Abstract: A therapeutic intubation device may comprise a tube, a first probe channel, a second probe channel, a first probe and a second probe. In various embodiments, a tube may have an elongate body having a proximal end and a distal end. The body may define a first channel between the proximal end and the distal end. A first probe channel may be defined in the body. A second probe channel defined in the body. A first probe may comprise a first body portion and a first end portion, the first end portion comprising a first ultraviolet-c (“UVC”) light emitting device. The first probe may be installable the first probe channel such that the first end portion of the first probe is adjacent the distal end of the tub during operation.

Abstract: A protective ferrule for an end-firing optical fiber arrangement combines a spherical or rounded shape with a planar end. The combination of the spherical or rounded shape and planar end provides protection for the working channel of an endoscope or catheter through which the fiber is inserted while confining and minimizing erosion of the active surface area of the fiber. The protective ferrule of may be fitted to the end of the optical fiber by the steps of heating the ferrule to expand an inside diameter so that it fits over the end of the fiber, with subsequent cooling of the ferrule causing it to contract and create a compression fit.

Abstract: An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.

Abstract: A pneumatic tyre including a tread portion, wherein the tread portion has a groove which is oriented at an angle between +45 and ?45 degrees with respect to the rolling direction of the tyre, the groove having a depth extending in the radial dimension, wherein the groove includes a plurality of protrusions extending along the direction of the groove, wherein each protrusion has a length in the direction of the groove, a width perpendicular to its length and a height. Each protrusion has a length of at least 75% of the circumferential length of the tyre tread.

Abstract: A system for corneal treatment includes a light source that activates cross-linking in at least one selected region of a cornea treated with a cross-linking agent. The light source delivers photoactivating light to the at least one selected region of the cornea according to a set of parameters. The system includes a controller that receives input relating to the cross-linking agent and the set of parameters. The controller includes computer-readable storage media storing: (A) program instructions for determining cross-linking resulting from reactions involving ROS including at least peroxides, superoxides, and hydroxyl radicals, and (B) program instructions for determining cross-linking from reactions not involving oxygen. The controller executes the program instructions to output a calculated amount of cross-linking in the at least one selected region of the cornea. In response to the calculated amount of cross-linking, the light source adjusts at least one value in the set of parameters.

Abstract: A mold system and method for forming a casting article for investment casting is disclosed. The mold system includes a mold for receiving therein a selected core chosen from a plurality of varied cores. The mold includes a plurality of separable mold portions that are coupleable together to create the mold and configured to form a sacrificial material from a sacrificial material fluid about the selected core. At least one selected separable mold portion of the plurality of separable mold portions includes a set of varied interchangeable versions of the at least one selected separable mold portion. Each varied interchangeable version of the selected separable mold portion is configured to accommodate a different core of the plurality of varied cores. A number of systems for controlling a temperature of the mold are also disclosed.

Abstract: Provided are a means to detect a plurality of dynamics, a processing unit that calculates a temporal change in the detected dynamics, and an evaluation device that determines exacerbation of clinical conditions in heart failure of a patient based on the calculated change in the patient's dynamics over time. The present invention makes it possible to detect, early and with high accuracy, that the onset of acute heart failure is imminent.

Abstract: An implantable phototherapy device includes a power receiver element configured to receive power from an external power transmitter, a light delivery element powered by the power receiver, and configured to deliver phototherapy to a target treatment area, and a tether element is coupled to the light delivery element and the power receiver element. The tether element is configured to deliver power between the power receiver element and the light delivery element.

Abstract: A support mechanism for a medical device may include an adjustable support that includes a plurality of elongate members movable relative to one another. The support mechanism may also include a bracket coupled to the adjustable support. The bracket may be adapted to be coupled to a first medical device that extends along a longitudinal axis. The support mechanism may also include an instrument holder that extends along a central axis. The instrument holder may be movably coupled to the bracket and adapted to be coupled to a second medical device. The bracket and the instrument holder may be oriented such that central axis of the instrument holder intersects the longitudinal axis at an angle.

Abstract: A method of enhancing penetration of a topical composition of 5-aminolevulinic acid (ALA) into tissue for photodynamic therapy includes topically applying ALA to a treatment area to be treated with photodynamic therapy. The method further includes, after the ALA is applied to the treatment area, covering the treatment area with a low density polyethylene barrier. The treatment area is covered with the low density polyethylene barrier prior to light treatment to minimize transepidermal water loss from the treatment area.

Abstract: A tire includes an outboard tread edge and an inboard tread edge to be located on an outboard side and an inboard side of a vehicle, respectively, circumferentially and continuously extending main grooves, and land portions divided by the main grooves. The land portions include an outboard shoulder land portion, an outboard middle land portion, an inboard shoulder land portion, and an inboard middle land portion. Each of the outboard shoulder land portion, the inboard shoulder land portion, and the inboard middle land portion is provided with axially extending lateral grooves. The outboard middle land portion is provided with outboard middle lateral grooves extending from an edge of the outboard middle land portion on the outboard tread edge side toward the inboard tread edge. The outboard middle lateral grooves are inclined with respect to a tire circumferential direction at angles smaller than those of the lateral grooves.

Abstract: Systems and methods for a laser-assisted topical treatment of nail fungal infections are provided. The laser-assisted topical treatment includes a laser that is configured to output a beam that penetrates the infected nail and creates a channel therethrough. The laser-assisted topical treatment further includes a treatment agent comprising a vehicle and a drug. The treatment agent is applied to an exterior surface of the infected nail so that the treatment agent may flow into the channel.

Abstract: A heavy truck tire tread (2) having a longitudinal direction (LgD), a lateral direction (LtD), a tread depth direction (TdD), a ground contact surface (CS) and a pair of opposing tread shoulders (3, 4) spaced apart along the lateral direction is provided. The tread has a shoulder zone (SZ, SZ?) adjacent each tread shoulder of the pair of opposing tread shoulders, the shoulder zones consisting of blocks (5, 6) adjacent to each other along the longitudinal direction and separated by lateral grooves (7, 8). A center zone (CZ) is defined between the shoulder zones. The center zone is decoupled from both shoulder zones by at least one longitudinal sipe (11) or groove, and each lateral groove (7) in a shoulder zone (SZ) is directly connected to an opposite lateral groove (8) in the opposite shoulder zone (SZ?) by a lateral sipe (10) of the center rib.

Abstract: The present invention relates to the use of light-emitting, water soluble nanoparticles in the treatment of disorders of the central nervous system.

Abstract: A system for treating and/or monitoring a patient includes a patient physiological parameter monitoring patch and a companion device. The patient physiological parameter monitoring patch including an energy harvesting module, an energy storage module, a sensor module and a communication module. The energy harvesting module harvesting energy from one or more ambient sources, the energy being storable in the energy storage module and usable by one or more components of the patient physiological parameter monitoring patch. The sensor module senses one or more physiological parameters of the patient and the communication module can transmit the sensed data. The companion device can receive the sensed physiological parameters and can send the same to a remote device or store the same.

Abstract: A tread block arrangement suitable for a tire or for a tread band for a tire. The tread block arrangement comprises a tread block that limits a first primary sipe. The first primary sipe comprises at least a first deep part and a second deep part separated from the first deep part by a first shallow part. A depth of the first deep part is at least three times a depth of the first shallow part and a depth of the second deep part is at least three times the depth of the first shallow part. The first deep part is limited in a longitudinal direction of the first primary sipe by a primary first end wall and a secondary first end wall such that a first angle between the primary first end wall and the secondary first end wall is from 1 degree to 30 degrees.

Abstract: An implantable active medical device system includes an active medical device and a lead extending between a proximal portion electrically coupled to the active medical device and a distal end portion configured to emit light. The distal end portion includes a solid state light source disposed within a light transmissive ring element. The light transmissive ring element forms an exterior segment of the distal end portion. The light transmissive ring element defines at least a portion of a hermetic cavity.

Abstract: The LEDs in a phototherapy LED pad are controlled so that the intensity of the light varies in accordance with a sinusoidal function, thereby eliminating the harmonics that are generated when the LEDs are pulsed digitally. This is accomplished analogically by using a sinusoidal wave to control the gate of a MOSFET connected in series with the LEDs or by using a digital-to-analog converter to control the gate of the MOSFET with a stair step function representative of the values of a sinusoidal function at predetermined intervals. Alternatively, pulse-width modulation is used to control the gate of the MOSFET in such a way that the average current through the LEDs simulates a sinusoidal function. In additional to using a simple sine wave function, the LED current may also be controlled in accordance with “chords” containing multiple sine waves of different frequencies.

Abstract: A photo-treatment device includes a non-opaque treatment substrate and a radiation-collector beside the substrate. The substrate is sized for a person at which radiation is to be emitted from above the substrate. The substrate has a front surface for receiving the person thereon and a back surface. The radiation-collector captures excess radiation peripheral to the substrate and redirects the excess radiation to the back surface of the substrate.

Abstract: A pneumatic tire includes a land portion having a circumferential direction sipe extending in a direction inclined with respect to the tire circumferential direction, a partial land portion positioned on at least one of the land portion partitioned with the circumferential direction sipe, and a plurality of cross sipes extending in a direction intersecting with the circumferential direction sipe in the partial land portion. The partial land portion includes a wide end portion and a narrow end portion. The plurality of cross sipes include a wide portion sipe located closest to a wide end of the partial land portion, and a narrow portion sipe located closest to a narrow end of the partial land portion. The wide portion sipe has a distal end positioned in a sipe projection portion, and the narrow portion sipe has a distal end positioned in a non-sipe projection portion.