Patents Assigned to ZymoGenetics
  • Mammalian cytokine-like polypeptide-10
    Publication number: 20040143097
    Abstract: A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto 10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto 10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.
    Type: Application
    Filed: February 27, 2004
    Publication date: July 22, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Betty A. Haldeman
  • Human 2-19 protein homologue, z219c
    Publication number: 20040137575
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for z219c, a novel member of the human 2-19 protein family. The polypeptides, and polynucleotides encoding them, may be used for detecting various human disease states and chromosomal abnormalities. The present invention also includes antibodies to the z219c polypeptides.
    Type: Application
    Filed: January 23, 2004
    Publication date: July 15, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Hal Blumberg, Theresa A. Deisher
  • Mammalian adhesion protease peptides
    Patent number: 6762044
    Abstract: The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for MAPP, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the MAPP polypeptides.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: July 13, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Nand Baindur, Paul D. Bishop
  • Helical cytokine zalpha33
    Patent number: 6761882
    Abstract: Novel cytokine polypeptides, materials and methods for making them, and method of use are disclosed. The polypeptides comprise at least nine contiguous amino acid residues of SEQ ID NO:2 or SEQ ID NO:4, and may be prepared as polypeptide fusions comprise heterologous sequences, such as affinity tags. The polypeptides and polynucleotides encoding them may be used within a variety of therapeutic, diagnostic, and research applications.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: July 13, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Zeren Gao
  • Mammalian Transforming growth factor beta-9
    Publication number: 20040132136
    Abstract: Novel mammalian Ztgf&bgr;-9 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.
    Type: Application
    Filed: December 16, 2003
    Publication date: July 8, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, David W. Taft, Kevin P. Foley
  • Protein zlmda33
    Patent number: 6756214
    Abstract: Novel polypeptides, polynucleotides encoding them, materials and methods for making them, antibodies that specifically bind to them, and methods of using the polypeptides, polynucleotides, and antibodies are disclosed. The polypeptides comprise at least nine contiguous amino acid residues of SEQ ID NO:2 or SEQ ID NO:5, and may be prepared as polypeptide fusions comprising heterologous sequences, such as affinity tags. The polypeptides and polynucleotides encoding them may be used within a variety of therepeutic, diagnostic, and research applications, including in vitro diagnosis and in vivo imaging of cancers and other sites of abnormal cell proliferation.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: June 29, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Zeren Gao
  • Human Zven1 proteins
    Patent number: 6756479
    Abstract: The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: June 29, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Paul D. Bishop
  • Murine cytokine receptor
    Publication number: 20040121388
    Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new murine cytokine receptor designated as “Zcytor14.
    Type: Application
    Filed: November 21, 2003
    Publication date: June 24, 2004
    Applicant: ZymoGenetics, Inc.
    Inventor: Zeren Gao
  • Fermentation medium and method
    Patent number: 6750045
    Abstract: A yeast fermentation medium that does not contain yeast cell extract but is comprised of a mixture of oleic acid, lactic acid and palmitic acid. Using this fermentation medium yields of factor XIII were increased 250%.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: June 15, 2004
    Assignee: ZymoGenetics, Inc.
    Inventor: Bruce L. Zamost
  • Cytokine zalpha11 ligand
    Publication number: 20040110932
    Abstract: The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Application
    Filed: September 10, 2003
    Publication date: June 10, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Julia E. Novak, Scott R. Presnell, Cindy A. Sprecher, Donald C. Foster, Richard D. Holly, Jane A. Gross, Janet V. Johnston, Andrew J. Nelson, Stacey R. Dillon, Angela K. Hammond
  • Adipocyte complement related protein zacrp13
    Publication number: 20040106777
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zacrp13, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. Novel zacrp13 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp13 protein or fragments thereof.
    Type: Application
    Filed: October 17, 2003
    Publication date: June 3, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Brian A. Fox, James L. Holloway
  • Novel FGF homologs
    Publication number: 20040096936
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF-5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells and may be used for remodelling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF-5 polypeptides.
    Type: Application
    Filed: October 19, 2001
    Publication date: May 20, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella Raymond, Thomas R. Bukowski, Susan D. Holderman, Birgit Hansen, Paul O. Sheppard
  • Zinsi polypeptide composition stimulating pancreatic islet growth
    Patent number: 6737509
    Abstract: The present invention provides compositions for stimulating an increase in islet proliferation and &bgr;-cell mass using an insulin homolog polypeptide. The present invention also includes methods for treating diabetes by stimulating islet proliferation and &bgr;-cell mass increases and affecting insulin levels.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: May 18, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Stephen R. Jaspers, Katherine H. Sprugel, Hong Ping Ren, Jacqueline M. Humes, Ross C. Hoffman, Darrell C. Conklin
  • Testis-specific insulin homolog polypeptides
    Publication number: 20040086509
    Abstract: The present invention provides testis-specific insulin homolog polypeptides and polynucleotides encoding the polypeptides, as well as related compositions and methods are disclosed. The polypeptides and polynucleotides may be used within methods for enhancing viability of cryopreserved sperm, for enhancing sperm motility, to enhance fertilization in methods of assisted reproduction, as contraceptives and other related uses.
    Type: Application
    Filed: November 3, 2003
    Publication date: May 6, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Si Lok, Darrell C. Conklin, Catherine E. Lofton-Day
  • Adipocyte complement related protein ZACRP3X2
    Publication number: 20040086971
    Abstract: Novel zacrp3x2 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp3x2 protein or fragments thereof.
    Type: Application
    Filed: November 21, 2003
    Publication date: May 6, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Betty A. Haldeman, Edward C. Thayer, Paul O. Sheppard
  • Methods for generating a continuous nucleotide sequence from noncontiguous nucleotide sequences
    Patent number: 6730500
    Abstract: The increased use of nucleotide sequence data mining techniques has amplified the demand for efficient methods of producing recombinant proteins in host cells. New genes identified from genomic sequences may lack an identified source for obtaining an mRNA template to produce cDNA. A strategy is provided for generating nucleic acid molecules comprising a continuous amino acid-encoding sequence using a genomic template that contains non-continuous amino acid-encoding sequences.
    Type: Grant
    Filed: August 23, 2001
    Date of Patent: May 4, 2004
    Assignee: ZymoGenetics, Inc.
    Inventor: Si Lok
  • Human cytokine receptor
    Publication number: 20040077052
    Abstract: Cytokines and their receptors have proven usefulness in both basic research and as therapeutics. The present invention provides a new human cytokine receptor designated as “Zcytor 18.
    Type: Application
    Filed: November 19, 2003
    Publication date: April 22, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Rolf E. Kuestner, Zeren Gao
  • Class II cytokine receptor-7
    Publication number: 20040072229
    Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in kidneys, pancreas, prostate, adrenal cortex and nervous tissue. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of these organs.
    Type: Application
    Filed: August 7, 2003
    Publication date: April 15, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Si Lok, Choon J. Kho, Anna C. Jelmberg, Robyn L. Adams, Theodore E. Whitmore, Theresa M. Farrah
  • Adipocyte complement related protein zacrp13
    Patent number: 6716965
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zacrp13, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. Novel zacrp13 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp13 protein or fragments thereof.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: April 6, 2004
    Assignee: ZymoGenetics, Inc.
    Inventors: Brian A. Fox, James L. Holloway
  • UMLR polypeptides
    Publication number: 20040063132
    Abstract: Novel secreted and membrane bound tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligands, agonists and antagonists. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate inflammation, tumor growth and metastasis, infection, immunity, and cellular maturation.
    Type: Application
    Filed: September 12, 2003
    Publication date: April 1, 2004
    Applicant: ZymoGenetics, Inc.
    Inventors: Wenfeng Xu, Catherine E. Lofton-Day, Randal M. Henne, Scott R. Presnell, Yue Yao, Julia E. Novak