable salts, ##STR1## in which R.sup.1 is hydrogen or hydroxy; R.sup.2 is hydrogen; or R.sup.1 and R.sup.2 are joined together so that CR.sup.1 -CR.sup.2 is a double bond; Ar.sup.1 is a phenylene moiety; Ar.sup.2 is a 6-membered heteroaryl moiety containing one or two nitrogen atoms; and wherein one or both of Ar.sup.1 and Ar.sup.
    Type: Grant
    Filed: June 9, 1994
    Date of Patent: September 10, 1996
    Assignee: Zeneca Limited
    Inventor: Keith B. Mallion
  • Antibiotic compounds
    Patent number: 5554606
    Abstract: The present invention provides a compound of the formula (I) ##STR1## wherein: R.sup.1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl;R.sup.2 is hydrogen or C.sub.1-4 alkyl;R.sup.3 and R.sup.4 are ortho with respect to one another wherein R.sup.3 and R.sup.4 are independently hydroxy or in vivo hydrolyzable esters thereof; the benzene ring being optionally further substituted; or a pharmaceutically acceptable salt or in vivo hydrolyzable ester thereof.
    Type: Grant
    Filed: October 26, 1994
    Date of Patent: September 10, 1996
    Assignee: Zeneca Limited
    Inventors: Michael J. Betts, Gloria A. Breault
  • Process for the preparation of 1,1'-methane-bis (Hydantoin)
    Patent number: 5554762
    Abstract: This invention relates to method for the preparation of 1,1'-methane-bis(hydantoin). 1,1'-methane-bis(hydantoin) is an intermediate in the preparation of N-(phosphonomethyl)glycine which is a well known herbicide and plant growth regulator.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: September 10, 1996
    Assignee: Zeneca Limited
    Inventor: Jeffrey D. Robbins
  • Multiple oligonucleotide containing oligomers and the cleanable linkers used in their preparation
    Patent number: 5552535
    Abstract: A method for the synthesis of a plurality of oligonucleotides comprising the steps of(i) forming a first oligonucleotide on a first cleavable link attached to a solid support;(ii) attaching to the first oligonucleotide a cleavable linker moiety;(iii) forming a second oligonucleotide on the cleavable linker moiety; and(iv) cleaving the first cleavable link and the cleavable linker moiety to give a plurality of oligonucleotides; wherein the cleavable linker moiety is of the Formula (1): ##STR1## in which A.sup.1, A.sup.2 and E are as defined herein, and novel compounds which may be used in the operation of the method.
    Type: Grant
    Filed: November 7, 1994
    Date of Patent: September 3, 1996
    Assignee: Zeneca Limited
    Inventors: Michael J. McLean, David Holland, Andrew J. Garman, Robert C. Sheppard
  • Methanoanthrancenyl piperidyl antipsychotics
    Patent number: 5550136
    Abstract: Compounds of formula I ##STR1## wherein X and Y are H or halo; R.sup.2 is: [structures Ia, Ib or Ic;] ##STR2## R.sup.3 is selected from unsubstituted or substituted alkyl, aryl or heteroaryl groups;R.sup.4 is selected from H or (C1-6)alkyl,and pharmaceutically acceptable salts thereof, useful in the treatment of neuropsychiatric disoders such as psychoses; pharmaceutical compositions comprising a compound of formula I and a pharmaceutically acceptable diluent or carrier; and methods of treating neuropschiatric disorders comprising administering to a mammal (including man) in need of such treatment an effective mount of a compound of formula I, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 19, 1995
    Date of Patent: August 27, 1996
    Assignee: Zeneca Limited
    Inventors: Robert T. Jacobs, Cyrus J. Ohnmacht, Diane A. Trainor
  • Polyester composition
    Patent number: 5550173
    Abstract: A polymer composition comprising at least one structural polymer and at least one oligomer of at least one polymer selected from the group; polyhydroxyalkanoates, polylactide, polycaprolactone and co-polymers thereof.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: August 27, 1996
    Assignee: Zeneca Limited
    Inventors: Timothy Hammond, Jasbinder S. Bal
  • Pharmaceutical compositions for the treatment of hereditary tyosinemia type I
    Patent number: 5550165
    Abstract: The invention concerns novel pharmaceutical compositions containing as an active ingredient a 2-benzoyl-1,3-cyclohexanedione which is an inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase (HPPD). The compositions are valuable in the treating those disorders and diseases in which it is desirable to intervene in the metabolic sequences catalysed by HPPD, such as in treating tyrosinemia type I.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: August 27, 1996
    Assignee: Zeneca Limited
    Inventors: Martin K. Ellis, Sven T. Lindstedt, Edward A. Lock, Maj E. H. Markstedt, Linda C. Mutter, Michael P. Prisbylla
  • Oxalate decarboxylate
    Patent number: 5547870
    Abstract: The present invention relates, in general, to an enzyme that degrades oxalic acid. In particular, the invention relates to the enzyme oxalate decarboxylase and to a DNA sequence encoding same. The invention further relates to a recombinant molecule comprising the oxalate decarboxylase encoding sequence and to a host cell transformed therewith. In addition, the invention relates to a method of protecting a plant from the deleterious effects of oxalic acid and to a method of reducing the oxalic acid content of a plant.
    Type: Grant
    Filed: October 18, 1994
    Date of Patent: August 20, 1996
    Assignee: Zeneca Limited
    Inventors: Asis Datta, Anuradha Mehta, K. Natarajan
  • Aqueous coating compositions
    Patent number: 5547710
    Abstract: Aqueous curable polymer dispersion comprising a polyester and/or polyurethane and a polymeric product having a Tg from 25.degree.-100.degree. C. obtainable by free-radical polymerisation of a mixture of (a) an olefinic monomer free from epoxy and epoxy reactive groups, (b) a monomer and/or oligomer having at least two epoxy groups and (c) a group reactive towards epoxy groups.
    Type: Grant
    Filed: November 3, 1994
    Date of Patent: August 20, 1996
    Assignee: Zeneca Limited
    Inventors: Rajasingham Satgurunathan, David C. Hinde, John C. Padget, John G. Carey