Patents Assigned to ZymoGenetics
  • Adipocyte-specific protein homologs
    Patent number: 6566499
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zsig37, a novel member of the family of proteins bearing a collagen-like domain and a globular domain. The polypeptides, and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zsig37 polypeptides.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: May 20, 2003
    Assignee: ZymoGenetics, Inc.
    Inventor: Paul O. Sheppard
  • Zalpha13: a human secreted protein
    Publication number: 20030092117
    Abstract: Secreted proteins perform many functions that are essential for the metabolism and differentiation of cells. As such, this class of proteins often provides therapeutically useful pharmaceuticals. The present invention provides a new human secreted protein, designated “Zalpha13.
    Type: Application
    Filed: June 13, 2002
    Publication date: May 15, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Zeren Gao
  • Method of treating fibrosis
    Publication number: 20030087870
    Abstract: Materials and methods for treating fibrosis in a mammal are disclosed. The methods comprise administering to a mammal a composition comprising a therapeutically effective amount of a zvegf3 antagonist in combination with a pharmaceutically acceptable delivery vehicle. Zvegf3 antagonists include anti-zvegf3 antibodies, mitogenically inactive receptor-binding zvegf3 variant polypeptides, and inhibitory polynucleotides. Within one embodiment of the invention the fibrosis is liver fibrosis.
    Type: Application
    Filed: October 3, 2002
    Publication date: May 8, 2003
    Applicant: ZymoGenetics, Inc.
    Inventor: Debra G. Gilbertson
  • Murine interferon-&agr;
    Patent number: 6548056
    Abstract: Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain autoimmune diseases, the treatment of particular cancers, and the enhancement of the immune response against infectious agents. The present invention provides a new form of murine interferon-&agr;, which has applications in diagnosis and therapy.
    Type: Grant
    Filed: September 12, 2001
    Date of Patent: April 15, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Andrew L. Feldhaus, Zeren Gao
  • Kunitz domain polypeptide Zkun11
    Patent number: 6544760
    Abstract: Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. The enzymatic activity of the serine proteases is regulated in part by protease inhibitors that comprise a Kunitz domain. Zkun11 is a new member of the Kunitz domain protein family.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: April 8, 2003
    Assignee: ZymoGenetics, Inc.
    Inventor: James L. Holloway
  • Interferon-epsilon
    Patent number: 6544505
    Abstract: Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain autoimmune diseases, the treatment of particular cancers, and the enhancement of the immune response against infectious agents. To date, four types of interferons have been found in humans: interferon-&agr;, interferon-&bgr;, interferon-&ggr;, and interferon-&ohgr;. The present invention provides new forms of human and murine interferon, “interferon-&egr;,” which have applications in diagnosis and therapy.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: April 8, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Francis J. Grant, Mark W. Rixon, Wayne Kindsvogel
  • Inhibitors for use in hemostasis and immune function
    Patent number: 6544946
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for use as inhibitors in hemostasis and immune function. Such inhibitors are members of the family of proteins bearing a collagen-like domain and a globular domain. The inhibitors are useful for promoting blood flow in the vasculature by reducing thrombogenic and complement activity. The inhibitors are also useful for pacifying collagenous surfaces and modulating wound healing.
    Type: Grant
    Filed: July 19, 2000
    Date of Patent: April 8, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Gerald W. Lasser, Paul D. Bishop
  • Helical cytokine zalpha33
    Publication number: 20030064479
    Abstract: Novel cytokine polypeptides, materials and methods for making them, and method of use are disclosed. The polypeptides comprise at least nine contiguous amino acid residues of SEQ ID NO:2 or SEQ ID NO:4, and may be prepared as polypeptide fusions comprise heterologous sequences, such as affinity tags. The polypeptides and polynucleotides encoding them may be used within a variety of therapeutic, diagnostic, and research applications.
    Type: Application
    Filed: May 2, 2002
    Publication date: April 3, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Zeren Gao
  • Four-helical bundle protein zsig81
    Patent number: 6531576
    Abstract: This present invention is directed to polypeptide and polynucleotide molecules that encode a four-helical bundle cytokine. The cytokine has been designated zsig81, and has restricted expression in primarily heart, lung and liver. zsig81 has been shown to stimulate proliferation of hematopoietic cells and will be useful expansion of these cells, as well as conditions associated with hematopoietic cells. The invention is directed to antibodies and methods of making zsig81 polypeptides, as well.
    Type: Grant
    Filed: June 1, 2000
    Date of Patent: March 11, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Christopher S. Piddington, James W. West, Richard D. Holly, Steven K. Burkhead
  • Mammalian cytokine-like factor-7
    Patent number: 6528621
    Abstract: Novel mammalian zcyto7 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.
    Type: Grant
    Filed: July 6, 2000
    Date of Patent: March 4, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Teresa Gilbert
  • Growth factor homolog zvegf3
    Patent number: 6528050
    Abstract: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
    Type: Grant
    Filed: November 6, 2000
    Date of Patent: March 4, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Zeren Gao, Charles E. Hart, Christopher S. Piddington, Paul O. Sheppard, Kimberly E. Shoemaker, Debra G. Gilbertson, James W. West
  • Polynucleotide encoding human serpin
    Patent number: 6524822
    Abstract: Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. The enzymatic activity of the serine proteases is regulated in part by serpins, serine protease inhibitors. Serpin dysfunction is associated with various disorders, including emphysema, blood clotting disorders, cirrhosis, Alzheimer disease, and Parkinson disease. Zserp11 is a new member of the serine protease inhibitor family.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: February 25, 2003
    Assignee: ZymoGenetics, Inc.
    Inventor: James L. Holloway
  • Adipocyte complement related protein homolog zacrp3
    Patent number: 6521233
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zacrp3, a novel member of the family of proteins bearing a collage-like domain and a C1q domain. The polypeptides and polynucleotides encoding them, are involved in dimerization or oligomerization and may be used in the study thereof. The present invention also includes antibodies to the zacrp3 polypeptides.
    Type: Grant
    Filed: April 19, 2000
    Date of Patent: February 18, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Christopher S. Piddington, Paul D. Bishop
  • New member of the human syntaxin/epimorphin family
    Publication number: 20030032778
    Abstract: The syntaxin/epimorphin family comprises members that play central roles in protein transport and epithelial cell morphogenesis. While the syntaxins regulate vesicle-mediated protein transport, epimorphin is a key morphoregulatory molecule for mammary epithelial cells. The present invention provides a new member of the human syntaxin/epimorphin family, designated “Zempo1.
    Type: Application
    Filed: February 26, 2002
    Publication date: February 13, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, David W. Taft
  • Human 2-19 protein homologue, z219a
    Publication number: 20030032792
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for z219a, a novel member of the human 2-19 protein family. The polypeptides, and polynucleotides encoding them, may be used for detecting human chromosomal abnormalities. The present invention also includes antibodies to the z219a polypeptides.
    Type: Application
    Filed: October 26, 2001
    Publication date: February 13, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Hal Blumberg
  • FGF homologs
    Patent number: 6518236
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells, in particular cardiac cells and may be used for remodeling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF5 polypeptides.
    Type: Grant
    Filed: January 13, 1999
    Date of Patent: February 11, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella Raymond, Thomas R. Bukowski, Susan D. Holderman, Birgit Hansen, Paul O. Sheppard
  • Tryptase-like polypeptide ztryp1
    Patent number: 6514741
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for mouse ztryp1, a novel member of the serine protease family of proteins. The polynucleotides encoding mouse ztryp1 can be used to identify a human ortholog or to create a mouse model associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Grant
    Filed: August 9, 2000
    Date of Patent: February 4, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, David W. Taft
  • Interferon-epsilon
    Publication number: 20030013162
    Abstract: Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain autoimmune diseases, the treatment of particular cancers, and the enhancement of the immune response against infectious agents. To date, four types of interferons have been found in humans: interferon-&agr;, interferon-&bgr;, interferon-&ggr;, and interferon-&ohgr;. The present invention provides new forms of human and murine interferon, “interferon-&egr;,” which have applications in diagnosis and therapy.
    Type: Application
    Filed: October 4, 2001
    Publication date: January 16, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, Francis J. Grant, Mark W. Rixon, Wayne Kindsvogel
  • Novel FGF homologs
    Publication number: 20030008351
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for ZFGF5 a novel member of the FGF family. The polypeptides, and polynucleotides encoding them, are proliferative for muscle cells, in particular cardiac cells and may be used for remodeling cardiac tissue and improving cardiac function. The present invention also includes antibodies to the zFGF5 polypeptides.
    Type: Application
    Filed: February 21, 2002
    Publication date: January 9, 2003
    Applicant: ZymoGenetics, Inc.
    Inventors: Theresa A. Deisher, Darrell C. Conklin, Fenella C. Raymond, Thomas R. Bukowski, Susan D. Holderman, Paul O. Sheppard
  • Mammalian cytokine-like factor 7
    Patent number: 6500928
    Abstract: Novel mammalian zcyto7 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.
    Type: Grant
    Filed: July 21, 2000
    Date of Patent: December 31, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Scott R. Presnell, Teresa Gilbert, Theresa Martinez, Ross C. Hoffman