Patents Examined by Alma Pipic
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Patent number: 11760823Abstract: The invention relates in general to hydrophilic, biocompatible dendronised polymers, to complexes comprising the dendronised polymers, to methods of preparing the dendronised polymer and to uses of the dendronised polymer as a non-viral transfection agent for the delivery of biomolecules, in particular, genome editing tools, into a cell.Type: GrantFiled: September 12, 2018Date of Patent: September 19, 2023Assignee: The University of Western AustraliaInventors: Killugudi Swaminatha Iyer, Marck Norret, Jessica Kretzmann, Diwei Ho
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Patent number: 11752235Abstract: Wound dressing compositions comprising of a bioresorbable sponge encapsulated within a polysaccharide envelope. The bioresorbable sponge is preferably comprised of collagen and oxidised regenerated cellulose. The outer polysaccharide envelope is preferably comprised of chitosan. The outer polysaccharide envelope functions to modulate the rate at which the bioresorbable sponge breaks down within a wound.Type: GrantFiled: August 14, 2017Date of Patent: September 12, 2023Assignee: KCI Licensing, Inc.Inventors: Craig Delury, Alexander Waite
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Patent number: 11752077Abstract: This oily moisturizer is composed of either an esterified product of a component A that is ditrimethylolpropane, and a component B that is one fatty acid, or two or more fatty acids, selected from among saturated fatty acids of 6 to 12 carbon atoms, or an esterified product of the component A, the component B, and a component C that is one fatty acid, or two or more fatty acids, selected from among fatty acids of 13 to 28 carbon atoms, wherein the hydroxyl value of the esterified product is not more than 140 mgKOH/g, and the mass ratio between fatty acid residues derived from the component B and fatty acid residues derived from the component C within the fatty acid residues that constitute the esterified product of the component A, the component B and the component C is within a range from 99.9:0.1 to 60:40.Type: GrantFiled: November 22, 2019Date of Patent: September 12, 2023Assignee: THE NISSHIN OILLIO GROUP, LTD.Inventors: Hirofumi Denda, Tadashiro Hirose, Hisanori Kachi
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Patent number: 11744748Abstract: The present disclosure relates to absorbent garments having a dryness layer that can comprise one or more laminates and one or more channels to facilitate liquid acquisition and retention. Laminate(s) can include an absorbent lamina disposed between substrate laminae, each comprising tissue and/or a nonwoven. Some dryness layers can have a folded laminate that defines a longitudinally-extending channel. Some dryness layers can have two or more laminate strips that are laterally spaced apart along a width of the dryness layer such that one or more longitudinally-extending channels are defined therebetween.Type: GrantFiled: May 28, 2019Date of Patent: September 5, 2023Assignee: ATTENDS HEALTHCARE PRODUCTS, INC.Inventors: Harry Chmielewski, Michael Kalmon, Matthew Ashcraft, Paul Ducker
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Patent number: 11738091Abstract: A combination therapy involving different therapeutic molecules can enhance and improve the therapeutic potentials. An effective therapeutic strategy conjugates silica (SiO2) nanoparticles with, e.g., 3-glycidyloxypropyl, trimethoxysilane and azoles, e.g., 1,2,4-triazole (Tri), 3-aminotriazole (ATri), 5-aminetetrazole (Atet), imidazole (Imi). These exemplary materials—classified as SiO2-3GPS-Tri (Conj. 1), SiO2-3GPS-Atri (Conj. 2), SiO2-3GPS-Atet (Conj. 3), SiO2-3GPS-Btri (Conj. 4), and SiO2-3GPS-Imi (Conj. 5)—can amplify targeting of therepeutics for human colorectal carcinoma cells (HCT-116), enhancing anti-cancer effects.Type: GrantFiled: November 17, 2022Date of Patent: August 29, 2023Assignee: Imam Abdulrahman Bin Faisal UniversityInventors: Sarah Mousa Asiri, Firdos Alam Khan, Ayhan Bozkurt
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Patent number: 11738113Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.Type: GrantFiled: November 6, 2022Date of Patent: August 29, 2023Assignee: 3-D Matrix, Ltd.Inventors: Marika G. Rioult, Eun Seok Gil, Elton Aleksi, Naoki Yamamoto
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Patent number: 11738114Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.Type: GrantFiled: December 2, 2022Date of Patent: August 29, 2023Assignee: 3-D Matrix, Ltd.Inventors: Marika G. Rioult, Eun Seok Gil, Elton Aleksi, Naoki Yamamoto
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Patent number: 11732139Abstract: There is provided a method for decreasing leakage of matter from an object to a surrounding, said object being coated with a coating at least partially applied on the object, said coating comprising an at least partially covering layer comprising silver, said object optionally comprising area(s) without said layer, said coating comprising metal particles applied on the layer and optionally on areas without said layer, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, niobium, neodymium and platinum and wherein the amount of the metal particles is in the interval 0.01-8 ?g/cm2. Advantages include that leakage of matter such as latex allergens of metal ions can be reduced while the coating is both biocompatible and antimicrobial. Further, the blood clotting can be reduced.Type: GrantFiled: April 24, 2019Date of Patent: August 22, 2023Assignee: BACTIGUARD ABInventors: Billy Södervall, Javier Sanchez
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Patent number: 11730479Abstract: The present invention is directed to a nerve regeneration conduit including a resorbable tube having a matrix therein. The matrix is characterized by substantially parallel, axially aligned pores extending the length of the matrix. The matrix is formed by the axial freezing of a slurry having little or no significant radial thermal gradient during the freezing process. The matrix is used to bridge the gap between the severed ends of a nerve and provide a scaffold for nerve regeneration.Type: GrantFiled: November 8, 2021Date of Patent: August 22, 2023Assignee: Integra LifeSciences CorporationInventors: Simon J. Archibald, Fergal O'Brien, Amos Matsiko
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Patent number: 11723363Abstract: Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.Type: GrantFiled: June 1, 2021Date of Patent: August 15, 2023Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Chuan Yang, Yi Yan Yang
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Patent number: 11701335Abstract: Methods of normalizing amino acid metabolism in subjects on restricted protein diets and supplemental amino acids, using specially formulated amino acids that mimic the absorption and metabolism of naturally occurring proteins, are described.Type: GrantFiled: August 16, 2019Date of Patent: July 18, 2023Assignee: APR Applied Pharma Research s.a.Inventors: Alberto Reiner, Giorgio Reiner
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Patent number: 11701325Abstract: A stable liquid formulation is provided. The liquid formulation includes a composition of active ingredients paeonol and apocynin. Methods of production of such a formation and treatment of diseases administering such a formulation are also provided.Type: GrantFiled: November 22, 2018Date of Patent: July 18, 2023Assignee: AKL RESEARCH & DEVELOPMENT LTDInventor: Nicholas John Larkins
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Patent number: 11696885Abstract: The invention relates to a dispersion containing at least one rhamnolipid derivative and also to the use of the rhamnolipid derivatives as emulsifier or dispersing aid.Type: GrantFiled: August 14, 2018Date of Patent: July 11, 2023Assignee: Evonik Operations GmbHInventors: Xin Lu, Sandra Nattland, Achim Friedrich, Hans Henning Wenk
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Preventative mannose therapy and treatment of viral infections using mannose-containing compositions
Patent number: 11672822Abstract: Methods and compositions are provided for preventing and/or treating infection by disrupting interactions at or near the surface of mannosylated pathogens or other pathogens exhibiting carbohydrate-carbohydrate self-interaction, thus enhancing the immune system's ability to recognize and destroy such pathogens. In some forms, carrier molecules are provided to delivering polymers or other molecules capable of disrupting intra-cellular interaction and/or self-interaction of surface markers on cells.Type: GrantFiled: December 1, 2017Date of Patent: June 13, 2023Assignee: HOWARD UNIVERSITYInventor: Preethi Chandran -
Patent number: 11666682Abstract: A method and kit for stopping cerebrospinal fluid (CSF) leaks, comprising penetrating and passing through a dural tissue an applicator to access an interior dural space, injecting from the applicator a fibrinogen-containing solution into said dural space, applying a sealing member containing a fibrinogen polymerizing agent onto an exterior surface of the dural tissue, and forming a polymerized fibrinogen or polymerized fibrin clot by contacting the injected fibrinogen-containing solution and the fibrinogen polymerizing agent.Type: GrantFiled: August 31, 2020Date of Patent: June 6, 2023Assignee: Ethicon, Inc.Inventors: Ashley Deanglis, Salim Ghodbane, Kevin Shaun Weadock
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Patent number: 11660349Abstract: Non-linear multiblock copolymer-drug conjugates for the treatment and prevention of diseases and disorders of the eye are provided. The polymer-drug conjugates can form nanoparticles, microparticles, and implants that are capable of effectively delivering therapeutic levels of one or more active agents for an extended period of time. Administration to the eye of an active agent in the form of a non-linear multiblock copolymer-drug conjugate produces decreased side effects when compared to administration of the active agent alone. Also provided are methods of treating intraocular neovascular diseases, such as wet age-related macular degeneration as well as diseases and disorders of the eye associated with inflammation, such as uveitis.Type: GrantFiled: February 24, 2021Date of Patent: May 30, 2023Assignee: THE JOHNS HOPKINS UNIVERSITYInventors: Jie Fu, Peter A. Campochiaro, Justin Scot Hanes
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Patent number: 11643509Abstract: The invention relates to a hydrogel product comprising glycosaminoglycan molecules as the swellable polymer, wherein the glycosaminoglycan molecules are covalently crosslinked via crosslinks comprising a spacer group selected from the group consisting of di-, tri-, tetra-, and oligosaccharides.Type: GrantFiled: November 29, 2022Date of Patent: May 9, 2023Assignee: Galderma Holding SAInventors: Hotan Mojarradi, Johan Olsson, Craig Steven Harris, Jean-Guy Boiteau, Thibaut Gerfaud, Loïc Tomas
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Patent number: 11617367Abstract: Techniques regarding chemical compounds with antimicrobial functionality are provided. For example, one or more embodiments describe herein can comprise a monomer that can comprise a molecular backbone. The molecular backbone can comprise a bis(urea)guanidinium structure covalently bonded to a functional group, which can comprise a radical. Also, the monomer can have supramolecular assembly functionality.Type: GrantFiled: March 29, 2021Date of Patent: April 4, 2023Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: James L. Hedrick, Mareva B. Fevre, Nathaniel H. Park, Victoria A. Piunova, Yi Yan Yang, Pang Kern Jeremy Tan
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Patent number: 11617712Abstract: The present disclosure provides pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. In particular, the pharmaceutical compositions comprise at least one pharmaceutically active ingredient, at least one non-cellulose polysaccharide, at least one hydrophilic gelling polymer, and an effervescent system.Type: GrantFiled: July 1, 2015Date of Patent: April 4, 2023Assignee: SpecGX LLCInventors: Alex Micka, Kai Feng, Tsz Chung Lai, Jonathan Gaik
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Patent number: 11607394Abstract: The present invention provides a rotigotine-containing patch comprising: a backing layer; and an adhesive agent layer, wherein the adhesive agent layer contains rotigotine and/or a pharmaceutically acceptable salt thereof, the adhesive agent layer further contains a styrene-based thermoplastic elastomer, a petroleum-based resin and/or a terpene-based resin, an aliphatic alcohol, and a cross-linked polyvinylpyrrolidone, and in the adhesive agent layer, a mass ratio of a content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form and a content of the cross-linked polyvinylpyrrolidone (content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form:content of the cross-linked polyvinylpyrrolidone) is 10:3 to 1:3.Type: GrantFiled: December 14, 2018Date of Patent: March 21, 2023Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Hiroyuki Araki, Yuka Takagi, Yoko Fujiwara, Hiroaki Kobayashi, Takao Kurokawa