Patents Assigned to ZymoGenetics
  • Method of treating fibroproliferative disorders
    Patent number: 6630142
    Abstract: Materials and methods for reducing cell proliferation or extracellular matrix production in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf4 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Exemplary zvegf4 antagonists include anti-zvegf4 antibodies, inhibitory polynucleotides, inhibitors of zvegf4 activation, and mitogenically inactive, receptor-binding variants of zvegf4. The materials and methods are useful in the treatment of, inter alia, fibroproliferative disorders of the kidney, liver, and bone.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: October 7, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Charles E. Hart, Stavros Topouzis, Debra G. Gilbertson
  • Mammalian growth factor-7
    Patent number: 6630571
    Abstract: Novel mammalian zcyto7 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: October 7, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Teresa Gilbert, Charles E. Hart, Joyce M. Lehner
  • TML peptides
    Patent number: 6627729
    Abstract: The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies, host cells expressing the cDNA encoding the novel TML peptides and methods for increasing gastric motility and secretion of digestive proteins and hormones using the novel TML peptides.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: September 30, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Theresa A. Deisher, Stephen R. Jaspers, Paul D. Bishop
  • Islet cell antigen 1851
    Patent number: 6627735
    Abstract: A mammalian islet cell antigen polypeptide involved in the development of insulin-dependent diabetes mellitus (IDDM) is disclosed. This islet cell antigen polypeptide, 1851, was found to contain regions of homology to the protein tyrosine phosphatase family. Methods for diagnosis and treatment, including use in immunoprecipitation assays and the induction of immune tolerance using the recombinant mammalian polypeptides and antibodies specific to mammalian islet cell antigen 1851 polypeptides are presented.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: September 30, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Wayne Kindsvogel, Laura J. Jelinek, Paul O. Sheppard, William A. Hagopian, James M. LaGasse
  • Novel FGF homolog ZFGF12
    Publication number: 20030180890
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF12 a novel member of the FGF family. The present invention also includes antibodies to the zFGF12 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Application
    Filed: January 17, 2003
    Publication date: September 25, 2003
    Applicant: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • SGIP peptides
    Publication number: 20030176640
    Abstract: The present invention is directed to polynucleotides, polypeptides, peptides, variants and uses thereof for novel peptide fragments which have homology to motilin. Tissue distribution of the mRNA for the novel polypeptide fragment is specific to the stomach, small intestine and pancreas. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies and host cells expressing the cDNA encoding the novel SGIP peptide.
    Type: Application
    Filed: July 1, 2002
    Publication date: September 18, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Stephen R. Jaspers, Theresa A. Deisher, Paul D. Bishop
  • Secreted salivary zsig32 polypeptides
    Publication number: 20030176645
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for secreted salivary zsig32 polypeptides. The polypeptides, and polynucleotides encoding them modulate adhesion or modulate or indicate salivary gland function. The present invention also includes antibodies and binding proteins for the zsig32 polypeptides.
    Type: Application
    Filed: February 22, 2002
    Publication date: September 18, 2003
    Applicant: ZymoGenetics, Inc.
    Inventor: Paul O. Sheppard
  • Adipocyte-specific protein homologs
    Publication number: 20030176659
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig37, a novel member of the family of proteins bearing a collagen-like domain and a globular domain. The polypeptides, and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zsig37 polypeptides.
    Type: Application
    Filed: March 20, 2003
    Publication date: September 18, 2003
    Applicant: ZymoGenetics, Inc.
    Inventor: Paul O. Sheppard
  • Adipocyte-specific protein homologs
    Publication number: 20030176658
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig37, a novel member of the family of proteins bearing a collagen-like domain and a globular domain. The polypeptides, and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zsig37 polypeptides.
    Type: Application
    Filed: March 20, 2003
    Publication date: September 18, 2003
    Applicant: ZymoGenetics, Inc.
    Inventor: Paul O. Sheppard
  • Mammalian adhesion protease peptides
    Publication number: 20030175262
    Abstract: The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for MAPP, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the MAPP polypeptides.
    Type: Application
    Filed: June 21, 2002
    Publication date: September 18, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Nand Baindur, Paul D. Bishop
  • Beta-1,3-galactosyltransferase homologs
    Publication number: 20030175922
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for znssp2, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp2 polypeptides.
    Type: Application
    Filed: June 21, 2002
    Publication date: September 18, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Gayle Yamamoto, Stephen R. Jaspers, Zeren Gao
  • Cytokine receptor zalpha11
    Publication number: 20030175825
    Abstract: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalphall, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Application
    Filed: April 14, 2003
    Publication date: September 18, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Darrell C. Conklin, Julia E. Novak, Angela K. Hammond
  • Adipocyte complement related protein homolog zacrp2
    Patent number: 6620909
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zacrp2, a novel member of the family of proteins bearing a collagen-like domain and a Clq domain. The polypeptides and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zacrp2 polypeptides.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: September 16, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Christopher S. Piddington, Paul D. Bishop
  • Mammalian secretory peptide - 9
    Publication number: 20030171542
    Abstract: Novel mammalian secretory polypeptides, polynucleotides encoding the polypeptides (called Zsig9), and related compositions and methods including antibodies and anti-idiotypic antibodies. Overexpression of these proteins is indicative of the presence of cancer. Antibodies and anti-sense nucleotides can be used therapeutically to treat the disease. Furthermore, antibodies to Zsig9 and nucleotide primers and probes can be used to diagnose the presence of tumors.
    Type: Application
    Filed: October 19, 2001
    Publication date: September 11, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Laura J. Jelinek
  • Secreted protein zacrp4
    Publication number: 20030170781
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zacrp4, a secreted protein having tandem C1q globular domains. Zacrp4 is highly expressed in neuronal and reproductive tissues and may be used in the study cell-cell communication and the regulation of cellular processes therein. The present invention also includes antibodies to the zacrp4 polypeptides.
    Type: Application
    Filed: February 27, 2002
    Publication date: September 11, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: James L. Holloway, Si Lok
  • Adipocyte-specific protein homologs
    Publication number: 20030171547
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig39, a novel member of the family of proteins bearing a collagen-like domain and a globular domain. The polypeptides, and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zsig39 polypeptides.
    Type: Application
    Filed: July 16, 2002
    Publication date: September 11, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Jacqueline M. Humes
  • Novel beta-defensins
    Publication number: 20030166913
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the &bgr;-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.
    Type: Application
    Filed: April 7, 2003
    Publication date: September 4, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: David A. Adler, James L. Holloway, Nand Baindur, Stephanie Beigel-Orme, Paul O. Sheppard
  • Novel beta-defensins
    Publication number: 20030166912
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the &bgr;-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.
    Type: Application
    Filed: April 7, 2003
    Publication date: September 4, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: David A. Adler, James L. Holloway, Nand Baindur, Stephanie Beigel-Orme, Paul O. Sheppard
  • Islet cell antigen 1851
    Publication number: 20030166067
    Abstract: A mammalian islet cell antigen polypeptide involved in the development of insulin-dependent diabetes mellitus (IDDM) is disclosed. This islet cell antigen polypeptide, 1851, was found to contain regions of homology to the protein tyrosine phosphatase family. Methods for diagnosis and treatment, including use in immunoprecipitation assays and the induction of immune tolerance using the recombinant mammalian polypeptides and antibodies specific to mammalian islet cell antigen 1851 polypeptides are presented.
    Type: Application
    Filed: April 16, 2002
    Publication date: September 4, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Wayne Kindsvogel, Laura J. Jelinek, Paul O. Sheppard, William A. Hagopian, James M. LaGasse
  • Mammalian neuro-growth factor like protein
    Publication number: 20030166907
    Abstract: Novel mammalian Zneu1 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.
    Type: Application
    Filed: May 10, 2001
    Publication date: September 4, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Laura J. Jelinek