Abstract: Disclosed are: a polymer for treating the surface of a medical device such as a contact lens to suppress the reduction in lubricity of the device even when the device is scrubbed; a medical device having the polymer on the surface so that the reduction in lubricity over time is suppressed; and a wetting agent containing the polymer. The polymer for treating the surface is a copolymer which is water-soluble and includes as constitutional units the following monomers A and B: monomer A: a monomer containing a (meth)acryloyl group and an ester or amide structure in a molecule, in which the ester or amide structure is not constituted by including a part of the (meth)acryloyl group; monomer B: a monomer containing a (meth)acrylamide group in a molecule and having a structure different from that of the monomer A.
Abstract: The present disclosure provides pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. In particular, the pharmaceutical compositions comprise at least one pharmaceutically active ingredient, at least one non-cellulose polysaccharide, at least one hydrophilic gelling polymer, and an effervescent system.
Type:
Grant
Filed:
August 11, 2020
Date of Patent:
February 21, 2023
Assignee:
SpecGX LLC
Inventors:
Alex Micka, Kai Feng, Tsz Chung Lai, Jonathan Gaik
Abstract: The present invention relates to a methods for producing bio-oils from vegetation high in lignin. The invention further relates to antimicrobial compositions comprising bio-oil extracted from vegetation high in lignin.
Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self-assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.
Abstract: A condom apparatus including at least one of a condom containing a compound of Formula 1 wherein the condom is configured to deliver one or more active ingredients selected from the group consisting of arginine, a vasodilator, nitrates, an ergot alkaloid, a long acting alpha-adrenoceptor blocker, a short acting alpha-adrenoceptor blocker, an anti-hypertensive, a prostaglandin, and a phosphodiesterase inhibitor is disclosed.
Type:
Grant
Filed:
November 9, 2020
Date of Patent:
December 20, 2022
Assignee:
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
Abstract: The present disclosure generally provides complexes including a pharmaceutically active agent and a functionalized polymer, wherein the functionalized polymer includes repeat units, the repeat units including ionizable repeat units having at least one ionizable side group and/or ionizable end group, a plurality of the at least one ionizable groups forming non-covalent bonds with the pharmaceutically active agent. Polymers which may be used to form such complexes as well as methods of making and using the complexes and related compositions are also provided.
Type:
Grant
Filed:
July 21, 2020
Date of Patent:
December 20, 2022
Assignee:
DURECT CORPORATION
Inventors:
Michael Sekar, Felix Theeuwes, Keith Edward Branham, John W Gibson, James Matriano, Whitney Moro, John Tipton, William Van Osdol, Su Il Yum
Abstract: The invention relates to a hydrogel product comprising glycosaminoglycan molecules as the swellable polymer, wherein the glycosaminoglycan molecules are covalently crosslinked via crosslinks comprising a spacer group selected from the group consisting of di-, tri-, tetra-, and oligosaccharides.
Type:
Grant
Filed:
December 28, 2016
Date of Patent:
December 20, 2022
Assignee:
Galderma Holding SA
Inventors:
Hotan Mojarradi, Johan Olsson, Craig Steven Harris, Jean-Guy Boiteau, Thibaut Gerfaud, Loïc Tomas
Abstract: Techniques regarding killing of a pathogen with one or more ionene compositions having antimicrobial functionality are provided. For example, one or more embodiments can comprise a method, which can comprise contacting a Mycobacterium tuberculosis microbe with a chemical compound. The chemical compound can comprise an ionene unit. Also, the ionene unit can comprise a cation distributed along a molecular backbone. The ionene unit can have antimicrobial functionality. The method can further comprise electrostatically disrupting a membrane of the Mycobacterium tuberculosis microbe in response to the contacting.
Type:
Grant
Filed:
October 16, 2020
Date of Patent:
December 13, 2022
Assignees:
INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventors:
Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Chuan Yang, Yi Yan Yang
Abstract: The present disclosure provides pharmaceutical compositions that provide immediate release of active ingredients and have abuse deterrent properties. In particular, the pharmaceutical compositions comprise at least one pharmaceutically active ingredient, at least one non-cellulose polysaccharide, at least one hydrophilic gelling polymer, and an effervescent system.
Type:
Grant
Filed:
June 7, 2018
Date of Patent:
December 6, 2022
Assignee:
SpecGX LLC
Inventors:
Alex Micka, Kai Feng, Tsz Chung Lai, Jonathan Gaik
Abstract: The present invention relates to the use of spray-dried sorbitol, such as Parteck® SI, as plasticizer for polymer containing compositions processed by (hot) melt extrusion. Due to its improved properties, achieved by its special manufacturing process (spray drying), this direct compressible excipient shows more additional benefits than the same substance in crystalline state.
Type:
Grant
Filed:
May 10, 2017
Date of Patent:
November 29, 2022
Assignee:
MERCK PATENT GMBH
Inventors:
Dieter Lubda, Mengyao Zheng, Alessandro Giuseppe Elia, Nicole Di Gallo
Abstract: Pesticidal compositions are provided that include at least one pesticidal active ingredient and benzyl alcohol. Adjuvant compositions and associated methods are provided for use with at least one pesticidal active ingredient that include benzyl alcohol.
Type:
Grant
Filed:
May 10, 2021
Date of Patent:
November 22, 2022
Assignee:
GJB APPLIED TECHNOLOGIES, INC.
Inventors:
James Holt LeFiles, Paul Andrew Patterson
Abstract: The invention relates to an adhesive composition having a main fraction of synthetic tackifying resin, and a fraction of at least one macromolecular component, characterised in that said at least one macromolecular component comprises a copolymer of at least two different monomers taken from the alpha olefins and ethylene, to give the composition for strip-free hair removal mechanical or adhesive properties.
Abstract: Disclosed herein are methods for modifying a substrate having a hydrophobic surface. Also disclosed are modified hydrophobic substrates. The modified hydrophobic substrates and methods disclosed herein advantageously improve cell affinity and antithrombogenicity of hydrophobic surfaces.
Abstract: This invention relates to a bone regeneration product comprising at least one stem cell, at least one scaffold, and at least one stem cell. The stem cells suitable for this invention may comprise stem cells suitable for a dense bone regeneration, stem cells suitable for a spongy bone regeneration, or a combination thereof. The bone regeneration product may further comprise a growth factor. This invention also relates to a bone regeneration method and treatment of any bone that has a critical size defect. This invention also relates to a scaffold. This invention further relates to a 3D printed scaffold comprising hydroxyapatite (HA) and tricalcium phosphate (TCP). This invention also relates to a scaffold comprising a polymer. The polymer of this invention may be prepared by using photocurable polymers and/or monomers. The scaffold of this invention may comprise a growth factor and a small molecule. The small molecule N may be a Smurf1 inhibitor.
Type:
Grant
Filed:
November 8, 2018
Date of Patent:
November 1, 2022
Assignee:
ALFRED E. MANN INSTITUTE FOR BIOMEDICAL ENGINEERING AT THE UNIVERSITY OF SOUTHERN CALIFORNIA
Inventors:
Yang Chai, Yong Chen, Yuan Yuan, Yuxing Guo, Xiangjia Li, Zoe Johnson
Abstract: A composition for the delivery of a nucleic acid compound is provided which comprises a cationic peptide or polymer and a lipidoid compound. The nucleic acid compound may be any chemically modified or unmodified DNA or RNA. The amount of the lipidoid in the composition is preferably low, relative to the cationic peptide or polymer.
Type:
Grant
Filed:
June 9, 2017
Date of Patent:
October 25, 2022
Assignee:
CureVac AG
Inventors:
Patrick Baumhof, Carolin Thiele, Joanna Rejman
Abstract: Cosmetic process for treating keratin fibres, comprising the application of a base composition and a composition comprising a polyol The present invention relates to a cosmetic process for treating keratin fibres, preferably human keratin fibres such as the hair, in particular for conditioning keratin fibres, using a combination of at least two different compositions, the first composition comprising one or more oxyalkylenated, preferably oxyethylenated, silicones, one or more cationic surfactants, and less than 10% by weight of water relative to the total weight of the composition, and the second composition comprising water and one or more polyols. The invention also relates to a kit comprising the two compositions. Finally, the invention relates to a ready-to-use cosmetic composition for treating keratin fibres.
Type:
Grant
Filed:
March 30, 2018
Date of Patent:
September 20, 2022
Assignee:
L'OREAL
Inventors:
Anne-Sophie Brac De La Perriere, Sandrine Maggio