Patents Assigned to ZymoGenetics
  • Pichia methanolica glyceraldehyde-3-phosphate dehydrogenase 1 promoter and terminator
    Patent number: 6613547
    Abstract: Transcription promoter and terminator sequences from the Pichia methanolica glyceraldehyde-3-phosphate dehydrogenase 1 gene (GAP1 gene) are disclosed. The sequences are useful within DNA constructs for the production of proteins of interest in cultured P. methanolica cells. Within the expression vectors, a GAP1 promoter and/or a GAP1 terminator is operably linked to a DNA segment encoding the protein of interest.
    Type: Grant
    Filed: March 6, 2001
    Date of Patent: September 2, 2003
    Assignees: ZymoGenetics, Inc.
    Inventors: Christopher K. Raymond, Erica Vanaja, Brady G. Miller, James S. Sloan
  • Kunitz domain polypeptide zkun10
    Publication number: 20030162259
    Abstract: Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a motif of amino acid residues as shown in SEQ ID NO:4, and the sequence of the Kunitz domain is shown in residues 57 through 107 of SEQ ID NO:2. The polypeptide also includes an N-terminal collagen domain in which a von Willebrand domain resides, and is shown in SEQ ID NO: 5. Also disclosed are methods for making the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and as inhibitors of protease degradation of plasma proteins.
    Type: Application
    Filed: December 9, 2002
    Publication date: August 28, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Brian A. Fox
  • Method for treating inflammation using soluble receptors to interleukin-20
    Patent number: 6610286
    Abstract: A method for treating IL-20 induced inflammation. An antagonist to IL-20 is administered to treat inflammation and associated diseases. The antagonist can be an antibody that binds to IL-20 or its receptor or a soluble receptor that binds to IL-20. Examples of such diseases are adult respiratory disease, psoriasis, eczema, contact dermatitis, atopic dermatitis, septic shock, multiple organ failure, inflammatory lung injury, bacterial pneumonia, inflammatory bowel disease, rheumatoid arthritis, asthma, ulcerative colitis and Crohn's disease.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: August 26, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Penny Thompson, Donald C. Foster, Wenfeng Xu, James D. Kelly, Hal Blumberg, Yasmin A. Chandrasekher
  • Disintegrin homologue, MAHBP
    Publication number: 20030153064
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for MAHBP, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are believed to be cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the MAHBP polypeptides.
    Type: Application
    Filed: September 27, 2002
    Publication date: August 14, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Nand Baindur, Theresa A. Deisher, Paul D. Bishop, David W. Taft
  • Methods of using zalpha11 ligand
    Patent number: 6605272
    Abstract: The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: August 12, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Julia E. Novak, Scott R. Presnell, Cindy A. Sprecher, Donald C. Foster, Richard D. Holly, Jane A. Gross, Janet V. Johnston, Andrew J. Nelson, Stacey R. Dillon, Angela K. Hammond
  • Human Zven1 proteins
    Publication number: 20030148317
    Abstract: The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
    Type: Application
    Filed: August 2, 2002
    Publication date: August 7, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Paul D. Bishop
  • Cytokine receptor zalpha11
    Publication number: 20030148447
    Abstract: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Application
    Filed: September 13, 2002
    Publication date: August 7, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Darrell C. Conklin, Julia E. Novak, Angela K. Hammond
  • Interleukin-1 homolog zil1a4
    Publication number: 20030148467
    Abstract: Homologs of interleukin-1, materials and methods for making them, compositions comprising them, and methods of using them are disclosed. The invention includes polypeptides comprising residues 60 through 218 of SEQ ID NO:7 or residues 1 through 157 of SEQ ID NO:10. Polypeptides and polynucleotides of the invention are useful within diagnostic, therapeutic, and analytical fields, including modulation of immune responses.
    Type: Application
    Filed: November 22, 2002
    Publication date: August 7, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Robert R. West, Paul O. Sheppard, Zeren Gao
  • Adipocyte complement related protein homolog zacrp7
    Publication number: 20030129698
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zacrp7, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. The polypeptides and polynucleotides encoding them, are involved in homo and heterotrimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zacrp7 polypeptides.
    Type: Application
    Filed: August 30, 2002
    Publication date: July 10, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Christopher S. Piddington, Paul O. Sheppard
  • Kunitz domain polypeptide Zkun8
    Publication number: 20030129577
    Abstract: Proteinase inhibitors comprising a Kunitz domain are disclosed. The Kunitz domain comprises a motif of amino acid residues as shown in SEQ ID NO:7, wherein the sequence is at least 90% identical to residues 328 through 378 or 386 through 436 of SEQ ID NO:2. Also disclosed are methods for producing the proteinase inhibitors, and expression vectors and cultured cells that are useful within the methods. The proteinase inhibitors may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.
    Type: Application
    Filed: December 9, 2002
    Publication date: July 10, 2003
    Applicant: ZymoGenetics, Inc.
    Inventor: Paul O. Sheppard
  • Novel cytokine zalpha11 ligand
    Publication number: 20030125524
    Abstract: The present invention relates to zalpha11 Ligand polynucleotide and polypeptide molecules. The zalpha11 Ligand is a novel cytokine. The polypeptides may be used within methods for stimulating the proliferation and/or development of hematopoietic cells in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Application
    Filed: November 15, 2002
    Publication date: July 3, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Julia E. Novak, Scott R. Presnell, Cindy A. Sprecher, Donald C. Foster, Richard D. Holly, Jane A. Gross, Janet V. Johnston, Andrew J. Nelson, Stacey R. Dillon, Angela K. Hammond
  • Tryptase-like polypeptide ztryp1
    Publication number: 20030119035
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for mouse ztryp1, a novel member of the serine protease family of proteins. The polynucleotides encoding mouse ztryp1 can be used to identify a human ortholog or to create a mouse model associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Application
    Filed: October 1, 2002
    Publication date: June 26, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, David W. Taft
  • Antibodies that bind human Zven1
    Publication number: 20030108994
    Abstract: The present invention provides two members of a new family of human proteins, designated as “Zven.” The Zven1 gene, which resides in human chromosome 3p21.1-3p14.3, is expressed in testicular tissue and peripheral blood lymphocytes.
    Type: Application
    Filed: August 2, 2002
    Publication date: June 12, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Paul D. Bishop
  • Beta-defensins
    Patent number: 6576755
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the &bgr;-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: June 10, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: David A. Adler, James L. Holloway, Nand Baindur, Stephanie Beigel-Orme, Paul O. Sheppard
  • Mammalian cytokine-like polypeptide-10
    Patent number: 6576743
    Abstract: A mammalian cytokine-like polypeptide, called Mammalian Cytokine-like polypeptide-10, (Zcyto10), polynucleotides encoding the same, antibodies which specifically bind to the polypeptide, and anti-idiotypic antibodies which bind to the antibodies. Zcyto10 is useful for promoting the healing of wounds and for stimulating the proliferation of platelets.
    Type: Grant
    Filed: May 17, 1999
    Date of Patent: June 10, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Betty A. Haldeman
  • Cytokine receptor zalpha11
    Patent number: 6576744
    Abstract: Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zalpha11, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zalpha11, are located on chromosome 16, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: June 10, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Darrell C. Conklin, Julia E. Novak, Angela K. Hammond
  • Methods for promoting growth of bone, ligament, and cartilage using zvegf4
    Publication number: 20030105015
    Abstract: Methods for promoting growth of bone, ligament, or cartilage in a mammal are disclosed. The methods comprise administering to said mammal a composition comprising a pharmacologically effective amount of zvegf4 in combination with a pharmaceutically acceptable delivery vehicle. Also disclosed are methods for promoting proliferation or differentiation of osteoblasts, osteoclasts, chondrocytes, or bone marrow stem cells comprising culturing the cells in an effective amount of zvegf4.
    Type: Application
    Filed: August 23, 2002
    Publication date: June 5, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Debra G. Gilbertson, Charles E. Hart
  • Cystine knot protein and materials and methods for making it
    Patent number: 6573363
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig51, a novel member of the cystine knot family of polypeptides. The polypeptides comprise a sequence of amino acid residues that is at least 80% identical in amino acid sequence to residues 1 through 106 of SEQ ID NO:2. The invention further provides therapeutic and diagnostic methods utilizing the polynucleotides, polypeptides, and antagonists of the polypeptides.
    Type: Grant
    Filed: February 12, 1999
    Date of Patent: June 3, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Si Lok
  • Crib protein ZMSE1
    Patent number: 6573069
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zmse1, a novel human CRIB protein. The polypeptides, and polynucleotides encoding them, may be used for detecting human chromosomal abnormalities and cancers. The present invention also includes antibodies to the zmse1 polypeptides.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: June 3, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: James L. Holloway, Zeren Gao, Theodore E. Whitmore
  • Methods for promoting production of myelin by Schwann cells
    Patent number: 6569419
    Abstract: A method for promoting the expression of myelin or Protein Zero in Schwann cells using Zcyto7 or IL-17. Zcyto7 or IL-17 are further used to promote myelination of the peripheral nervous system. This is particularly useful in treating diseases dymyelinating diseases such as diabetic neuropathy, Guillain-Barré Syndrome, chronic demyelinating disease, acute demyelinating polyneuropathy and human immunodeficiency viral demyelinating neuropathy or demyelination caused by trauma.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: May 27, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Emma E. Moore, Julia E. Novak