Patents Assigned to Zeneca
  • Patent number: 5478892
    Abstract: Blends of biodegradable polymers of hydroxybutyric acid and polyolefines of improved properties are produced by incorporating a compatibilising agent which comprises a block copolymer in which at least half of the mass of one block is represented by alkyl side chains and at least half of the mass of another block is represented by side chains which comprise hydroxy acid residues.
    Type: Grant
    Filed: August 24, 1994
    Date of Patent: December 26, 1995
    Assignee: Zeneca Limited
    Inventors: Alfred J. P. Buckman, Denis G. H. Ballard
  • Patent number: 5478539
    Abstract: Metal values (especially uranium values) are extracted from aqueous solutions of metal oxyions in the absence of halogen ion using an imidazole of defined formula. Especially preferred extractants are 1-alkyl imidazoles and benzimidazoles having from 7 to 25 carbon atoms in the alkyl group.
    Type: Grant
    Filed: March 9, 1995
    Date of Patent: December 26, 1995
    Assignee: Zeneca Limited
    Inventor: Raymond F. Dalton
  • Patent number: 5478842
    Abstract: The invention concerns ether derivatives of the formula IQ.sup.1 --X--Ar--Q.sup.2 IwhereinQ.sup.1 is an optionally substituted 9-, 10- or 11-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur;X is oxy, thio, sulphinyl or sulphonyl;Ar is optionally substituted phenylene, pyridinediyl, pyrimidinediyl, thiophenediyl, furandiyl, thiazolediyl, oxazoiediyl, thiadiazoiediyl or oxadiazolediyl; andQ.sup.2 is selected from the groups of the formulae II and III: ##STR1## wherein R.sup.1 is hydrogen, (2-5C)alkanoyl or optionally substituted benzoyl;R.sup.2 is (1-4C)alkyl; andR.sup.3 is hydrogen or (1-4C)alkyl;or R.sup.2 and R.sup.3 are linked to form a methylene, vinylene, ethylene or trimethylene group;or a pharmaceutically-acceptable salt thereof;processes for their preparation; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: December 26, 1995
    Assignees: Zeneca Limited, Zeneca Pharma S.A.
    Inventors: Thomas G. C. Bird, Graham C. Crawley, Michael S. Large, Patrick Ple
  • Patent number: 5478843
    Abstract: The invention concerns a thiazole derivative of the formula I ##STR1## wherein Q is 2-oxo-1,2,3,4-tetrahydroquinolin-6-yl or 2-oxo-1,2-dihydroquinolin-6-yl which bears on the nitrogen atom at the 1-position a (1-4C)alkyl substituent;X.sup.1 is thio, sulphinyl or sulphonyl;Ar is thiazolediyl;R.sup.1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; andR.sup.2 and R.sup.3 together form a group of the formula --A.sup.2 --X.sup.2 --A.sup.3 -- which together with the carbon atom to which A.sup.2 and A.sup.3 are attached define a ring having 5 or 6 ring atoms, wherein A.sup.2 and A.sup.3, which may be the same or different, each is (1-3C)alkylene and X.sup.2 is oxy, and which ring may bear one or two (1-4C)alkyl substituents;or a pharmaceutically-acceptable salt thereof;processes for their preparation; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
    Type: Grant
    Filed: July 20, 1994
    Date of Patent: December 26, 1995
    Assignees: Zeneca Limited, Zeneca Pharma S.A.
    Inventor: Thomas G. C. Bird
  • Patent number: 5478820
    Abstract: The present invention relates to carbapenems and provides a compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein:R.sup.1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl;R.sup.2 is hydrogen or C.sub.1-4 alkyl;R.sup.3 is hydrogen or C.sub.1-4 alkyl;R.sup.4 and R.sup.5 are the same or different and are selected from hydrogen, halo, cyano, C.sub.1-4 alkyl, nitro, hydroxy, carboxy, C.sub.1-4 alkoxy, C.sub.1-4 alkoxycarbonyl, aminosulphonyl, C.sub.1-4 alkylaminosulphonyl, di-C.sub.1-4 alkylaminosulphonyl, carbamoyl, C.sub.1-4 alkylcarbamoyl, di-C.sub.1-4 alkylcarbamoyl, trifluoromethyl, sulphonic acid, amino, C.sub.1-4 alkylamino, di-C.sub.1-4 alkylamino, C.sub.1-4 alkanoylamino, C.sub.1-4 alkanoyl(N-C.sub.1-4 alkyl)amino, C.sub.1-4 alkanesulphonamido and C.sub.1-4 alkylS(O).sub.n -- wherein n is zero, one or two:with the proviso that there is no hydroxy or carboxy substituent in a position ortho to the --NR.sup.2 --.
    Type: Grant
    Filed: October 4, 1993
    Date of Patent: December 26, 1995
    Assignee: Zeneca Ltd.
    Inventors: Michael J. Betts, Gareth M. Davies, Michael L. Swain
  • Patent number: 5476524
    Abstract: Sunflower seed color is determined by pigmentation of three layers of the sunflower pericarp (hull), epidermis, hypodermis, and phytomelanin layer. The present invention identifies RFLP markers linked to factor(s) affecting seed hypodermis pigmentation and identifies the relation between this trait and oil percentage in the sunflower seed. Seeds with white hypodermis had lower oil percentage than those with unpigmented hypodermis. The Hyp factor was found located in the same map interval region as one QTL with major effects on seed oil percentage. The linkage between the top factor and the QTL with the seed oil can be employed in breeding sunflowers to improve seed oil percentage.
    Type: Grant
    Filed: December 9, 1993
    Date of Patent: December 19, 1995
    Assignee: Zeneca Limited
    Inventors: Alberto J. Leon, Simon T. Berry, George K. Rufener, II, Ronald P. Mowers
  • Patent number: 5475001
    Abstract: The invention concerns quinazoline derivatives of the formula I ##STR1## wherein R.sup.1 includes hydroxy, amino, hydroxyamino, (1-4C)alkoxy, (1-4C)alkylamino and di-[(1-4C)alkyl]amino;R.sup.3 is halogeno;n is 1, 2 or 3 and R.sup.2 includes hydrogen, hydroxy, halogeno and (1-4C)alkyl;or a pharmaceutically-acceptable salt thereof;processes for their preparation; pharmaceutical compositions containing them; and the use of the receptor tyrosine kinase inhibitory properties of the compounds in the treatment of cancer.
    Type: Grant
    Filed: July 19, 1994
    Date of Patent: December 12, 1995
    Assignee: Zeneca Limited
    Inventor: Andrew J. Barker
  • Patent number: 5474580
    Abstract: A process for the coloration of a substrate, especially a textile, comprising the steps of:(a) applying to the substrate a mixture comprising an aqueous solvent and a water-soluble dye comprising molecules which contain a nucleophilic group and an electrophilic group; and(b) heating or basifying or heating and basifying the dye thereby causing molecules of the dye to join together.Also claimed are dyes, polymers and oligomers.
    Type: Grant
    Filed: November 29, 1993
    Date of Patent: December 12, 1995
    Assignee: Zeneca Limited
    Inventors: Andrew H. M. Renfrew, Andrew P. Shawcross
  • Patent number: 5473053
    Abstract: A compound of Formula (1) and salts thereof:Ar.sup.1 N.dbd.N--J--X--L--X--J--N.dbd.NAr.sup.2 (1)wherein: ##STR1## Ar.sup.1 and Ar.sup.2 are each independently aryl containing at least two carboxy groups; andL is a group of the Formula (3a) or (3b): ##STR2## in which T.sup.1 and T.sup.2 each independently is C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy or C.sub.3-4 -alkenyl;T.sup.3 and T.sup.4 each independently is H, C.sub.1-4 -alkyl, C.sub.1-4 -alkoxy or C.sub.3-4 -alkenyl provided that T.sup.3 and T.sup.4 are not both H;each X independently is a group of the Formula (4), (5) or (6): ##STR3## each Z independently is H, halogen, alkyl, NR.sup.1 R.sup.2, SR.sup.3 or 0R.sup.3 ;each Y independently is Z, SR.sup.4 or OR.sup.4 ;each E independently is Cl or CN; andR.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each as defined in the specification.A compound of Formula (1) is suitable for use in the coloration of cellulosic substrates, such as paper, to give bright prints with good light and water fastness.
    Type: Grant
    Filed: January 7, 1994
    Date of Patent: December 5, 1995
    Assignee: Zeneca Limited
    Inventors: Ronald W. Kenyon, Prahalad M. Mistry
  • Patent number: 5471000
    Abstract: A process for the manufacture of aminomethanephosphonic acid comprises:a) reacting a compound of formula R--CH.sub.2 --NH--CO--NH--CH.sub.2 --R' wherein R and R', which may be the same or different, represent a phosphonation leaving group with a phosphonating agent and subsequentlyb) hydrolysing the product of step (a) to form aminomethanephosphonic acid.
    Type: Grant
    Filed: March 24, 1994
    Date of Patent: November 28, 1995
    Assignee: Zeneca Limited
    Inventors: Kenneth R. Randles, Paul G. LeGras
  • Patent number: 5470819
    Abstract: This invention relates to derivatives of acrylic acid useful in agriculture (especially as fungicides but also as plant growth regulators, insecticides and nematocides), to processes for preparing them, to agricultural (especially fungicidal) compositions containing them, and to methods of using them to combat fungi, especially fungal infections in plants, to regulate plant growth and to kill or control insect or nematode pests.The invention provides a compound having the formula (I): ##STR1## and stereoisomers thereof, wherein W is a substituted pyridinyl or substituted pyrimidinyl group linked to A by any of its ring carbon atoms; A is either an oxygen atom or S(O).sub.n wherein n is 0, 1 or 2; X, Y and Z, which are the same or different, are hydrogen or halogen atoms, or hydroxy, optionally substituted alkyl (including haloalkyl), optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted alkoxy.
    Type: Grant
    Filed: May 9, 1994
    Date of Patent: November 28, 1995
    Assignee: Zeneca Limited
    Inventors: Vivienne M. Anthony, John M. Clough, Paul deFraine, Christopher R. A. Godfrey, Ian Ferguson, Patrick J. Crowley, Michael G. Hutchings
  • Patent number: 5468747
    Abstract: Compounds having the formula (I): ##STR1## in which any two of K, L and M are nitrogen and the other is CE; X and Y are independently hydrogen, halogen, C.sub.1-4 alkyl, C.sub.3-6 cycloalkyl, C.sub.2-4 alkenyl, C.sub.2-4 alkynyl, C.sub.2-4 alkynyloxy, phenyl, benzyloxy, cyano, isocyano, isothiocyanato, nitro, NR.sup.1 R.sup.2, NR.sup.1 OR.sup.2,N.sub.3, NHCOR.sup.1, NR.sup.1 CO.sub.2 R.sup.2, NHCONR.sup.1 R.sup.2, N.dbd.CHNR.sup.1 R.sup.2, NHSO.sub.2 R.sup.1, OR.sup.1, OCOR.sup.1, OSO.sub.2 R.sup.1, SR.sup.1, SOR.sup.1, SO.sub.2 R.sup.1, SO.sub.2 OR.sup.1, SO.sub.2 NR.sup.1 R.sup.2, COR.sup.1, CR.sup.1 .dbd.NOR.sup.2, CHR.sup.1 CO.sub.2 R.sup.2, CO.sub.2 R.sup.1, CONR.sup.1 R.sup.2, CSNR.sup.1 R.sup.2, CH.sub.3 O.sub.2 C.C:CH.OCH.sub.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: November 21, 1995
    Assignee: Zeneca Limited
    Inventors: John M. Clough, Christopher R. A. Godfrey, Ian T. Streeting, Rex Cheetham
  • Patent number: 5468903
    Abstract: A process for preparing a compound comprising a monocyclic aromatic ring having at least a first substituent and a substituted sulphonyl group at the position para to the first substituent, the process comprising mixing a reactant comprising the monocyclic aromatic ring with the first substituent and hydrogen in the position of the ring para to the first substituent, with a sulphonic acid halide derivative in the presence of a naturally occurring or synthetic zeolite capable of catalyzing a sulphonylation reaction between the reactant and the sulphonic acid halide, under conditions in which the reaction will occur.
    Type: Grant
    Filed: March 1, 1993
    Date of Patent: November 21, 1995
    Assignee: Zeneca Limited
    Inventors: Kenneth R. Randles, Brian G. Gott, Stephen T. A. K. Daley
  • Patent number: 5466814
    Abstract: Compounds of the general formula ##STR1## are cyclized to the corresponding isothiazolinone using a carbonyl halide of the formula RCOX where R is halogen or alkyl and X is halogen. R.sup.3 and R.sup.4 are preferably such as to form a 5 or 6 membered ring. Useful carbonyl halides are phosgene and propionyl chloride. Using acyl halides such as propionyl chloride, a mixture of the isothiazolinone and a salt of the carboxylic acid can be obtained, for example an essentially equimolar mixture of 2-methyl-4,5-trimethyl-4-isothiazolin-3-one and sodium propionate.
    Type: Grant
    Filed: April 21, 1994
    Date of Patent: November 14, 1995
    Assignee: Zeneca Limited
    Inventors: Frank S. Moffatt, David Winstanley
  • Patent number: 5466821
    Abstract: Fungicidal triazole and imidazole compounds are disclosed. Intermediate for preparing these compounds include, for example, compounds of the formula: ##STR1## wherein R.sup.1 is phenyl optionally substituted by halogen, nitro, alkyl, haloalkyl, alkoxy, haloalkoxy, phenyl or halophenyl; R.sup.4 is hydrogen; and R.sup.5 is optionally substituted phenyl.
    Type: Grant
    Filed: November 7, 1994
    Date of Patent: November 14, 1995
    Assignee: Zeneca Limited
    Inventor: Paul A. Worthington
  • Patent number: 5466662
    Abstract: A method for killing or controlling weeds in a soya crop, which method comprises applying to the crop or to the location thereof a compound of formula (I): ##STR1## in an amount sufficient to kill the weeds but insufficient to kill the crop.
    Type: Grant
    Filed: April 26, 1994
    Date of Patent: November 14, 1995
    Assignee: Zeneca Limited
    Inventors: Harjinder Singhbansal, John C. Ormrod
  • Patent number: 5464822
    Abstract: Polypeptides, in particular the polypeptide of formula I: ##STR1## and analogues thereof which possess inhibitory activity against human leukocyte elastase. The polypeptides may be obtained by expression using plasmidic expression systems in hosts such as E. Coli and yeast, the polypeptide of formula I being also obtainable from psoriatic plaques.
    Type: Grant
    Filed: August 10, 1992
    Date of Patent: November 7, 1995
    Assignee: Zeneca Limited
    Inventors: Enno Christophers, Oliver Wiedow, Jens-Michael Schroder
  • Patent number: 5464765
    Abstract: Plant cells are transformed by bringing them into contact with a a multiplicity of needle-like bodies on which the cells may be impaled. This causes a rupture in the cell wall allowing entry of transforming DNA either from a surrounding liquid medium or of DNA previously bound to or otherwise entrapped in the needle-like projections.
    Type: Grant
    Filed: January 14, 1994
    Date of Patent: November 7, 1995
    Assignee: Zeneca Limited
    Inventors: Ronald A. Coffee, James M. Dunwell
  • Patent number: 5464851
    Abstract: A composition which contains a 2-halo-2-halomethyl glutaronitrile and a 4,5-polymethylene-4-isothiazolin-3-one. The compositions exhibit anti-microbial activity and certain combinations of isothiazolinones together with the glutaronitrile are surprisingly effective against both bacteria and fungi.
    Type: Grant
    Filed: July 29, 1994
    Date of Patent: November 7, 1995
    Assignee: Zeneca Limited
    Inventor: Fraser F. Morpeth
  • Patent number: 5463011
    Abstract: The invention concerns allophanic acid derivatives of formula IR.sup.1 --N(R.sup.2)CO--N(R.sup.3)CO--X.sup.1 --Q--X.sup.2 --GIand pharmaceutically acceptable metabolically labile esters or amides thereof, and pharmaceutically acceptable salts thereof, in which R.sup.1, R.sup.2, R.sup.3, X.sup.1, Q, X.sup.2 and G have the meanings given in the specification. The invention also concerns processes for the preparation of the allophanic acid derivatives of formula I, pharmaceutical compositions containing them and their use as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: October 31, 1995
    Assignee: Zeneca Limited
    Inventors: George R. Brown, Richard E. Shute