Abstract: A pneumatic tyre includes a tread portion, two axially spaced sidewall portions extending radially inwardly from the tread portion, at least one of the sidewall portions being provided with a side protector that protrudes axially outwardly and having an inner end located radially outwardly of a tyre-maximum-width position, and two axially spaced bead portions connected to radially inward of the respective sidewall portions. Each bead portion includes a bead apex rubber having an outer end in the tyre radial direction being located radially inwardly of the tyre-maximum-width position. A radial length of a tyre inner region from a bead baseline to the outer end of each bead apex rubber is in a range of from 0.8 to 1.2 times a radial length of a tyre outer region from a radially outermost position of the tread portion to the inner end of the side protector.

Abstract: The invention provides for a heavy truck tire having a sub-casing, a belt package and a rubber tread, the tread comprising a center zone separating two shoulder zones. The upper shoulder layer consisting of an upper shoulder rubber compound being different from a lower shoulder rubber compound, wherein: the upper shoulder rubber compound has a G*50 of at least 1.3 Mpa and a max tan(?) of at least 0.12; the lower shoulder rubber compound has a max tan(?) not greater than the max tan(?) of a center rubber compound in the center zone being intended to come into contact with the ground; and the center rubber compound has a max tan(?) of at most 0.09.

Abstract: Devices, systems, and methods for a treating dementia or Alzheimer's disease in a subject in need thereof. In one example, combined auditory and visual stimuli having a frequency of about 20 Hz to about 60 Hz, and more specifically about 40 Hz, are non-invasively delivered to the subject to induce synchronized gamma oscillations in at least one brain region of the subject. In particular, pursuant to various treatment and exposure protocols, combined auditory and visual stimulation (as opposed to auditory or visual stimulation alone) promotes a microglia response in the medial prefrontal cortex (mPFC). More generally, combined auditory and visual stimulation induces an extended microglia clustering response in the auditory cortex, the visual cortex, and the mPFC.

Abstract: A plurality of main grooves extending from a tread center region including a tire equator to ground contact ends so as to be inclined with respect to a tire width direction are provided on a tread section at intervals in a tire circumferential direction. Sub-grooves extending in a direction crossing the tire width direction with a narrower groove width than the main grooves in the tread center region are provided. Tie bars connecting blocks separated by the sub-grooves are provided inside the sub-grooves.

Abstract: An Illumination device (100) for photodynamic therapy is provided, the illumination device comprising at least one electromagnetic radiation emitting unit (10), the at least one electromagnetic radiation emitting unit comprising at least one electromagnetic radiation source (1), the electromagnetic radiation source being configured to generate radiation for the irradiation of a region of an irradiation object in an illumination session, wherein the irradiation object is to be arranged at a predetermined object location (300), wherein the predetermined object location is arranged at a distance relative to a radiation output area (11) of the radiation emitting unit through which the radiation generated by the at least one electromagnetic radiation source exits the radiation emitting unit during operation of the illumination device (100).

Abstract: Systems, methods, and other embodiments associated with characterizing Radio Frequency Ablation (RFA) lesions using Optical Coherence Tomography (OCT) are described. One example method includes acquiring an OCT signal from a Region Of Interest (ROI) in an ablated material. The example method may also include determining whether a lesion was formed by the ablation by analyzing optical properties of the ROI as recorded in the OCT signal.

Abstract: A pneumatic tire comprises a belt layer disposed in the tread portion. The average cord angle ?n and average cord count Nn of the belt layer are constant or gradually increases or decreases from a center position to shoulder positions. The ratio ?ns/?nc of the average cord angle ?ns at the shoulder positions to the average cord angle ?nc at the center position is 1.30 or less. The ratio Nns/Nnc of the average cord count Nns at the shoulder positions to the average cord count Nnc in the center position is 0.77 or more.

Abstract: A device for fusing two or more tissues is disclosed. The device comprises a hand held probe comprising a fluid receiving opening, a channel and an outlet in fluid communication whereby fluid passes through the channel and exits the outlet where it is directed to at least one of the two or more tissues and/or a space in-between. A disruptive emitter, in the form of a laser, is comprised on the probe which emits a force sufficient to fuse the two or more tissues. The device finds particular application to treatment of a detached retina by fusing the retina and the retinal pigmented epithelium. A method of fusing two or more tissues including a retina and underlying retinal pigmented epithelium is also disclosed.

Abstract: A treatment system can include a channel generation system configured to expose an infected region of a target tissue with a laser beam traveling along an optical axis and focused at a focal volume located in or adjacent to the target tissue. The laser beam can have a wavelength ranging from about 100 nm to about 400 nm. The laser beam can be configured to generate at least a first channel in the infected region. The treatment system can also include a detection system configured to detect a first radiation generated by one or more of (i) the target tissue, (ii) a fungi coupled to the infected region in the target tissue, and (iii) an adjacent tissue located proximal to the target tissue as a result of interaction with the laser beam. The treatment system can also include a delivery system configured to deposit an active treatment agent in the at least first channel.

Abstract: The present invention relates to patient monitoring, such as hemodynamic monitoring. In order to perform provide monitoring in various scenarios, a patient monitoring device (10) is provided that comprises a patient medical monitoring unit (12) and an information unit (14). The patient medical monitoring unit is configured to perform monitoring at least one physiological parameter of a patient. The information unit is configured to provide a data carrier signal (16) indicative of information about the patient medical monitoring unit, for example, upon connection to a monitoring system. The data carrier signal is provided as an analogue sequence (18) comprising a predetermined waveform (20) indicative of the information about the patient medical monitoring unit.

Abstract: A system for corneal treatment includes a light source that activates cross-linking in at least one selected region of a cornea treated with a cross-linking agent. The light source delivers photoactivating light to the at least one selected region of the cornea according to a set of parameters. The system includes a controller that receives input relating to the cross-linking agent and the set of parameters. The controller includes computer-readable storage media storing: (A) program instructions for determining cross-linking resulting from reactions involving ROS including at least peroxides, superoxides, and hydroxyl radicals, and (B) program instructions for determining cross-linking from reactions not involving oxygen. The controller executes the program instructions to output a calculated amount of cross-linking in the at least one selected region of the cornea. In response to the calculated amount of cross-linking, the light source adjusts at least one value in the set of parameters.

Abstract: The present disclosure relates to a phototherapy device that can deliver light to tissues to activate photoactive agents that have been applied to the tissues or that are included within a fiber optic tip member of the device which may be coupled to a light source using a sleeve. The present disclosure also relates to methods of phototherapy using the phototherapy device such as anti-bactericidal treatment, anti-fungal treatment, anti-parasitic treatment, anti-viral treatment.

Abstract: A process for the production of a traction or carrying means built up from a plurality of components or assemblies of extruded elastomeric material, wherein, in a first substep, a first component, provided with reinforcing members or cables, of the traction or carrying means is produced and, in further substeps, a traction or carrying means, which is connected to further components or provided with further layers of elastomeric material, fabric layers or reinforcing-member layers, is successively completed, and optionally said traction or carrying means is shaped on one or more sides, wherein the individual substeps follow one another such that a component processed or completed in the respectively preceding substep is fed at room temperature (Rt), after a maximum of 1 to 10 minutes, to the subsequent substep, and such that the temperature of the component does not drop below 30° C. between a respectively preceding substep and the subsequent substep.

Abstract: A portable electronic device includes a battery, a transcutaneous electrical nerve stimulation (TENS) circuit, a power management circuit, a first output unit, and a second output unit. The TENS circuit provides a TENS electrical current. The power management circuit is coupled to the battery and the TENS circuit for managing a power distribution of the portable electronic device. The first output unit receives the TENS electrical current from the TENS circuit and outputs the TENS electrical current to a user. The second output unit receives a power signal from the battery and outputs the power signal to an external electronic device.

Abstract: The pneumatic tire according to the disclosure includes a resin-coated belt comprising a wire coated with a coating resin. A base ring is formed at a tire radial inside of the resin-coated belt, while being in contact with a tire widthwise outer end of the resin-coated belt. A concavo-convex portion is formed on at least one of surfaces of the base ring.

Abstract: An ophthalmological apparatus includes a handle for manually holding and applying the ophthalmological apparatus, fastening abilities for fixing the ophthalmological apparatus at an eye, a light source, and a light projector for the focused projection of light pulses for punctiform tissue breakdown at a focal point in the interior of the eye tissue. The ophthalmological apparatus also includes a movement driver for moving the light projector. The movement of the light projector and therefore that of the focal point with the assistance of the movement driver permits a dimensioning of the optical projection system of the light projector which is substantially smaller than in the case of an ophthalmological apparatus where the focal point is moved exclusively by an optical projection system.

Abstract: At least one of at least one data-dependent scale factor or at least one data-dependent detection threshold is determined responsive to at least one block of time-series data of an auscultatory-sound signal generated by an auscultatory-sound sensor operatively coupled to a portion of the skin of a test-subject, wherein the at least one data-dependent scale factor or at least one data-dependent detection threshold provides a measure of a range of values of the at least one block of time-series data in relation to a predetermined metric, and is used to determine whether or not the auscultatory-sound sensor is either debonded or detached from the skin of the test-subject.

Abstract: The present disclosure is directed to a method of determining a position of a medical instrument. The method may include inserting a first material into a body and adjacent to the medical instrument, analyzing at least one characteristic of the inserted first material, and determining the position of the medical instrument based on the analysis of the at least one characteristic.

Abstract: An apparatus is provided for irradiating at least a portion of a patient's brain with electromagnetic radiation to treat stroke, Parkinson's Disease, Alzheimer's Disease, or depression. The apparatus includes a source of the electromagnetic radiation. The apparatus further includes an output optical element including a rigid and substantially thermally conductive material and a surface configured to be in thermal communication with the patient's body. The apparatus further includes a cooler thermally coupled to the output optical element to remove heat from the output optical element. The apparatus further includes a heat sink thermally coupled to the cooler, wherein the heat sink is positioned so that the electromagnetic radiation from the source propagates through the heat sink and through the output optical element.

Abstract: In a pneumatic tire are defined: a first imaginary line VL1 passing through a ground contact surface in a meridian cross section of a tread, a second imaginary line VL2 passing through a bottom of a shoulder groove and parallel to VL1, an intersection point P between VL2 and a surface of a shoulder land outward of a ground contact edge T in a lateral direction, and an equatorial plane CL. Given A as a distance in the lateral direction between P and CL, B as a groove depth of the shoulder groove, and C as a distance in the lateral direction between T and CL, 0.80?(B+C)/A?1.15 is satisfied. Given Q as a distance in the lateral direction between CL and an end of a belt ply that has a shorter dimension in the lateral direction, 0.75?Q/C?0.95 is satisfied.