Patents Examined by Alma Pipic
  • Patent number: 10722609
    Abstract: The present invention relates to a method that includes providing a formulation having an isocyanate-functional prepolymer and a curing component comprising an amino-functional aspartic ester of the general formula (I) applying the formulation to a cell tissue; and curing the formulation such that the loss of blood (haemostatic) or tissue fluids is staunched or leaks in cell tissues are sealed.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: July 28, 2020
    Assignee: Adhesys Medical GmbH
    Inventors: Heike Heckroth, Burkhard Köhler, Sebastian Dörr
  • Patent number: 10711106
    Abstract: The present invention features linear and three-dimensional supramolecular materials self-assembled from block co-polymers comprising oligo(ethylene sulfide) (OES). The block copolymers assemble into fibrils, micelles, or matrices. The fibrillar materials are sensitive to oxidation, which leads to decreased OES block hydrophobicity and crystallinity, and increased water solubility of the polymer constituents. Molecular loading options, coupled with oxidative sensitivity, allow implantable or injectable fibrillar suspensions or cross-linked three-dimensional matrices to demonstrate significant biomedical potential, especially in the context of extracellular and intracellular molecular delivery and applications related to infection and disease.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: July 14, 2020
    Assignee: The University of Chicago
    Inventors: Jeffrey A. Hubbell, Carrie E. Brubaker, Diana Velluto
  • Patent number: 10709791
    Abstract: Polymeric carriers for the delivery of therapeutic agents and methods for making and using the same. The polymeric carriers include copolymers, diblock copolymers, polymeric architectures that include the copolymers and diblock copolymers, and particles assemblies comprising the copolymers, diblock copolymers, and polymeric architectures that include the copolymers.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: July 14, 2020
    Assignee: University of Washington
    Inventors: Patrick S. Stayton, Anthony J. Convertine, Daniel M. Ratner, Debobrato Das, Selvi Srinivasan
  • Patent number: 10709717
    Abstract: There is provided a polymer comprising: (i) a repeat unit derived from a compound of formula (I) (Formula (I)) wherein, R1 and R2 are each independently selected from OH, OR?, SH, SR?, NH2, NHR? and NR?2; R? is C1-20 hydrocarbyl; each n is independently 0 or an integer between 1 and 6; each m is independently 0 or an integer between 1 and 4, and preferably at least one m is 1; and q is an integer between 1 and 8; and; (ii) a biologically active molecule, wherein said biologically active molecule is covalently bonded to said repeat unit; as well as methods for preparing such polymers, particles comprising said polymers and uses of said polymers and particles including use in the treatment of disease.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: July 14, 2020
    Assignee: SPIREA LIMITED
    Inventors: Myriam Marie Ouberai, Mark Welland
  • Patent number: 10687530
    Abstract: Techniques regarding ionene and/or polyionene compositions with antimicrobial functionality and enhanced hydrophilicity are provided. For example, one or more embodiments can regard a chemical compound that can comprise an ionene unit, which can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. The ionene unit can have antimicrobial functionality. Further, the chemical compound can comprise a hydrophilic functional group covalently bonded to the ionene unit. Also, the chemical compound can have carbohydrate mimetic functionality.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: June 23, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Yi Yan Yang, Mu San Zhang
  • Patent number: 10687528
    Abstract: Techniques regarding ionene and/or polyionene compositions with antimicrobial functionalities are provided. For example, one or more embodiments can comprise a chemical compound, which can comprise an ionene unit. The ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a norspermidine structure having a carbonyl group. Also, the ionene unit can have antimicrobial functionality.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: June 23, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Chuan Yang, Yi Yan Yang
  • Patent number: 10688071
    Abstract: The present invention relates to a novel oil in water emulsion aerosol foam composition containing an active agent for the treatment of various chronic and acute skin conditions, particularly acne and psoriasis; and processes for preparing the emulsion aerosol foam compositions. In particular, the present invention relates to oil in water emulsion aerosol foam compositions containing a retinoid in the oil phase.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: June 23, 2020
    Assignee: MAYNE PHARMA LLC
    Inventor: Leon Loupenok
  • Patent number: 10682313
    Abstract: The subject matter of this invention relates to block copolymers (BCPs) and, more particularly, to block copolymers capable of self-assembly into nanoparticles for the delivery of hydrophobic cargos. The BCPs include a hydrophobic block that contains a thioether functional group that is susceptible to oxidation, transforming the solubility of the block from hydrophobic to hydrophilic, thereby releasing the hydrophobic cargo of the nanoparticle.
    Type: Grant
    Filed: June 25, 2019
    Date of Patent: June 16, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, INSTITUTE OF BIOENGINEERING AND NANOTECHNOLOGY, BIOMEDICAL SCIENCES INSTITUTE
    Inventors: Dylan Boday, Willy Chin, Mareva B. Fevre, Jeannette Garcia, James L. Hedrick, Eunice Leong, Nathaniel H. Park, Rudy J. Wojtecki, Yi Yan Yang
  • Patent number: 10667514
    Abstract: Techniques regarding amine monomers that can form ionene compositions with antimicrobial functionality are provided. For example, one or more embodiments described herein can comprise a monomer, which can comprise a molecular backbone. The molecular backbone can comprise a norspermidine structure. The norspermidine structure can comprise a tertiary amino group. Also, the tertiary amino group can comprise a functional group, and an amino group of the norspermidine structure can be capable of being ionized.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: June 2, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Chuan Yang, Yi Yan Yang
  • Patent number: 10653813
    Abstract: Described herein is the synthesis of reinforced adhesive complex coacervates and their use thereof. The reinforced adhesive complex coacervates are composed of (a) at least one polycation, (b) at least one polyanion, and (c) a reinforcing component. The adhesive complex coacervates described herein can be subsequently cured to produce strong, cohesive adhesives. The reinforced adhesive complex coacervates have several desirable features when compared to conventional adhesives. The reinforced adhesive complex coacervates are effective in wet or underwater applications. The reinforced adhesive complex coacervates described herein, being phase separated from water, can be applied underwater without dissolving or dispersing into the water. The reinforced adhesive complex coacervates have numerous biological applications as bioadhesives and bioactive delivery devices.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: May 19, 2020
    Assignee: University of Utah Research Foundation
    Inventor: Russell J. Stewart
  • Patent number: 10653142
    Abstract: Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: May 19, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Chuan Yang, Yi Yan Yang
  • Patent number: 10632101
    Abstract: A composition for supporting endogenous systems related to life span, inhibiting mTOR, and reducing damage associated with oxidative phosphorylation. The composition comprises an upregulating compound mixture configured to upregulate an endogenous antioxidant system, an exogenous antioxidant mixture configured to inhibit oxidation of biomolecules by reactive oxygen species, and a mineral mixture configured to provide one or more cofactors to a endogenous antioxidant enzyme. The endogenous antioxidant system includes regulation of mitophagy through mTOR mediated regulation, and a Nrf2 transcription factors that promotes transcription of antioxidant genes.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: April 28, 2020
    Assignee: USANA Health Sciences, Inc.
    Inventors: Mark Brown, John Cuomo, Jeremy Tian
  • Patent number: 10603274
    Abstract: A solid matrix sustained release ophthalmic formulation for topical delivery of a solid ophthalmic drug to the eye, medical devices, drug cores, drug inserts and drug delivery systems comprising the formulation, methods of manufacturing the formulation, medical devices and their methods thereof for delivering the ophthalmic drug for a treatment period provided herein. The formulation disclosed herein is an admixture of an ophthalmic drug, and a combination of a hydrophobic polymer, a hydrophilic polymer and a surfactant, wherein the drug is eluted daily over an extended period of time at therapeutic dose of drug.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: March 31, 2020
    Assignee: Mati Therapeutics Inc.
    Inventors: Deepank Utkhede, Catherine Jones, David Wiseman
  • Patent number: 10595527
    Abstract: Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: March 24, 2020
    Assignee: International Business Machines Corporation
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Yi Yan Yang
  • Patent number: 10568859
    Abstract: The present invention relates to a novel oil in water emulsion aerosol foam composition containing an active agent for the treatment of various chronic and acute skin conditions, particularly acne and psoriasis; and processes for preparing the emulsion aerosol foam compositions. In particular, the present invention relates to oil in water emulsion aerosol foam compositions containing a retinoid in the oil phase.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: February 25, 2020
    Assignee: MAYNE PHARMA LLC
    Inventor: Leon Loupenok
  • Patent number: 10563025
    Abstract: A polymer film has an average film thickness T0 along a straight line D passing through the center of gravity of a two-dimensional projection such that the area of the polymer film is maximized, satisfies equation (a), the average value L of distances 1 from the center of gravity to edges satisfies equation (b), the Young's modulus E satisfies equation (c), and the thickness deviation ? defined by equation (d) satisfies equation (e); and a dispersion liquid and an agglomerate using the same. (a) 10 nm?T0?1000 nm, (b) 0.1 ?m?L?500 ?m, (c) 0.01 GPa?E?4.3 GPa, (d) ?=1?T1/T2, (e) 0.346E×10?9?1.499<?<?0.073E×10?9+0.316.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: February 18, 2020
    Assignees: Toray Industries, Inc., Nanotheta Co, Ltd.
    Inventors: Motonori Hochi, Yuki Sekido, Ichiro Itagaki, Toru Arakane, Shinya Ohtsubo, Shinji Takeoka, Atsushi Murata, Mao Fujii, Yuya Ishizuka, Shuichi Shoji, Jun Mizuno, Takashi Kasahara
  • Patent number: 10555939
    Abstract: Pharmaceutical compositions and single unit dosage forms of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione, or a pharmaceutically acceptable stereoisomer, prodrug, salt, solvate, hydrate, or clathrate, are provided herein. Also provided are methods of treating, managing, or preventing various disorders, such as cancer or an inflammatory disease.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: February 11, 2020
    Assignee: Celgene Corporation
    Inventors: Anthony J. Tutino, Michael T. Kelly
  • Patent number: 10525141
    Abstract: It is provided a polyglycerol derivative, comprising a dendritic polyglycerol backbone and at least one substituent in the nature of a covalently bound negatively charged group chosen from the group consisting of sulfates, sulfonates, phosphates, phosphonates, bisphosphonates, carboxylates and combinations thereof. The substituent is bound to the polyglycerol backbone via a linker, the linker being chosen from the group consisting of moieties being or comprising a carbamate group, an ester group, an orthoester group, an amide group, a disulfide bridge group, an acetal group, an imine group and combinations thereof.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: January 7, 2020
    Assignee: FREIE UNIVERSITÄT BERLIN
    Inventors: Rainer Haag, Sabine Reimann, Jens Dernedde
  • Patent number: 10518114
    Abstract: An oral care composition and method are described in which the composition includes a film or a plurality of film fragments entrained in a carrier. The film or plurality of film fragments comprises zinc oxide. The composition and methods provide benefits including increased stability and shelf-life ensuring the delivery and bioavailability of zinc oxide.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: December 31, 2019
    Assignee: Colgate-Palmolive Company
    Inventors: Paloma Pimenta, Shira Pilch, James Masters, Betty Won
  • Patent number: 10517988
    Abstract: Provided is tunable biopolymer hydrogel produced from two processed natural polysaccharides for use as a hemostat. If desired, the hydrogel formation can be tuned so that the hydrogel forms within seconds when applied to a tissue lesion. The resulting hydrogel can adhere to tissue and, without swelling, produce hemostasis within seconds after application to tissue of interest. The hydrogel also captures, aggregates and concentrates platelets and red blood cells at the site of the tissue lesion thereby initiating a clotting cascade at the site of the lesion. The hemostat can be used to prevent blood loss during surgical procedures, for example, during brain, spine or other surgical procedures where hemostasis is desirable, and is particularly useful during surgical procedures where swelling of the hemostat (e.g., in the brain or spine) would be detrimental to the subject.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: December 31, 2019
    Assignee: Endomedix, Inc.
    Inventors: Piyush Modak, Malavika Nadig, Richard Russo